主持课题情况
1 局麻药激活TRPV1通道介导糖尿病小鼠神经毒性损伤的机制研究，国家自然科学基金青年科学基金项目（81501082）。起止时间：2016.01.01 -2018.12.31，直接经费17.5万，间接经费3.5万元，主持，已结题。
2 基于nAchR-NO副交感神经通路探讨异氟烷对糖尿病小鼠脑血流量的影响：国家自然科学基金面上项目（81974192）。起止时间：2020.01.01-2023.12.31，直接经费55万元，主持，已结题。
3 TRPV1肽能感觉神经介导的血管功能异常在糖尿病微循环障碍中的作用研究：国家自然科学基金面上项目（82271392）。起止时间：2023.01.01-2026.12.31，直接经费52万元，主持，在研。
4 伤害性感受的周围神经机制：南方医科大学珠江医院院长基金杰青培育项目（zjjj2022rc02）。起止时间：2023.12.01-2024.12.01，50万元，主持。
5 肥大细胞介导感觉神经IL4Ra-JAK1通路活化在糖尿病自发性瘙痒中的作用研究，广东省基础与应用基础研究基金自然科学基金面项，起止时间：2024.01.01-2026.12.31，15万元，主持，在研。
6 脂肪细胞通过瘦素介导痒觉神经可塑性改变在糖尿病瘙 痒中的机制研究：国家自然科学基金面上项目（82471252）。起止时间：2025.01.01-2028.12.31，直接经费49万元，主持，在研
专著：
1.《麻醉学临床病例图解》张鸿飞（主译）; 周祥勇（副主译）; 李凤仙（副主译）。世界图书出版公司，出版时间：2018-06-01,（ISBN：9787519247867）
2.《麻醉学临床病例精解》张鸿飞（主译）; 赵高峰（副主译）; 李凤仙（副主译）；刘岗（副主译）。北京大学医学出版社，出版时间：2021-12-01（ISSN:978-7-5659-2524-5）
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主要发表文章：1-43
1. Zhang P, Yuan D, Luo C, Guo W, Li F: Role of pterygopalatine ganglion in regulating isoflurane-induced cerebral hyper-perfusion. J Cereb Blood Flow Metab 2024: 271678x241275351
2. Yao ZJ, Jiang YP, Yuan D, Hong P, He MJ, Li FX, Xu SY, Lin HB, Zhang HF: Decreased connexin 40 expression of the sinoatrial node mediates ischemic stroke-induced arrhythmia in mice. Exp Neurol 2024; 376: 114773
3. Luo JM, Lin HB, Weng YQ, Lin YH, Lai LY, Li J, Li FX, Xu SY, Zhang HF, Zhao W: Inhibition of PARP1 improves cardiac function after myocardial infarction via up-regulated NLRC5. Chem Biol Interact 2024; 395: 111010
4. Lin HB, Hong P, Yin MY, Yao ZJ, Zhang JY, Jiang YP, Huang XX, Xu SY, Li FX, Zhang HF: Monocyte-Derived Macrophages Aggravate Cardiac Dysfunction After Ischemic Stroke in Mice. J Am Heart Assoc 2024; 13: e034731
5. Li X, Yuan D, Zhang P, Luo C, Xie X, Zhang Y, Wei Z, Wang M, Cai Y, Zeng Y, Lai L, Che D, Ling H, Shi S, Zhang HF, Wang F, Li F: A neural-mast cell axis regulates skin microcirculation in diabetes. Diabetes 2024
6. Zhi Y, Wu X, Chen Y, Chen X, Chen X, Luo H, Yi X, Lin X, Ma L, Chen Y, Cao Y, Li F, Zhou P: A novel TWIK2 channel inhibitor binds at the bottom of the selectivity filter and protects against LPS-induced experimental endotoxemia in vivo. Biochem Pharmacol 2023; 218: 115894
7. Zhang J, Lin H, Li F, Wu K, Yang S, Zhou S: Involvement of endoplasmic reticulum stress in trigeminal ganglion corneal neuron injury in dry eye disease. Front Mol Neurosci 2023; 16: 1083850
8. Huang XX, Zhang QQ, Pang XX, Lin HB, He WY, Yuan D, Guo WJ, Zhang HF, Li FX: Role of galectin-3 in cardiac dysfunction induced by subarachnoid hemorrhage. Exp Neurol 2023; 365: 114418
9. Huang X, Li F, Wang F: Neural Regulation of Innate Immunity in Inflammatory Skin Diseases. Pharmaceuticals (Basel) 2023; 16
10. Guo C, Jiang H, Huang CC, Li F, Olson W, Yang W, Fleming M, Yu G, Hoekel G, Luo W, Liu Q: Pain and itch coding mechanisms of polymodal sensory neurons. Cell Rep 2023; 42: 113316
11. Zhang YJ, Guo WJ, Tang ZY, Lin HB, Hong P, Wang JW, Huang XX, Li FX, Xu SY, Zhang HF: Isoflurane Attenuates Cerebral Ischaemia-Reperfusion Injury via the TLR4-NLRP3 Signalling Pathway in Diabetic Mice. Oxid Med Cell Longev 2022; 2022: 2650693
