目录
更新日期:2025年10月9日
姓 名 陈烨 性 别
民 族 汉族 导师层次 博士导师
技术职称 教授 导师类型 学术&专业型
最后学历 博士研究生毕业 最后学位 医学博士学位
行政职务 副院长 Email chenye_2013@163.com
工作单位 南方医科大学深圳医院 邮政编码 510515
个人简介

陈烨,女,2000年获第一军医大学医学博士学位,2002.9-2006.8美国贝勒医学院博士后/副研究员,2018.8-2019.8哈佛大学医学院BIDMC高级访问学者,现为南方医科大学教授、主任医师、博士生导师,南方医科大学深圳医院副院长、消化学术带头人、整合微生态诊疗中心主任。

擅长复杂胃肠道疾病的诊疗,尤其是难治性幽门螺杆菌感染、难治性腹泻、炎症性肠病以及胃肠神经内分泌肿瘤等的综合诊治。长期从事胃肠微生态失衡相关疾病的基础、临床与转化研究,主持国家自然科学基金、国家重点研发计划子课题等省部级以上课题10余项,发表署名文章100余篇,其中第一/通讯作者发表SCI 文章50余篇;是我国幽门螺杆菌感染处理、艰难梭菌感染性腹泻诊断、消化道微生态调节剂临床应用等标准和共识的主要起草人之一。获得教育部“新世纪优秀人才”、广东省高校“千百十工程”省级培养对象和广东省“珠江学者”特聘教授等称号。

现任

中华医学会消化病学分会常务委员、幽门螺杆菌学组组长、微生态学组副组长、

中国医师协会消化医师分会委员、

中国医师协会消化女医师分会副主委、

中华预防医学会微生态学分会常委、

中国医药教育协会微生态与健康教育专委会副主委、

广东省医师学会消化医师分会主委等社会职务。

 

 

研究领域

胃肠微生态失衡相关疾病的基础、临床与转化研究

个人成果

核心期刊论文:

