目录
更新日期:2025年9月29日
姓 名 颜晓慧 性 别
民 族 汉族 导师层次 博士导师
技术职称 主任技师 导师类型 专业型
最后学历 硕士研究生毕业 最后学位 医学硕士学位
行政职务 其他 Email gzyanxh@126.com
工作单位 南方医科大学南方医院临床研究中心 邮政编码
跨学科招生
跨学科招生专业1 生物与医药 招生层次类型1 专业学位博导
跨学科招生专业2 招生层次类型2
个人简介

颜晓慧,主任技师,博士生导师,南方医科大学南方医院医学实验中心,长期致力于分子医学、液体活检、生物传感、DNA纳米技术的开发,以第一作者或通讯作者的身份在Biosensors and Bioelectronics, ACS Sensors, Journal of NanobiotechnologyAnalytica Chimica Acta, Microchimica Acta等国际知名学术杂志发表论文数篇,先后主持国家国家自然科学基金面上项目两项、广东省自然科学基金面上项目四项。

研究领域

1. 分子医学:肿瘤发生的分子机理,肿瘤的免疫逃逸。

2. 液体活检:循环肿瘤细胞、循环DNA、外泌体等新型循环标志物的临床应用研究。

3. 生物传感、DNA纳米技术、纳米诊疗一体化药物等先进功能材料与前沿技术的生物医学应用研究。

个人成果

 

Ye Zhang, Wenbin Li, Siting Chen, Yu Zhang, Yitong Zhu, Fei Lan, Huijun Du, Rui Fan, Junfang Zhu, Weilun Pan, Bo Situ, Lei Zheng, Shihua Luo, and Xiaohui Yan;Layered-Responsive Multivalent Tetrahedral DNA Framework-Decorated CRISPR-Cas12a Nanocapsule Enables Precise and Enhanced Tumor Chemotherapy,ACS Nano 2025 19 (20), 19274-19286 IF=16 小类一区

Zhang, Ye; Chen, Siting; Luo, Shihua; Li, Wenbin; Zhang, Lifeng; Lan, Fei; Zhu, Yitong;Du, Huijun; Li, Ke; Liu, Chunchen; Bo, Situ; Li, Bo; Yan, Xiaohui Y ; High-Performance Cooperative DNA Nanodevice Enables Sensitive Circular RNA Imaging and Precise Tumor Growth Suppression, Small Structures, 2024, 5(12): 2400255 IF=11.3 小类一区

Wenbin Li, Wen Wang, Shihua Luo, Siting Chen, Tingting Ji, Ningcen Li, Weilun Pan, Xiaohe Zhang, Xiaojing Wang, Ke Li, Ye Zhang, Xiaohui Yan. A sensitive and rapid electrochemical biosensor for sEV-miRNA detection based on domino-type localized catalytic hairpin assembly. Journal of Nanobiotechnology. 2023, 21: 328. IF=10.2 小类一区

Ye Zhang; Wenbin Li; Tingting Ji; Shihua Luo; Jiuxiang Qiu; Bo Situ; Bo Li; Xiaohe Zhang; Tiange Zhang; Wen Wang; Yunju Xiao; Lei Zheng, Xiaohui Yan. Localized DNA tetrahedrons assisted catalytic hairpin assembly for the rapid and sensitive profiling of small extracellular vesicle-associated microRNAs. Journal of Nanobiotechnology. 2022, 20: 503. IF=10.2 小类一区

Zhang Y, Wu Y, Luo S, Yang C, Zhong G, Huang G, Zhang X, Li B, Liu C, Li L, Yan X*, Zheng L*, Situ B*. DNA nanowire guided-catalyzed hairpin assembly nanoprobe for into profiling of circulating extracellular vesicle associated microRNAs. ACS Sensors. 2022. 2022, 7, 4: 1075-1085. IF=8.9 小类一区

Ye Zhang, Zihua Li, Wanting Su, Guangzhi Zhong, Xiaohe Zhang, Yuan Wu, Bo Situ, Yunju Xiao, Xiaohui Yan, Lei Zheng. A highly sensitive and versatile fluorescent biosensor for pathogen nucleic acid detection based on toehold-mediated strand displacement initiated primer exchange reaction. Analytica Chimica Acta. 2022, 1221:340125. IF=6.2 小类一区

Xiaohe Zhang, Guoni Huang, Ye Zhang, Bo Situ, Shihua Luo, Yuan Wu, Lei Zheng, Xiaohui Yan. Metastable DNA hairpins driven isothermal amplification for in situ and intracellular analysis. Analytica Chimica Acta. 2022, 1221: 340125. IF=6.2 小类一区

Yuan Wu; Ye Zhang; Xiaohe Zhang; Shihua Luo; Xiaohui Yan; Yurong Qiu; Lei Zheng. Research advances for exosomal miRNAs detection in biosensing: From the massive study to the individual study. Biosensors & Bioelectronics. 2021,177: 112962. IF=12.6 小类一区

Ye Zhang; Shihua Luo; Bo Situ; Xinyi Ye; Yifang Huang; Bo Li; Xiujuan Jiang; Xueping Chen; Lei Zheng; Xiaohui Yan; A fluorescent immunosensor for determination and imaging of circulating tumor cells based on bifunctional DNA nanomachine. Microchimica Acta. 2020, 187(5): 259. IF=5.7 小类二区

Situ, Bo; Cao, Nannan; Li, Bo; Liu, Qinlan; Lin, Li; Dai, Zong; Zou, Xiaoyong; Cai, Zhen; Wang, Qian; Yan, Xiaohui; Zheng, Lei; Sensitive electrochemical analysis of BRAF V600E mutation based on an amplification-refractory mutation system coupled with multienzyme functionalized Fe3O4/Au nanoparticles., Biosensors and Bioelectronics, 2013, 43: 257-263. IF=12.6 小类一区

Hu, Xiu-Mei; Yan, Xiao-Hui; Hu, Yan-Wei; Huang, Jin-Lan; Cao, Shun-Wang; Ren, Ting-Yu; Tang, Yue-Ting; Lin, Li; Zheng, Lei; Wang, Qian; miRNA-548p suppresses hepatitis B virus X protein associated hepatocellular carcinoma by downregulating oncoprotein hepatitis B x-interacting protein. Hepatology Research, 2016, 46(8): 804-815. IF= 4.2 小类二区

Lv, Weifeng; Zhao, Jiamin; Situ, Bo; Li, Bo; Ma, Wen; Liu, Jumei; Wu, Zixian; Wang, Wen; Yan, Xiaohui; Zheng, Lei; A target-triggered dual amplification strategy for sensitive detection of microRNA., Biosensors and Bioelectronics, 2016, 83: 250-255. IF=12.6 小类一区