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更新日期：2025年9月27日
姓 名 徐学清 性 别 男
民 族 汉族 导师层次 博士导师
技术职称 教授 导师类型 学术型
最后学历 博士研究生毕业 最后学位 理学博士学位
行政职务 系主任 Email XU2003@SMU.EDU.CN
工作单位 药学院 邮政编码 510155
个人简介

受教育经历

  1. 09/2004-07/2007中国科学院，昆明动物研究所，博士
  2. 09/2001-07/2004南京农业大学，动物医学院，硕士
  3. 09/1997-07/2001湖北农学院，动物科学系，学士

研究工作经历

  1. 04/2020-至今 南方医科大学，珠江医院，教授
  2. 03/2018-至今 南方医科大学，药学院，教授
  3. 12/2012-03/2018 南方医科大学，药学院，副教授
  4. 10/2009-09/2012美国国立卫生研究院，过敏原与传染病研究所，博士后
  5. 05/2009-09/2009美国弗吉尼亚大学，药学院，博士后
  6. 07/2007-05/2009南方医科大学，药学院，讲师

获奖情况:

  1. 云南省科学技术奖自然科学一等奖（获奖人排名：赖仞、杨世隆、徐学清、杨海龙、张治业、安舒、李东升），云南省政府，2018
  2. 霍英东青年教师奖（三等奖），霍英东教育基金会，2010；
  3. 优秀科技论文特等奖(获奖人排名：徐学清、杨海龙、马东莹、武静、赖仞)，云南省科学技术协会，2010；
  4. 云南省科学技术奖突出贡献类自然科学一等奖（获奖人排名：赖仞、张云、李建许、张亚平、郑永唐、徐学清、杨海龙、李文辉），云南省政府，2008；
  5. 先进工作者荣誉称号；南方医科大学，2008；
  6. 院长奖优秀奖，中国科学院，2007；

课题申情况

  1. 国家自然科学基金国际(地区)合作与交流项目，31911530077，花姬蛙皮肤小分子丝氨酸蛋白酶抑制剂的结构与功能研究，2019/01-2020/12，10万元, 在研，主持；
  2. 国家自然科学基金国际(地区)合作与研究项目,31861143050，埃及蝎毒新型抗肿瘤肽的分子鉴定和研发，2019/01-2021/12，170万元, 在研，主持；
  3. 国家自然科学基金面上项目，31772476，花姬蛙皮肤潜在药用多肽的结构与功能研 究，2018/01-2021/12，70万元，在研，主持；
  4. 国家自然科学基金面上项目，31370782，印鼠客蚤FS50肽抑制Nav1.5钠通道的结构 基础和作用机制，2014/01-2017/12，80万元，结题，主持 ；
  5. 国家自然科学金，30800185，蛴螬活血化瘀的分子机制研究，2009/01-2011/12，20万元，结题，主持；
  6. 南方医科大学杰青培养计划项目，蛋白质与多肽生物化学，2014/01-2016/12，45 万元，结题，主持；
  7. 广州市产学研协同创新重大专项产业技术研究项目，重组人透明质酸酶的细胞株开发与工艺优化研究、2016/01-2018/12，60万元，结题，共同主持；

