项目课题情况:
1)广州市科技计划 负载唑来膦酸的Ca-NMOFs@AuNSs用于骨质疏松症骨折后愈合的诊疗一体化研究2022.01-2023.12,5万,主持,在研;经费尚未拨付
2)广东省自然科学基金项目,2018A03031300198,hUCMSCs通过调控NLRP3炎症小体抑制内毒素血症的机制研究,2018.05-2021.4,10万,主持,在研;
3)广州市科学技术协会,南方医科大学第三附属医院携手广州赛莱拉干细胞科技股份有限公司对接华工社区实施“走近干细胞---点燃生命之美”科普益民项目,20190101, 2019.01-2019.12,10万,主持,结题;
4)广州市天河区科技计划项目,201704KW035,hUCMSCs对内毒素血症小鼠模型治疗作用的研究,2017.01-2019.12,1万,主持,结题。
5)天河区重大专项 10万 ,主持,结题。
近5年发表代表性论文如下:
1.Shuqin Zhang, Linrui Jiang, Huazhong Hu, Hong Wang, Xiaoyan Wang, Jiaohua Jiang, Yanyan Ma, Jing Yang, Yu Hou, Denghui Xie, Qun Zhang*. Pretreatment of exosomes derived from hUCMSCs with TNF-α ameliorates acute liver failure by inhibiting the activation of NLRP3 in macrophage. Life Sci. 2020 Apr 1;246:117401. (通讯作者,JCR 3区,IF: 3.4)
2. Shuqin Zhang, Yu Hou, Jing Yang, Denghui Xie, Linrui Jiang, Huazhong Hu, Jingjing Hu, Caizhu Luo, Qun Zhang*. Application of mesenchymal stem cell exosomes and their drug-loading systems in acute liver failure. J Cell Mol Med. 2020 Jul;24(13):7082-7093. (通讯作者,JCR 3区,IF:4.486)
3. Linrui Jiang, Shuqin Zhang, Huazhong Hu, Jing Yang, XiaoYan Wang, Yanyan Ma, JiaoHua Jiang, JinHong Wang, Lin Zhong, Ming Chen, Hong Wang, Yu Hou, RuiRui Zhu, Qun Zhang*. Exosomes derived from human umbilical cord mesenchymal stem cells alleviate acute liver failure by reducing the activity of the NLRP3 inflammasome in macrophages. Biochem Biophys Res Commun. 2019 Jan 15;508(3):735-741. (通讯作者,JCR 3区,IF:2.985)
4. Ting Wu, Haixin Li, Qunsheng Lan, Ze-An Zhao, Ying Cao, Pingzheng Zhou, Shanhe Wan, Jiajie Zhang, Hong Jiang, Qun Zhang*, Jianxin Pang*. Protective effects of S-carvedilol on doxorubicin-induced damages to human umbilical vein endothelial cells and rats. J Appl Toxicol. 2019 Aug;39(8):1233-1244. (JCR 3区,IF:2.997)
5. Haixin Li, Ying Huang, Xian Wu, Ting Wu, Ying Cao, Qimei Wang, Yuchang Qiu, Weiming Fu, Qun Zhang*, Jianxin Pang*. Effects of hemocoagulase agkistrodon on the coagulation factors and its procoagulant activities. Drug Des Devel Ther. 2018 May 23;12:1385-1398. (JCR 3区,IF:3.216)
6. Hai Liu#, Huangrong Zhu#, Liang Cheng#, Yitao Zhao, Xizhong Chen, Jintao Li, Xin Xv, Zhisheng Xiao, Wei Li, Jianying Pan, Qun Zhang* Chun Zeng*, Jinshan Guo*, Denghui Xie*, Daozhang Cai. TCP/PLGA composite scaffold loaded rapamycin in situ enhances lumbar fusion by regulating osteoblast and osteoclast activity. J tissue Engineering and Regenerative Medicine. 2021.02.24. (JCR 2区,IF:3.07)
7. Wei Li#, Jianying Pan#, Huangrong Zhu#, Qun Zhang*, Jinshan Guo*, Denghui Xie*. The application of platelet-rich plasma in the treatment of knee osteoarthritis: A literature review. J Orthop Sci, 2021.01.19. (JCR 3区,IF:1.25)
8.杨静,胡华钟,张书勤,姜琳瑞,程远雄,谢浩俊,王小燕,姜交华,王红,张群*.脐带间充质干细胞来源的外泌体通过抑制上皮间质转化缓解肺纤维化[J].南方医科大学报,2020,40(07):988-994.(通讯作者)