  1. Liu L, Liang L, Mai G, Chen Y: A novel fatty acid metabolism-related gene signature predicts the prognosis, tumor immune properties, and immunotherapy response of colon adenocarcinoma patients. FASEB Bioadv 2022, 4(9):585-601.1
  2. Hu W, Chen ZM, Li XX, Lu L, Yang GH, Lei ZX, You LJ, Cui XB, Lu SC, Zhai ZY et al: Faecal microbiome and metabolic signatures in rectal neuroendocrine tumors. Theranostics 2022, 12(5):2015-2027.1IF=11.6
  3. Yan Y, Peng X, Chen Y: [Fecal microbiota transplantation in the treatment of acute intestinal pseudo obstruction secondary to intracerebral hemorrhage: a case report and literature review]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2022, 34(3):306-310.1
  4. Wang Z, Wang Z, Wang Y, Wu J, Yu Z, Chen C, Chen J, Wu B, Chen Y: High risk and early onset of cancer in Chinese patients with Peutz-Jeghers syndrome. Front Oncol 2022, 12:900516.1IF=5.738
  5. Wang Y, Wang Z, Yang H, Chen S, Zheng D, Liu X, Jiang Q, Chen Y: Metformin Ameliorates Chronic Colitis-Related Intestinal Fibrosis via Inhibiting TGF-β1/Smad3 Signaling. Front Pharmacol 2022, 13:887497.1IF=5.988
  6. Wang S, Deng W, Li F, Xiang L, Lv P, Chen Y: Treatment with butyrate alleviates dextran sulfate sodium and Clostridium difficile-induced colitis by preventing activity of Th17 cells via regulation of SIRT1/mTOR in mice. J Nutr Biochem 2022, 111:109155.1IF=6.117
  7. Lin M, Li Z, Lin Q, Wang P, Liu W, Yuan J, Hong Z, Chen Y: Development and clinical application of a rapid and visual loop-mediated isothermal amplification test for tetM gene in Clostridioides difficile strains cultured from feces. Int J Infect Dis 2022, 122:676-684.1IF=12.073
  8. Liang L, Yang C, Liu L, Mai G, Li H, Wu L, Jin M, Chen Y: Commensal bacteria-derived extracellular vesicles suppress ulcerative colitis through regulating the macrophages polarization and remodeling the gut microbiota. Microb Cell Fact 2022, 21(1):88.IF=6.352
  9. Liang L, Mai S, Mai G, Chen Y, Liu L: DNA damage repair-related gene signature predicts prognosis and indicates immune cell infiltration landscape in skin cutaneous melanoma. Front Endocrinol (Lausanne) 2022, 13:882431.1IF=6.055
  10. Liang L, Liu L, Zhou W, Yang C, Mai G, Li H, Chen Y: Gut microbiota-derived butyrate regulates gut mucus barrier repair by activating the macrophage/WNT/ERK signaling pathway. Clin Sci (Lond) 2022, 136(4):291-307.1IF=6.876
  11. Li Z, Ke H, Lin Q, Shen Z, Chen Y: Global trends in gut microbiota and clostridioides difficile infection research: A visualized study. J Infect Public Health 2022, 15(7):806-815.1IF=7.537
  12. Deng W, Wang S, Li F, Wang F, Xing YP, Li Y, Lv Y, Ke H, Li Z, Lv PJ et al: Gastrointestinal symptoms have a minor impact on autism spectrum disorder and associations with gut microbiota and short-chain fatty acids. Front Microbiol 2022, 13:1000419.1IF=6.064
  13. Zhou Y, He Y, Liu L, Zhou W, Wang P, Hu H, Nie Y, Chen Y. Alterations in Gut Microbial Communities Across Anatomical Locations in Inflammatory Bowel Diseases. Front Nutr. 2021 Feb 26;8:615064. doi: 10.3389/fnut.2021.615064. PMID: 33718417; PMCID: PMC7952524.IF=6.589
  14. Yang C, Liang L, Lv P, Liu L, Wang S, Wang Z, Chen Y. Effects of non-viable Lactobacillus reuteri combining with 14-day standard triple therapy on Helicobacter pylori eradication: A randomized double-blind placebo-controlled trial. Helicobacter. 2021 Oct 10:e12856. doi: 10.1111/hel.12856. Epub ahead of print. PMID: 34628695.IF=5.182
  15. Liu L, Liang L, Yang C, Zhou Y, Chen Y. Extracellular vesicles of Fusobacterium nucleatum compromise intestinal barrier through targeting RIPK1-mediated cell death pathway. Gut Microbes. 2021 Jan-Dec;13(1):1-20. doi: 10.1080/19490976.2021.1902718. PMID: 33769187; PMCID: PMC8007154. IF=9.434