授权发明专利

  1. 赖仞，徐学清.胡蜂抗菌肽及其制备方法和应用, 2009.04, 中国，200510010664.7；
  2. 赖仞，徐学清，梁建国，韩曜平，杨海龙，李建许.棕点湍蛙抗菌肽及其基因和在制药中的应用，2007.11, 中国，200610010627.0。
  3. 赖仞，徐学清，梁建国，韩曜平，杨海龙，李建许. 棕点湍蛙活性多肽及其基因和在制药中的应用，2007.11, 中国，200710010628.3。
  4. 赖仞，李健许，徐学清，杨海龙.中华硬蜱神经肽及其制备方法和应用，2006.11, 中国，ZL 200510010665.1
  5. 赖仞，李建许，梁建国，徐学清，李东升，李宗杰. 无指盘臭蛙胰岛素释放促进肽和在制药中的应用，2006.03, 中国，ZL 200610010770.X
  6. 赖仞，李建许，徐春花，李宗杰，吕毅，李东升，徐学清，赖仞. 无指盘臭蛙丙精肽、基因和变异体，2008.05, 中国，ZL 200610010931.5
  7. 赖仞，李建许，韩曜平，李东升，梁建国，徐学清.无指盘臭蛙丝氨酸蛋白酶抑制剂及其应用，2010.01, 中国，ZL 200610010930.0
  8. 赖仞，李建许，徐学清，徐春花，李东升，吕毅.无指盘臭蛙抗菌肽. 2009.08中国，ZL 200610010928.3.
  9. 徐学清，刘叔文，一种印鼠客蚤抗心律失常的多肽及其制备方法，中国，201410 636262.7。
  10. 徐学清，李琳，刘叔文，一种具有血小板聚集抑制功能的抗HIV白纹伊蚊蛋白及其制备方法，中国，201410636317.4
  11. 徐学清，陈新,曾白霜，张贝.一种花狭口蛙的基因及其编码的多肽和该多肽的用途。专利号：201610905430.7
  12. 徐学清，杨洁，曾白霜，张贝.一种泽陆蛙基因及其编码的多肽和该多肽的用途。专利号：201610905417.1
  13. 徐学清，曾白霜，张贝.黑框蟾蜍抗氧化肽及其基因和在制药中的应用。专利号：201610917911.X
  14. 徐学清，陈新，曾白霜，张贝. 虎纹蛙蛋白酶抑制肽及其基因和在制药中的应用。专利号：201610915371.1
  15. 徐学清，曾白霜，张贝.花姬蛙促胰岛素释放肽及其基因和在制药中的应用。专利号：201610915763.8
  16. 徐学清，陈新，曾白霜，张贝.花姬蛙抗菌肽及其基因和在制药中的应用。专利号：201610917932.1
  17. 徐学清，陈新，曾白霜，张贝.花姬蛙抗氧化肽及其基因和在制药中的应用。专利号：20161091792.4
  18. 徐学清，张贝，邓振晖.印鼠客蚤多肽及其基因和应用。专利号：201610980072.6
  19. 徐学清，曾白霜，柴金为.沼水蛙分泌肽及其基因和在制药中的应用。专利号：201610982013.2
  20. 徐学清，曾白霜，陈文斌，柴金为，梁晓玲.沼水蛙皮肤丝氨酸蛋白酶抑制肽及其基因和在制药中的应用.专利号：201610982021.7

 

研究领域

南方医科大学药学院教授，博导。主要从事动物来源的生物活性物质的结构与功能研究，通过蛋白质组学方法结合基因组学、药理学手段揭示动物适应环境的分子机制与物质基础。到目前为止，主持包括国际合作在内的国家自然科学基金5项，共获得国家发授权明专利20项，在包括Molecular and Cellular Proteomics，The FASEB Journal，Journal of Biological Chemistry、Thrombosis and Haemostasis，Acta Crystallogr D Biol Crystallogr、J Med Chem和Chemical Reviews等在内的刊物上发表第一、通讯作者SCI论文23篇，发表论文被他引200次，单篇最高被引用125次，总影响因子142，Web of Science 源H指数为 21。先后获得过云南省科学技术奖自然科学一等奖、云南省科学技术奖突出贡献类自然科学一等奖、优秀科技论文特等奖、霍英东青年教师奖。

