立项课题：
1、《同时携带KPC与NDM碳青霉烯酶肺炎克雷伯菌的流行传播及其分子机制研究》，广东省自然科学基金项目，2025A1515011869，10万元，2025年1月-2027年1月，主持
2、《基于细胞感染模型的副流感病毒检测新方法学性能验证》，迈瑞生物医疗电子股份有限公司横向合作项目，2023.9-2025.12, 30万元，主持
3、《医院感染中环境与住院患者耐药组学交互进化机制的研究》，国家卫生健康委医药卫生科技发展研究中心临床应用研究专项，MTP2022D027, 2022.9-2024.9，10万元，主持
4、《基于单细胞拉曼技术的细菌异质性耐药原位检测及其机制研究》，国家自然科学基金面上项目，81974318，55万元，2020年1月-2023年12月，主持
5、《携带qnrVC基因革兰阴性杆菌的分子流行病学和检测方法研究》，广东省自然科学基金项目，2018A030313279，10万元，2018年7月-2021年7月，主持
6、《食源性致病微生物科学大数据构建》，广东省重点领域研发计划项目，2019B020209001，650万元，2019年1月-2022年12月，子课题（50万元）主持
7、《碳青霉烯耐药香港海鸥型菌的流行特点与分子机制研究》，华南应用微生物国家重点实验室开放基金课题，SKLAM007-2018，6万元，2019年5月-2021年4月，主持
8、《香港海鸥型菌中喹诺酮类抗生素的耐药机制研究》，国家自然科学基金青年项目，81201341，23万元，2013年1月-2015年12月，主持
9、《低浓度β-内酰胺类抗生素压力下金黄色葡萄球菌生物被膜形成的分子调控机制》，广东省天然产物绿色加工与产品安全重点实验室开放课题，KL-2018-14，3万元，2019年1月-2020年1月，主持
10、《广州地区多重耐药香港海鸥型菌的分子流行病学研究》，广州医科大学实验室开放项目，B185004120，5万元，2018年1月-2020年1月，主持
11、《丹参酮胶囊联合临床常用抗生素对耐甲氧西林金黄色葡萄球菌的抗菌作用研究》，广东省中医药局面上科研项目，20191206, 1万元，2019年1月-2021年12月，主持
12、《香港海鸥型菌中质粒介导的抗生素耐药性分子机理研究》，广州医学院科研基金青年项目，2010A13，3万元，2010年12月～2013年12月，主持
13、《基于miR-21调控PTEN/PI3K信号途径探讨针刺改善PCOS卵巢局部IR的机制》，国家自然科学基金面上项目，57万元，2016年1月-2019年12月，第二参与人
14、《基于水通道蛋白探讨电针改善超促排卵PCOS大鼠卵母细胞质量和发育潜能的作用与机制》，国家自然科学基金面上项目，57万元，2018年1月-2021年12月，第二参与人
15、广州医科大学附属第一医院优秀青年项目，10万元，2016年1月-2020年12月，主持
16、《登革病毒血清抗体快速分型方法的建立与临床应用》，广东省科技计划项目，2014A020212351，10万元，2015年7月-2017年12月，第二参加人
17、《转移性肺癌当中排斥性导向分子RGMs的功能和机制研究及其与BMP信号通路的关联》，国家自然科学基金青年项目， 81201845， 23万元，2013年1月-2015年12月，第六参与人
发表论文：
1.Zhang HM, Ding JC, Tang JX, Dai LT, Ling JH, Zou MX, Cao XW, Lin LJ, Liu WT, Yuan PB*, Chen DQ*. 2025. Polymicrobial bloodstream infections: A retrospective cohort study on clinical manifestations, co-infection patterns, and survival outcomes. Microb Pathog. doi: 10.1016/j.micpath.2025.107774. Epub 2025 Jun 7. IF-3.5
2. Zhong Y, Yuan P, Dai L, Yang L, Xu Z, Chen D*. 2025. First report of blaVEB-3 and blaKPC-2 coexistence with a novel blaKPC-2 transposon in Klebsiella michiganensis. Infect Genet Evol. doi: 10.1016/j.meegid.2025.105740. Epub 2025 Mar 15. IF=2.6
3. Ding JC, Dai LT, Tang JX, Zhang HM, Zhai LL, Cai CY, Xiao ZR, Chen ZM, Ling JH, Zou MX, Cao XW, Lin LJ, Xu ZH, Yuan PB*, Chen DQ*. 2025. Accelerated detection of carbapenem resistance in Klebsiella pneumoniae via single-cell Raman spectroscopy. World J Microbiol Biotechnol. 41(5):158. IF=4.2
4. Dai L, Zhang H, Cao Y, Ding J, Tang J, Xiao Z, Chen Z, Ling J, Zou M, Cao X, Lin L, Xu Z, Liu W, Chen D*, Yuan P*. 2025. Transcriptomic Insights into Adaptive Strategies of Klebsiella pneumoniae Co-Producing KPC-2 and NDM-5 Carbapenemases Under Meropenem Stress. Infect Drug Resist. 18:3383-3394. IF=2.9
5. Li X, Zhang S, Sheng H, Zhen Y, Wu B, Li Z, Chen D*, Zhou H*. 2025. Oral Fusobacterium nucleatum resists the acidic pH of the stomach due to membrane erucic acid synthesized via enoyl-CoA hydratase-related protein FnFabM. J Oral Microbiol. 21;17(1):2453964. IF=5.5
