官道刚，男，南方医科大学基础医学院生化与分子生物学系教授。目前主要从事复杂生命活动尤其是肿瘤发生发展过程中关键基因调控网络的构建及其分子机理的计算建模，先后建立了多组学分析平台及组合药物筛选平台可以分析从芯片数据到单细胞测序在内的多种高通量数据及FDA批准药物组合效应的分子机理，在前期研究中，基于多尺度组学数据，建立了多个数理统计和组学整合分析模型，并成功应用于多物种 miRNA 探测，人类头颈肿瘤，乳腺癌，大肠癌，小鼠干细胞分化及线虫细胞命运决定, 拟南芥开花等生物过程的关键调控节点的探测及开关网络的建立成功解读了这些复杂生物过程中的关键基因及通路。

• 高通量数据分析及基于高通量多组学数据解码复杂疾病的分子机制  
• 疾病发生、细胞命运决定、胚胎发育过程中复杂基因调控网络的数学建模及量化  
• 非编码 RNA 探测及功能挖掘 
• 系统生物学、转化医学和计算机辅助药物设计  

1. Dao-Qiang Lu, Dahai Liu, Justin Liu, Wen-Xing Li, Yilong Ai, Jun Wang, Guan D (通讯). Facile synthesis of chitosan-based nanogels through photo-crosslinking for doxorubicin delivery. International Journal of Biological Macromolecules 2022, 10.1016/j.ijbiomac.2022.07.112. （一区，IF:8.025）
2. Wu J, Wang K, Liu Q, Li Y, Huang Y, Liu Y, Cai J, Yin C, Li X, Yu H, Meng W, Wang H, Lu A*, Li Y*, Guan D* (通讯). An Integrative Pharmacology Model for Decoding the Underlying Therapeutic Mechanisms of Ermiao Powder for Rheumatoid Arthritis. Front Pharmacol 2022, 13:801350. 10.3389/fphar.2022.801350. （二区，IF: 5.988）
3. Liu Y, Liu Q, Yin C, Li Y, Wu J, Chen Q, Yu H, Lu A*, Guan D* (通讯). Uncovering Hidden Mechanisms of Different Prescriptions Treatment for Osteoporosis via Novel Bioinformatics Model and Experiment Validation. Front Cell Dev Biol 2022, 10:831894. 10.3389/fcell.2022.831894. （二区，IF: 6.081）
4. Wang KX, Yin CH, Ye XM, Chen QL, Wu J, Chen YP, Li Y, Wang J, Duan CZ, Lu AP, Guan DG (通讯). A metabolic driven bio-responsive hydrogel loading psoralen for therapy of rheumatoid arthritis. Small. 2023. (一区，IF: 15.153)
5. Guan D, Yan B, Thieme C, Hua J, Zhu H, Boheler KR, Zhao Z, Kragler F, Xia Y, Zhang S. PlaMoM: a comprehensive database compiles plant mobile macromolecule. Nucleic Acids Res. 2017 Jan 4;45(D1): D1021-D1028. （一区，IF: 11.147）
6. Guan D, Xia Y, Zhang S. Analyzing and Predicting Phloem Mobility of Macromolecules with an Online Database; Methods Mol Biol. 2019; 2014:433-438;
7. Guan D, Shao J, Zhao Z, Wang P, Qin J, Deng Y, Boheler KR, Wang J, Yan B: PTHGRN: unraveling post-translational hierarchical gene regulatory networks using PPI, ChIP-seq and gene expression data. Nucleic Acids Res 2014, 42:W130-136. (cover story) （一区，IF: 11.147）
8. Guan D, Shao J, Deng Y, Wang P, Zhao Z, Liang Y,Wang J, Yan B: CMGRN: a web server for constructing multilevel gene regulatory networks using ChIP-seq and gene expression data. Bioinformatics , 2014, 30(8): 1190-1192. （一区，IF: 4.531）
9. Guan DG, Liao JY, Qu ZH, Zhang Y, Qu mirExplorer: detecting microRNAs from genome and next generation sequencing data using the AdaBoost method with transition probability matrix and combined features. RNA Biol 2011, 8(5):922-934. （二区，IF: 5.477）
10. Yan B#, Guan D# (Co-first author), Wang C, Wang J, He B, Qin J, KR Boheler, Lu A, Zhang G, Zhu H. An integrative method to decode regulatory logics in gene transcription. Nature Communications, 2017, 8(1): 1044-1044. （一区，IF: 11.878）
