张福建，南方医科大学南方医院肾内科、器官衰竭防治国家重点实验室、国家肾脏病临床医学研究中心、广东省肾脏病研究所教授，博士生导师、博士后合作导师。主要从事肾脏再生的细胞与分子基础的研究工作。由于哺乳动物肾脏不能从头再生，目前广泛使用的实验动物小鼠模型无法满足肾脏再生研究的需要。我们开创性的建立了蝾螈肾脏再生研究模型，利用单细胞测序和遗传谱系示踪策略，寻找参与肾脏再生的细胞来源，并进一步探究肾脏再生的分子机制，为哺乳动物肾脏再生的转化研究提供理论基础和新的思路。以第一作者或通讯作者在Nature Reviews Nephrology, Kidney International, Journal of Clinical Investigation, Journal of the American Society of Nephrology, Theranostics, J Biol Chem, Mol Cell Proteomics等国际一流杂志上发表多篇SCI论文。主持国家重点研发计划“干细胞及转化研究”专项子课题1项，国家自然科学基金面上项目1项，广东省自然科学基金面上项目1项。担任Faculty 1000的撰稿人和Life Sciences，Theranostics等国际学术杂志的审稿人。学术兼职担任中国细胞生物学会细胞器分会委员，广东省精准医学应用学会遗传病分会常务委员。

肾脏再生的细胞与分子基础

Li J, Chen LT, Wang YL, Kang MX, Liang ST, Hong XZ, Hou FF, Zhang F^#. Inhibition of HIF-prolyl hydroxylase promotes renal tubule regeneration via the reprogramming of renal proximal tubular cells. Acta Pharmacol Sin. (2025) (IF=8.42) (#Corresponding author)

Chen L, Li J, Ou Y, Kang M, Deng J, Wang Y, Hong X, Gong S, Fei JF,  Hou FF^# and Zhang F^#. The axolotl kidney: a novel model to study kidney regeneration. Kidney International. 2023; 104(3):599-604. doi: 10.1016/j.kint.2023.05.020  (IF=19.6) (#Corresponding author)

Liang S, Wang Y, Kang M, Deng J, Chen L, Hong X, Hou FF^# and Zhang F^#. Generation and characterization of an inducible renal proximal tubule- specific CreERT2 mouse. Front. Cell Dev. Biol. 2023; 11:1171637. doi: 10.3389/fcell.2023.1171637  (IF=5.5) (#Corresponding author)

Hong X, Nie H, Deng J, Liang S, Chen L, Li J, Gong S, Wang G, Zuo W, Hou FF^#, Zhang F^#. WT1⁺ glomerular parietal epithelial progenitors promote renal proximal tubule regeneration after severe acute kidney injury. Theranostics. 2023; 13(4):1311-1324.

doi: 10.7150/thno.79326. (IF=12.4) (#Corresponding author)

Feng X, Hong X, Fan Q, Chen L, Li J, Deng J, Gong S, Hou FF^#, Zhang F^#. dCubilin- or dAMN-mediated protein reabsorption in Drosophila nephrocytes modulates longevity. Dis Model Mech. 2021; 14(9):dmm047464. doi: 10.1242/dmm.047464. (IF=5.73) (#Corresponding author)

Wen P*, Zhang F*, Fu Y, Zhu JY, Han Z. Exocyst Genes Are Essential for Recycling Membrane Proteins and Maintaining Slit Diaphragm in Drosophila Nephrocytes. J Am Soc Nephrol. 2020; 31(5):1024-1034. (IF=14.98) (*Co-first author)

Fu Y*, Zhu JY*, Zhang F*, Richman A, Zhao Z, Han Z. Comprehensive functional analysis of Rab GTPases in Drosophila nephrocytes. Cell Tissue Res. 2017; 368(3):615-627. (IF=4.05) (*Co-first author)

Fu Y, Zhu JY, Richman A, Zhao Z, Zhang F, Ray PE, Han Z. A Drosophila model system to assess the function of human monogenic podocyte mutations that cause nephrotic syndrome. Hum Mol Genet. 2017; 26(4):768-780. (IF=6.39)

Gee HY*, Zhang F*, Ashraf S, Kohl S, Sadowski CE, Vega-Warner V, Zhou W, Lovric S, Fang H, Nettleton M, Zhu JY, Hoefele J, Weber LT, Podracka L, Boor A, Fehrenbach H, Innis JW, Washburn J, Levy S, Lifton RP, Otto EA, Han Z, Hildebrandt F. KANK deficiency leads to podocyte dysfunction and nephrotic syndrome. Journal of Clinical Investigation. 2015; 125(6):2375-84. (IF=19.46) (*Co-first author)

Zhang F^#, Chen X. The Drosophila nephrocyte has a glomerular filtration system. Nature Reviews Nephrology. 2014; 10(9) 491  (IF=42.43) (#Corresponding author)

Luo CJ*, Zhang F*, Zhang L, et al.  Mesenchymal stem cells ameliorate sepsis-associated acute kidney injury in mice. Shock. 2014; 41(2):123-9. (IF=2.6) (*Co-first author)

Zhang F, Zhao Y, Chao Y, Muir K, Han Z. Cubilin and amnionless mediate protein reabsorption in Drosophila nephrocytes. Journal of the American Society of Nephrology. JASN 2013; 24(2): 209-216  (IF=9.66)

Zhang F, Zhao Y, Han Z.  An In vivo functional analysis system for renal gene discovery in Drosophila pericardial nephrocytes.  Journal of the American Society of Nephrology.  JASN 2013; 24(2): 191-197 (IF=9.66)

Ström AL, Shi P, Zhang F, Gal J, Kilty R, Hayward LJ, Zhu H. Interaction of ALS-related mutant copper-zinc superoxide dismutase with the dynein-dynactin complex contributes to inclusion formation. J Biol Chem. 2008; 283(33):22795-805. (IF=5.6)

Zhang F, Ström AL, Fukada K, Lee S, Hayward LJ, Zhu H. Interaction between familial amyotrophic lateral sclerosis (ALS)-linked SOD1 mutants and the dynein complex. J Biol Chem. 2007; 282(22):16691-9. (IF=5.6)

Gal J, Strom AL, Kilty R, Zhang F, Zhu H.  p62 accumulates and enhances aggregate formation in model systems of familial amyotrophic lateral sclerosis.  J Biol Chem 2007; 282(15):11068-77. (IF=5.6)

Zhang F and Zhu, H.  In vivo conformational alterations of mutant SOD1 and its implications for fALS-associated SOD1 mutant induced motor neuron cell death. BBA General Subject 2006; 1760(3):404-14. (IF=5.0)

Fukada K, Zhang F, Vien A, Cashman NR, Zhu H. Mitochondrial proteomic analysis of a cell line model of familial amyotrophic lateral sclerosis. Mol Cell Proteomics. 2004; 12: 1211-23. (IF=8.35)