12. Xie Z, Feng J, Cai T, McCarthy R, Eschbach MD, 2nd, Wang Y, Zhao Y, Yi Z, Zang K, Yuan Y, Hu X, Li F, Liu Q, Das A, England SK, Hu H: Estrogen metabolites increase nociceptor hyperactivity in a mouse model of uterine pain. JCI Insight 2022; 7
13. Wu W, Jia J, Li F, Peng W, Liu H, Chen H, Shi Y: Editorial: Pain-related neural networks and regulation mechanisms. Front Mol Neurosci 2022; 15: 1051335
14. Li F, Wang C, Hu D, Zhang X, Shen R, Zhou Y, Yang Y, Zhu C, Tang Z, Yu G: mMrgprA3/mMrgprC11/hMrgprX1: Potential therapeutic targets for allergic contact dermatitis-induced pruritus in mice and humans. Contact Dermatitis 2022; 86: 286-294
15. Lai L, Wang Y, Peng S, Guo W, Wei G, Li L, Xia Z, Li F, Xu S: Bupivacaine Induces ROS-Dependent Autophagic Damage in DRG Neurons via TUG1/mTOR in a High-Glucose Environment. Neurotox Res 2022; 40: 111-126
16. Lai L, Wang Y, Peng S, Guo W, Li F, Xu S: P53 and taurine upregulated gene 1 promotes the repair of the DeoxyriboNucleic Acid damage induced by bupivacaine in murine primary sensory neurons. Bioengineered 2022; 13: 7439-7456
17. Wang F, Trier AM, Li F, Kim S, Chen Z, Chai JN, Mack MR, Morrison SA, Hamilton JD, Baek J, Yang T-LB, Ver Heul AM, Xu AZ, Xie Z, Dong X, Kubo M, Hu H, Hsieh C-S, Dong X, Liu Q, Margolis DJ, Ardeleanu M, Miller MJ, Kim BS: A basophil-neuronal axis promotes itch. Cell 2021; 184: 422-440.e17
18. Lin HB, Lin YH, Zhang JY, Guo WJ, Ovcjak A, You ZJ, Feng ZP, Sun HS, Li FX, Zhang HF: NLRP3 Inflammasome: A Potential Target in Isoflurane Pretreatment Alleviates Stroke-Induced Retinal Injury in Diabetes. Front Cell Neurosci 2021; 15: 697449
19. Lin HB, Li FX, Zhang JY, You ZJ, Xu SY, Liang WB, Zhang HF: Cerebral-Cardiac Syndrome and Diabetes: Cardiac Damage After Ischemic Stroke in Diabetic State. Front Immunol 2021; 12: 737170
20. Li F, Wang F: TRPV1 in Pain and Itch. Adv Exp Med Biol 2021; 1349: 249-273
21. Li F, Jiang H, Shen X, Yang W, Guo C, Wang Z, Xiao M, Cui L, Luo W, Kim BS, Chen Z, Huang AJW, Liu Q: Sneezing reflex is mediated by a peptidergic pathway from nose to brainstem. Cell 2021; 184: 3762-3773.e10
22. He W, Cui Z, Chen Y, Wang F, Li F: Status of N-of-1 Trials in Chronic Pain Management: A Narrative Review. Pain Ther 2021; 10: 1013-1028
23. Zhang HF, Bo L, Lin Y, Li FX, Sun S, Lin HB, Xu SY, Bian J, Yao S, Chen X, Meng L, Deng X: Response of Chinese Anesthesiologists to the COVID-19 Outbreak. Anesthesiology 2020; 132: 1333-1338
24. Wang Y, Lai L, Guo W, Peng S, Liu R, Hong P, Wei G, Li F, Jiang S, Wang P, Li J, Lei H, Zhao W, Xu S: Inhibition of Ku70 in a high-glucose environment aggravates bupivacaine-induced dorsal root ganglion neurotoxicity. Toxicol Lett 2020; 318: 104-113
25. Liu M, Li Z, Wang S, Liu Y, Zhong X, He R, Li F: Application via mechanical dropper alleviates sufentanil-induced cough: a prospective, randomized, single-blinded trial. Trials 2019; 20: 170
26. Li F, Yang W, Jiang H, Guo C, Huang AJW, Hu H, Liu Q: TRPV1 activity and substance P release are required for corneal cold nociception. Nat Commun 2019; 10: 5678
27. Hong P, Gu RN, Li FX, Xiong XX, Liang WB, You ZJ, Zhang HF: NLRP3 inflammasome as a potential treatment in ischemic stroke concomitant with diabetes. J Neuroinflammation 2019; 16: 121