个人成果
  1. Wang X, Gao Y, Nguyen T, Chai J, Chen X*, Xu X*. Scorpion venom peptide S6540 induces caspase-independent apoptosis in non-small cell lung cancer A549 cells. Toxicol Appl Pharmacol. 2025 Nov:504:117498 (2025 IF: 3.4/Q2) (中科院大类3区小类2区)
  2. Yang J, Gao Y, Liu J, Zeng Q, Xiao Z, Chai J, Osman AAK, Lu W, Chen X, Xu X. FS145 exerts anti-inflammatory and analgesic effects through blocking integrin αvβ3 on macrophages. Eur J Pharmacol. 2025, 1003: 177891. (2025 IF: 4.2/Q2) (中科院大类3区小类2区)
  3. Li J, Xiong W, Yang J, Liao W, Gao Y, Chai J, Wu J, Liu S*, Xu X*. Characterization of the First Antimicrobial Peptide from Sea Seal with Potent Therapeutic Effect in Septic Mice.  Biochem Pharmacol. 2025 Mar 25;236:116891 (2025 IF: 5.3/Q2) (中科院大类2区小类2区)
  4. Wu J, Wang X, Chai J, Yang J, Gao Y, Xiong W, Huang X, Gong Y, Chen X*, Xu X*. Cath-HG exhibits anti-acne activities via multiple mechanisms. Eur J Pharmacol. 2025 Mar 7: 998: 177493. (2025 IF: 4.2/Q2) (中科院大类3区小类2区)
  5. Li J, Xiong W, Yang J, Gao Y, Chai J, Tian M, Chu X, Huang X, Kotsyfakis M, Chen X, Xu X. Cathelicidin-HG alleviates psoriasis by targeting glycoprotein VI to inhibit platelet-neutrophil complexes formation. Eur J Pharmacol. 2025 Mar 15:991: 177330. (2024 IF: 4.2/Q2) (中科院大类3区小类2区)
  6. Xiao S, Tian M, Liao H, Xie J, Chai J, Li J, Nguyen T, Wu J, Gao Y, Li J, Chen X, Xu X*, Qingwen W*. The first Ranatuerin antimicrobial peptide with LPS-neutralizing and anti-inflammatory activities in vitro and in vivo. Life Sci. 2025 Feb 15; 363:123375. (2024 IF: 5.2/Q2) (中科院大类3区小类2区)
  7. Chai J, Wu J, Yang J, Ye T, Gao Y, Zeng B, Xiong W, Kotsyfakis M, Dijkgraaf I, Liu J, Chen X, Xu X. Cath-HG improves the survival rates and symptoms in LPS-induced septic mice due to its multifunctional properties. Int Immunopharmacol. 2024 Dec 25;143(Pt 1): 113332 (2024 IF: 5.0/Q2) (中科院大类2区小类2区)
  8. Wang K, Nguyen T, Gao Y, Guo R, Fan C, Liao H, Li J, Chai J, Xu X*, Gong Y*, Chen X*. Androcin 18−1, a novel scorpion-venom peptide, shows a potent antitumor activity against human U87 cells via inducing mitochondrial dysfunction. Insect Biochem Mol Biol. 2024 Jul:170:104137 (2023 IF: 3.2/Q2) (中科院大类2区小类2区)
  9. Xiong W, Chai J, Wu J, Li J, Lu W, Tian M, Jmel MA, Ippel JH, Kotsyfakis M, Dijkgraaf I, Liu S, Xu X. Cathelicidin-HG Alleviates Sepsis-Induced Platelet Dysfunction by Inhibiting GPVI-Mediated Platelet Activation. Research (Wash D C). 2024 Jun 5;7:0381. (2023 IF: 8.5/Q1) (中科院大类1区小类2区)
  10. Lu W, Xiao Z, Liao H, Xie J, Gao Y, Xiong W, Zeng Q, Deng Z, Wu J, Chai J, Chen X, Xu X. FS145, the first flea-derived disintegrin, inhibits Angiogenesis through Specifically binding integrin αvβ3. Int J Biol Macromol. 2024 Jan 9;259(Pt 2):129289 (2023 IF: 7.7/Q2) (中科院大类1区小类2区)
  11. Lu H, Chai J, Xu Z, Wu J, He S, Liao H, Huang P, Huang X, Chen X, Jiang H, Qu S*, Xu X*. Cath-KP, a novel peptide identified from a frog skin, prevents oxidative stress damage in Parkinson’s disease model. Zool Res. 2024 Jan 18;45(1):108−124 (2022 IF: 4.0/Q1) (中科院大类1区小类1区)
