目录
更新日期:2025年10月13日
姓 名 蔡开灿 性 别
民 族 汉族 导师层次 博士导师
技术职称 主任医师 导师类型 学术&专业型
最后学历 博士研究生毕业 最后学位 医学博士学位
行政职务 主任 Email doc_cai@163.com
工作单位 南方医科大学南方医院 邮政编码 510515
个人简介
南方医科大学南方医院胸外科学术带头人、二级教授、主任医师、博士生导师、博士后导师。
  擅长胸外科各类微创手术(胸腔镜、达芬奇辅助下):肺结节、肺癌、食管癌、胸腔肿瘤、纵隔肿瘤、胸壁畸形、多汗症等。是国内最早开展纵隔镜联合腹腔镜食管癌手术的学者之一,首创性开展“三孔式”食管癌根治术。善于处理复杂疑难手术:肺癌扩大根治术(上腔静脉重建,支气管、肺动脉袖式切除,隆突重建),胸壁、胸腔、纵隔巨大肿瘤切除术,慢性阻塞性肺疾病肺气肿性肺大疱切除术(肺减容术)等。 
  现任中国医药教育协会胸外科专业委员会主任委员、广东省医学会胸外科学分会主任委员、国家胸外科医疗质量控制中心委员、广东省医学会胸外科学分会青年委员会主任委员、 中华医学会胸心血管外科学分会委员兼胸腔镜外科学组委员、中国医师协会胸外科分会委员兼创伤外科专委会副主任委员、中国抗癌协会食管癌专业委员会委员、世界华人肿瘤医师协会胸部肿瘤专委会副主任委员、中国胸外科肺癌联盟委员、中国医师协会整合医学分会胸外科专委会常务委员、中国整形美容协会肿瘤整复分会常务委员、海峡两岸医药卫生交流协会胸外科分会常务委员、吴阶平医学基学会模拟医学部胸外科专业委员会副主任委员、广东省抗癌协会副理事长、广东省抗癌协会食管癌专委会副主任委员、广州抗癌协会肺癌专业委员会副主任委员、广东省医疗行业协会胸外科管理分会副主任委员、海峡两岸肿瘤防治专家委员会胸部肿瘤专业副主任委员、广州市医学会血液保护分会副主任委员。主编、副主编专著4部,获广东省科技进步一等奖1项,广东省医学科技二等奖1项,中国医药教育协会科学技术奖创新二等奖3项,全军医疗成果三等奖1项,负责承担国家级课题3项(2022年国家自然科学基金面上项目负责人,DNA解旋酶HELQ通过相分离调控DNA损伤修复介导肺癌化疗耐药的分子机制研究;2023年科技部重点研发项目子课题负责人,肺外周结节前瞻性临床队列及大数据平台建立;2025年国家自然科学基金面上项目负责人,DNA解旋酶HELQ调控R-loop解旋调节食管鳞癌免疫治疗疗效的机制研究),广东省、广州市科技计划项目6项,发表各类学术论文100多篇,SCI 20多篇。培养研究生30多人。理论基础扎实,外科手术技能精湛,为国内胸外科领域知名的胸外科专家,荣获岭南名医、羊城好医生等称号。连续举办全国性胸腔镜微创手术高级研习班8届,带领的胸外科微创培训中心通过英国皇家外科学院论证。
 
 

 

研究领域

肺癌、食管癌及胸部常规微创手术的研发及推广;

肺癌、食管癌综合治疗;

肺癌、食管癌发病、进展、化疗耐药分子机制研究。

 

个人成果

1.Shi, X., Dong, X., Zhai, J., Liu, X., Lu, D., Ni, Z., Wu, H., & Cai, K. (2021). Current Evidence of the Efficacy and Safety of Neoadjuvant EGFR-TKIs for Patients With Non-small Cell Lung Cancer. Frontiers in oncology.

2.Lu, Di et al. “Classification of Metastatic and Non-Metastatic Thoracic Lymph Nodes in Lung Cancer Patients Based on Dielectric Properties Using Adaptive Probabilistic Neural Networks.” Frontiers in oncology vol. 11 640804. 5 Mar. 2021

3.Diao, Dingwei et al. “Delivery of gefitinib with an immunostimulatory nanocarrier improves therapeutic efficacy in lung cancer.” Translational lung cancer research vol. 10,2 (2021): 926-935. 

4.Lu, Di et al. “Differential effects of adjuvant EGFR tyrosine kinase inhibitors in patients with different stages of non-small-cell lung cancer after radical resection: an updated meta-analysis.” Cancer management and research vol. 11 2677-2690. 2 Apr. 2019.

5.Feng, Siyang et al. “TUSC3 accelerates cancer growth and induces epithelial-mesenchymal transition by upregulating claudin-1 in non-small-cell lung cancer cells.” Experimental cell research vol. 373,1-2 (2018): 44-56. 

6.Shi, Xiaoshun et al. “IRGS: an immune-related gene classifier for lung adenocarcinoma prognosis.” Journal of translational medicine vol. 18,1 55. 4 Feb. 2020.

7.Lu, Di et al. “Clinicopathological features, survival outcomes, and appropriate surgical approaches for stage I acinar and papillary predominant lung adenocarcinoma.” Cancer medicine vol. 9,10 (2020): 3455-3462. 