  16. Zhou W, Wang M, Liang L, Liu L, Zheng D, Silvester JA, Ma W, Wu W, Ji G, Xu Y, Xu X, Kelly CP, Chen Y. Prevalence of Celiac Disease in China: Meta-analysis and Serological Survey in High-risk Populations. J Dig Dis. 2021 Sep 5. doi: 10.1111/1751-2980.13049. Epub ahead of print. PMID: 34482631.IF=3.366
  17. Ke H, Li J, Lu B, Yang C, Wang J, Wang Z, Liu L, Chen Y. The appropriate cutoff gastric pH value for Helicobacter pylori eradication with bismuth-based quadruple therapy. Helicobacter. 2021 Feb;26(1):e12768. doi: 10.1111/hel.12768. Epub 2020 Oct 21. PMID: 33089598.IF=5.182
  18. L. Zeng, J. Tan, M. Xue, L. Liu, M. Wang, L. Liang, J. Deng, W. Chen, and Y. Chen, An engineering probiotic producing defensin-5 ameliorating dextran sodium sulfate-induced mice colitis via Inhibiting NF-kB pathway. Journal of translational medicine. 2020;18(1):107.IF=8.439
  19. F. Li, R. Xu, C. L. Lin, B. E. Low, L. Cai, S. Li, P. Ji, L. Huang, M. V. Wiles, Y. A. Hannun, L. M. Obeid, Y. Chen, and C. Mao,Maternal and fetal alkaline ceramidase 2 is required for placental vascular integrity in mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020;34(11):15252-68.IF=5.833
  20. Ming-Yue Wu, Le Liu, Er-Jin Wang, Hai-Tao Xiao, Cui-Zan Cai, Jing Wang,Huanxing Su, Yitao Wang, Jieqiong Tan, Zhuohua Zhang, Juan Wang, Maojing,Yao,De-Fang Ouyang, Zhenyu Yue, Min Li, Ye Chen, Zhao-Xiang Bian,Jia-Hong Lu: PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation. Autophagy.2020;190(13)IF=13.391
  21. Haoran Ke1 | Jing Li1,2 | Bingyun Lu1,3 | Chenghai Yang1 | Jiamin Wang1,4 |Zhiqing Wang1 | Le Liu1 | Ye Chen1; The appropriate cutoff gastric pH value for Helicobacter pylori. Helicobacter;2020;216(1)IF=5.182
  22. Wang S, Lv D, Jiang S, Jiang J, Liang M, Hou F,Chen Y: Quantitative reduction in short-chain fatty acids, especially butyrate, contributes to the progression of chronic kidney disease.Clinical Science 2019;133:1857-1870.IF=6.876
  23. Lu B, Wang J, Li J, Liu L, Chen Y: Half-dose clarithromycin-containing bismuth quadruple therapy is effective and economical in treating helicobacter pylori infection: A single-center, open-label, randomized trial. Helicobacter 2019;24:e12566.IF=5.182
  24. Liu L, Liang L, Liang H, Wang M, Lu B, Xue M, Deng J, Chen Y: Fusobacterium nucleatum aggravates the progression of colitis by regulating m1 macrophage polarization via akt2 pathway. Frontiers in immunology 2019;10:1324.IF=8.786
  25. Zhou Y, Xu ZZ, He Y, Yang Y, Liu L, Lin Q, Nie Y, Li M, Zhi F, Liu S, Amir A, González A, Tripathi A, Chen M, Wu GD, Knight R, Zhou H, Chen Y: Gut microbiota offers universal biomarkers across ethnicity in inflammatory bowel disease diagnosis and infliximab response prediction. mSystems 2018;3IF=7.324
  26. Deng J, Zeng L, Lai X, Li J, Liu L, Lin Q, Chen Y: Metformin protects against intestinal barrier dysfunction via ampkα1-dependent inhibition of jnk signalling activation. Journal of cellular and molecular medicine 2018;22:546-557.IF=5.295
  27. Jiang S, Xie S, Lv D, Wang P, He H, Zhang T, Zhou Y, Lin Q, Zhou H, Jiang J, Nie J, Hou F, Chen Y: Alteration of the gut microbiota in chinese population with chronic kidney disease. Scientific reports 2017;7:2870.IF=4.995
  28. Zhang Y, Wang Z, Liu J, Zhang S, Fei J, Li J, Zhang T, Wang J, Park PW, Chen Y: Cell surface-anchored syndecan-1 ameliorates intestinal inflammation and neutrophil transmigration in ulcerative colitis. Journal of cellular and molecular medicine 2017;21:13-25.IF=5.295
  29. Zhang Y, Wang Z, Liu J, Zhang Z, Chen Y: Suppressing syndecan-1 shedding ameliorates intestinal epithelial inflammation through inhibiting nf-κb pathway and tnf-α. 2016;2016:6421351.IF=1.919
  30. Jiang S, Xie S, Lv D, Zhang Y, Deng J, Zeng L, Chen Y: A reduction in the butyrate producing species roseburia spp. And faecalibacterium prausnitzii is associated with chronic kidney disease progression. Antonie van Leeuwenhoek 2016;109:1389-1396.IF=2.158