  12. Wu J, Xiong W, Li J, Liao H, Chai J, Huang X, Lai S, Kozlov S, Chu X, Xu X. Peptide TK-HR from the Skin of Chinese Folk Medicine Frog Hoplobatrachus Rugulosus Accelerates Wound Healing via the Activation of the Neurokinin‑1 Receptor. J Med Chem. 2023 Dec 14;66(23):16002-16017 (2023 IF: 6.8/Q1) (中科院大类1区小类1区)
  13. Xiong W, Xie J, Liang Y, Chai J, Guo R, Zeng B, Wu J, Lai S, Zhang H, Huang X, Chen X*, Xu X*. Cath-DM-NT, a peptide derived from the skin of Duttaphrynus melanostictus, shows dual lectin-like and antioxidant activity. Eur J Pharmacol, 2023, Oct 5; 956: 175941 (2022 IF: 4.2/Q2) (中科院大类2区小类2区)
  14. Chai J, Wu J, Li J, Liao H, Lu W, Guo R, Shao Z, Jmel MA, Martins LA, Hackeng T, Ippel H, Dijkgraaf I, Kotsyfakis M, Xu X. Novel Amphibian Bowman−Birk-Like Inhibitor with Antioxidant and Anticoagulant Effects Ameliorates Pancreatitis Symptoms in Mice. J Med Chem. 2023 Sep 14; 66(17):11869-11880. (2023 IF: 6.8/Q1) (中科院大类1区小类1区)
  15. Deng Z, Gao Y, Nguyen T, Chai J, Wu J, Li J, Abdel-Rahman MA, Xu X*, Chen X*. The potent antitumor activity of Smp43 against non-small cell lung cancer A549 cells via inducing membranolysis and mitochondrial dysfunction. Toxins (Basel). 2023 May 19;15(5): 347. (2022 IF: 5.075/Q2) (中科院大类2区小类1区)
  16. Li J#, Liang Y#, Su M#, Wu J, Chai J, Xiong W, Mo G, Chen X*, Xu X*. Characterization of a Novel LTA/LPS-Binding Antimicrobial and Anti-Inflammatory Temporin Peptide from the skin of Fejervary limnocharis (Anura: Ranidae). Biochem Pharmacol. 2023 Apr; 210: 115471 (2022 IF: 6.100/Q2) (中科院大类2区小类2区)
  17. Tian M#, Wang W#, Liang Y#, Chai J, Wu J, Zhang Z, Huang X, Chen X*, Xu X*. The first Brevinin-1 antimicrobial peptide with LPS-neutralizing and anti-inflammatory activities in vitro and in vivo. Front Microbiol. 2023. Mar 3;14:1102576 (2022 IF: 6.064/Q2) (中科院大类2区小类2区)
  18. Nguyen TT, Deng Z, Guo RY, Chai JW, Li R, Zeng QY, Lai SA, Chen X*, Xu XQ*. Periplaneta americana extract ameliorates LPS-induced acute lung injury via reducing inflammation and oxidative stress. Curr Med Sci. 2023 Jun;43(3):445-455. (2022 IF: 2.640/Q4) (中科院大类3区小类4区)
  19. Xiong W#, Fan H#, Zeng Q, Deng Z, Li G, Lu W, Zhang B, Lai S, Chen X*, Xu X*. The in vitro anticancer effects of FS48 from salivary glands of Xenopsylla cheopis on NCI-H460 cells via its blockage of voltage-gated K+ channels. Acta Pharm. 2023 Jan 24; 73(1):145-155. (2022 IF: 3.299/Q3) (中科院大类4区小类4区) 
  20. Nguyen T#, Guo R#, Chai J, Wu J, Liu J, Chen X, Abdel-Rahman MA, Xia H*, Xu X*. Smp24, a Scorpion Venom Peptide, Exhibits Potent Antitumor Effects against Hepatoma HepG2 Cells via Multi-Mechanisms In Vivo and In Vitro. Toxins (Basel). 2022 Oct 21;14 (10):717. (2022 IF: 5.075/Q2) (中科院大类2区小类1区) 
  21. Chai J#, Liu J#, Tian M, Liao H, Wu J, Xie J, Lai S, Mo G, Chen X*, Xu X*. Multiple mechanistic action of Brevinin-1FL peptide against oxidative stress effects in an acute inflammatory model of carrageenan-induced damage. Oxid Med Cell Longev. 2022. Sep 5:2022:2615178 (2022 IF: 7.310/Q2) (中科院大类2区小类2区) 