28. Guo Z, Qiu CS, Jiang X, Zhang J, Li F, Liu Q, Dhaka A, Cao YQ: TRESK K(+) Channel Activity Regulates Trigeminal Nociception and Headache. eNeuro 2019; 6
29. Liu M, Wu H, Yang D, Li F, Li Z, Wang S, He R: Effects of small-dose remifentanil combined with index of consciousness monitoring on gastroscopic polypectomy: a prospective, randomized, single-blinded trial. Trials 2018; 19: 392
30. Huang CC, Yang WS, Guo CX, Jiang HW, Li FX, Xiao ML, Davidson S, Yu G, Duan B, Huang TW, Huang AJW, Liu Q: Anatomical and functional dichotomy of ocular itch and pain. Nature Medicine 2018; 24: 1268-+
31. Hong P, Li FX, Gu RN, Fang YY, Lai LY, Wang YW, Tao T, Xu SY, You ZJ, Zhang HF: Inhibition of NLRP3 Inflammasome Ameliorates Cerebral Ischemia-Reperfusion Injury in Diabetic Mice. Neural Plast 2018; 2018: 9163521
32. Deng HB, Li FX, Cai YH, Xu SY: Waste anesthetic gas exposure and strategies for solution. J Anesth 2018; 32: 269-282
33. Yu XJ, Zhao W, Li YJ, Li FX, Liu ZJ, Xu HL, Lai LY, Xu R, Xu SY: Neurotoxicity Comparison of Two Types of Local Anaesthetics: Amide-Bupivacaine versus Ester-Procaine. Sci Rep 2017; 7: 45316
34. Yang JM, Li F, Liu Q, Rüedi M, Wei ET, Lentsman M, Lee HS, Choi W, Kim SJ, Yoon KC: A novel TRPM8 agonist relieves dry eye discomfort. BMC Ophthalmol 2017; 17: 101
35. Liu MQ, Li FX, Han YK, He JY, Shi HW, Liu L, He RL: Administration of fentanyl via a slow intravenous fluid line compared with rapid bolus alleviates fentanyl-induced cough during general anesthesia induction. J Zhejiang Univ Sci B 2017; 18: 955-962
36. Li YJ, Zhao W, Yu XJ, Li FX, Liu ZT, Li L, Xu SY: Activation of p47phox as a Mechanism of Bupivacaine-Induced Burst Production of Reactive Oxygen Species and Neural Toxicity. Oxid Med Cell Longev 2017; 2017: 8539026
37. Hu D, Wang C, Li F, Su S, Yang N, Yang Y, Zhu C, Shi H, Yu L, Geng X, Gu L, Yuan X, Wang Z, Yu G, Tang Z: A Combined Water Extract of Frankincense and Myrrh Alleviates Neuropathic Pain in Mice via Modulation of TRPV1. Neural Plast 2017; 2017: 3710821
38. Zhang H, Xiong X, Liu J, Gu L, Li F, Wan Y, Xu S: Emulsified Isoflurane Protects Against Transient Focal Cerebral Ischemia Injury in Rats via the PI3K/Akt Signaling Pathway. Anesth Analg 2016; 122: 1377-84
39. Yu G, Yang N, Li F, Chen M, Guo CJ, Wang C, Hu D, Yang Y, Zhu C, Wang Z, Shi H, Gegen T, Tang M, He Q, Liu Q, Tang Z: Enhanced itch elicited by capsaicin in a chronic itch model. Mol Pain 2016; 12
40. Huang CC, Kim YS, Olson WP, Li F, Guo C, Luo W, Huang AJW, Liu Q: A histamine-independent itch pathway is required for allergic ocular itch. J Allergy Clin Immunol 2016; 137: 1267-1270.e6
41. Li F, Guo CJ, Huang CC, Yu G, Brown SM, Xu S, Liu Q: Transient receptor potential A1 activation prolongs isoflurane induction latency and impairs respiratory function in mice. Anesthesiology 2015; 122: 768-75
42. Hin N, Alt J, Zimmermann SC, Delahanty G, Ferraris DV, Rojas C, Li F, Liu Q, Dong X, Slusher BS, Tsukamoto T: Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors. Bioorg Med Chem 2014; 22: 5831-7
43. Zhang FW, Li H, Tong J, Li FX, Cai SR: Endovascular stent-graft exclusion of adult giant patent ductus arteriosus through a hybrid transabdominal approach. Ann Thorac Surg 2013; 95: 696-9