  31. Zhang T, Lin QY, Fei JX, Zhang Y, Lin MY, Jiang SH, Wang P, Chen Y: Clostridium difficile infection worsen outcome of hospitalized patients with inflammatory bowel disease. Scientific reports 2016;6:29791.IF=4.995
  32. Zhou Y, Chen H, He H, Du Y, Hu J, Li Y, Li Y, Zhou Y, Wang H, Chen Y, Nie Y: Increased enterococcus faecalis infection is associated with clinically active crohn disease. Medicine 2016;95:e5019.IF=1.817
  33. Lin M, Liu W, Wang P, Tan J, Zhou Y, Wu P, Zhang T, Yuan J, Chen Y: Rapid detection of ermb gene in clostridium difficile by loop-mediated isothermal amplification. Journal of medical microbiology 2015;64:854-861.IF=3.196
  34. Wang Z, Li R, Tan J, Peng L, Wang P, Liu J, Xiong H, Jiang B, Chen Y: Syndecan-1 acts in synergy with tight junction through stat3 signaling to maintain intestinal mucosal barrier and prevent bacterial translocation. Inflammatory bowel diseases 2015;21:1894-1907.IF=7.290
  35. Zhou Y, He H, Wang P, Zhang T, Lin M, Wang H, Nie Y, Chen Y: Infliximab for the treatment of crohn's disease: Efficacy and safety in a chinese single-center retrospective study. European journal of gastroenterology & hepatology 2015;27:1270-1275.IF=2.586
  36. Zhou YL, Xie S, Wang P, Zhang T, Lin MY, Tan JS, Zhi FC, Jiang B, Chen Y: Efficacy and safety of infliximab in treating patients with ulcerative colitis: Experiences from a single medical center in southern china. Journal of digestive diseases 2014;15:483-490.IF=3.366
  37. Wang P, Zhou Y, Wang Z, Xie S, Zhang T, Lin M, Li R, Tan J, Chen Y, Jiang B: Identification of clostridium difficile ribotype 027 for the first time in mainland china. Infection control and hospital epidemiology 2014;35:95-98.IF=6.520
  38. Wang XF, Li AM, Li J, Lin SY, Chen CD, Zhou YL, Wang X, Chen CL, Liu SD, Chen Y: Low molecular weight heparin relieves experimental colitis in mice by downregulating il-1β and inhibiting syndecan-1 shedding in the intestinal mucosa. PloS one 2013;8:e66397.IF=3.752
  39. Zhang S, Qing Q, Wang Q, Xu J, Zhi F, Park PW, Zhang Y, Chen Y: Syndecan-1 and heparanase: Potential markers for activity evaluation and differential diagnosis of crohn's disease. Inflammatory bowel diseases 2013;19:1025-1033.IF=7.290
  40. Zhang S, Qing Q, Bai Y, Mao H, Zhu W, Chen Q, Zhang Y, Chen Y: Rebamipide helps defend against nonsteroidal anti-inflammatory drugs induced gastroenteropathy: A systematic review and meta-analysis. Digestive diseases and sciences 2013;58:1991-2000.IF=3.486
  41. Wang X, Chen Y, Song Y, Zhang S, Xie X, Wang X: Activated syndecan-1 shedding contributes to mice colitis induced by dextran sulfate sodium. Digestive diseases and sciences 2011;56:1047-1056.IF=3.486
  42. Ma F, Chen Y, Li J, Qing HP, Wang JD, Zhang YL, Long BG, Bai Y: Screening test for anti-helicobacter pylori activity of traditional chinese herbal medicines. World journal of gastroenterology 2010;16:5629-5634.IF=5.374
  43. Hayashida K, Chen Y, Bartlett AH, Park PW: Syndecan-1 is an in vivo suppressor of gram-positive toxic shock. The Journal of biological chemistry 2008;283:19895-19903.
  44. Chen Y, Götte M, Liu J, Park PW: Microbial subversion of heparan sulfate proteoglycans. Molecules and cells 2008;26:415-426.IF=4.250
  45. Chen Y, Hayashida A, Bennett AE, Hollingshead SK, Park PW: Streptococcus pneumoniae sheds syndecan-1 ectodomains through zmpc, a metalloproteinase virulence factor. The Journal of biological chemistry 2007;282:159-167.
  46. Tang W, Pei M, Li J, Xu N, Xiao W, Yu Z, Zhang J, Hong L, Guo Z, Lin J, Dai W, Xiao Y, Wu X, Liu G, Zhi F, Li G, Xiong J, Chen Y, Zhang H, Xiang L, Li A, Liu S, Wang J: The miR-3648/FRAT1-FRAT2/c-Myc negative feedback loop modulates the metastasis and invasion of gastric cancer cells. Oncogene 2022;41(43), 4823-4838.IF=8.765
  47. Li Z, Ke H, Wang Y, et al. Global trends in Akkermansia muciniphila research: A bibliometric visualization. Front Microbiol. 2022;13:1037708. IF=6.06
  48. 杨荟平, 王志青, 刘乐, 等. 炎症性肠病中应用益生菌的临床疗效与潜在风险[J]. 中华炎性肠病杂志, 2022,06(2):155-160.
 