  22. Guo R#, Chen X#, Nguyen T, Chai J, Gao Y, Wu J, Li J, Abdel-Rahman MA, Chen X*, Xu X*. The Strong Anti-Tumor Effect of Smp24 in Lung Adenocarcinoma A549 Cells Depends on Its Induction of Mitochondrial Dysfunctions and ROS Accumulation. Toxins (Basel). 2022 Aug 27;14(9):590. (2022 IF:5.075/Q1) (中科院大类2区小类1区) 
  23. Guo R#, Liu J#, Chai J, Gao Y, Abdel-Rahman MA, Xu X. Scorpion Peptide Smp24 Exhibits a Potent Antitumor Effect on Human Lung Cancer Cells by Damaging the Membrane and Cytoskeleton In Vivo and In Vitro. Toxins (Basel). 2022 Jun 28; 14(7):438. (2022 IF:5.075/Q1) (中科院大类2区小类1区) 
  24. Gao Y, Chai J, Wu J, Zeng Q, Guo R, Chen X*, Xu X*. Molecular Cloning and Characterization of a Novel Antimicrobial Peptide from the Skin of Kaloula Pulchra. Curr Pharm Biotechnol. 2022; 23(15):1873-1882. (2022 IF:2.89/Q4) (中科院大类4区小类4区) 
  25. Zeng Q#, Lu W#, Deng Z, Zhang B, Wu J, Chai J, Chen X*, Xu X*. The toxin mimic FS48 from the salivary gland of Xenopsylla cheopis functions as a Kv1.3 channel-blocking immunomodulator of T cell activation. J Biol Chem. 2022 Jan; 298(1):101497. (2021 IF:5.157/Q2) (中科院大类2区小类2区) 
  26. Xiong W#, Li J#, Feng Y, Chai J, Wu J, Hu Y, Tian M, Lu W, Xu X*, Zou M*. Brevinin-2GHk, a Peptide Derived from the Skin of Fejervarya limnocharis, Inhibits Zika Virus Infection by Disrupting Viral Integrity. Viruses. 2021 Nov 28;13(12):2382. (2021 IF:5.818/ Q2) (中科院大类3区小类2区) 
  27. Chai J, Yang W, Gao Y, Guo R, Peng Q, Abdel-Rahman MA, Xu X. Antitumor Effects of Scorpion Peptide Smp43 through Mitochondrial Dysfunction and Membrane Disruption on Hepatocellular Carcinoma. J Nat Prod. 2021 Dec 24;84(12):3147-3160. (2021 IF:4.803/Q2) (中科院大类2区小类2区)
  28. Tian M#, Liu J#, Chai J, Wu J, Xu X. Antimicrobial and Anti-inflammatory Effects of a Novel Peptide From the Skin of Frog Microhyla pulchra. Front Pharmacol. 2021 Dec 16;12: 783108. (2021 IF: 5.988/Q1) (中科院大类2区小类2区) 
  29. Wu J#, Guo R#, Chai J, Xiong W, Tian M, Lu W, Xu X. The Protective Effects of Cath-MH With Anti-Propionibacterium Acnes and Anti-Inflammation Functions on Acne Vulgaris. Front Pharmacol. 2021 Dec 9; 12:788358. (2021 IF:5.988/Q1) (中科院大类2区小类2区) 
  30. Wu J#, Zhang H#, Chen X, Chai J, Hu Y, Xiong W, Lu W, Tian M, Chen X*, Xu X*. FM-CATH, A Novel Cathelicidin From Fejervarya Multistriata, Shows Therapeutic Potential for Treatment of CLP-Induced Sepsis. Front Pharmacol. 2021 Aug 16; 12:731056. (2021 IF:5.988/Q1) (中科院大类2区小类2区) 
  31. Chai J#, Chen X#, Ye T, Zeng B, Zeng Q, Wu J, Kascakova B, Martins LA, Prudnikova T, Smatanova IK, Kotsyfakis M, Xu X. Characterization and functional analysis of cathelicidin-MH, a novel frog-derived peptide with anti-septicemic properties. Elife. 2021 Apr 20; 10:e64411. (2021 IF:8.713/Q1) (中科院大类1区小类1区) 
  32. Deng Z#, Zeng Q#, Tang J, Zhang B, Chai J, Andersen JF, Chen X*, Xu X*. Anti-inflammatory effects of FS48, the first potassium channel inhibitor from the salivary glands of the flea Xenopsylla cheopis. J Biol Chem. 2021 Jan-Jun; 296:100670. (2021 IF: 5.486/Q2) (中科院大类2区小类2区)
