郭志刚，男，1963年2月，毕业于第一军医大学军医系，医学博士，南方医科大学南方医院惠侨医疗中心副主任；心血管内科教授、主任医师、博士生导师、博士后合作导师；全科医学硕士生导师。

现为中国病理生理学会动脉粥样硬化专业委员会、国际动脉粥样硬化学会中国分会逆胆固醇转运专家组委员；中国老年学和老年医学学会心血管病分会委员；广东省医疗行业协会心源性卒中管理分会副主任委员；广东省精准医学应用学会精准老年慢病分会副主任委员；广东省保健协会老年医学与保健分会副主任委员；广东省医学会涉外与特需医疗服务分会常委；广东医师协会心血管内科医师分会委员。

从事心血管临床工作30余年、冠脉介入20余年，主管心脏重症室（CCU）10余年，临床经验丰富，擅长冠心病、心力衰竭等心脏重症的救治。研究方向为冠心病（CAD）、动脉粥样硬化（AS）、高脂血症的发病机制基础及临床研究。多次受邀在国内大型学术会议上讲课。主持国家自然科学基金面上项目4项，省市级课题多项，已在国内外杂志上发表论文100余篇，专利3项，编写专著5部。近5年在Nature Reviews Cardiol（IF:32.4）, Theranostics (IF:11.5)，Redox Biology（IF:11.7），J Mol Cell Cardiol (IF:5.0)，Clinical Science（IF:6.1），J Immunol (IF:5.4)等杂志发表多篇文章。共招收40余名硕士/博士研究生，多人获国家奖学金、南方医科大学优秀研究生，毕业后已在国内三甲医院担任心血管内科重要职务。

冠心病与高脂血症的临床诊治与研究；HDL代谢与动脉粥样硬化/冠心病的基础研究。

1. Hangyu Pan, Zhongzhou Guo, Ping Lv, Kexin Hu, Tongwei Wu，Zixiang Lin, Yazhi Xue, Yanan Zhang*, Zhigang Guo*. Proline/serine-rich coiled-coil protein 1 inhibits macrophage inflammation and delays atherosclerotic progression by binding to Annexin A2. Clin Transl Med, 2023, 13: e1220
2. Luo T, Liu D, Guo Z, Chen P, Guo Z, Ou C, Chen M. Deficiency of proline/serine-rich coiled-coil protein 1 (PSRC1) accelerates trimethylamine N-oxide-induced atherosclerosis in ApoE^-/-mice. J Mol Cell Cardiol. 2022 Sep;170:60-74.
3. Luo T, Guo Z, Liu D, Guo Z, Wu Q, Li Q, Lin R, Chen P, Ou C, Chen M. Deficiency of PSRC1 accelerates atherosclerosis by increasing TMAO production via manipulating gut microbiota and flavin monooxygenase 3. Gut Microbes. 2022 Jan-Dec;14(1):2077602.
4. Mengzhuo Yin，Jianwen Lu，Zhongzhou Guo, Yanan Zhang, Jichen Liu，Tongwei Wu, Kai Guo, Tiantian Luo, Zhigang Guo*. Reduced SULT2B1b xpressionalleviatesox-LDL-induced inflammation by upregulating miR-148-3P via inhibiting the IKKb/NF-kB pathway in macrophages. Aging, 2021, 13(3): 3428-3442
5. Yanan Zhang, Zhongzhou Guo, Tongwei Wu, Jichen Liu, Bin Zhang, Wenyan Lai, Wenwei T2, Zhigang Guo*, Tiantian Luo*. SULT2B1b inhibits reverse cholesterol transport and promotes cholesterol accumulation and inflammation in lymphocytes from AMI patients with low LDL-C levels. Clinical Science, 2020, 134:273-287   
6. Jichen Liu, Zhongzhou Guo, Yanan Zhang, Tongwei Wu, Yusheng Ma, Wenyan Lai, Zhigang Guo*. LCK inhibitor attenuates atherosclerosis in ApoE-/- mice via regulating T cell differentiation and reverse cholesterol transport. J Mol Cell Cardiol, 2020, 139: 87-97
7. Jiankai Zhong, Ying Tan, Jianhua Lu, Jichen Liu, Xiaochan Xiao, Pinji Zhu, Sainan Chen, Sulin Zheng, Yuying Chen, Yunzhao Hu, Zhigang Guo*. Therapeutic contribution of melatonin to the treatment of septic cardiomyopathy: A novel mechanism linking Ripk3-modified mitochondrial performance and endoplasmic reticulum function. Redox Biology, 2019, 26, 101287  
8. Jichen Liu, Kai Guo, Lu Hu, Tiantian Luo, Yusheng Ma, Yanan Zhang, Wenyan Lai, Zhigang Guo*. ZAP70 deficiency promotes reverse cholesterol transport through MAPK/ERK pathway in Jurkat cell. Molecular Immunology, 2019, 107: 21-28
9. Dan Xi, Jinzhen Zhao, Kai Guo, Lu Hu, Hui Chen, Weijun Fu, Wenyan Lai, Zhigang Guo*. Serum amyloid P component therapeutically attenuates atherosclerosis in mice via its effects on macrophages. Theranostics, 2018, 8(12): 3214-3223  
10. Kai Guo, Lu Hu, Dan Xi, Jinzhen Zhao, JichenLiu, Tiantian Luo, Yusheng Ma, Wenyan Lai, Zhigang Guo*. PSRC1 overexpression attenuates atherosclerosis progression in apoE-/- mice by modulating cholesterol transportation and inflammation. J Mol Cell Cardiol, 2018 Feb 2; 116: 69-80.  
11. Lu Hu, Kai Guo, Zhigang Guo*. Bivalirudin for patients with STEMI at high risk of bleeding undergoing PPCI. Nature Reviews Cardiology, 14 Sep 2017, doi: 10.1038/nrcardio.2017.141    
12. Tiantian Luo, Jing Hu, Dan Xi, Haowei Xiong, Wenshuai He, Jichen Liu, Menghao Li, Hao Lu, Jinzhen Zhao, Wenyan Lai, Zhigang Guo*. Lck Inhibits Heat Shock Protein 65-Mediated Reverse Cholesterol Transport in T Cells. The Journal of Immunology, 2016, 197(10): 3861-3870  
13. Dan Xi, Tiantian Luo, Haowei Xiong, Hao Lu, Menghao Li, Yuqing Hou, Zhigang Guo*. SAP: history, structure, and immne-related diseases. International Journal of Cardiology  (INT J CARDIOL), 2015, 187: 20-26
14. Haige Sun, Jiangang Shen, Tingrong Liu, Ying Tan, Di Tian, Tiantian Luo, Wen Yan Lai, Meng Dai, Zhigang Guo*. Heat shock protein 65 promotes atherosclerosis through impairing the properties of high density lipoprotein. Atherosclerosis, 2014, 237: 835-861