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更新日期：2025年10月1日
姓 名 许乙凯 性 别 男
民 族 汉族 导师层次 博士导师
技术职称 教授 导师类型 学术&专业型
最后学历 博士研究生毕业 最后学位 医学博士学位
行政职务 主任 Email yikaivip@163.com
工作单位 南方医科大学南方医院 邮政编码 510515
跨学科招生 是
跨学科招生专业1 医学技术 招生层次类型1 专业学位硕导
跨学科招生专业2 招生层次类型2
个人简介

许乙凯教授，现任南方医科大学南方医院影像诊断科（医学影像中心）学术带头人、国家级一流本科专业及国家级一流本科课程《医学影像学》负责人。主任医师、二级教授、博士研究生及博士后合作导师。

1984年毕业于第一军医大学医疗系，1989年师从国内磁共振影像诊断先驱、前全军放射医学诊疗委员会主任委员黄其鎏教授，于第一军医大学获医学影像学硕士学位，1995年师从郭庆林教授于第四军医大学获医学影像学博士学位。2000年因医疗、科研业绩突出，被破格聘为教授、主任医师、博士生导师。

主要学术团体任职有：中华放射学会全国质量控制与管理学组全国委员、中华放射学会全国分子影像学组全国委员、中华医学会广东省放射学分会副主任委员、广东省卫健委放射诊断质量控制中心主任、广东省环保厅辐射防护协会医学专委会主任委员、广东省中西结合学会影像学分会副主任委员、全国CT理论与应用学会常委。《影像诊断与介入放射学》副主编、《中国CT与MRI杂志》编委、《CT理论与应用》编委、《实用医学影像杂志》编委。

医疗工作方面，长期从事临床影像诊断工作，具备丰富的临床疾病影像诊断经验，尤其在神经系统、呼吸系统及消化系统方面具有深入研究。参与开发小型的远程会诊系统，在MRI功能序列对神经系统肿瘤、小肝癌、乳腺癌及肺结节的早期诊断及双源CT心血管成像等方面颇有建树。

科研工作方面，主要的研究方向为磁共振功能成像及分子影像学，在国内较早开展分子影像学研究，长期致力于新型靶向对比剂的制备及表征，作为课题负责人先后主持国家自然科学基金面上项目8项、国家重点研发计划1项、教育部基金1项，以第一参与人负责国家自然科学基金重点项目1项；此外，先后主持开展了脑肿瘤氢谱成像、缺血缺氧性脑病序列优化及磷谱成像研究、癫痫的脑结构功能成像、普美显的肝脏靶向增强研究、地中海贫血肝心脏铁的定量测定技术、颈动脉斑块成像技术、小肠的CTE和MRE成像研究、心肌缺血的动态MRI增强技术、肺良恶性结节和肝脏病变的多b值DWI成像研究等。

近年来以通讯作者在国内外放射学核心杂志发表论文200余篇，其中发表SCI论文50余篇，代表性论著发表在Nature Communications, Advanced Materails, Small, Radiology, Hum Brain Mapp,  Eur Radiol, JMRI等；曾获国家发明专利3项（均为第一申请人）、军队科技进步二等奖2项；2011年“放射性肝损失动态MRI表现的临床研究”获解放军医疗成果三等奖；主编专著13部，包括《脊柱及脊髓疾病影像诊断学》、《磁共振造影剂及临床应用》、《肝胆胰脾影像诊断学》等由人民卫生出版社出版。