11. Zhuo Z#, Wan Y#, Guan D# (Co-first author), Ni S#, Wang L#, Zhang Z, Liu J, Liang C, Yu Y, Lu A, Zhang G, Zhang B. A Loop-Based and AGO-Incorporated Virtual Screening Model Targeting AGO-Mediated miRNA-mRNA Interactions for Drug Discovery to Rescue Bone Phenotype in Genetically Modified Mice. Advanced Science, May 2020,DOI: 10.1002/advs.201903451. （一区，IF:15.804）
12. Zhang Z#, Li J#, Guan D# (Co-first author), Liang C#, Zhuo Z, Liu J, Lu A, Zhang G, Zhang B. A newly identified lncRNA MAR1 acts as a miR-487b sponge to promote skeletal muscle differentiation and regeneration. Journal of Cachexia, Sarcopenia and Muscle, 2018, 9(3): 613-626. （一区，IF: 10.754）
13. Zhang Z#, Li J#, Guan D# (Co-first author), Liang C#, Zhuo Z, Liu J, Lu A, Zhang G, Zhang B. Long Noncoding RNA lncMUMA Reverses Established Skeletal Muscle Atrophy Following Mechanical Unloading, Molecular Therapy , 2018, 26(11): 2669-2680. （一区，IF: 8.402）
14. Liang C#, Peng S#, Li J#, Lu J#, Guan D# (Co-first author), Jiang F#, Lu Cheng, Li F, He X, Zhu H, Au D, Yang D, Zhang B, Lu A, Zhang G. Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age2 related osteoporosis. Nature Communications, 2018, 9(1): 3428. （一区，IF: 11.878）
15. Ho VW#, Wong MK#, An X#, Guan D# (Co-first author), Shao J, Ng HC, Ren X, He K, Liao J, Ang Y, Chen L, Huang X, Yan B, Xia Y, Chan LL, Chow KL, Yan H, Zhao Z: Systems- level quantification of division timing reveals a common genetic architecture controlling asynchrony and fate asymmetry. Mol Syst Biol 2015, 11(6):814. （一区，IF: 9.800）
16. Wang C, Ren Q, Chen X, Song Z, Ning Z, Gan J, Ma X, Liang D, Guan D*(Corresponding author), Liu Z*, Lu A*. System Pharmacology-Based Strategy to Decode the Synergistic Mechanism of Zhi-zhu Wan for Functional Dyspepsia. Front Pharmacol. 2018, 9, 841. （二区，IF: 4.225）
17. Chen X, Zheng C, Wang C, Guo Z, Gao S, Ning Z, Huang C, Lu C, Fu Y, Guan D*(Corresponding author), Lu A*, Wang Y*. Systems-Mapping of Herbal Effects on Complex Diseases Using the Network-Perturbation Signatures. Front Pharmacol. 2018 Oct. 9, 1174. （二区，IF: 4.225）
18. Guo Q, Li L, Zheng K, Zheng G, Shu H, Shi Y, Lu C, Shu J, Guan D*(Corresponding author), Lu A*, He X*. Imperatorin and β-sitosterol have synergistic activities in alleviating collagen-induced arthritis. J Leukoc Biol. 2020 May 11. (三区，IF: 3.78)
19. Ke-xin Wang, Y Gao, Cheng Lu, Yao Li, Bo-ya Zhou, Xiao meng Qin, Guan-Hua Du, Li Gao, Dao-gang Guan* (Corresponding author), Ai-ping Lu*. Uncovering the Complexity Mechanism of Different Formulas Treatment for Rheumatoid Arthritis Based on a Novel Network Pharmacology Model. July 2020，Frontiers in Pharmacology 11:1035. （二区，IF: 4.225）