9.姜琳瑞,王小燕,张群*,张书勤,杨静,王红,胡华钟.脐带间充质干细胞对脓毒症小鼠的器官保护作用及其机制[J].解放军医学杂志,2018,43(10):860-865.(通讯作者)
10. 张书勤, 张群*,谢登辉*. 柠檬酸在骨质疏松疾病中作用的研究进展[J].中华老年骨科与康复电子杂志, 2021,7(4):245-251.(共同通讯)
11. Yinghua Zhao,1 Qun Zhang*,1 Wei Li,1 Yanqiu Feng,2 Yihao Guo,2 Zhiming Xiang,3 and Shaolin Li1,4.Assessment of Correlation between Intravoxel Incoherent Motion Diffusion Weighted MR Imaging and Dynamic Contrast-Enhanced MR Imaging of Sacroiliitis with Ankylosing Spondylitis.(共一,JCR3区,3.246)
12. Shuqin Zhang, Denghui Xie*, Qun Zhang*;Mesenchymal stem cells plus bone repair materials as a therapeutic strategy for abnormal bone metabolism: Evidence of clinical efficacy and mechanisms of action implied. (通讯作者,JCR 2区,IF: 7.68)
13. Yu Hou, Cai-Zhu Luo, Deng-Hui Xie, Jing-Jing Hu, Jin-Xiang Chen, Nai-Han Huang,Hong Wang, Shu-Qing Zhang, and Qun Zhang*. Convenient synthesis of zwitterionic calcium(II)-carboxylate metal organic frameworks with efficient activities for thetreatment of osteoporosis.(通讯作者,JCR 2区,IF: 5.8)
14. Zean Zhaoa#, Jin Liua#, Peihua Kuanga#, Jian Luoa, Goverdhan Surinenia, Xiaolin Cenb, Ting Wua, Ying Caoa, Pingzheng Zhoua, Jianxin Panga*, Qun Zhangb*, Jianjun Chena*Discovery of Novel Verinurad Analogs as Dual Inhibitors of URAT1 and GLUT9 with Improved Druggability for the Treatment of Hyperuricemia(通讯作者,JCR1区,IF:7.09)
15. Zean Zhaoa#, Jin Liua#, Lin Yuana#, Zichao Yanga#, Peihua Kuanga, Hui Liaoa, Jian Luoa, Huancun Fengb, Fengxin Zhenga, Yongjun Chena, Ting Wua, Jiayin Guoa, Ying Caoa, Yang Yanga, Cuiting Lina, Qun Zhangb*, Jianjun Chena*, Jianxin Panga*Discovery of Novel Benzbromarone Analogs with Improved Pharmacokinetics and Benign Toxicity Profiles as Antihyperuricemic Agents.(通讯作者,JCR1区,IF:6.514)
16. Zean Zhao, Jian Luo, Hui Liao, Fengxin Zheng, Xinhua Chen, Jiajun Luo, Yongjun Chen, Kunlu Zhao, Shuqin Zhang, Jinhong Tian, Ting Wu, Yongmei Li, Lu Li, Yang Yang, Cuiting Lin, Qun Zhang* , Yuanxin Tian*, Jianxin Pang*.Pharmacological evaluation of a novel skeleton compound isobavachin (4',7-dihydroxy-8-prenylflavanone) as a hypouricemic agent: Dual actions of URAT1/GLUT9 and xanthine oxidase inhibitory activity. (通讯作者,JCR1区,IF:5.31)
近期发表的管理论文
1. 孙林敏,蔡道章,昌远婷,邱洁,李永强,张群.基于智能模拟人的医学模拟教学效果评价[J].现代医院管理,2021,19(01):64-66+87.(通讯作者)
2. 孙林敏,蔡道章,张群,孙昌朋,林萍,郎朗,陈望忠.基于COSO框架的公立医院物资采购内部控制评价指标体系构建研究[J].成都医学院学报,2021,16(02):245-248.
3. 孙林敏,陈望忠,张群,冯晓晴,蔡道章.借鉴国外医院成本控制对我国医疗控费的启示及对策探讨[J].中国医药导报,2021,18(07):161-164.
4.王亚洲,张群,蒋明珠,黄冠朝,陈进发.新形势下高校社区电子商务的可持续发展战略选择.电子商务,2016,(10):61-64. (通讯作者)
5.王亚洲,蒋明珠,张群.零边际成本趋势下分享经济的发展问题探讨[J].电子商务,2017(02):11-12+14.(通讯作者)
6. 张群,蔡道章,王亚男,李德龙,邓金泉,刘俐,邓永萍,张华英,费蔚春,杨世胜,李亮亮.3G智能血压计的开发及其测量老年人血压的准确性评价[J].中国全科医学,2017,20(17):2147-2149.