  33. Xiong W#, Zhou C#, Yin S, Chai J, Zeng B, Wu J, Li Y, Li L*, Xu X*. Fejerlectin, a Lectin-like Peptide from the Skin of Fejervarya limnocharis, Inhibits HIV-1 Entry by Targeting Gp41. ACS Omega. 2021 Feb 24;6(9):6414-6423. (2021 IF:4.132/Q2) (中科院大类3区小类3区)
  34. Yang J, Zhang B, Huang Y, Liu T, Zeng B, Chai J, Wu J, Xu X. Antiviral activity and mechanism of ESC-1GN from skin secretion of Hylarana guentheri against influenza A virus. J Biochem. 2021 Sep 7;169(6):757-765. (2021 IF:3.2417/Q3) (中科院大类4区小类4区)
  35. Zeng Q, Zeng B, Chai J, Wu J, Guo R, Gao Y, Han X, Yang J, Kotsyfakis M, Xu X. Antioxidant properties and neuroprotective effects of Esc-1GN through the regulation of MAPK and AKT signaling. Life Sci. 2020 Aug 1;254: 117753. (2020 IF: 5.037/Q2) (中科院大类2区小类2区)
  36. Zeng Q, Lu W, Deng Z, Wu J, Guo R, Xu X. Tablysin-15 inhibits osteoclastogenesis and LPS-induced bone loss via attenuating the integrin αvβ3 pathway. Chem Biol Interact. 2020 Aug 25; 327:109179. (2020 IF:5.192/Q2) (中科院大类2区小类2区)
  37. Deng Z, Zeng Q, Chai J, Zhang B, Zheng W, Xu X*, Wu J*. Disintegrin Tablysin-15 Suppresses Cancer Hallmarks in Melanoma Cells by Blocking FAK/Akt/ERK and NF-κB Signaling. Curr Cancer Drug Targets. 2020;20(4):306-315. (2020 IF:3.428/Q3) (中科院大类4区小类4区)
  38. Ye T, Wu J, Xu Z, Chai J, Zeng Q, Zeng B, Gao Y, Guo R, Chen X*, Xu X*. Esc-1GN shows therapeutic potentials for acne vulgaris and inflammatory pain. J Pept Sci. 2020 Aug; 26(8): e3269. (2020 IF:1.905/Q4) (中科院大类4区小类4区)
  39. Nguyen T#, Chen X#, Chai J, Li R, Han X, Chen X, Liu S, Chen M*, Xu X*. Antipyretic, anti-inflammatory and analgesic activities of Periplaneta americana extract and underlying mechanisms. Biomed Pharmacother. 2020 Mar;123:109753. (2020 IF:6.530/Q1) (中科院大类2区小类1区)
  40. Deng Z, Chai J, Zeng Q, Zhang B, Ye T, Chen X, Xu X. The anticancer properties and mechanism of action of tablysin-15, the RGD-containing disintegrin, in breast cancer cells. Int J Biol Macromol. 2019 May 15; 129:1155-1167. (2019 IF: 5.162/Q1) (中科院大类1区小类1区)
  41. Zeng B, Chai J, Deng Z, Ye T, Chen W, Li D, Chen X, Chen M, Xu X. Functional Characterization of a Novel Lipopolysaccharide-Binding Antimicrobial and Anti-Inflammatory Peptide in Vitro and in Vivo. J Med Chem. 2018 Dec 13;61(23):10709-10723. (2018 IF: 6.054/Q1) (中科院大类1区小类1区)
  42. Zhang B, Deng Z, Zeng B, Yang S, Chen X, Xu X*, Wu J*. In-vitro effects of the FS50 protein from salivary glands of Xenopsylla cheopis on voltage-gated sodium channel activity and motility of MDA-MB-231 human breast cancer cells. Anticancer Drugs. 2018 Oct;29(9): 880-889. (2018 IF: 1.801/Q4) (中科院大类4区小类4区)
  43. Xu X*, Zhang B, Yang S, An S, Ribeiro JM, Andersen JF. Structure and Function of FS50, a salivary protein from the flea Xenopsylla cheopis that blocks the sodium channel NaV1.5. Sci Rep. 2016 Nov 7;6: 36574. (2016 IF: 4.259/Q1) (中科院大类3区小类3区)
  44. Xu X*, Liu W, Li W, Liu S*. Anticoagulant activity of crude extract of Holotrichia diomphalia larvae. J Ethnopharmacol. 2016 Jan 11; 177:28-34. (2016 IF: 2.981/Q2) (中科院大类2区小类1区)
  45. Xu X, Lai R. The chemistry and biological activities of peptides from amphibian skin secretions. Chem Rev. 2015 Feb 25;115(4):1760-846. (2015 IF: 37.369/Q1) (中科院大类1区小类1区)