研究领域

1.分子影像学；2.磁共振功能成像；3.机器学习

个人成果

代表性论文【均为（共同）通讯作者】：

  1. Wu Z, Gao M, Li Q, Lan H, Zheng Y, Zheng S, Hou M, Xu Y, Shen Z, Zhao B, Yan C. Copper metal-organic framework-based multifaceted strategy for boosting cancer therapy via synergistic cuproptosis and disulfidptosis. Biomaterials. 2026 Feb;325:123592. (1区，IF=12.8)
  2. Zheng Y, Zheng S, Liao Y, Wu Z, He C, Li Q, Hu H, Shen Z, Xu Y, Yan C, Zhao B, Hou M. Nanosensitizer for Cancer Radioimmunotherapy via Anti-IL-35 Blockade Boosted Innate Immunity Activation. Adv Sci (Weinh). 2025 Sep;12(36):e04252. (1区，IF=14.3)
  3. Liu Q, Lu X, Lin Q, Zhu N, Xu Y. Correlation between perfusion and dual-layer spectral-detector CT in patients with cerebrovascular disorders. Eur Radiol. 2025 Apr 29. (2区，IF=4.7)
  4. Ding L, Chen M, Li X, Wu Y, Li J, Deng S, Xu Y, Chen Z, Yan C. Ultra-low dose dual-layer detector spectral CT for pulmonary nodule screening: image quality and diagnostic performance. Insights Imaging. 2025 Jan 10;16(1):11. (2区，IF=4.1)
  5. Hu H, Zheng S, He C, Zheng Y, Wei Q, Chen S, Wu Z, Xu Y, Zhao B, Yan C. Radiotherapy-sensitized cancer immunotherapy via cGAS-STING immune pathway by activatable nanocascade reaction. J Nanobiotechnology. 2024 May 9;22(1):234. (1区，IF=10.4)
  6. Wu Z, Li Q, Zhu K, Zheng S, Hu H, Hou M, Qi L, Chen S, Xu Y, Zhao B, Yan C. Cancer Radiosensitization Nanoagent to Activate cGAS-STING Pathway for Molecular Imaging Guided Synergistic Radio/Chemo/Immunotherapy. Adv Healthc Mater. 2024 Jun;13(14):e2303626.  (2区，IF=10.0)
  7. Zhang K, Zhang J, Li M, Liu X, Xu Y. Prediction of histologic grade of hepatocellular carcinoma using dual-layer spectral-detector computed tomography (CT): comparison of two region of interest plotting methods. Quant Imaging Med Surg. 2024 Jun 1;14(6):3887-3900.  (3区，IF=2.9)
  8. Ding L, Li X, Lin J, Deng S, Chen M, Deng W, Xu Y, Chen Z, Yan C. Impact on Image Quality and Diagnostic Performance of Dual-Layer Detector Spectral CT for Pulmonary Subsolid Nodules: Comparison With Hybrid and Model-Based Iterative Reconstruction. J Comput Assist Tomogr. 2024 Jul 30.  (4区，IF=1.0)
  9. Huang J, Hao P, Chen Z, Deng K, Liu B, Xu Y. Quantitative assessment of hyperperfusion using arterial spin labeling to predict hemorrhagic transformation in acute ischemic stroke patients with mechanical endovascular therapy. Eur Radiol. 2024 Jan;34(1):579-587. (2区，IF=5.9)
  10. Huang L, Feng J, Zhu J, Yang J, Xiong W, Lu X, Chen S, Yang S, Li Y, Xu Y, Shen Z. A Strategy of Fenton Reaction Cycloacceleration for High-Performance Ferroptosis Therapy Initiated by Tumor Microenvironment Remodeling. Adv Healthc Mater. 2023 Jul;12(18):e2203362.  (2区，IF=10.0)
  11. Yang J, Feng J, Yang S, Xu Y, Shen Z. Exceedingly Small Magnetic Iron Oxide Nanoparticles for T<sub>1</sub> -Weighted Magnetic Resonance Imaging and Imaging-Guided Therapy of Tumors. Small. 2023 Dec;19(49):e2302856.  (2区，IF=13.0)
