南方医科大学南方医院口腔医学中心副研究员、博士后,四川大学华西口腔医学院博士
美国Tufts大学牙学院访问学者,中华口腔医学会第八届牙周病学专业委员会 青年委员
研究方向:主要从事牙周病分子药物开发及牙周细胞通讯研究。主持国家自然科学基金青年项目、中国博士后基金面上项目、广东省自然科学基金青年项目、广州市基础与应用基础研究青年博士启航项目、广东省口腔医学重点实验室开放课题、广东省医学科研基金项目等。以第一或通讯作者(含共同)发表SCI源刊物论文22篇,包括J Adv Res、Br J Pharmacol、J Clin Periodontol、Adv Healthc Mater、Int J Oral Sci、Clin Oral Implants Res 等。申请国家发明专利1项,授权美国发明专利1项。
出版专著:
第一版 四川大学精品立项教材《口腔微生物学实验指导》,参编第三章口腔微生物的鉴定技术部分. 成都:四川大学出版社,字数:7.8万字 (2016年)
发明专利:
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发明人(1/4). 一种新型脂联素受体激动剂及其用途. 2021-12-08. 中国. CN202111494315.2. (国家发明专利)
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发明人(5/5). Using adiponectin receptor agonists to treat inflammation and bone diseases in diabetes. 2021-12-14. 美国. 17/550,834. (国际发明专利)
荣誉和奖励:
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2023.08 第九届“全国大学生基础医学创新研究暨实验设计论坛”本科院校总决赛(国家级)口腔医学赛道创新研究银奖 指导教师
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2023.09 中华口腔医学会口腔科研管理分会“青年科学家报告”二等汇报
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2023.06 中华口腔医学会牙周专委会 “高水平论文汇报”鳌头之星
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2021.12 第一届中国博士后创新创业大赛“海外赛”总决赛
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2018.09 美国骨与矿化研究学会(ASMBR) 2018年会“旅行经费补贴”奖
主要从事牙周病小分子药物开发及牙周细胞通讯机制方向研究。
科研课题(主持国科金1项,省自然1项,博后基金1项,总经费超60万元):
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课题负责人(1/1). 广州市基础与应用基础研究青年博士“启航”项目. 课题名称:牙髓干细胞外泌体通过ceRNA方式调控神经干细胞分化修复脊髓损伤的研究. 课题编号:2024A04J5105. 课题经费:5万元. 时间:2024.01.01-2025.12.31
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课题负责人(1/5). 广东省口腔医学重点实验室开放课题. 课题名称:新型脂联素受体激动剂AdipoAI抑制破骨细胞分化治疗糖尿病型牙周炎的功能和机制研究. 课题编号:KF2022120103. 课题经费:3万元. 时间:2023.01.01-2024.12.31
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课题负责人(1/1). 国家自然科学基金青年项目. 课题名称:新型脂联素受体激动剂AdipoAI通过APPL1/MyD88/c-Maf新途径抑制糖尿病型牙周炎破骨细胞分化的作用和机制研究. 课题编号:82101024. 课题经费:30万元. 时间:2022.01.01-2024.12.31
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课题负责人(1/1). 广东省区域联合基金青年项目. 课题名称:APPL1/MyD88/c-Maf轴介导脂联素受体激动剂治疗糖尿病大鼠种植体周围炎的机制研究. 课题编号:2020A1515110027. 课题经费:10万元. 时间:2020.10.01-2023.9.30
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课题负责人(1/5). 广东省医学科学技术研究基金项目. 课题名称:脂联素受体激动剂AdipoAI调控糖尿病型牙周炎症疾病骨代谢的研究. 课题编号:A2020090. 课题经费:1万元. 时间:2020.07.01-2022.06.30
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课题负责人(1/1). 中国博士后科学基金面上项目. 课题名称:AdipoAI治疗糖尿病型牙周炎症性疾病的研究. 课题编号:2019M663009. 课题经费:8万元. 时间:2020.01.01-2021.12.31
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课题负责人(1/8). 南方医院院长基金面上项目. 课题名称:新型脂联素受体激动剂AdipoAI治疗糖尿病型牙周炎症性疾病的研究及机制初探. 课题编号:2019B002. 课题经费:5万元. 时间:2020.01.01-2022.12.31
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指导老师(1/1). 大学生创新创业训练计划项目(省级). 课题名称:AdipoAI抑制牙龈成纤维细胞necroptosis治疗牙周炎的机制研究. 课题编号:S202312121170. 课题经费:0.5万元. 起止时间:2023.01.01-2024.12.31
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指导老师(1/1). 大学生创新创业训练计划项目(省级). 课题名称:新型小分子化合物治疗种植体周围炎骨损伤. 课题编号:S202212121115. 课题经费:0.5万元. 起止时间:2022.01.01-2023.12.31
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指导老师(2/2). 大学生创新创业训练计划项目(校级). 课题名称:新型脂联素受体激动剂AdipoAI局部用药缓解小鼠实验性牙周炎的研究. 课题编号:202112121199. 课题经费:0.2万元. 起止时间:2021.01.01-2022.12.31
发表文章(以第一或通讯发表SCI论文22篇,中科院1区5篇,总IF>108):
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Wei Qiu#, Ruiming Guo#, Hongwen Yu#, Xiaoxin Chen, Zehao Chen, Dian Ding, Jindou Zhong, Yumeng Yang, Fuchun Fang*. Single-cell atlas of human gingiva unveils a NETs-related neutrophil subpopulation regulating periodontal immunity. J Adv Res. 2024; S2090-1232(24): 00312-6.