  46. Xu X, Chang BW, Mans BJ, Ribeiro JM, Andersen JF. Structure and ligand-binding properties of the biogenic amine-binding protein from the saliva of a blood-feeding insect vector of Trypanosoma cruzi. Acta Crystallogr D Biol Crystallogr. 2013 Jan;69(Pt 1):105-13. (2013 IF: 7.232/Q1) (中科院大类4区小类3区)
  47. Xu X#, Oliveira F#, Chang BW, Collin N, Gomes R, Teixeira C, Reynoso D, My Pham V, Elnaiem DE, Kamhawi S, Ribeiro JM, Valenzuela JG, Andersen JF. Structure and function of a "yellow" protein from saliva of the sand fly Lutzomyia longipalpis that confers protective immunity against Leishmania major infection. J Biol Chem. 2011 Sep 16; 286(37): 32383-93. (2011 IF: 4.773/Q1) (中科院大类2区小类2区)
  48. Xu X, Francischetti IM, Lai R*, Ribeiro JM, Andersen JF*. Structure of protein having inhibitory disintegrin and leukotriene scavenging functions contained in single domain. J Biol Chem. 2012 Mar 30;287(14):10967-76. (2012 IF:4.651/Q1) (中科院大类2区小类2区)
  49. Ma D#, Xu X#, An S, Liu H, Yang X, Andersen JF, Wang Y, Tokumasu F, Ribeiro JM, Francischetti IM*, Lai R*. A novel family of RGD-containing disintegrins (Tablysin-15) from the salivary gland of the horsefly Tabanus yao targets αIIbβ3 or αVβ3 and inhibits platelet aggregation and angiogenesis. Thromb Haemost. 2011 Jun;105(6):1032-45. (2011 IF:5.731/Q1) (中科院大类2区小类2区)
  50. Xu X#, Yang H#, Ma D#, Wu J, Wang Y, Song Y, Wang X, Lu Y, Yang J, Lai R. Toward an understanding of the molecular mechanism for successful blood feeding by coupling proteomics analysis with pharmacological testing of horsefly salivary glands. Mol Cell Proteomics. 2008 Mar;7(3):582-90. (2008 IF:8.834/Q1) (中科院大类1区小类1区)
  51. Li J#, Xu X#, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J. Anti-infection peptidomics of amphibian skin. Mol Cell Proteomics. 2007 May;6(5):882-94. (IF:9.425/Q1) (中科院大类1区小类1区)
  52. Li J#, Zhang C#, Xu X#, Wang J, Yu H, Lai R*, Gong W*. Trypsin inhibitory loop is an excellent lead structure to design serine protease inhibitors and antimicrobial peptides. FASEB J. 2007 Aug;21(10):2466-73. (2007 IF:6.791/Q1) (中科院大类2区小类2区)
  53. Xu X#, Li J#, Lu Q, Yang H, Zhang Y, Lai R. Two families of antimicrobial peptides from wasp (Vespa magnifica) venom. Toxicon. 2006 Feb;47(2):249-53. (2006 IF:2.509/Q2) (中科院大类4区小类3区)
  54. Xu X#, Li J#, Han Y, Yang H, Liang J, Lu Q, Lai R. Two antimicrobial peptides from skin secretions of Rana grahami. Toxicon. 2006 Mar 15;47(4):459-64. (2006 IF:2.509/Q2) (中科院大类4区小类3区)
  55. Xu X#, Yang H#, Yu H, Li J, Lai R. The mastoparanogen from wasp. Peptides. 2006 Dec;27(12):3053-7. (2006 IF:2.701/Q2) (中科院大类3区小类3区)
  56. Yang H#, Xu X#, Ma D, Zhang K, Lai R. A phospholipase A1 platelet activator from the wasp venom of Vespa magnifica (Smith). Toxicon. 2008 Feb;51(2):289-96 (2008 IF:2.460/Q2) (中科院大类4区小类3区)
  57. Li J#, Xu X#, Yu H, Yang H, Huang Z, Lai R. Direct antimicrobial activities of PR-bombesin. Life Sci. 2006 Mar 20;78(17):1953-6. (2006 IF:2.389/Q2) (中科院大类3区小类3区)