20. Gao Y, Wang KX, Wang P, Li X, Chen JJ, Zhou BY, Tian JS, Guan DG* (Corresponding author), Qin XM*, Lu AP*. A Novel Network Pharmacology Strategy to Decode Mechanism of Lang Chuang Wan in Treating Systemic Lupus Erythematosus. Front Pharmacol. 2020 Oct 2;11:512877. （二区，IF: 4.225）
21. Wang KX, Gao Y, Gong WX, Ye XF, Fan LY, Wang C, Gao XF, Gao L, Du GH, Qin XM*, Lu AP*, Guan DG* (Corresponding author). A Novel Strategy for Decoding and Validating the Combination Principles of Huanglian Jiedu Decoction From Multi-Scale Perspective. Front Pharmacol. 2020.（二区，IF: 4.225）
22. He K#, Li WX#, Guan D# (Co-first author), Gong M, Ye S, Fang Z, Huang JF, Lu A. Regulatory network reconstruction of five essential microRNAs for survival analysis in breast cancer by integrating miRNA and mRNA expression datasets. Funct Integr Genomics. 2019 Mar 12.
23. Kan He, Guoying Wu, Wen-Xing Li, Daogang Guan(Co-first author), Wenwen Lv, Mengting Gong, Shoudong Ye, Aiping Lu,A transcriptomic study of myogenic differentiation under the overexpression of PPARγ by RNA-Seq. Scientific reports, 2017.
24. Zhang C, Guan D(Co-first author), Jiang M, Liang C, Li L, Zhao N, Zha Q, Zhang W, Lu C, Zhang G, Liu J, Lu A. Efficacy of leflunomide combined with ligustrazine in the treatment of rheumatoid arthritis: prediction with network pharmacology and validation in a clinical trial; Chin Med. 2019 Aug 2;14:26.
25. Zheng Y, Wang X, Zhang Z, Guo B, Dang L, He B, Zhang C, Zhou J, Shi W, Zhao Y, Zhan H, Xu Y, Liang C, Liu J, Guan D, Wang L, Wu X, Li J, Zhuo Z, Lin Z, Qiu H, Zhong L, Bian Z, Shi Y, Zhang B, Zhang G, Lu A. Bushen yijing fang reduces fall risk in late postmenopausal women with osteopenia: a randomized double-blind and placebo-controlled trial. Scientific reports, 2019, 9(1): 2089.
26. Zhang C, Guan D, Jiang M, Liang C, Li L, Zhao N, Zha Q, Zhang W, Lu C, Zhang G, Liu J, Lu A. Efficacy of leflunomide combined with ligustrazine in the treatment of rheumatoid arthritis: prediction with network pharmacology and validation in a clinical trial; Chin Med. 2019 Aug 2;14:26.
27. Zhang Y, Guan DG, Yang JH, Shao P, Zhou H, Qu LH: ncRNAimprint: a comprehensive database of mammalian imprinted noncoding RNAs. RNA 2010, 16(10):1889-1901.
28. Zhang C, Zhou W, Guan DG, Wang YH, Lu AP. Network Intervention, a Method to Address Complex Therapeutic Strategies. Front Pharmacol. 2018 Jul 12;9:754.
29. ENY Poon*, B Hao, D Guan, MJ Li, J Lu, Y Yang, B Wu, SE Webb, SCM Wu, ALMiller, Y Liang, X Yao, J Wang, B Yan*, KR Boheler. Integrated transcriptomics and regulatory network analyses identify microRNA-200c as a novel repressor of differentiation and maturation of human pluripotent stem cell-derived cardiomyocytes. Cardiovascular Research 2018.
