傅海燕，女，博士，现任南方医科大学南方医院肾内科、器官衰竭防治国家重点实验室、国家肾脏病临床医学研究中心、广东省肾脏病研究所教授，博士生导师、博士后合作导师。是南方医科大学高层次引进人才、国家教育部和外专局引智项目中方成员、广东省自然科学基金研究团队核心成员。学术兼职担任中国病理生理学会肾脏病专业委员会委员，广东省精准医学学会疾病模型分会常务委员，广东省医学教育协会生物化学及分子生物学学会常务委员等。

     主要从事肾脏疾病的发病机制和靶向药物研究。先后主持科技部重点研发项目子课题、国家自然科学基金委重大研究计划、面上项目等课题7项，人才计划3项。在SCI收录期刊发表论著40余篇，以第一/通讯作者身份在Science Advances、Kidney International、J Am Soc Nephrol等权威期刊发表原始论著，单篇最高影响因子33.883。研究成果多次获得国际学术组织Facutly 1000的高度评价和大力推荐或配发述评。授权国家发明专利3项，成果转化1项。以第一完成人获省部级奖1项。荣立军队三等功1次。参编国家或省部级教材专著5部。现任《Journal of Biomarkers》《Frontiers in Medicine》客座编辑，任《Frontiers in Pharmocology》编委。担任国家科技部、教育部、基金委等科研项目评审专家。

1、肾脏疾病的发病机制探索和靶向药物研究；

2、基于组织微环境的药物筛选平台的建立和应用。

近5年以通讯/第一作者发表的代表性论著（*为通讯）：

1. Zhanji Zhan, Jiongcheng Chen, Xue Hong, Li Li, Xianhui Qin, Haiyan Fu*,Youhua Liu*. Chronic alcohol consumption aggravates acute kidney injury through integrin β1/JNK signaling. Redox Biol. 2024;77:103386.  IF:11.4
2. Yinyi Long, Dongyan Song, Liuyan Xiao, Yadie Xiang, Dier Li, Xiaoli Sun, Xue Hong, Fan Fan Hou, Haiyan Fu*,Youhua Liu*. m6A RNA methylation drives kidney fibrosis by upregulating β-catenin signaling. Int J Biol Sci. 2024;20(8):3185-3200. IF:9.2
3. Xianke Zhou, Yadie Xiang, Dier Li, Menghua Zhong, Xue Hong, Yuan Gui, Wenjian Min, Yudan. Chen, Xi Zeng, Haili Zhu, Youhua Liu, Shijia Liu, Peng Yang, Fanfan Hou, Dong Zhou, Haiyan Fu*. Limonin, a natural ERK2 agonist, protects against ischemic acute kidney injury. Int J Biol Sci. 2023;19(9):2860-2878. IF:9.2
4. Xi Zeng, Xianke Zhou, Jiayi Zhou, Hong Zhou, Xue Hong, Dier Li, Yadie Xiang, Menghua Zhong, Yudan Chen, Dongning Liang, Haiyan Fu*. Limonin mitigates cisplatin-induced acute kidney injury through metabolic reprogramming. Biomed Pharmacother. 2023,167:115531.  IF:7.5
5. Yadie Xiang, Xianke Zhou, Hong Zhou, Dier Li, Menghua Zhong, Xue Hong, Dongyan Song, Yinyi Long, Xi Zeng, Yudan Chen, Jiayi Zhou, Dongning Liang, Haiyan Fu*. Limonin ameliorates cisplatin-induced acute liver injury by inhibiting 11β-hydroxysteroid dehydrogenase type 1. Biomed Pharmacother. 2023,168:115680. IF:7.5
6. Li Li, Meizhi He, Xiaoman Tang, Junxin Huang, Jing Li, Xue Hong, Haiyan Fu*, Youhua Liu*. Proteomic landscape of the extracellular matrix in the fibrotic kidney. Kidney International. 2023;103(6):1063-1076. IF:18.998 
        ☆配发述评，现任国际肾脏病学会（ISN）主席、东京大学医学院院长Kidney International杂志副主编、国际肾病顶级专家Masaomi Nangaku，意大利加莫大学教授Andrea Remuzzi称赞这一成果具有里程碑式的意义。
7. Yiling Peng, Li Li, Jingyue Shang, Haili Zhu, Jinlin Liao, Xue Hong, Fan Fan Hou, Haiyan Fu*, Youhua Liu*. Macrophage promotes fibroblast activation and kidney fibrosis by assembling a vitronectin-enriched microenvironment. Theranostics. 2023;13(11):3897-3913. doi: 10.7150/thno.85250. IF=12.4
        ☆被选为封面论文
8. Dongyan Song, Jingyue Shang, Yinyi Long, Menghua Zhong, Li Li, Jiongcheng Chen, Yadie Xiang, Huishi Tan, Haili Zhu, Xue Hong, Fan Fan Hou, Haiyan Fu*, Youhua Liu*. Insulin-like growth factor 2 mRNA-binding protein 3 promotes kidney injury by regulating β-catenin signaling. JCI Insight. 2023;8(2):e162060.  IF:9.484
9. Li Li, Jinlin Liao, Qian Yuan, Xue Hong, Jing Li, Yiling Peng, Meizhi He, Haili Zhu, Mingsheng Zhu, Fan Fan Hou, Haiyan Fu*, Youhua Liu*. Fibrillin-1-enriched microenvironment drives endothelial injury and vascular rarefaction in chronic kidney disease. Sci Adv. 2021:27;7(5):eabc7170. IF:14.957 
    ☆现任国际肾脏病学会主席Agnes Fogo作重点推荐并述评
10. Haiyan Fu, Yuan Gui, Silvia Liu, Yuanyuan Wang, Sheldon Ira Bastacky, Yi Qiao, Rong Zhang, Christopher Bonin, Geneva Hargis, Yanbao Yu, Donald L Kreutzer, Partha Sarathi Biswas, Yanjiao Zhou, Yanlin Wang, Xiao-Jun Tian, Youhua Liu, Dong Zhou*. The hepatocyte growth factor/c-met pathway is a key determinant of the fibrotic kidney local microenvironment. iScience. 2021;24(10):103112. IF:6.107
11. Dongning Liang, Hanwen Mai, Fangyi Ruan, Haiyan Fu*. The Efficacy of Triptolide in Preventing Diabetic Kidney Diseases: A Systematic Review and Meta-Analysis. Front Pharmacol. 2021;12:728758. IF:5.998
12. Haili Zhu, Jinlin Liao, Xianke Zhou, Xue Hong, Dongyan Song, Fan Fan Hou, Youhua Liu*, Haiyan Fu*. Tenascin-C promotes acute kidney injury to chronic kidney disease progression by impairing tubular integrity via αvβ6 integrin signaling. Kidney Int.2020;97(5):1017-1031. IF:18.998
13. Haiyan Fu, Silvia Liu, Sheldon I Bastacky, Xiaojie Wang, Xiao-Jun Tian , Dong Zhou. Diabetic Kidney Diseases Revisited: A New Perspective for A New Era. Molecular Metabolism. 2019; 30:250-263. IF:8.568
14. Haiyan Fu*, Dong Zhou, Haili Zhu, Jinlin Liao, Fanfan Hou, Youhua Liu*. Matrix metalloproteinase-7 protects against AKI by priming renal tubules to survival and regeneration. Kidney Int. 2019; 95(5):1167-1180. IF:18.998 
         ☆被评为Kidney Int.杂志亮点文章
15. Haiyan Fu, Yuan Tian, Lili Zhou, Dong Zhou, Roderic J Tan, Donna B Stolz, Youhua Liu*. Tenascin-C Is a Major Component of the Fibrogenic Niche in Kidney Fibrosis. J Am Soc Nephrol. 2017; 28(3):785-801. IF:14.978     
         ☆被国际学术组织F1000 Prime推荐 
         ☆被评为 J Am Soc Nephrol.杂志当季亮点文章
16. Shuangqin Chen, Haiyan Fu (co-first author), Songzhao Wu, Wenjuan Zhu, Jinlin Liao, Xue Hong, Jinhua Miao, Congwei Luo, Yongping Wang, Fanfan Hou, Lili Zhou, Youhua Liu*. Tenascin-C protects against acute kidney injury by recruiting Wnt ligands. Kidney Int. 2019; 95(1):62-74. IF: 18.998 
         ☆配发述评：How to sharpen a novel sword from AKI basic research. Kidney Int. 2019;95:19-20.

