杨芳

南方医科大学珠江医院 胎儿医学与产前诊断科主任

香港大学产前诊断与胎儿医学专业博士

学术型&专业型博士生导师，博士后合作导师

国家妇幼司全国产前诊断专家组专家、国际妇产科超声学会(ISUOG)国际讲者（international speaker）、ISUOG官方中文翻译、ISUOG中国区委员、中国医师学会超声医师分会妇产超声学组委员、中国医学影像技术研究会超声分会妇产科专业委员会常委、中华预防医学会出生缺陷预防与控制专业委员会产前超声诊断学组委员、广东省超声医学工程学会常务理事、广东省医师协会超声医师分会妇产专业组委员、广东省医学会产前诊断学分会副主任委员等。

目前主持国家重点研发计划项目子课题1项、国家科技支撑计划课题1项、国家自然科学基金2项、广东省自然科学基金3项、广东省科技计划项目等省级以上课题13项。发表SCI文章40余篇，其中IF＞10分 3篇。擅长英语教学，曾获南方医科大学中青年教师授课大赛英语组一等奖。主译人民卫生出版社《Callen妇产科超声学》第六版及《胎儿治疗学》第二版。

无创产前诊断、胎儿生长受限的致病机制研究、单基因遗传病的致病机制研究、妇产超声学

1.Guo Y, Huang C, Xu C, Qiu L, Yang F. Dysfunction of ZNF554 promotes ROS-induced apoptosis and autophagy in Fetal Growth Restriction via the p62-Keap1-Nrf2 pathway. Placenta. 2023 Sep 30;143:34-44. 

2. Qianwen Lu # , Zhiwei Guo #, Jun Zhang #, Ke Wang, Qi Tian, Siping Liu , Kun Li, Cailing Xu, Caimin Li , Zenglu Lv, Zhigang Zhang*, Xuexi Yang*, Fang Yang*. Performance of whole-genome promoter nucleosome profling of maternal plasma cell-free DNA for prenatal noninvasive prediction of fetal macrosomia: a retrospective nested case-control study in mainland China. BMC Pregnancy Childbirth. 2022 Sep 10;22(1):698. 

3. Qiu L, Li C, Zheng G, Yang T, Yang F*. Microduplication of BTRC detected in a Chinese family with split hand/foot malformation type 3. Clin Genet. 2022 Jul 30.

4. Bo-Wei HAN, Fang YANG#, Zhi-Wei GUO#, Guo-Jun OUYANG, Zhi-Kun LIANG, Rong-Tao WENG, Xu YANG, Li-Ping HUANG, Ke WANG, Fen-Xia LI, Jie HUANG, Xue-Xi YANG*,Ying-Song WU*. Noninvasive inferring expressed genes and in vivo monitoring of the physiology and pathology of pregnancy using cell-free DNA. American Journal of Obstetrics and Gynecology,2020. 

5. Cailing Xu, Zhiwei Guo#, Jun Zhang# , Qianwen Lu, Qi Tian, Siping Liu, Kun Li, Ke Wang, Zixin Tao, Caimin Li, Zenglu Lv, Zhigang Zhang*, Xuexi Yang*, Fang Yang*. Non-invasive prediction of fetal growth restriction by whole-genome promoter profiling of maternal plasma DNA: a nested case-control study. BJOG, 2021,128(2):458-466.doi:10.1111/1471-0528.16292.

6. ZhiWei Guo; Fang Yang#; Jun Zhang#; Zhigang Zhang#; Kun Li; Qi Tian; Hongying Hou; Cailing Xu; Qianwen Lu; Zhonglu Ren; Xiaoxue Yang; Zenglu Lv; Ke Wang; Xinping Yang*; Yingsong Wu*; Xuexi Yang*. Whole-Genome Promoter Profiling of Plasma DNA Exhibits Diagnostic Value for Placenta-Origin Pregnancy Complications. Adv Sci, 2020;7(7):1901819. DOI: 10.1002/advs.201901819.

7. Liu S，Song L，Cram D S，Xiong L，Wang K，Wu R，Liu J，Deng K，Jia, B，Zhong M*，Yang F*，Traditional karyotyping vs copy number variation sequencing for detection of chromosomal abnormalities associated with spontaneous miscarriage. Ultrasound Obstet Gynecol,2015,46(4):472-477

8. Yang F，Leung K-Y，Hou Y-W，Yuan Y，Tang M H-Y，Birth-weight prediction using three-dimensional sonographic fractional thigh volume at term in a Chinese population. Ultrasound Obstet Gynecol,2011,38(4):425-433

9. Yang F，Leung K Y，Lee Y P，Chan H Y，Tang M H Y，Fetal biometry by an inexperienced operator using two- and three-dimensional ultrasound. Ultrasound Obstet Gynecol,2010,35(5):566-571

10. Wu J, Fu J, Li X, Xiong F*, Yang F*. Down-regulation of MYO1A inhibits trophoblast cell proliferation and migration through SMURF2/Hedgehog signaling pathway and leads to fetal growth restriction. Placenta. 2025 May 2;164:73-83

11.Xiao Y, Li M, Zheng S, Pan X, Peng Y, Ning P, Zhu G, Wan D, Hu D, Yang F*. Xu C, Alterations in maternal-fetal gut and amniotic fluid microbiota associated with fetal growth restriction. BMC Pregnancy Childbirth, 2024 Nov 8;24(1):728.

12.Guo Y, Huang C, Qiu L, Fu J, Xu C, Yang F* CircTHBS1 promotes trophoblast cell migration and invasion and inhibits trophoblast apoptosis by regulating miR-136-3p/IGF2R axis. FASEB J. 2024 Apr 15;38(7):e23598.