30. Shao P, Liao JY, Guan DG, Yang JH, Zheng LL, Jing Q, Zhou H, Qu LH: Drastic expression change of transposon-derived piRNA-like RNAs and microRNAs in early stages of chicken embryos implies a role in gastrulation. RNA Biol 2012, 9(2):212-227. (cover story)
31. Li F, Lu J, Liu J, Liang C, Wang M, Wang L, Li D, Yao H, Zhang Q, Wen J, Zhang Z, Li J, Lu Q, He X, Guo B, Guan D, Yu Y, Dang L, Wu X, Li Y, Chen G, Jiang F, Sun S, Zhang B, Lu A, Zhang G. A water-soluble nucleolin aptamer-paclitaxel conjugate fortumor-specific targeting in 1 ovarian cancer. Nature Communications 2017.
32. Wang L, Liang C, Li F, Guan D, Wu X, Fu X, Lu A, Zhang G. PARP1 in carcinomas and PARP1 inhibitors as antineoplastic drugs. Int J Mol Sci. 2017. 18 (10), 2111
33. Lv Q, Meng Z, Yu Y, Jiang F, Guan D, Liang C, Zhou J, Lu A, Zhang G. Molecular Mechanisms and Translational Therapies for Human Epidermal Receptor 2 Positive Breast Cancer. Int J Mol Sci. 2016 Dec 14;17(12).
34. Lv H, Jiang F, Guan D, Lu C, Guo B, Chan C, Peng S, Liu B, Guo W, Zhu H, Xu X, Lu A,Zhang G. Metabolomics and Its Application in the Development of Discovering Biomarkers for Osteoporosis Research. Int J Mol Sci. 2016 Dec 2;17(12).
35. Wong MK, Guan D, Ng HC, Ho VW, An X, Li R, Ren X, Zhao Z: Timing of Tissue-specific Cell Division Requires a Differential Onset of Zygotic Transcription during Metazoan Embryogenesis. Journal of Biological Chemistry,2016
36. Zhang J, Yan B, Spath SS, Qun H, Cornelius S, Guan D, Shao J, Hagiwara K, Van WaesC, Chen Z, Su X, Bi Y: Integrated transcriptional profiling and genomic analyses reveal RPN2 and HMGB1 as promising biomarkers in colorectal cancer. Cell Biosci 2015, 5:53.
37. Wang J, Yan B, Liu SM, Sun H, Pan Y, Guan D, Zhang X, Xu J, Ma H: Transcriptomic and Functional Pathway Analysis of Human Cervical Carcinoma Cancer Cells Response to Microtubule Inhibitor. J Cancer 2015, 6(10):930-937.
38. Wen JZ, Liao JY, Zheng LL, Xu H, Yang JH, Guan DG, Zhang SM, Zhou H, Qu LH: A contig-based strategy for the genome-wide discovery of microRNAs without complete genome resources. PLoS One 2014, 9(2):e88179.
39. Yan B, Li H, Yang X, Shao J, Jang M, Guan D, Zou S, Van Waes C, Chen Z, Zhan M: Unraveling regulatory programs for NF-kappaB, p53 and microRNAs in head and neck squamous cell carcinoma. PLoS One 2013, 8(9):e73656.
40. Shao P, Yang JH, Zhou H, Guan DG, Qu LH: Genome-wide analysis of chicken snoRNAs provides unique implications for the evolution of vertebrate snoRNAs. BMC Genomics 2009, 10:86.
41. Liu N, Xiao ZD, Yu CH, Shao P, Liang YT, Guan DG, Yang JH, Chen CL, Qu LH, Zhou H: SnoRNAs from the filamentous fungus Neurospora crassa: structural, functional and evolutionary insights. BMC Genomics 2009, 10:515.