  12. Wei X, Lin B, Huang Y, Yang S, Huang C, Shi L, Liu D, Zhang P, Lin J, Xu B, Guo D, Li C, He H, Liu S, Xue Y, Xu Y, Zhang H. Effects of Time-Restricted Eating on Nonalcoholic Fatty Liver Disease: The TREATY-FLD Randomized Clinical Trial. JAMA Netw Open. 2023 Mar 1;6(3):e233513. (1区，IF=13.8)
  13. Sun Z, Wang W, Huang W, Zhang T, Chen C, Yuan Q, Chen Y, Zhou K, Han Z, Feng H, Chen H, Liang X, Hu Y, Yu J, Liu H, Yu L, Xu Y, Li G, Jiang Y. Noninvasive imaging evaluation of peritoneal recurrence and chemotherapy benefit in gastric cancer after gastrectomy: a multicenter study. Int J Surg. 2023 Jul 1;109(7):2010-2024. (1区，IF=15.3)
  14. Yang J, Feng J, Yang S, Xu Y, Shen Z. Exceedingly Small Magnetic Iron Oxide Nanoparticles for T1 -Weighted Magnetic Resonance Imaging and Imaging-Guided Therapy of Tumors. Small. 2023 Dec;19(49):e2302856. (1区，IF=13.3)
  15. Huang L, Feng J, Zhu J, Yang J, Xiong W, Lu X, Chen S, Yang S, Li Y, Xu Y, Shen Z. A Strategy of Fenton Reaction Cycloacceleration for High-Performance Ferroptosis Therapy Initiated by Tumor Microenvironment Remodeling. Adv Healthc Mater. 2023 Jul;12(18):e2203362. (1区，IF=10.0)
  16. Huang W, Jiang Y, Xiong W, Sun Z, Chen C, Yuan Q, Zhou K, Han Z, Feng H, Chen H, Liang X, Yu S, Hu Y, Yu J, Chen Y, Zhao L, Liu H, Zhou Z, Wang W, Wang W, Xu Y, Li G. Noninvasive imaging of the tumor immune microenvironment correlates with response to immunotherapy in gastric cancer. Nat Commun. 2022 Aug 30;13(1):5095. (1区，IF=17.694)
  17. Cong Huang, Bingquan Lin, Chuyao Chen, Huaiming Wang, Xiaosheng Lin, Jiamin Liu, Qingfan Ren, Jia Tao, Peng Zhao, Yikai Xu. Synergistic Reinforcing of Immunogenic Cell Death and Transforming Tumor-Associated Macrophages Via a Multifunctional Cascade Bioreactor for Optimizing Cancer Immunotherapy. Adv Mater. 2022 Dec;34(51):e2207593. (1区，IF=32.086)
  18. Zhou H, Lu X, Du C, Zhou Z, Feng J, Liang Z, Xu Y, Qiu X, Shen Z. Cycloacceleration of Reactive Oxygen Species Generation Based on Exceedingly Small Magnetic Iron Oxide Nanoparticles for Tumor Ferroptosis Therapy. Small. 2022 Sep;18(35):e2202705. (1区，IF=15.153)
  19. Hou M, Zhu K, Hu H, Zheng S, Wu Z, Ren Y, Wu B, Qi L, Wu D, Xu Y, Yan C, Zhao B. Rapid synthesis of 'yolk-shell'-like nanosystem for MR molecular and chemo-radio sensitization. J Control Release. 2022 Jul;347:55-67. (1区，IF=11.467)
  20. Chen C, Huang S, Chen Z, Liu Q, Cai Y, Mei Y, Xu Y, Guo R, Yan C. Kartogenin (KGN)/synthetic melanin nanoparticles (SMNP) loaded theranostic hydrogel scaffold system for multiparametric magnetic resonance imaging guided cartilage regeneration. Bioeng Transl Med. 2022 Jun 29;8(1):e10364. (2区，IF=10.684)