6. Yuan PB, Dai LT, Zhang QK, Zhong YX, Liu WT, Yang L, Chen DQ*. 2024. Global emergence of double and multi-carbapenemase producing organisms: epidemiology, clinical significance, and evolutionary benefits on antimicrobial resistance and virulence. Microbiol Spectr. 12(7):e0000824. IF=3.8
7. Liu W, Liao K, Wu J, Liu S, Zheng X, Wen W, Fu L, Fan X, Yang X, Hu X, Jiang Y, Wu K, Guo Z, Li Y, Liu W, Cai M, Guo Z, Guo X, Lu J, Chen E, Zhou H*, Chen D*.Blood culture quality and turnaround time of clinical microbiology laboratories in Chinese Teaching Hospitals: A multicenter study. J. Clin. Lab Anal. 2024 Jan. 38(1-2):e25008. IF=2.6
8. Xu Q, Lin H, Liu W, Zhong Y, Zhou Y, Xu, Z*, Chen D*. Genomic Characterization of Escherichia coli Co-Producing KPC-2 and NDM-5 Carbapenemases Isolated from Intensive Care Unit in a Chinese Hospital. Microb. Drug Resist. 2023 Dec. 30(1):27-36. IF=2.3
9. Chen S#, Liang J#, Chen D#, Huang Q, Sun K, Zhong Y, Lin B, Kong J, Sun J, Gong C, Wang J, Gao Y, Zhang Q, Sun H. Cerebrospinal Fluid Metabolomic and Proteomic Characterization of Neurologic Post-acute Sequelae of SARS-CoV-2 Infection. Brain Behav. Immun. 2023 Oct. 115:209-222. IF=8.8
10.Wang L, Chen H, Liu W, Yang L, Xu Z*, Chen D*.Resistome and Genome Analysis of an Extensively Drug- Resistant Klebsiella michiganensis KMIB106: Characterization of a Novel KPC Plasmid pB106-1 and a Novel Cointegrate Plasmid pB106- IMP Harboring blaIMP-4 and blaSHV-12. Antibiotics . 2023 Sept .12(9):1463 IF=4.3
11. Liu J, Xu Z*, Tan Y, Gan RY, Qu G, Chen D*. New Insights in Molecular Mechanisms in Antimicrobial Resistance and Strategies in Anti-Biofilms. Antibiotics (Basel). 2023 Mar 23;12(4):634. IF=4.8
12. Xiao Z, Qu L, Chen H, Liu W, Zhan Y, Ling J, Shen H, Yang L, Chen D*. Raman-Based Antimicrobial Susceptibility Testing on Antibiotics of Last Resort. Infect Drug Resist. 2023 Aug 21;16:5485-5500.IF=3.9
13. Zhao Y#, Chen D#, Ji B, Zhang X, Anbo M, Jelsbak L. Whole-genome sequencing reveals high-risk clones of Pseudomonas aeruginosain Guangdong, China. Front Microbiol. 2023 Apr 14;14:1117017. IF=5.2
14. Zhao Y, # Chen D#, Chen K#, Xie M, Guo J, Chan EWC, Xie L, Wang J, Chen E, Chen S, Chen W, Jelsbak L. Epidemiological and Genetic Characteristics of Clinical Carbapenem-Resistant Pseudomonas aeruginosa Strains in Guangdong Province, China. Microbiol Spectr. 2023 Jun 15;11(3):e0426122. IF=3.7
15. Yuan PB, Ling JH, Zhu JH, Peng C, Chen EZ, Zhong YX, Liu WT, Wang LJ, Yang L, Chen DQ*. Proteomics profiling of ertapenem challenged major porin deficient carbapenem-resistant Klebsiella pneumoniae. J Proteomics. 2022 Sep 30;268:104715. IF=3.3
16. Yuan PB, Zhan Y, Zhu JH, Ling JH, Chen EZ, Liu WT, Wang LJ, Zhong YX, Chen DQ*. Pan-Genome Analysis of Laribacter hongkongensis: Virulence Gene Profiles, Carbohydrate-Active Enzyme Prediction, and Antimicrobial Resistance Characterization. Front Microbiol. 2022 Mar 31;13:862776. IF=5.2
