在研课题:
(1) 主持国家自然科学基金面上项目,同源细胞膜包裹P-DNA@MOF荧光/MRI双模态探针的构建及其癌症靶向诊断功能研究,项目编号:21874064,项目金额:64万,起止时间:2019年1月-2022年12月。
Construction of Bimodal Florescence/MRI Probe Based on Homotypic Cell Membrane Camouflaged P-DNA@MOF and Its application in Cancer Targeting Diagnosis, the Natural Science Foundation of China, General Program, 2019/01-2022/12.
(2) 主持广州市科技计划项目,荧光/MRI双模态探针CCMs+P-DNA@MOF的构建及其精准靶向癌症早期诊疗功能研究;项目编号:201904010410,项目金额:20万,起止时间:2019年4月-2022年3月。
获得的专利:
1. Jin-Xiang Chen; Bao-Ping Xie; Gui-Hua Qiu; Pei-Pei Hu; Zhen Liang; Ye-Mei Liang; Bin Sun; Li-Ping Bai; Zhi-Hong Jiang; Crystalline Copper-Based Coordination Polymers and Their Use. 澳洲发明专利,专利号:AU: 2017100590.
2. Jin-Xiang Chen; Bin Sun; Bao-Ping Xie; Zhi-Hong Jiang; Li-Ping Bai; Crystalline Lanthanum-Carboxylate Coordination Polymers and Their Use. 澳洲发明专利,AU: 2017100565.
3. Jin-Xiang Chen; Bin Sun; Hai-Qing Zhao; Bao-Ping Xie; Li-Ping Bai; Zhi-Hong Jiang; Zwitterionic Zinc(II) Carboxylate Compounds and Their Use. 澳洲发明专利,专利号:AU: 2016101528.
4. Zhi-Hong Chen; Jian-Xin Pang; Shu-Wen Liu; Li-Ping Bai; Zhi-Hong Jiang; Crystalline Contrast Agent for Magnetic Resonance Imaging, kit and Composition Comprising It and Their Use. 澳洲发明专利,专利号:AU: 2016101702
5. Jin-Xiang Chen; Bin Sun; Hai-Qing Zhao; Bao- Ping Xie; Li-Ping Bai; Zhi-Hong Jiang; Zwitterionic Zinc(II) Carboxylate Compounds and Their Use. 美国发明专利,专利号:US 10,023,594 B2.
6. Jin-Xiang Chen; Bin Sun; Bao-Ping Xie; Zhi-Hong Jiang; Li-Ping Bai; Crystalline Lanthanum-Carboxylate Coordination Polymers and Their Use. 美国发明专利,专利号:US 10.260.114 B2.
7. Jin-Xiang Chen; Bao-Ping Xie; Gui-Hua Qiu; Pei-Pei Hu; Zhen Liang; Ye-Mei Liang; Bin Sun; Li-Ping Bai; Zhi-Hong Jiang; Crystalline Copper-Based Coordination Polymers and Their Use.美国发明专利,专利号:US 10.519.500 B2.
8. Jin-Xiang Chen; Jian-Xin Pang; Shu-Wen Liu; Li-Ping Bai; Zhi-Hong Jiang; Crystalline ContrastAgent for Magnetic ResonanceImaging, kit and Composition ComprisingIt and Their Use. 美国发明专利,专利号:US 10.759.757 B2.
9. 陈金香,杨水平,陈文华,一种两性羧酸镧金属有机骨架及其合成方法和应用,中国发明专利,专利号:ZL2015 1 0952885.X.
10. 陈金香,覃亮,陈文华,刘叔文,庞建新,一种基于锰的两性羧酸金属配位聚合物及其制备方法,中国发明专利,专利号:ZL 2016 1 0404049.2.
11. 陈金香,覃亮,陈文华,刘叔文,庞建新,一种基于钆的两性羧酸金属配位聚合物及其制备方法,中国发明专利,专利号:ZL 2016 1 0403497.0.
12. 陈金香,覃亮,陈文华,刘叔文,谢宝平,孙斌,一种两性羧酸四核铜金属配位聚合物及其制备方法,中国发明专利,专利号:ZL 2016 1 0403491.3.
13. 陈金香,覃亮,陈文华,刘叔文,谢宝平,孙斌,一种两性羧酸双核铜金属配位聚合物及其制备方法,中国发明专利,专利号:ZL 2016104041067.