8.Mai, Shijie et al. “Oesophageal squamous cell carcinoma-associated IL-33 rewires macrophage polarization towards M2 via activating ornithine decarboxylase.” Cell proliferation vol. 54,2 (2021): e12960. 

9.Ren P, Zhai J, Wang X, Yin Y, Lin Z, Cai K, Wang H. Inhibition of BPHL inhibits proliferation in lung carcinoma cell lines. Transl Lung Cancer Res. 2023 May 31;12(5):1051-1061. doi: 10.21037/tlcr-23-225. Epub 2023 May 29. PMID: 37323178; PMCID: PMC10261862 (IF:4.0)

10.Chen Z, Cai Y, Ou T, Zhou H, Li H, Wang Z, Cai K. Global burden of mesothelioma attributable to occupational asbestos exposure in 204 countries and territories: 1990-2019. J Cancer Res Clin Oncol. 2024 May 28;150(5):282. doi: 10.1007/s00432-024-05802-6. PMID: 38806867; PMCID: PMC11133219(IF:2.7)

11.Chen Z, Zhang X, Zhai J, Fan J, Cai Y, Ye T, Wang Z, Cai K. Global burden of esophageal cancer attributable to high BMI in 204 countries and territories: 1990-2019. Thorac Cancer. 2024 Mar;15(9):681-692. doi: 10.1111/1759-7714.15239. Epub 2024 Feb 5. PMID: 38316627; PMCID: PMC10961222.(IF:2.3)

12.Lu D, Wu X, Wu W, Wu S, Li H, Zhang Y, Yan X, Zhai J, Dong X, Feng S, Zhang X, Sun F, Wang S, Cai K. Plasma cell-free DNA 5-hydroxymethylcytosine and whole-genome sequencing signatures for early detection of esophageal cancer. Cell Death Dis. 2023 Dec 19;14(12):843. doi: 10.1038/s41419-023-06329-3. PMID: 38114477; PMCID: PMC10730877.(IF:8.1)

13.Guo Q, Yu W, Tan J, Zhang J, Chen J, Rao S, Guo X, Cai K. Remodelin delays non-small cell lung cancer progression by inhibiting NAT10 via the EMT pathway. Cancer Med. 2024 Jun;13(11):e7283. doi: 10.1002/cam4.7283. PMID: 38826095; PMCID: PMC11145023.(IF:3.1)

14.Liu T, Zou B, He M, Hu Y, Dou Y, Cui T, Tan P, Li S, Rao S, Huang Y, Liu S, Cai K, Wang D. LncReader: identification of dual functional long noncoding RNAs using a multi-head self-attention mechanism. Brief Bioinform. 2023 Jan 19;24(1):bbac579. doi: 10.1093/bib/bbac579. PMID: 36575567.(IF:9.5)

15.Wang Y, Cao N, Cui X, Liu Z, Yuan X, Chen S, Xu H, Yi M, Ti Y, Zheng F, Cai K. Detection of circulating tumor cells using a microfluidic chip for diagnostics and therapeutic prediction in mediastinal neuroblastoma. Eur J Pediatr. 2024 Dec 20;184(1):93. doi: 10.1007/s00431-024-05896-7. PMID: 39702653.(IF:2.6)

16.Chen Z, Yang Z, Liu Y, Zhou Z, Men B, Yun L, Jiang J, Ge H, Dian M, He Y, Zhang R, Cai K, Rao X, Rao S. Jaceosidin overcomes osimertinib resistance in lung cancer by inducing G2/M cycle arrest through targeting DDB1. Toxicology and applied pharmacology. 2025 Jun;499:117327. doi: 10.1016/j.taap.2025.117327. Epub 2025 Apr 3. PMID: 40187661.(IF:3.4)

17.Wang Z, Cai Y, Tong Y, Li H, Zhou H, Ou T, Ye T, Zhang J, Cai K, Chen Z. Global, regional, and national burden of fracture of sternum and/or fracture of one or more ribs: a systematic analysis of incidence, YLDs with projections to 2030. Frontiers in public health. 2025 Apr 3;13:1565478. doi: 10.3389/fpubh.2025.1565478. PMID: 40247872; PMCID: PMC12003264.(IF:3.4)

18.Jiang J, Zhang Y, Men B, He Y, Yun L, Li F, Rao X, Cai K, Rao S. Prognostic Significance of R-Loops in Lung Adenocarcinoma: Implications for Immune Response and Drug Sensitivity. Cancer management and research. 2025 Aug 12;17:1625-1642. doi: 10.2147/CMAR.S533571. PMID: 40821703; PMCID: PMC12357588.(IF:2.6)

19.Dian M, Yun L, Meng Q, Lin S, Ji M, Zhou Y, Liu W, Yang Z, Zhao Y, Li G, Jiang J, Hao W, Chen Z, Zhou Z, Zhang R, Liu T, He Y, Yan T, Wang H, Cronin SJF, Penninger JM, Cai K, Rao S. Targeting DDX3X suppresses progression of KRAS-driven lung cancer by disrupting antioxidative homeostasis and inducing ferroptosis. Cell death & disease. 2025 Aug 30;16(1):660. doi: 10.1038/s41419-025-07980-8. PMID: 40885716; PMCID: PMC12398621.(IF:9.6)