目录
更新日期:2025年10月10日
姓 名 张惠杰 性 别
民 族 汉族 导师层次 博士导师
技术职称 教授 导师类型 学术&专业型
最后学历 博士研究生毕业 最后学位 医学博士学位
行政职务 主任 Email huijiezhang2005@126.com
工作单位 南方医科大学南方医院 邮政编码 510515
跨学科招生
跨学科招生专业1 营养与食品卫生学 招生层次类型1 学术学位博导
跨学科招生专业2 招生层次类型2
个人简介

南方医院内分泌代谢科主任、教授、主任医师,博导,国家杰出青年,科技创新2030重大项目首席,教育部“长江奖励计划”青年学者,广东省杰出青年医学人才,毕业于上海交通大学,曾在美国杜兰大学公共卫生学院从事博士后研究。长期致力于2型糖尿病、脂肪肝病和心肌肥厚等代谢性疾病的研究,揭示其代谢调控网络,并鉴定了多个潜在的治疗靶点和临床干预模式。获吴阶平—保罗·杨森医学药学奖,亚洲糖尿病协会(AASD)Masato Kasuga Award 杰出成就奖,AHA的 Scott Grundy代谢杰出研究奖和美国心脏预防协会青年研究奖,研究成果入选美国AHA 2015年度优秀研究、2016年度中国内分泌优秀研究成果、2016年度中国糖尿病“十大研究”和2020年、2023年改变临床实践的中国原创研究“十大青年研究者”,入选2022NEJM重磅论文榜,入选第六届国之名医优秀风范。任广东省糖尿病学会常委、广东省内分泌学会委员、中华医学会糖尿病分会青年委员兼任秘书、中华医学会糖尿病分会肥胖学组委员、中华医学会糖尿病分会转化学组委员、中国生物化学与分子生物学会代谢专业委员。在N. Engl. J. MedCellBMJ、JAMA Inter MedDiabetes CarePNASADV SCICirc Res等杂志以第一作者或通讯作者发表SCI论文50余篇。主持国家自然科学杰出青年基金、地区联合重点项目,科技部国家重点研发计划,以及多项省市科技基金,以第一完成人获得广东省科技进步奖一等奖、市科技进步奖一等奖和市科技创新杰出人才奖。

 

研究领域

肥胖、糖脂紊乱、糖尿病、非酒精性脂肪肝病等代谢性疾病的发生机理和干预策略

个人成果

一、代表性论著:

1. Liu DY, Huang Y, Huang CS, Yang SY, Wei XY, Zhang PZ, Guo D, Lin JY, Xu BY, Li CW, He H, He J, Liu SQ, Linna Shi, Xue YM, Zhang HJ. Calorie Restriction with or without Time-Restricted Eating in Weight Loss. The New England Journal of Medicine. 2022 Apr 21;386(16):1495-1504.

2.Jiayang Lin, Yan Huang, Bingyan Xu, Xuejiang Gu, Junlin Huang, Jia Sun, Lijing Jia, Jiang He, Chensihan Huang, Xueyun Wei, Jinjun Chen, Xiaomin Chen, Jingping Zhou, Lixian Wu, Peizhen Zhang, Yaxin Zhu, Huimin Xia, Ge Wen, Yating Liu, Shiqun Liu, Yanmei Zeng, Lin Zhou, Hongxia Jia, Hua He, Yaoming Xue, Fenglin Wu, Huijie Zhang. Effect of dapagliflozin on metabolic dysfunction-associated steatohepatitis: multicentre, double blind, randomised, placebo controlled trial. BMJ.2025 Jun 4:389:e083735. doi: 10.1136/bmj-2024-083735.

3.Yuejun Liu, Ying Chen, Jianhua Ma, Jiayang Lin, Changqin Liu , Xuejun Li, Yong Xu, Hongyu Kuang, Lixin Shi, Yaoming Xue, Bo Feng, Dalong Zhu, Guang Wang, Jinkui Yang, Xinhua Xiao, Xuefeng Yu, Jiaqiang Zhou, Yuqian Bao, Qing Su, Minzhi Lyu, Xiaomu Li, Huijie Zhang, Xiaoying Li. Dapagliflozin plus calorie restriction for remission of type 2 diabetes: multicentre, double blind, randomised, placebo controlled trial.BMJ.2025 Jan 22:388:e081820.

4. Xiaoli Hu, Fengyi Chen, Liangjie Jia, Aijun Long, Ying Peng, Xu Li, Junfeng Huang, Xueyun Wei, Xinlei Fang, Zihua Gao, Mengxian Zhang, Xiao Liu, Ye-Guang Chen, Yan Wang, Huijie Zhang, Yiguo Wang. A gut-derived hormone regulates cholesterol metabolism. Cell. 2024 Mar 28;187(7):1685-1700.e18.

5. Liu WH, You DM, Lin JY, Zou HR, Zhang L, Luo SJ, Yuan YW, Wang ZY, Qi JW, Wang WW, Ye XR, Yang XY, Deng YJ, Teng F, Zheng XJ, Lin YH, Huang ZW, Huang Y, Yang Z, Zhou X, Zhang YN, Chen RX, Xu LL, Li J, Yang W, Zhang HJ. SGLT2 inhibitor promotes ketogenesis to improve MASH by suppressing CD8+ T cell activation. Cell Metabolism. 2024 Oct 1;36(10):2245-2261.e6. doi: 10.1016/j.cmet.2024.08.005. Epub 2024 Sep 6.