14. 陈金香,覃亮,陈文华,刘叔文,谢宝平,孙斌,一种两性羧酸六核铜金属配位聚合物及其制备方法,中国发明专利,专利号:ZL 2016104041086
代表性论文
(1) Wei-Lun Pan#, Yong Tan#, Wei Meng, Nai-Han Huang, Yi-Bang Zhao, Zhi-Qiang Yu, Zhong Huang, Wen-Hua Zhang, Bin Sun*, Jin-Xiang Chen*, Microenvironment-driven sequential ferroptosis, photodynamic therapy, and chemotherapy for targeted breast cancer therapy by a cancer-cell-membrane-coated nanoscale metal-organic framework, Biomaterials 283 (2022) 121449.(IF=12.479,小类1区,大类1区)
(2) Ting Huang1, Guixun Chen1, Birong Liu, Zizhong Yang, Yuanwei Huang, Baoping Xie, Min-Min Li, Jin-Xiang Chen**, Jun Chen*, Zong Dai, An intramolecular DNAzyme-based amplification for miRNA analysis with improving reaction kinetics and high sensitivity, Talanta 239 (2022) 123137 (IF=6.057,小类1区,大类2区)
(3) Yun Chen,‡ Ling-Yan Zhai,‡ Li-Min Zhang, Xiao-Shan Ma, Zheng Liu, Min-Min Li, Jin-Xiang Chen* and Wen-Jun Duan,* Breast cancer plasma biopsy by in situ determination of exosomal microRNA-1246 with a molecular beacon, Analyst, 2021, 146(7):2264-2276 DOI: 10.1039/d0an02224a.(IF=4.616,JCR 一区,小类2区)
(4) Ke-Yang Wu#, Ming Chen#, Nai-Hai Huang, Rong-Tian Li, Wei-Lun Pan, Wen-Hua Zhang, Wen-Hua Chen, Jin-Xiang Chen*, Facile and Recyclable Dopamine Sensing By a Label-free Terbium(III) metal−Organic Framework, Talanta, 2021, 221, 121399. (IF=6.057,小类1区,大类2区)
(5) Jun Chen, Yan-fei Zhang, Bao-Ping Xie, Bin Sun, Wen-Jun Duan, Min-Min Li, Jin-Xiang Chen*, Zong Dai**, Xiao-yong Zou, A Protein Triggering Exponential Amplification Reaction Enables Label- and Wash-Free One-Pot Protein Assay with High Sensitivity, Talanta. 2021,225,121980. (IF=6.057,小类1区,大类2区)
(6) Nai-Han Huang, Yan Liu, Rong-Tian Li, Jing Chen, Pei-Pei Hu, David J. Young, Jin-Xiang Chen*, Wen-Hua Zhang*, Sequential Ag+/biothiol and Synchronous Ag+/Hg2+ Biosensing with Zwitterionic Cu2+-based Metal−Organic Frameworks, Analyst, 2020, 145, 2779-2788. (IF = 4.616, 大小类2区)
(7) Hai-Ling Chen, Rong-Tian Li, Ke-Yang Wu, Pei-Pei Hu, Zhe Zhang, Nai-Han Huang, Wen-Hua Zhang *, Jin-Xiang Chen*, Experimental and Theoretical Validations of a One-Pot Sequential Sensing of Hg2+ and Biothiols by a 3D Cu-based Zwitterionic Metal−Organic Framework, Talanta, 2020, 210, 120596. (IF=6.057,小类1区)
(8) Rong-Tian Li, Zhen Liang, Meng-Chu Li, Yong Tan, Bao-Ping Xie, Wen-Jun Duan, Chun-Tao Ning, Jin-Xiang Chen*, Bin Sun*, Speedy, Specific, Synchronous Sensing Platforms with Ruthenium Complexes for Multiplexed MicroRNA Detection, Inorg. Chem. 2019, 58, 22, 15126-15137. (IF = 5.165, 小类1区,大类2区)
(9) Bao-Ping Xie, Gui-Hua Qiu, Bin Sun, Zi-Feng Yang, Wen-Hua Zhang*, Jin-Xiang Chen*, Zhi-Hong Jiang*, Synchronous Sensing of Three Conserved Sequences of Zika Virus by a DNAs@MOF hybrid: Experimental and Molecular Simulation Studies, Inorg. Chem. Frontier. 2019, 6, 148-152. (IF = 6.569,小类1区,大类2区)