17. Zhong Y, Liu W, Yuan P, Yang L, Xu Z, Chen D*. Occurrence of Serratia marcescens Carrying blaIMP-26 and mcr-9 in Southern China: New Insights in the Evolution of Megaplasmid IMP-26. Antibiotics (Basel). 2022 Jun 28;11(7):869.IF=4.8
18. Liu YX, Zhou YH, Jiang CH, Liu J, Chen DQ*. Prevention, treatment and potential mechanism of herbal medicine for Corona viruses: A review. Bioengineered. 2022 Mar;13(3):5480-5508. IF=4.9
19. Zhao N#, Cao J#, Xu J#, Liu B#, Liu B#, Chen D#, Xia B, Chen L, Zhang W, Zhang Y, Zhang X, Duan Z, Wang K, Xie F, Xiao K, Yan W, Xie L, Zhou H, Wang J. 2021. Targeting RNA with Next- and Third-Generation Sequencing Improves Pathogen Identification in Clinical Samples. Adv. Sci. 2021 Dec;8(23):e2102593.IF=15.1
20. Liu WT, Chen EZ, Yang L, Peng C, Wang Q, Xu Z*, Chen DQ*. 2021. Emerging resistance mechanisms for 4 types of common anti-MRSA antibiotics in Staphylococcus aureus: A comprehensive review. Microb. Pathog. 156:104915. IF=3.8
21. Wang LJ, Chen EZ, Yang L, Feng DH, Xu Z*, Chen DQ*. 2021. Emergence of Clinical Pseudomonas aeruginosa Isolate Guangzhou-PaeC79 Carrying crpP, blaGES-5, and blaKPC-2 in Guangzhou of China. Microb. Drug Resist. Accepted.IF=2.6
22. Chen DQ#, Huang T#, Wang Q, Bai C, Yang L. 2020. Analysis on the virulomes and resistomes of multi-drug resistance clinical Escherichia coli isolates, as well as the interactome with gut microbiome. Microb. Pathog. 148:104423. IF=3.8
23. Peng L#, Chen DQ#, Jiang GM, Ou JY, Jiang Q, Zeng LT, Xiao Y, Jiang QY, Yang L, Ning Sun. 2020. Transcriptome Analysis of Two Strains of Proteus mirabilis with Swarming Migration Deficiency Isolated from Patients with Urinary Tract Infection. Curr. Microbiol. 77(8):1381-1389. IF=2.6
24. Lin J#, Chen DQ#, Hong J, Huang H, Xu X. Prevalence of qnrVC Genes in Pseudomonas aeruginosa Clinical Isolates from Guangdong, China. 2020. Curr. Microbiol. 77(8):1532-1539. IF=2.6
25. Peng L, Jiang YQ, Jiang GM, Ou JY, Zeng LT, Zhang HH, Chen DQ*, Jiang YT*. 2019. Molecular identification and biological characteristic analysis of an Apiotrichum mycotoxinivorans (formerly Trichosporon mycotoxinivorans) strain isolated from sputum specimens of a pediatric patient with pneumonia. J Mycol Med. 29(2):120-126. IF= 3.6
26. Chen D#, Wen S#, Feng D, Xu R, Liu J, Peters BM, Su D, Lin Y, Yang L, Xu Z, Shirtliff ME. 2018. Microbial virulence, molecular epidemiology and pathogenic factors of fluoroquinolone-resistant Haemophilus influenzae infections in Guangzhou, China. Ann. Clin. Microbiol. Antimicrob. 17(1):41. IF=5.7
27. Chen D, Yang L, Peters BM, Liu J, Li L, Li B, Xu Z, Shirtliff ME. 2019. Complete Sequence of a Novel Multidrug-Resistant Pseudomonas putida Strain Carrying Two Copies of qnrVC6. Microb. Drug Resist. 25(1):1-7.IF=2.6