  21. Hu H, Zheng S, Hou M, Zhu K, Chen C, Wu Z, Qi L, Ren Y, Wu B, Xu Y, Yan C, Zhao B. Functionalized Au@Cu-Sb-S Nanoparticles for Spectral CT/Photoacoustic Imaging-Guided Synergetic Photo-Radiotherapy in Breast Cancer. Int J Nanomedicine. 2022 Jan 25;17:395-407. (2区，IF=7.033)
  22. Xuanyi Lu, Huimin Zhou, Zhiyu Liang, Jie Feng , Yudie Lu, Lin Huang, Xiaozhong Qiu, Yikai Xu, Zheyu Shen Biodegradable and biocompatible exceedingly small magnetic iron oxide nanoparticles for T1-weighted magnetic resonance imaging of tumors. J Nanobiotechnology. 2022 Jul 30;20(1):350. (2区，IF=10.435)
  23. Baoer Liu, Qingyuan Zeng, Jianbin Huang, Jing Zhang, Zeyu Zheng, Yuting Liao, Kan Deng, Wu Zhou, Yikai Xu. IVIM using convolutional neural networks predicts microvascular invasion in HCC. Eur Radiol. 2022 Oct;32(10):7185-7195. (2区，IF=11.467)
  24. Chen C, Huang C, Liu J, Tao J, Chen Y, Deng K, Xu Y, Lin B, Zhao P. Hofmeister Effect-Based T1-T2 Dual-Mode MRI and Enhanced Synergistic Therapy of Tumor. ACS Appl Mater Interfaces. 2022 Nov 1. doi: 10.1021/acsami.2c15295. Epub ahead of print. PMID: 36317744. (2区，IF=10.383)
  25. Chenggong Yan , Lingfeng Wang , Jie Lin, Jun Xu, Tianjing Zhang, Jin Qi, Xiangying Li , Wei Ni , Guangyao Wu , Jianbin Huang, Yikai Xu(*), Henry C Woodruff, Philippe Lambin(*). A fully automatic artificial intelligence-based CT image analysis system for accurate detection, diagnosis, and quantitative severity evaluation of pulmonary tuberculosis. Eur Radiol. 2022 32(4):2188-2199. (2区，IF=5.315)
  26. Meirong Hou(#), Chenggong Yan (#), Zelong Chen, Qingliang Zhao, Misomiao Yuan, Yikai Xu(*),Bingxia Zhao(*). Multifunctional NIR-responsive poly(vinylpyrrolidone)-Cu-Sb-S nanotheranostic agent for photoacoustic imaging and photothermal/photodynamic therapy. Acta Biomater. 2018，doi: 10.1016/j.actbio.2018.05.011. (1区，IF=6.319)
  27. Chenggong Yan, Jun Xu, Chunyi Liang, Qi Wei, Yuankui Wu, Wei Xiong, Huan Zheng, Yikai Xu(*). Radiation Dose Reduction by Using CT with Iterative Model Reconstruction in Patients with Pulmonary Invasive Fungal Infection. Radiology. 2018, doi: 10.1148/radiol.2018172107. (1区，IF=7.648)
  28. Zelong Chen(#) ; Chenggong Yan (#) ; Shina Yan; Qin Liu; Meirong Hou; Yikai Xu(*) ; Rui Guo (*) ,Non-invasive monitoring of in vivo hydrogel degradation and cartilage regeneration by multiparametric MR imaging, Theranostics, 2018. 8(4): 1146~1158 (1区，IF=8.766)
  29. Yuming Jiang (#), Chuanli Chen(#), Jingjing Xie (#), Wei Wang , Xuefan Zha, Wenbing Lv, Hao Chen, Yanfeng Hu , Tuanjie Li , Jiang Yu, Zhiwei Zhou(*), Yikai Xu (*) Guoxin Li(*). Radiomics signature of computed tomography imaging for prediction of survival and chemotherapeutic benefits in gastric cancer. EBioMedicine. 2018 S2352-3964(18)30364-5. (1区，IF=6.183)
