目录
更新日期:2022年9月23日
姓 名 张璐 性 别
民 族 汉族 导师层次 博士导师
技术职称 教授 导师类型 学术型
最后学历 博士研究生毕业 最后学位 医学博士
行政职务 主任 Email zlulu70@126.com
工作单位 广东省蛋白质组学重点实验室 邮政编码 510515
个人简介

张璐,南方医科大学基础医学院二级教授,博士生导师,博士后合作导师,广东省蛋白质组学重点实验室主任,病理生理学教研室副主任,精神健康研究教育部重点实验室PI。广东省“珠江学者”特聘教授,教育部新世纪优秀人才,广东省高等学校“千百十工程”省级培养对象。主要从事神经精神疾病信号机制与防治策略研究。主持国家自然科学基金重点项目及面上项目、广东省自然科学基金重点项目及粤港关键领域重点突破项目等二十多项基金课题。近五年通讯作者论文发表在Biological Psychiatry (13.382), Biomaterials (15.304), Aging Cell(11.005), Theranostics(11.6), Clin Microbiol Infect(13.31)等国际著名刊物上,SCI他引超过1800次。授权发明专利3项。

研究领域

围绕神经精神疾病的信号调控机制及防治策略开展了系列原创性工作。聚焦神经精神疾病神经可塑性机制,运用多组学、转基因/基因敲除小鼠、神经环路示踪技术及光/化学遗传学等方法,解析了神经精神疾病发生发展中突触可塑性变化及信号机制,鉴定了若干关键靶蛋白分子并进行功能学探讨,为神经退行性疾病及药物成瘾的防治提供新的思路和方法。