28. Wu HK, Chen JH, Yang L, Li AR, Su DH, Lin YP, Chen DQ*. 2018. Emergence and genomic analysis of multi-drug resistant Laribacter hongkongensis strain HLGZ1 from Guangzhou, China. J. Antimicrob. Chemother. 73(3):643-647. IF=5.2
29. Liu J, Xie J, Yang L, Chen D*, Peters BM, Xu Z*, Shirtliff ME. 2018. Identification of the KPC plasmid pCY-KPC334: new insights on the evolution pathway of the epidemic plasmids harboring fosA3-blaKPC-2 genes. Int. J. Antimicrob. Agents 52(4):510-511.IF=10.8
30. Liu J, Yang L, Chen D*, Peters BM, Li L, Li B, Xu Z*, Shirtliff ME. 2018. Complete sequence of pBM413, a novel multidrug resistance megaplasmid carrying qnrVC6 and blaIMP-45 from Pseudomonas aeruginosa. Int. J. Antimicrob. Agents. 51(1):145-150. IF=10.8
31. Liu J, Yang L, Li L, Li B, Chen D*, Xu Z*. 2018. Comparative genomic analyses of two novel qnrVC6 carrying multidrug-resistant Pseudomonas. spp strains. Microb. Pathog. 123:269-274. IF=3.8
32. Chen D, Feng D, Wen S, Yang L. 2018. High flux isothermal assays on the pathogenic features of Mycoplasma pneumoniae. Microb. Pathog. 120:219-222.IF=3.8
33. Xu Z, Xie J, Yang L, Chen D*, Peters BM, Shirtliff ME. 2018. Complete Sequence of pCY-CTX, a Plasmid Carrying a Phage-Like Region and an ISECP1-Mediated Tn2 Element from Enterobacter cloacae. Microb. Drug Resist. 24(3):307-313.IF=2.6
34. Wen S, Feng D, Lu Z, Liu J, Peters BM, Tang H, Su D, Lin YP, Yang L, Xu Z*, Shirtliff ME, Chen D*. 2018. Microbial infection pattern, pathogenic features and resistance mechanism of carbapenem-resistant Gram negative bacilli during long-term hospitalization. Microb. Pathog. 117:356-360.IF=3.8
35. Liu J, Li L, Peters BM, Li B, Chen D*, Xu Z*, Shirtliff ME. 2018. Complete genomic analysis of multidrug-resistance Pseudomonas aeruginosa Guangzhou-Pae617, the host of megaplasmid pBM413. Microb Pathog. 117:265-269.IF=3.8
36. Li L, Yang L, Fu J, Yan M, Chen D*, Zhang L*. 2018. Genotyping and high flux sequencing of the bacterial pathogenic elements - integrons. Microb. Pathog. 116:22-25. IF=3.8
37. Li Y, Bai C, Yang L, Fu J, Yan M, Chen D*, Zhang L*. 2018. High flux isothermal assays on pathogenic, virulent and toxic genetics from various pathogens. Microb. Pathog. 116:68-72.IF=3.8
38. Chen DQ, Jiang YT, Feng DH, Wen SX, Su DH, Yang L. 2018. Integron mediated bacterial resistance and virulence on clinical pathogens. Microb. Pathog. 114:453-457. IF=3.8
39. Miao J, Liang Y, Chen L, Wang W, Wang J, Li B, Li L, Chen D*, Xu Z*. 2017. Formation and development of Staphylococcus biofilm: with focus on food safety. J. Food Safety e12358. IF=2.4
40. Li Y, Yang L, Fu J, Yan M, Chen D*, Zhang L*. 2017. The novel loop-mediated isothermal amplification based confirmation methodology on the bacteria in Viable but Non-Culturable (VBNC) state. Microb. Pathog. 111:280-284. IF=3.8