  30. Meirong Hou (#); Xiaodan Lu; Zhide Zhang; Qi Xia; Chenggong Yan; Zhiqiang Yu; Yikai Xu(*) ; Ruiyuan Liu(*) ,Conjugated Polymer Containing Organic Radical for Optical/MR Dual-Modality Bioimaging, ACS Appl Mater Interfaces, 2017, 9(51): 44316~44323 (2区，IF=7.504)
  31. Bing-Quan Lin (#), Wen-Biao Zhang (#), Jing Zhao (#), Xu-Hui Zhou (#) , Yong-Jiang Li , Jun Deng, Qin Zhao, Gui Fu, Chuan-Miao Xie, Yi-Kai Xu(*), Guo-Kai Feng(*). An Optimized Integrin α6-Targeted Magnetic Resonance Probe for Molecular Imaging of Hepatocellular Carcinoma in Mice. J Hepatocell Carcinoma. 2021;8:645-656. (3区, IF=5.828)
  32. Yuefa Tan(#) ; Jun Xu; Ruiying Chen; Bin Chen; Juan Xu; Daokun Ren; Queenie Chan; Yingjie Mei; Yuankui Wu; Yikai Xu(*) ,Use of T1 relaxation time in rotating frame (T1 ρ) and apparent diffusion coefficient to estimate cerebral stroke evolution, Journal of Magnetic Resonance Imaging, 2018, doi: 10.1002/jmri.25971 (2区，IF=3.083)
  33. Xixi Zhao(#) ; Ru Yang (#); Kewan Wang (#); Zhongping Zhang; Junling Wang; Xiangliang Tan; Jiajun Zhang; Yingjie Mei; Queenie Chan; Jun Xu; Qianjin Feng (*);Yikai Xu(*),Connectivity-based parcellation of the nucleus accumbens into core and shell portions for stereotactic target localization and alterations in each NAc subdivision in mTLE patients, Hum Brain Mapp, 2018, 39(3): 1232~1345 (2区，IF=4.530)
  34. Qin Liu, Longbao Feng , Zelong Chen , Yong Lan , Yu Liu, Dan Li, Chenggong Yan(*), Yikai Xu(*). Ultrasmall Superparamagnetic Iron Oxide Labeled Silk Fibroin/Hydroxyapatite Multifunctional Scaffold Loaded With Bone Marrow-Derived Mesenchymal Stem Cells for Bone Regeneration. Front Bioeng Biotechnol. 2020 Jun 30;8:697. (3区，IF=5.890)
  35. Xiaodan Lu, Zhide Zhang, Qi Xia, Meirong Hou, Chenggong Yan, Zelong Chen, Yikai Xu(*), Ruiyuan Liu(*). Glucose functionalized carbon quantum dot containing organic radical for optical/MR dual-modality bioimaging. Mater Sci Eng C Mater Biol Appl. 2018 1;82:190-196. (3区，IF=4.164)
  36. Chen Niu (#), Xiangliang Tan (#), Xiaojin Liu, Kai Han, Meiqi Niu, Jun Xu, Ling Zhao, Yuankui Wu, Feng Deng, Qin Huang,Xiaoyan Wu, Huiyuan Huang, Yikai Xu(*), Ruiwang Huang (*), Cortical thickness reductions associate with abnormal resting-state functional connectivity in non-neuropsychiatric systemic lupus erythematosus. Brain Imaging Behav. 2018, 12(3):674-684. (2区，IF=3.719)
  37. Ling Zhao(#), Xiangliang Tan(#), Junjing Wang, Kai Han, Meiqi Niu, Jun Xu, Xiaojin Liu, Xixi Zhao, Miao Zhong, Qin Huang, Yikai Xu(*), Ruiwang Huang(*), Brain white matter structural networks in patients with non-neuropsychiatric systemic lupus erythematosus. Brain Imaging Behav. 2018;12(1):142-155. (2区，IF=3.719)
  38. Xiaodan Lu, Meirong Hou, Qi Xia, Chenggong Yan, Yikai Xu(*), Ruiyuan Liu(*). Mitochondrial targeted fluorescent probe with AIE characteristics for bioimaging. Mater Sci Eng C Mater Biol Appl. 2017 Aug 1;77:129-135. (3区，IF=4.164)
