医学博士，博士后，副教授、副主任医师，硕士研究生导师。现任南方医科大学深圳口腔医院（坪山）医务部部长/儿童口腔科主任。主要从事龋病防治及牙齿发育再生相关研究，作为负责人承担国家自然科学基金1项，市厅及院校级项目5项，作为主要成员参与国家自然科学基金2项。申请并获国家专利1项，申请发明专利1项。国家级一流本科课程——《儿童口腔医学》负责人，广东省一流本科课程——《齿间的奥秘》负责人。从事口腔医、教、研工作14年，在国内外专业期刊发表论文30余篇，其中SCI收录15篇，参编专著4部。

   任职广东省口腔医学会口腔镇静镇痛专委会副主任委员；广东省口腔医学会儿童口腔医学专业委员会常务委员；广东省口腔医学会预防口腔医学专业委员会常务委员；先后赴美国德州大学、日本大阪齿科大学、台湾中山医学大学及国内多所高校交流访学。

龋病预防及流行病学，牙齿发育与再生相关研究

1. Chen L, Zhu M, Zhang C, Wang Z, Lyu X, Xu W, Wu B. Osteopontin interacts with dendritic cells and macrophages in pulp inflammation: Comprehensive transcriptomic analysis and laboratory investigations. Int Endod J. 2024 Apr;57(4):464-476. doi: 10.1111/iej.14028. Epub 2024 Jan 27. PMID: 38279773.
2. You Y, Yin M, Zheng X, Liang Q, Zhang H, Wu BL, Xu W. Saccharibacteria (TM7), but not other bacterial taxa, are associated with childhood caries regardless of age in a South China population. PeerJ. 2023 Jun 26;11:e15605. doi: 10.7717/peerj.15605. PMID: 37397017; PMCID: PMC10309052.
3. Tian T, Wang Z, Chen L, Xu W, Wu B. Photobiomodulation activates undifferentiated macrophages and promotes M1/M2 macrophage polarization via PI3K/AKT/mTOR signaling pathway. Lasers Med Sci. 2023 Mar 18;38(1):86. doi: 10.1007/s10103-023-03753-x. PMID: 36932298.
4. Yin M, You Y, Zheng X, Liang Q, Wu B, Xu W. Fungal composition in saliva and plaque in children with caries: Differences and influencing factors. Med Microecol. 2023 Mar. doi: 10.1016/j.medmic.2023.100076
5. Tian T, Chen L, Wang Z, Zhu M, Xu W, Wu B. Sema3A Drives Alternative Macrophage Activation in the Resolution of Periodontitis via PI3K/AKT/mTOR Signaling. Inflammation. 2023 Jan 4. doi: 10.1007/s10753-022-01777-z. Epub ahead of print. PMID: 36598593.
6. Wang Z, Tian T, Chen L, Zhang C, Zheng X, Zhong N, Wu B, Xu W. 980 nm Photobiomodulation Promotes Osteo/Odontogenic Differentiation of the Stem Cells from Human Exfoliated Deciduous Teeth Via the Cross talk Between BMP/Smad and Wnt/β-Catenin Signaling Pathways. Photochem Photobiol. 2022 Nov 27. doi: 10.1111/php.13751. Epub ahead of print. PMID: 36437584.
7. Li X, Xu W, Lin X, Wu J, Wu B. Effect of  LncRNA-MALAT1 on mineralization of dental pulp cells in a high-glucose microenvironment. Front Cell Dev Biol. 2022 Aug 11;10:921364. doi: 10.3389/fcell.2022.921364. PMID: 36035997; PMCID: PMC9402893.
8. Huang X, Qiu W, Pan Y, Li J, Chen Z, Zhang K, Luo Y, Wu B, Xu W. Exosomes from LPS-Stimulated hDPSCs Activated the Angiogenic Potential of HUVECs In Vitro. Stem Cells Int. 2021 Apr 15;2021:6685307. doi: 10.1155/2021/6685307. PMID: 33936213; PMCID: PMC8062194.
9. Chen Y, Li X, Wu J, Lu W, Xu W, Wu B. Dental pulp stem cells from human teeth with deep caries displayed an enhanced angiogenesis potential in vitro. J Dent Sci. 2021 Jan;16(1):318-326. doi: 10.1016/j.jds.2020.03.007. Epub 2020 Apr 5. PMID: 33384815; PMCID: PMC7770258.
10. Li X, Xu W, Wu J, Lin X, Chen Y, Wen J, Wu B. Differential expression of long noncoding RNAs from dental pulp stem cells in the microenvironment of the angiogenesis. Arch Oral Biol. 2020 May;113:104691. doi: 10.1016/j.archoralbio.2020.104691. Epub 2020 Mar 19. PMID: 32247880.
11. Lu W, Xu W, Li J, Chen Y, Pan Y, Wu B. Effects of vascular endothelial growth factor and insulin growth factor‑1 on proliferation, migration, osteogenesis and vascularization of human carious dental pulp stem cells. Mol Med Rep. 2019 Oct;20(4):3924-3932. doi: 10.3892/mmr.2019.10606. Epub 2019 Aug 23. PMID: 31485628.
12. Xu W, Chen S. Establishment of an Immortalized Mouse Bmp2 Knockout Dental Papilla Mesenchymal Cell Line. Methods Mol Biol. 2019;1922:13-19. doi: 10.1007/978-1-4939-9012-2_2. PMID: 30838560.
13. Xu W, Chen Q, Liu C, Chen J, Xiong F, Wu B. A novel, complex RUNX2 gene mutation causes cleidocranial dysplasia. BMC Med Genet. 2017 Feb 7;18(1):13. doi: 10.1186/s12881-017-0375-x. PMID: 28173761; PMCID: PMC5297198.
14. Xu W, Jiang S, Chen Q, Ye Y, Chen J, Heng BC, Jiang Q, Wu B, Ding Z, Zhang C. Systemically Transplanted Bone Marrow-derived Cells Contribute to Dental Pulp Regeneration in a Chimeric Mouse Model. J Endod. 2016 Feb;42(2):263-8. doi: 10.1016/j.joen.2015.10.007. Epub 2015 Dec 10. PMID: 26686823.
15. Zou Y, Li C, Shu F, Tian Z, Xu W, Xu H, Tian H, Shi R, Mao X. lncRNA expression signatures in periodontitis revealed by microarray: the potential role of lncRNAs in periodontitis pathogenesis. J Cell Biochem. 2015 Apr;116(4):640-7. doi: 10.1002/jcb.25015. PMID: 25399840.