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Wei Qiu#, Bangyi Zhou#, Yifei Luo#, Yuanting Chen#, Zehao Chen, Keke Wu 4, Hongle Wu, Buling Wu, Jinshan Guo, Fuchun Fang*. An Optimized Decellularized Extracellular Matrix from Dental Pulp Stem Cell Sheets Promotes Axonal Regeneration by Multiple Modes in Spinal Cord Injury Rats. Adv Healthc Mater. 2024; e2402312. doi: 10.1002/adhm.202402312.
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Dian Ding, Na Li, Yihong Ge, Hongle Wu, Jinzhao Yu, Wei Qiu*, Fuchun Fang*. Current status of superoxide dismutase 2 on oral disease progression by supervision of ROS. Biomed Pharmacother. 2024; 175: 116605. doi: 10.1016/j.biopha.2024.116605.
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Qiu W#, Sun Q#, Li N#, Chen Z, Wu H, Chen Z, Guo X, Fang F*. Superoxide dismutase 2 scavenges ROS to promote osteogenic differentiation of human periodontal ligament stem cells by regulating Smad3 in alveolar bone-defective rats. J Periodontol. 2024; 95(5): 469-482. (IF=4.3,中科院小类2区)
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Qiu W#, Wang Z#, Chen Z#, Sun Q, Wu H, Chen Z, Luan K, Liu Z, Ding D, Tu Q, Chen J, Wu B*, Fang F*. The adiponectin receptor agonist AdipoAI attenuates periodontitis in diabetic rats by inhibiting gingival fibroblast-induced macrophage migration. Br J Pharmacol. 2023; 180(18): 2436-2451. (IF=7.3,中科院小类1区)
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Qiu W#, Chen Z#, Wang Z#, Chen Y, Luan K, Zhang K, Yu H, Tu Q, Chen J, Wu H*, Fang F*. AdipoAI suppresses osteoclastogenesis by activating AdipoR1/APPL1: An in vivo experimental study in diabetes-associated peri-implantitis. Clin Oral Implants Res. 2023; 34(6): 602-617. (IF=4.3,中科院小类1区)
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Yu H#, Wu H#, Xie Q#, Liu Z, Chen Z, Tu Q, Chen J, Fang F*, Qiu W*. Construction of ceRNA and m6A-related lncRNA networks associated with anti-inflammation of AdipoAI. Front Immunol. 2023; 13: 1051654. (IF=7.3,中科院小类2区)
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Zhang K, Chen X, Zhou R, Chen Z, Wu B*, Qiu W*, Fang F*. Inhibition of gingival fibroblast necroptosis mediated by RIPK3/MLKL attenuates periodontitis. J Clin Periodontol. 2023; 50(9): 1264-1279. (IF=6.7,中科院小类1区Top期刊)
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Chen Y, Huang H, Li G, Yu J, Fang F*, Qiu W*. Dental-derived mesenchymal stem cell sheets: a prospective tissue engineering for regenerative medicine. Stem Cell Res Ther. 2022; 13(1): 38. (IF2022=8.079,中科院小类2区)
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Liu W#, Qiu W#, Huang Z, Zhang K, Wu K, Deng K, Chen Y, Guo R, Wu B*, Chen T*, Fang F*. Identification of nine signature proteins involved in periodontitis by integrated analysis of TMT proteomics and transcriptomics. Front Immunol. 2022; 13: 963123. (IF2022=8.786,中科院小类2区)
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Wu H#, Qiu W#, Zhu X, Li X, Xie Z, Carreras I, Dedeoglu A, Van Dyke T, Han YW, Karimbux N, Tu Q, Cheng L*, Chen J*. The Periodontal Pathogen Fusobacterium nucleatum Exacerbates Alzheimer's Pathogenesis via Specific Pathways. Front Aging Neurosci. 2022. 14: 912709. (IF2022=5.7,中科院小类3区)