(10) Ke-Yang Wu, Liang Qin, Cheng Fan, Shao-Lan Cai, Bin Sun, Bao-Ping Xie, Xiao-Yan Tang*, Jin-Xiang Chen*, Sequential and Recyclable Sensing of Fe3+ and Ascorbic Acid Based on a Water-stable Green-emitting Terbium(III) Metal−Organic Framework, Dalton Trans., 2019, 48, 8911-8919, doi: 10.1039/C9DT00871C. (IF = 4.174, 大小类2区)
(11) Shi-Xin Lin, Wei-Lun Pan, Ru-Jie Niu, Yan Liu, Jin-Xiang Chen*, Wen-Hua Zhang*, Jian-Ping Lang*, David J. Young, Effective Loading of Cisplatin into a Nanoscale UiO-66 Metal–Organic Framework with Preformed Defects, Dalton Trans., 2019, 48, 5308–5314. (IF = 4.174, 大小类2区)
(12) Xiang-Ming Hu, Rong-Tian Li, Miao-Miao Zhang, Ke-Yang Wu, Huan-Huan Li, Nai-Han Huang, Bin Sun*, Jin-Xiang Chen*, Phenanthroline-Linked Berberine Dimer and Fluorophore-Tagged DNA Conjugate for the Selective Detection of MicroRNA-185: Experimental and Molecular Docking Studies, Anal. Chim. Acta, 2019, 1051, 153-159. (IF = 6.558,分析化学小类2区,大类2区)
(13) Bao-Ping Xie, Gui-Hua Qiu, Pei-Pei Hu, Zhen Liang, Ye-Mei Liang, Bin Sun, Li-Ping Bai, Zhi-Hong Jiang, Jin-Xiang Chen∗, Simultaneous Detection of Dengue and Zika virus RNA Sequences with a Three-Dimensional Cu-based Zwitterionic Metal−Organic Framework, Comparison of Single and Synchronous Fluorescence Analysis, Sensor. Actuat. B-Chem. 2018, 254, 1133-1140. . (IF 7.46, 大小类均1区)
(14) Gui-Hua Qiu, Zi-Hua Weng, Pei-Pei Hu, Wen-Jun Duan, Bao-Ping Xie, Bin Sun, Xiao-Yan Tang∗, Jin-Xiang Chen∗, Synchronous Detection of Ebolavirus Conserved RNA Sequences and Ebolavirus-Encoded miRNA-like Fragment Based on a Zwitterionic Copper (II) Metal–Organic Framework, Talanta, 2018, 180, 396-402. (IF=6.057,大小类2区)
(15) Bin Sun, Zhen Liang, Bao-Ping Xie, Rong-Tian Li, Lin-Ze Li, Zhi-Hong Jiang, Li-Ping Bai, Jin-Xiang Chen∗, Fluorescence Sensing Platform Based on Ruthenium(II) Complexes as High 3S (Sensitivity, Specificity, Speed) and “on-off-on” Sensors for the miR-185 Detection, Talanta, 2018, 179, 658-667. (IF=6.057,大小类2区)
(16) Pei-Pei Hu, Ning Liu, Ke-Yang Wu, Ling-Yan Zhai, Bao-Ping Xie, Bin Sun, Wen-Jun Duan, Wen-Hua Zhang*, Jin-Xiang Chen*, Successive and Specific Detection of Hg2+ and I− by a DNA@MOF Biosensor: Experimental and Simulation Studies, Inorg. Chem. 2018, 57, 14, 8382-8389. (IF = 5.165, 小类1区, 大类2区)
(17) Ling-Yan Zhai#, Min-Xiang Li#, Wei-Lun Pan, Yun Chen, Min-Min Li, Jian-Xin Pang, Lei Zheng*, Jin-Xiang Chen*, Wen-Jun Duan*, In Situ Detection of Plasma Exosomal MicroRNA-1246 for Breast Cancer Diagnostics by an Au Nanoflare Probe, ACS Appl. Mater. Inter. 2018, 10, 39478-39486 (IF 9.229, 大类1区,小类2区)
(18) Liang Qin, Zi-Yan Sun, Kai Cheng, Shu-Wen Liu, Jian-Xin Pang, Li-Ming Xia, Wen-Hua Chen,* Zhen Cheng,* and Jin-Xiang Chen*, Zwitterionic Manganes and Gadolinium Metal–Organic Frameworks as Efficient Magnetic Resonance Contrast Agents for in Vivo Imaging, ACS Appl. Mater. Inter. 2017, 9,47, 41378-41386. (IF 9.229, 大类1区,小类2区)