  39. Chenggong Yan (#) ; Jun Xu(#) ; Wei Xiong; Qi Wei; Ru Feng; Yuankui Wu; Qifa Liu; Caixia Li; Queenie Chan; Yikai Xu(*),Use of intravoxel incoherent motion diffusion-weighted MR imaging for assessment of treatment response to invasive fungal infection in the lung, Eur Radiol, 2017, 27(1): 212~221 (2区，IF=3.967)
  40. Danting Cui (#); Xiaodan Lu; Chenggong Yan; Xiang Liu; Meirong Hou; Qi Xia; Yikai Xu (*),Ruiyuan Liu(*); Gastrin-releasing peptide receptor-targeted gadolinium oxide-based multifunctional nanoparticles for dual magnetic resonance/fluorescent molecular imaging of prostate cancer, Int J Nanomedicine, 2017, 12(0): 6787~6797 (2区，IF=4.300)
  41. Man Xua (#), Xiangliang Tan(#), Xinyuan Zhang, Yihao Guo, Yingjie Mei, Qianjin Feng, Yikai Xu(*), Yanqiu Feng(*), Alterations of white matter structural networks in patients with non-neuropsychiatric systemic lupus erythematosus identified by probabilistic tractography and connectivity-based analyses. Neuroimage Clin. 2016 Dec 20;13:349-360. (2区，IF=3.869)
  42. Xiaofen Ma, Shumei Li, Junzhang Tian, Guihua Jiang(*), Hua Wen, Tianyue Wang, Jin Fang, Wenfeng Zhan, Yikai Xu(*). Alterations of white matter structural networks in patients with non-neuropsychiatric systemic lupus erythematosus identified by probabilistic tractography and connectivity-based analyses. Neuroimage Clin. 2016,13:349-360. (2区，IF=4.348)
  43. Xiaofen Ma(#), Shumei Li (#), Junzhang Tian , Guihua Jiang (#), Hua Wen , Tianyue Wang, Jin Fang , Wenfeng Zhan, Yikai Xu(*). Altered brain spontaneous activity and connectivity network in irritable bowel syndrome patients: A resting-state fMRI study. Clin Neurophysiol. 2015;126(6):1190-7. (3区，IF=3.866)
  44. Lixia Huang (#); Chenggong Yan; Danting Cui; Yichen Yan; Xiang Liu; Xinwei Lu; Xiangliang Tan; Xiaodan Lu; Jun Xu; Yikai Xu(*) ; Ruiyuan Liu(*) ,Organic radical contrast agents based on polyacetylenes containing 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO): targeted MR /optical bimodal imaging of folate receptor expressing HeLa tumors in vitro and in vivo, Macromolecular Bioscience, 2015, 15(6): 788~798 (2区，IF=3.800)
  45. Chenggong Yan(#) ; Xiangliang Tan; Qi Wei; Ru Feng; Caixia Li; Yuankui Wu; Peng Hao; Queenie Chan; Wei Xiong; Jun Xu; Yikai Xu(*) ,Lung MRI of invasive fungal infection at 3 Tesla: evaluation of five different pulse sequences and comparison with multidetector computed tomography (MDCT) , Eur Radiol, 2015, 25(2): 550~557 (2区，IF=4.14)
  46. Chenggong Yan (#); Yuankui Wu; Jie Feng; Wufan Chen; Xiang Liu; Peng Hao; Ruimeng Yang; Juan Zhang; Bingquan Lin; Yikai Xu(*) ; Ruiyuan Liu (*),Anti-αvβ3 antibody guided three-step pretargeting approach using magnetoliposomes for molecular magnetic resonance imaging of breast cancer angiogenesis, International Journal of Nanomedicine, 2013, 0(8): 245~255 (2区，IF=4.383)