国家发明专利（第一发明人）：

1. 柠檬苦素在制备预防和治疗急性肾损伤药物中的用途；中国发明专利；专利号：ZL201910953530.0；
2. 用于慢性肾脏病血管损伤的生物标志物；中国发明专利；专利号：ZL202010120173.2；
3. 小分子多肽TP-7在制备治疗慢性肾脏病药物中的用途；中国发明专利；专利号：ZL 202010119798.7。

近5年国际会议报告：

1. Sreum amyloid A1 damages the peritubular capilary network and promotes renal fibrosis. 美国肾脏病年会（ASN），San Diego, CA, USA，2024.10.23-2024.10.27.  
2. The initating effect of A-SAA on acute kidney injury. 美国肾脏病年会（ASN），San Diego, CA, USA，2024.10.23-2024.10.27.  
3. Protective effect of targeted inhibition of cathepsin S activity on chronic kidney disease. 美国肾脏病年会（ASN），San Diego, CA, USA，2024.10.23-2024.10.27.  
4. Metabolomics reveals the efficacy of Limonin on mitigating cisplatin-induced acute kidney injury.美国肾脏病年会（ASN），San Diego, CA, USA，2021.11.02-2021.11.07.
5. Limonin protects against acute kidney injury by targeting ERK signaling.美国肾脏病年会（ASN），San Diego, CA, USA，2021.11.02-2021.11.07.
6. Metabolomics Reveals Signature of Diabetic Kidney Disease.美国生理学会美国肾脏病学会联合研讨会（APN-ASN），Charlottesville, VA, USA.，2019.06.23-2019.06.27.
7. Proteomics Reveals the Principle of Transition from AKI to CKD. 美国肾脏病年会（ASN），Washington, DC.，2019.11.05-2019.11.10.
8. Biomarker Identification for Diabetic Kidney Disease at the Early Stage. 年美国肾脏病年会（ASN），Washington, DC.， 2019.11.05-2019.11.10.