本人研究工作紧紧围绕传统中药，药用植物及微生物中新颖结构活性成分的发现、生物合成途径的解析以及天然活性成分的功能和应用这一主线展开。到目前为止，申请人在本领域国际期刊上发表SCI论文80多篇，其中第一作者以及通讯作者论文20篇，包括Nature Chemical Biology，Organic Letters，Molecular Plant Pathology, Journal of Agriculture and Food Chemistry，European Journal of Medicinal Chemistry等5篇中科院1区top期刊，影响因子总和达78以上，总引用次数为376；参与发表SCI论文40余篇（PNAS，mBio，Organic Letters等）。其中以第一作者发表在Nature Chemical Biology的论文被天然产物权威杂志Natural Products Reports评为当月热点研究工作（Hot off the press），该研究解决了长期以来悬而未决的一个科学问题，即P450酶催化九元吲哚内酰胺大环分子内的碳-氮键的形成机理。由于申请人的突出成绩，相关研究工作引起了国内外同行的广泛关注，被NPR, JACS, Angewandte Chemie, Chemistry-A European Journal等主流期刊广泛引用。

教育背景

2000/09-2004/06 广州中医药大学，中药学院本科，中药学专业

2004/06-2006/06 暨南大学，药学院，药物化学，硕士，导师：姚新生 教授

2006/09-2009/06 中科院昆明植物研究所，药物化学，博士，导师：孙汉董 教授

工作经历

2009/09 中国科学院南海海洋研究所，海洋生物室，助理研究员

2012/09 法国科学院国家自然历史博物馆，海洋天然产物化学研究实验室，研究助理

2013/10 华南农业大学，群体微生物研究中心，副研究员

2017/04 东京大学药学院，特聘研究员

2020/06 南方医科大学中医药学院，教授

研究领域主要涉及一下三个方面：

（一）天然活性成分的生物合成途径与新颖酶学催化机制研究

代表论文 Nature Chemical Biology, 2019, 15, 1206–1213.

（二）重要中药药效物质及微生物中新颖结构成分研究

代表论文

Organic letters, 2010, 12, 1208–1211.

Journal of Natural Products, 2018, 81, 1493–1496；2013, 76, 1182–1186.

J Antibiot. 2022, 75, 301–303

 Frontiers in Microbiology 2022, 13:1046099.

Marine Drugs,2016, 14, 233；2015, 13, 2617–2628. 

（三）天然来源小分子作用机制与应用开发

代表论文

Journal of Agricultural and Food Chemistry, 2018, 67, 112–119.

Frontiers in Pharmacology, 2021, doi: 10.3389/fphar.2020.594038.

Molecular Plant Pathology, 2020, 00, 1–12.

Microbial Biotechnology, 2018, 11, 1080–1089.

在本领域国际期刊上发表SCI论文60多篇，其中第一作者以及通讯作者论文18篇，包括Nature Chemical Biology，Organic Letters，Molecular Plant Pathology, Journal of Agriculture and Food Chemistry，European Journal of Medicinal Chemistry等5篇中科院1区top期刊，影响因子总和达78以上，总引用次数为376；参与发表SCI论文40余篇（PNAS，mBio，Organic Letters 等）。其中以第一作者发表在Nature Chemical Biology的论文被天然产物权威杂志Natural Products Reports评为当月热点研究工作（Hot off the press），该研究解决了长期以来悬而未决的一个科学问题，即P450酶催化九元吲哚内酰胺大环分子内的碳-氮键的形成机理。由于申请人的突出成绩，相关研究工作引起了国内外同行的广泛关注，被NPR, JACS, Angewandte Chemie, Chemistry-A European Journal等主流期刊广泛引用。主要发表论文如下：

1. Xiao, Q.; Liu, Q. M.; Jiang, R. C.; Chen, K.; Zhu, X.; Ma, L.; Li, W. X.; He, F. ^*; Huang, J. J. ^* Piperazine-derived  a_1D/1A antagonist 1- benzyl- N- (3- (4- (2-methoxyphenyl) piperazine- 1- yl) propyl)- 1H- indole- 2-carboxamide induces apoptosis in benign prostatic hyperplasia independently of a₁- adrenoceptor blocking, Frontiers in Pharmacology, 2021, doi: 10.3389/fphar.2020.594038. (共同通讯作者，IF=4.604, 药学2区)

2. Shen, F. F.; Yin, W. F.; Song, S. H.; Zhang, Z. H.; Ye, P. Y.; Zhang, Y.; Zhou, J. N.; He, F. *; Li, P. *; Deng, Y. Y. * Ralstonia solanacearum promotes pathogenicity by utilizing L-glutamic acid from host plant, Molecular Plant Pathology, 2020, 00, 1–12. (共同通讯作者，IF=4.550，农林1区top)

3. He, F.^#; Mori, T. ^#; Morita, I. ^#; Nakamura, H.; Alblova, M.; Hoshino, S.; Awakawa, T.; Abe, I. ^* Molecular basis for the P450-catalyzed C–N bond formation in indolactam biosynthesis, Nature Chemical Biology, 2019, 15, 1206–1213. (IF=13.824, 生物1区top)

4. Zhong, Y.; Yan, M. X.; Jiang, J. Y.; Zhang, Z. H.; Huang, J. J.; Zhang, L. H.; Deng, Y. Y.; Zhou, X. F.; He, F.^* Mycophenolic Acid as a Promising Fungal Dimorphism Inhibitor to Control Sugar Cane Disease Caused by Sporisorium scitamineum, Journal of Agricultural and Food Chemistry, 2018, 67, 112–119. (IF=4.290, 农林1区top)