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Luo Y#, Qiu W#, Wu B, Fang F*. An Overview of Mesenchymal Stem Cell-based Therapy Mediated by Noncoding RNAs in the Treatment of Neurodegenerative Diseases. Stem Cell Rev Rep. 2022; 18(2): 457-473. (IF2022=6.692, 中科院小类3区)
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Qiu W#, Wu H#, Hu Z, Wu X, Tu M, Fang F, Zhu X, Liu Y, Lian J, Valverde P, Van Dyke T, Steffensen B, Dong LQ, Tu Q, Zhou X*, Chen J*. Identification and characterization of a novel adiponectin receptor agonist AdipoAI and its anti-Inflammatory effects in vitro and in vivo. Br J Pharmacol. 2021. 178: 280–297. (IF2021=9.473,中科院小类1区Top期刊)
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Wang Z, Chen Z, Fang F*, Qiu W*. The role of adiponectin in periodontitis: Current state and future prospects. Biomed Pharmacother. 2021; 137: 111358. (IF2021=7.419, 中科院小类1区)
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Li J, Wang Z, Huang X, Wang Z, Chen Z, Wang R, Chen Z, Liu W, Wu B*, Fang F*, Qiu W*. Dynamic proteomic profiling of human periodontal ligament stem cells during osteogenic differentiation. Stem Cell Res Ther. 2021; 12(1): 98. (IF2021=8.079, 中科院小类2区)
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Chen Z, Wang Z, Qiu W*, Fang F*. Overview of Antibacterial Strategies of Dental Implant Materials for the Prevention of Peri-Implantitis. Bioconjugate Chem. 2021; 32(4): 627-638. (IF2021=6.069, 中科院小类2区)
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Qiu W, Wu BL, Fang FC*. Overview of noncoding RNAs involved in the osteogenic differentiation of periodontal ligament stem cells. World J Stem Cells. 2020; 12(4): 251-265. (IF2020=5.326, 中科院小类3区)
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Xiao X, Xin C, Zhang Y, Yan J, Chen Z, Xu H, Liang M, Wu B, Fang F*, Qiu W*. Characterization of odontogenic differentiation from human dental pulp stem cells using TMT-based proteomic analysis. Biomed Res Int. 2020. 2020: 3871496. (IF2020=3.411,中科院小类3区)
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Qiu W, Zhou Y, Li Z, Huang T, Xiao Y, Cheng L, Peng X, Zhang L*, Ren B*. Application of antibiotics/antimicrobial agents on dental caries. Biomed Res Int. 2020. 2020: 5658212. (IF2020=3.411,中科院小类3区)
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Qiu W#, Ren B#, Dai H, Zhang L, Zhang Q, Zhou X, Li Y*. Clotrimazole and econazole inhibit Streptococcus mutans biofilm and virulence in vitro. Arch Oral Biol. 2017. 73: 113-120. (IF2017=2.05,中科院小类3区)
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Jiang YL#, Qiu W#, Zhou XD, Li H, Lu JZ, Xu HH, Peng X, Li MY, Feng MY, Cheng L*, Ren B*. Quaternary ammonium induced multi-drug tolerant Streptococcus mutants persisters elevate cariogenic virulence in vitro. Int J Oral Sci. 2017. 9(12): e7,1-8. (IF2017=4.138,中科院小类2区)
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Qiu W#, Zheng X#, Wei Y, Zhou X, Zhang K, Wang S, Cheng L, Li Y, Ren B, Xu X, Li Y, Li M*. D-alanine metabolism is essential for growth and biofilm formation of Streptococcus mutans. Mol Oral Microbiol. 2016. 31(5): 435-444. (IF2016=2.908,中科院小类2区)