6. Peizhen Zhang; Dan Guo; Bingyan Xu,; Chensihan Huang; Shunyu Yang,; Weiwei Wang; Wenhui Liu; Yajuan Deng; Kangli Li; Deying Liu; Jiayang Lin; Xueyun Wei; Yan Huang; Huijie Zhang ; Association of Serum 25- Hydroxyvitamin D With Cardiovascular Outcomes and All-Cause Mortality in Individuals With Prediabetes and Diabetes: Results From the UK Biobank Prospective Cohort Study, Diabetes Care,2022 May 1;45(5):1219-1229.

7. Zhang HJ, Zhang T, Li SX, Guo Yj, Shen W, Camilo Fernandez 1, Fernandez C, Harville E, Bazzano LA, Urbina EM, He J, Chen W. Long-term Excessive Body Weight and Left Ventricular Hypertrophy Are Linked through Later Life Body Size and Blood Pressure: The Bogalusa Heart Study. Circulation Research. 2017 May 12;120(10):1614-1621.

8. Zhou, Bing; Jia, Lijing; Zhang, Zhijian; Xiang, Liping; Yuan, Youwen; Zheng, Peilin; Liu, Bin; Ren, Xingxing; Bian, Hua; Xie, Liwei; Li, Yao; Lu, Jieli; Zhang, Huijie; Lu, Yan ; The Nuclear Orphan Receptor NR2F6 Promotes Hepatic Steatosis through Upregulation of Fatty Acid Transporter CD36, Advanced Science2020 Sep 21;7(21):2002273.

9. Wei XY, Lin BQ, Huang Y, Yang SY, Huang CS, Shi LN, Liu DY, Zhang PZ, Lin JY, Xu BY, Guo D, Li CW, He H, Liu SQ, Xue YM, Xu YK, Zhang HJ. Effects of Time-Restricted Eating on Nonalcoholic Fatty Liver Disease: The TREATY-FLD Randomized Clinical Trial. JAMA Network Open. 2023 Mar 1;6(3):e233513.

10. Youwen Yuan, Kangli Li, Xueru Ye, Shiyi Wen, Yanan Zhang, Fei Teng, Xuan Zhou, Yajuan Deng, Xiaoyu Yang, Weiwei Wang, Jiayang Lin, Shenjian Luo, Peizhen Zhang, Guojun Shi, Huijie Zhang.CLCF1 inhibits energy expenditure via suppressing brown fat thermogenesis.PNAS.2024 Jan 16;121(3):e2310711121.

11. Yuan YW, Li KL, Teng F, Zhou X, Ye XR, Wang WW, Lin JY, Deng YJ, Liu WH, Luo SJ, Zhang PZ, Liu DY, Zheng MH, Li J, Lu Y, Zhang HJ. Leukemia inhibitory factor protects against non-acholic fatty liver disease.Journal of Biological Chemistry. 2022 Jun;298(6):101946.

12. Fei Teng; Fei Teng; Jingjing Jiang; Youwen Yuan; Kangli Li; Bing Zhou; Xuan Zhou; Wenhui
Liu; Peizhen Zhang; Deying Liu; Minghua Zheng; Yan Lu; Huijie Zhang ; The S100 calcium-binding protein A11 promotes hepatic steatosis through RAGE-mediated AKT-mTOR signaling, Metabolism-Clinical and Experimental,2021.Feb 9;117:154725.

13. Lu Y, Wang E, Chen Y, Zhou B, Zhao JJ, Xiang LP, Qian YL, Jiang J, Zhao L, Xiong XL, Lu ZQ, Wu DJ, Liu B, Yan J, Zhang R, Zhang HJ, Hu C, Li XY. Obesity-induced excess of 17-hydroxyprogesterone promotes hyperglycemia through activation of glucocorticoid receptor. Journal of clinical investigation. 2020 Jul 1;130(7):3791-3804. 

14. Zhang HJ, He J, Pan LL, Ma ZM, Han CK, Chen CS, Chen Z, Han HW, Chen S, Sun Q, Zhang JF, Li ZB, Yang SY, Li XJ, Li XY. Effects of Moderate and Vigorous Exercise on Nonalcoholic Fatty Liver Disease: A Randomized Clinical Trial. JAMA internal medicine. 2016 Aug 1;176(8):1074-82.

二、论著之外的代表性研究成果和学术奖励:

(1) 吴阶平—保罗·杨森医学药学奖,2025
(2) 亚洲糖尿病协会(AASD)Masato Kasuga Award 杰出成就奖,2025
(3) 广东省科技进步一等奖,2025
(4) 美国心脏协会(AHA)Scott Grundy 代谢杰出研究奖,2015
(5) 美国心脏预防协会(ASPC)青年研究奖, American Society for Preventive Cardiology(ASPC),2015
(6) 厦门市科技创新杰出人才奖, 厦门市人民政府, 科技进步,2016
(7) 福建省科技进步奖三等奖,2017
(8) 福建省自然科学奖三等奖,2022