5. Zhao, S.; Huang, J. J.; Sun, X. Y.; Huang, X. R.; Fu, S. N.; Yang, L.; Liu, X. W.; He, F.^*; Deng, Y. Y.^*(1-aryloxy-2-hydroxypropyl)-phenylpiperazine derivatives suppress Candida albicans virulence by interfering with morphological transition, Microbial Biotechnology, 2018, 11, 1080–1089. (^*共通迅作者，IF=5.298, 生物2区)

6. He, F.^*; Nakamura, H.; Hoshino, S.; Chin, J.; Yang, L.; Zhang, H. P.; Hayashi, F.; Abe, I.^* Hinduchelins A–D, Noncytotoxic Catechol Derivatives from Streptoalloteichus hindustanus, Journal of Natural Products, 2018, 81, 1493–1496. (第一加共通讯作者，IF=3.990, 生物2区)

7. Wu, Y. H.; Zhang, Z. H.; Huang, J. J.; Zhong, Y.; Li, X. X.; Deng, Y. Y.; Zhang, L. H.; He, F.^* Sumalactones A-D, Four New Curvularin-type Macrolides from a Marine Deep Sea Fungus Penicillium Sumatrense, RSC Advances, 2017, 7, 40015–40019. (IF=3.098, 化学3区)

8. Zhang, Z.H.; Min, X. T.; Huang, J. J.; Zhong, Y.; Wu, Y. H.; Li, X. X.; Deng, Y. Y.; Jiang, Z. D.; Shao, Z. Z.; Zhang, L. H.; He, F.^* Cytoglobosins H and I, New Antiproliferative Cytochalasans from Deep-Sea-Derived Fungus Chaetomium globosum.，Marine Drugs, 2016, 14, 233. (IF=4.877, 医学2区)

9. He, F.; Mai, L. H.; Longeon, A.; Copp, B. R.; Loaëc, N.; Bescond, A.; Meijer, L.; Bourguet-Kondracki, M. L. Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp. Marine Drugs, 2015, 13, 2617–2628. (IF=4.877, 医学2区)

10. Huang J. J. ^#; He, F.^#; Huang, M. Y.; Liu, X. W.; Xiong, Y.; Huang, Y. J.; Zhu, L.;   Yang, Y.; Xu, X. J.; Yuan, M. Novel naftopidil-related derivatives and their biological effects as alpha1-adrenoceptors antagonists and antiproliferative agents. European Journal of Medicinal Chemistry, 2015, 96, 83–91. (并列第一作者，IF=5.207, 医学1区top)

11. He, F.; Bao, J.; Zhang, X. Y.; Tu, Z. T.; Shi, Y. M.; Qi, S. H. Asperterrestide A, a Cytotoxic Cyclic Tetrapeptide from the Marine-Derived Fungus Aspergillus terreus SCSGAF0162, Journal of Natural Products, 2013, 76, 1182–1186. (IF=3.990, 生物2区)

12. He, F.; Liu, Z.; Yang, J.; Fu, P.; Peng, J.; Zhu, W. M.; Qi, S. H.  A Novel Antifouling Alkaloid from Halotolerant Fungus Penicillium sp. OUCMDZ-776, Tetrahedron Letters, 2012, 53, 2280–2283. (IF=2.275, 化学3区)

13. He, F.; Li, X. Y; Yang, G. Y.; Li, X. N.; Luo, X.; Zou, J.; Li, Y.; Xiao, W. L.; Sun, H. D. Nortriterpene constituents from Schisandra sphenanthera, Tetrahedron, 2012, 68, 440–446. (IF=2.040, 化学3区)

14. He, F.; Pu, J. X.; Huang, S. X.; Wang, Y. Y.; Xiao, W. L.; Li, L. M.; Liu, J. P.; Zhang, H. B.; Li, Y.; Sun, H. D. Schinalactone A, a New Cytotoxic Triterpenoid from Schisandra sphenanthera, Organic letters, 2010, 12, 1208–1211. (IF=6.091, 化学1区top)

15. He, F.; Xiao, W. L.; Pu, J. X.; Wu, Y. L.; Zhang, H. B.; Li, X. N.; Zhao, Y.; Yang, L. B.; Chen, G. Q.; Sun, H. D. Cytotoxic ent-kaurane diterpenoids from Isodon sinuolata, Phytochemistry, 2009, 70, 1462–1466. (IF=3.374, 生物2区)

16. He, F.; Han, Z; Peng, J; Qian, P.Y.; Qi, S.H. Antifouling Indole Alkaloids from Two Marine Derived Strains, Natural Product Communications, 2013, 8, 329–332. (IF=0.693, 工程技术4区)

17. He, F. ; Sun, Y.L. ; Liu, K.S. ; Zhang, X.Y. ; Qian, P.Y. ; Wang, Y.F. ; Qi, S.H. Indole Alkaloidsfrom Marine-DerivedFungiAspergillus sp. SCSIO 00305, Journal of Antibiotics, 2012, 65, 109–111. (IF=2.668, 医学3区)

18. He, F.; Pu, J. X.; Huang, S.X.; Xiao, W.L.; Yang, L.B.; Li, X.N.; Zhao, Y.; Ding, J.; Xu, C.H.; Sun, H.D. Eight New Diterpenoids from the Roots of Euphorbianematocypha, Helvetica Chimica Acta, 2008, 91, 2139–2147. (IF=2.309, 化学4区)

参编专著

1. He F., Mai L. H., Garderes J., Hussain A., ErakovicHaber V., and Bourguet-Kondracki M. L.， Major AntimicrobialRepresentativesfrom Marine Sponges and/or Their Associated Bacteria, Progress in molecular and subcellularbiology, 2017, 55, 35–89.

      2. 参编《中国海洋微生物多样性》第五章，第一节，科学出版社，2013