承担课题及所获荣誉:

主持863课题子课题2项、国家自然科学基金5项、其它省部级以上课题10余项,获得国家省部级以上科技进步二等奖4项,获授权发明专利4项;获得教育部“新世纪优秀人才”、广东省高校“千百十工程”省级培养对 象和广东省“珠江学者”特聘教授称号;担任国家自然科学基金、教育部长江学者奖励计划、复旦专科排行榜、广东省科技计划和优秀青年基金等项目评审专家。负责建立了我国首个肠道益生菌与致病菌菌种库,是我国历次幽门螺杆菌感染处理共识和消化道调节剂临床应用专家共识的主要起草人,是国内首批开展粪菌移植治疗艰难梭菌感染和炎症性肠病等新技术的团队之一,所在单位成为国内唯一常规检测肠道菌群失调的临床科室。

主要获奖项目:

  1. 2013年,广东省科技进步二等奖:海尔曼螺杆菌感染的基础与临床诊治系列研究,证书编号:B13-0-2-02-R01(第一完成人)
  2. 2004年,军队科技进步二等奖:幽门螺杆菌感染在南方战区和高原部队流行状况及其致病与防治的免疫机制研究,证书编号:2004-2-54-3
  3. 1998年,国家科技进步二等奖:幽门螺杆菌与海尔曼螺杆菌感染的流行病学、致病性与防治研究,证书编号:15-2-009-07
  4. 1997年,军队科技进步二等奖:幽门螺杆菌的动物宿主与流行病学研究,证书编号:97-2-90-4 等。
  5. 获评2023年第六届“国之名医”称号。
 

参与专利授权:

  1. 一种样本收集装置,中华人民共和国国家知识产权局专利申请号:12689444
  2. 人防御素mDH-5基因及其相关应用,中华人民共和国国家知识产权局专利申请号:201610835077X

(3)艰难梭菌二元毒素的LAMP检测方法及其专用引物与试剂盒2,中华人民共和国国家知识产权局专利申请号:201410673919.7 

(4)艰难梭菌AB毒素的LAMP检测方法及其专用引物与试剂盒,中华人民共和国国家知识产权局专利申请号:201410667259.1

(5)重组幽门螺杆菌血型抗原粘附素,中华人民共和国国家知识产权局专利申请号: 3109888.6

(6)重组幽门螺杆菌外膜蛋白15,中华人民共和国国家知识产权局专利申请号:31098878

(7)具有粘附功能的幽门螺杆菌膜孔素,中华人民共和国国家知识产权局专利申请号:31098878,03109886X

 

 

主持科研项目、课题:

序号

课题名称

起止时间

课题级别

出资单位

资助金额(万元)

1

《SCFAs通过PPARγ-FcγR轴调控巨噬细胞M2极化促进TNF-α抑制剂修复炎症性肠病黏膜屏障的作用及机制研究》

2023-01 ~ 2026-12

国家级

国家自然科学基金委

52

2

《丁酸-HDAC-巨噬细胞轴在溃疡性结肠炎黏膜损伤修复中的作用及机制研究》

2021-01 ~ 2024-12

国家级

国家自然科学基金委

55

3

菌群菌种移植重塑肠道微生物组的机制研究
 

2024-11 ~ 2029-12

国家级

国家自然科学基金委

427

4

《健康相关微生物大数据库建设与多组学分析》

2021-12 ~ 2026-11

国家级

中华人民共和国科学技术部

185

5

《中药治疗难治性幽门螺杆菌感染的应用研究》

2022-07 ~ 2025-07

地区级

深圳市可持续发展专项

300

6

深圳市胃肠道微生态与疾病重点实验室

2023-03~2025-03

地区级

深圳市科技创新委员会

500

7

深圳市肠菌移植工程中心项目

2021-07~ 2024-07

地区级

深圳市发展和改革委员会

500

8

深圳市临床医学研究中心

2023-01~2025-12

地区级

深圳市科技创新委员会

1000