41. Li Y, Yang L, Fu J, Yan M, Chen D*, Zhang L*. 2017. Microbial pathogenicity and virulence mediated by integrons on Gram-positive microorganisms. Microb. Pathog. 111:481-486. IF=3.8
42. Miao J, Chen L, Wang J, Wang W, Chen D*, Li L, Li B, Deng Y, Xu Z*. 2017. Evaluation and application of molecular genotyping on nosocomial pathogen-methicillin-resistant Staphylococcus aureus isolates in Guangzhou representative of Southern China. Microb. Pathog. 107:397-403. IF=3.8
43. Liu J, Li L, Peters BM, Li B, Chen D*, Xu Z*, Shirtliff ME. 2017. Complete genome sequence and bioinformatics analyses of Bacillus thuringiensis strain BM-BT15426. Microb Pathog. 108:55-60. IF=3.8
44. Chen DQ, Wu AW, Yang L, Su DH, Lin YP, Hu YW, Zheng L, Wang Q. 2016. Emergence and Plasmid Analysis of Klebsiella pneumoniae KP01 Carrying blaGES-5 from Guangzhou, China. Antimicrob. Agents Chemother. 60(10):6362-6364. IF=4.9
45. Xu Z*, Liang Y, Lin S, Chen D*, Li B, Li L, Deng Y. 2016. Crystal violet and XTT assays on Staphylococcus aureus biofilm quantification. Curr. Microbiol. 73(4): 474-482. IF=2.6
46. Xu Z*, Hou Y, Peters BM, Chen D*, Li B, Li L, Shirtliff ME. 2016. Chromogenic media for MRSA diagnostics. Mol. Biol. Rep. 43(11):1205-1212. IF=2.8
47. Yang L, Wu AW, Su DH, Lin YP, Chen DQ*, Qiu YR*. 2014. Resistome analysis of Enterobacter cloacae CY01, an extensively drug-resistant strain producing VIM-1 metallo-β-lactamase from China. Antimicrob. Agents Chemother. 58(10):6328-6330.IF=4.9
48. Su J, Liu X, Cui H, Li Y, Chen D*, Li Y*, Yu G. 2014. Rapid and simple detection of methicillin-resistance Staphylococcus aureus by orfX loop-mediated isothermal amplification assay. BMC Biotechnol. 14:8. IF=3.5
49. Chen DQ#, Yang L#, Luo YT, Mao MJ, Lin YP, Wu AW. 2013. Prevalence and characterization of quinolone resistance in Laribacter hongkongensis from aquatic products. J. Med. Microbiol. 62(1):1559-1564. IF=3
50. Chen DQ, Zeng Y, Zhou J, Yang L, Jiang S, Huang JD, Lu L, Zheng BJ. Association of candidate susceptible loci with chronic infection with hepatitis B virus in Chinese population. J. Med. Virol. 82(3):371-378.IF=12.7
51. Zhou J#, Chen DQ#, Poon VK, Zeng Y, Ng F, Lu L, Huang JD, Yuen KY, Zheng BJ. 2009. A regulatory polymorphism in interferon gamma receptor 1 promoter is associated with the susceptibility to chronic hepatitis B virus infection. Immunogenetics 61(6): 423-430. IF=3.2
52. Chen DQ, Zheng XC, Lu YJ. 2006. Identification and characterization of novel ColE1-derived, high-copy number plasmid mutants in Legionella pneumophila. Plasmid 56(3): 167-178.IF=2.6
53. Chen DQ, Huang SS, Lu YJ. 2006. Efficient transformation of Legionella pneumophila by high-voltage electroporation. Microbiol. Res. 161(3): 246-251.IF=6.7