(19) Shui-Ping Yang, Wei Zhao, Pei-Pei Hu, Ke-Yang Wu, Zhi-Hong Jiang, Li-Ping Bai, Min-Min Li, and Jin-Xiang Chen*, Lanthanum-Based Metal−Organic Frameworks for Specific Detection of Sudan Virus RNA Conservative Sequences Down to Single-Base Mismatch, Inorg. Chem. 2017, 56, 14880-14887. (IF = 5.165, 小类1区, 大类2区)
(20) Fan Wang, Yu-Ting Wang, Hong Yu*, Jin-Xiang Chen, Bin-Bin Gao, Jian-Ping Lang*, One Unique 1D Silver(I)-Bromide-Thiol Coordination Polymer Used for Highly Efficient Chemiresistive Sensing of Ammonia and Amines in Water, Inorg. Chem. 2016, 55, 9417−9423. (IF =5.165,化学大类2区,小类无机化学与核化学1区)
(21) Hai-Qing Zhao, Gui-Hua Qiu, Zhen Liang, Min-Min Li, Bin Sun, Liang Qin, Shui-Ping Yang, Wen-Hua Chen, Jin-Xiang Chen, A Zinc(II)-Based Two-Dimensional MOF for Sensitive and Selective Sensing of HIV-1 ds-DNA Sequences, Anal. Chim. Acta, 2016, 922, 55-63. (IF = 6.558,分析化学小类2区,大类2区)
(22) Liang Qin, Li-Xian Lin, Zhi-Ping Fang, Shui-Ping Yang, Gui-Hua Qiu, Jin-Xiang Chen*, Wen-Hua Chen*, A Water-Stable Metal-Organic Framework of a Zwitterionic Carboxylate with Dysprosium: a Sensing Platform for Ebolavirus RNA Sequences, Chem. Commu. 2016, 52, 132-135. (IF = 6.222,大类1区,小类2区)
(23) Hai-Qing Zhao, Shui-Ping Yang, Ni-Ni Ding, Liang Qin, Gui-Hua Qiu, Jin-Xiang Chen*, Wen-Hua Zhang*, Wen-Hua Chen*, T. S. Andy Hor*, A zwitterionic 1D/2D Polymer Co-crystal and its Polymorphic Sub-components: a Highly Selective Sensing Platform for HIV ds-DNA Sequences, Dalton Trans., 2016, 45, 5092–5100. (IF = 4.39, ISSN: 1477-9226,大小类均2区)
(24) Shui-Ping Yang, Shao-Rui Chen, Shu-Wen Liu, Xiao-Yan Tang, Liang Qin, Gui-Hua Qiu, Jin-Xiang Chen*, Wen-Hua Chen*, Platforms Formed from a 3D Cu-Based Zwitterionic Metal−Organic Famework and Probe ss-DNA: Selective Fluorescent Biosensors for HIV-1 ds-DNA and Sudan Virus RNA Sequences, Anal. Chem. 2015, 87, 12206-12214. (IF = 6.989, 大小类1区)
(25) Ming Chen, Xiao-Yan Tang, Shui-Ping Yang, Huan-Huan Li, Hai-Qing Zhao, Zhi-Hong Jiang, Jin-Xiang Chen*, Wen-Hua Chen*, Five Water-Soluble Zwitterionic Copper(II)-Carboxylate Polymers: Role of Dipyridyl Coligands in Enhancing the DNA-Binding, Cleaving and Anticancer Activities, Dalton Trans. 2015, 44, 13369-13377. (IF = 4.39, ISSN: 1477-9226,大小类均1区)
(26 Jin-Xiang Chen*, Ming Chen, Ni-Ni Ding, Wen-Hua Chen, Wen-Hua Zhang*, T. S. Andy Hor*, David J. Young*, Transmetalation of a Dodecahedral Na9 Aggregate-based Polymer: a Facile Route to Water Stable Cu(II) Coordination Networks, Inorg. Chem. 2014, 53, 7446-7545. (IF = 5.165, 大类2区,小类1区)
(27 Zi-Xuan Zhang, Ni-Ni Ding, Wen-Hua Zhang*, Jin-Xiang Chen*, David J. Young *, T. S. Andy Hor*,Stitching 2D Polymeric Layers into Flexible Interpenetrated Metal–Organic Frameworks within Single Crystals, Angew. Chem. Int. Ed. 2014, 53, 4628-4632. (IF = 15.336, 大小类均1区)