个人成果
  1. Li Ying, Jinlan Zhao, Yingshan Ye, Yutong Liu, Bin Xiao, Tao Xue, Hangfei Zhu, Yue Wu, Jing He, Sifei Qin, Yong Jiang, Fukun Guo, Lin Zhang*, N Liu* and Lu Zhang(张璐)*. Regulation of Cdc42 signaling by the dopamine D2 receptor in a mouse model of Parkinson’s disease. Aging Cell. 2022 May, 21(5): e13588 (IF= 11.005)
  2. Simin HuangXueer WangMin ZhangMianbo HuangYuan YanYinghua ChenYijia ZhangJinfu XuLingwei BuRuyi FanHuiyi TangCanjun ZengLu Zhang(张璐)* and Lin Zhang*. Activin B-activated Cdc42 signaling plays a key role in regulating adipose-derived mesenchymal stem cells-mediated skin wound healing. Stem Cell Res Ther. 2022 June 11, 13: 248 (IF= 8.079)
  3. Guohua Wang, Limei Chen, He Chen, Yitong Li, Yuesi Xu, Yanli Xing, Lu Zhang(张璐)* , Juan Li*. Affiliations Glutamate Receptor Interacting Protein 1 in the Dorsal CA1 Drives Alpha-amino-3-hydroxy-5-methyl-4-Isoxazolepropionic Acid Receptor Endocytosis and Exocytosis Bidirectionally and Mediates Forgetting, Exploratory, and Anxiety-like Behavior. Neuroscience. Neuroscience. 2022 Aug 21; 498:235-248.
  4. Liu Y, Montgomery SE, Juarez B, Morel C, Zhang S, Kong Y, Calipari ES, Nestler EJ, Zhang L(张璐)*, Han MH*. Different adaptations of dopamine release in Nucleus Accumbens shell and core of individual alcohol drinking groups of mice. Neuropharmacology. 2020 Jun 1;175:108176. (IF= 5.25)
  5. Genghong Tu, Li Ying, Liuzhen Ye, Jinlan Zhao, N Liu, Juan Li, Yutong Liu, Mengjuan Zhu, Yue Wu, Bin Xiao, Huidong Guo, Fukun Guo, Huijun Wang, Lin Zhang*, Lu Zhang(张璐)*. Dopamine D1 and D2 Receptors Differentially Regulate Rac1 and Cdc42 Signaling in the Nucleus Accumbens to Modulate Behavioral and Structural Plasticity After Repeated Methamphetamine Treatment. Biological Psychiatry. 2019 Dec 1; 86(11):820-835. (通讯作者) (IF= 13.382)
  6. Jinlan Zhao, Li Ying, Yutong Liu, N Liu, Genghong Tu, Mengjuan Zhu, Yue Wu, Bin Xiao, Liuzhen Ye, Juan Li, Fukun Guo, Lin Zhang*, Huijun Wang* and Lu Zhang(张璐)*. Different roles of Rac1 in the acquisition and extinction of methamphetamine-associated contextual memory in the nucleus accumbens. Theranostics. 2019 Sep 21; 9(23):7051-7071 (通讯作者) (IF= 11.556)
  7. Jinhua Xue, Yutong Liu, Mohammad Ali Darabic, Genghong Tu, Lu Huang, Li Ying, Bin Xiao, Yue Wu, Malcolm Xing, Lin Zhang*, Lu Zhang(张璐)*. An injectable conductive Gelatin-PANI hydrogel system serves as a promising carrier to deliver BMSCs for Parkinson's disease treatment. MAT SCI ENG C-MATER (通讯作者). 2019 July, 100:584-59 (IF=7.328)
  8. Min Zhang, Xueer Wang, Fukun Guo, Qin Jia, Yinghua Chen, Yuan Yan, Mianbo Huang, Huiyi Tang, Simin Huang, Ying Deng, Zhitao Zhou, Lu Zhang(张璐)*, and Lin Zhang*. Cdc42 deficiency leads to epidermal barrier dysfunction by regulating intercellular junctions and keratinization of epidermal cells during mouse skin development. Theranostics. Jul. 2019; 9(17): 5065-5084. (通讯作者) (IF= 11.556)
  9. Pei Tang, Xueer Wang, Min Zhang, Simin Huang, Chuxi Lin, Fang Yan, Ying Deng, Lu Zhang(张璐)* and Lin Zhang*. Activin B stimulates mouse vibrissae growth and regulates cell proliferation and cell cycle progression of hair matrix cells through ERK signaling. International Journal of Molecular Sciences, 2019; 20(4), 853,(通讯作者) (JCR 2 区) IF=5.923
  10. Xueer Wang, Pei Tang, Fukun Guo, Min Zhang, Yuan Yan, Mianbo Huang, Yinghua Chen, Lu Zhang(张璐)* and Lin Zhang*. mDia1 and Cdc42 regulate Activin B-induced migration of bone marrow-derived mesenchymal stromal cells. Stem Cells. 2019;37(1):150-162. (通讯作者)IF=6.022
  11. Lei Z, Singh G, Min Z, Shixuan C, Xu K, Pengcheng X, Xueer W, Yinghua C, Lu Z(张璐)*, Lin Z*. Bone marrow-derived mesenchymal stem cells laden novel thermo-sensitive hydrogel for the management of severe skin wound healing. MAT SCI ENG C-MATER , 2018 Sep 1;90:159-167 (通讯作者) (IF= 7.328)
  12. Yutong Liu, Juan Li, Kaige Xu, Jingjing Gu, Lu Huang, Lei Zhang, N. Liu, Jiming Kong, Malcolm Xing, Lin Zhang*, Lu Zhang*. Characterization of superparamagnetic iron oxide nanoparticle-induced apoptosis in PC12 cells and mouse hippocampus and striatum. Toxicol Lett. Aug. 2018; 292:151-161. (通讯作者) (IF: 4.372)
  13. Tian Z, Lv X, Zhang M, Wang X, Chen Y, Tang P, Xu P, Zhang L*, Wu B*, Zhang L*. Deletion of epithelial cell-specific Cdc42 leads to enamel hypermaturation in a conditional knockout mouse model. Biochim Biophys Acta -MOLECULAR BASIS OF DISEASE. 2018 Aug;1864 (8):2623-2632. (通讯作者) (IF=6.633)
  14. Pengcheng Xu, Min Zhang, Xueer Wang, Yuan Yan, Yinghua Chen, Wei Wu, Lu Zhang*, and Lin Zhang*. Antioxidative Effect of Quetiapine on Acute Ultraviolet-B-Induced Skin and HaCaT Cell Damage. International Journal of Molecular Sciences. 2018, 19(4), 953. (通讯作者), IF:4.556
  15. Lei Zhang, Lu Huang, Kangrong Lu, Yutong Liu, Genghong Tu, Li Ying, Mengjuan Zhu, Jinlan Zhao, N Liu, Fukun Guo, Lin Zhang*, and Lu Zhang*. Cocaine-induced synaptic structural modification is differentially regulated by dopamine D1 and D3 receptors-mediated signaling pathways. Addiction Biology. Nov. 2017 22(6) 1842-1855 (通讯作者), JCR 2区,  (IF: 5.578)
  16. Xionglin Chen, Min Zhang, Shixuan Chen, Xueer Wang, Zhihui Tian, Yinghua Chen, Pengcheng Xu, Lei Zhang, Lu Zhang*, Lin Zhang*. Peptide-modified Chitosan Hydrogel accelerates skin wound healing by promoting fibroblast proliferation, migration and secretion. Cell Transplantation. Aug. 2017;26(8) 1331–1340. (通讯作者)JCR 3 区, IF:4.064
  17. Xionglin Chen, Min Zhang, Xueer Wang, Yinghua Chen, Yuan Yan,Lu Zhang*, Lin Zhang*. Peptide-modified chitosan hydrogels promote skin wound healing by enhancing wound angiogenesis and inhibiting inflammation. American Journal of Translational Research. 2017 May 15;9(5):2352-2362. (通讯作者),JCR 3 区, IF:4.06
  18. Xueer Wang, Pei Tang, Fukun Guo, Min Zhang, Yinghua Chen, Yuan Yan, Zhihui Tian, Pengcheng Xu, Lei Zhang, Lu Zhang*, Lin Zhang*. RhoA regulates Activin B-induced stress fiber formation and migration of bone marrow-derived mesenchymal stromal cell through distinct signaling. BBA-General Subjects. Jan. 2017,1861:3011-3018. (通讯作者) (IF: 3.679)
  19. Juan Li, Mohammadali Darabi, Jingjing Gu, Junbing Shi, Jinhua Xue, Lu Huang, Yutong Liu, Lei Zhang, N Liu, Wen Zhong, Lin Zhang*, Malcolm Xing, Lu Zhang*. A drug delivery hydrogel system based on activin B for Parkinson's disease. Biomaterials. 2016 Sep,102:72-86 (通讯作者) (IF: 15.304