目录
更新日期:2025年9月11日
姓 名 陈陆馗 性 别
民 族 汉族 导师层次 博士导师
技术职称 教授 导师类型 专业型
最后学历 博士研究生毕业 最后学位 临床医学博士专业学位
行政职务 教研室主任 Email neuro_clk@hotmail.comm
工作单位 南方医科大学中西医结合医院 邮政编码
跨学科招生
跨学科招生专业1 中西医结合临床 招生层次类型1 学术学位硕导
跨学科招生专业2 招生层次类型2
个人简介

现任南方医科大学中西医结合医院(南方医科大学第四附属医院)党委委员,神经医学中心主任,外科学教研室主任,神经外科主任,主任医师、教授、医学博士、博士后(临床医学及生物医学工程)、博士生导师、博士后导师。羊城好医生,岭南名医。原东南大学附属中大医院神经外科主任(2012-2018年),东南大学功能神经外科研究所所长(2015-2018年),脑血管病中心主任,江苏省“名医民选”百姓信任的医疗专家,江苏省“333工程”学术技术带头人,江苏省六大人才高峰,江苏省苏北发展特聘专家。是美国神经外科医师协会(AANS)国际委员,曾获AANS最佳国际摘要奖,美国Baylor Scott & White Health医学中心客座教授。亚洲神经外科医师协会(ACNS)教育委员会执行委员,日本旭川红十字医院客座教授。国际神经修复学会中国委员会副主任委员,中国神经修复学会(筹)副主任委员。中国神经科学学会神经外科学基础与临床分会委员,世界华人神经外科协会功能神经外科专委会委员,中国医师协会脑胶质瘤专委会医师培训与教育委员会委员,中国老年医学学会神经医学分会常务委员,中国神经外科重症管理协作组委员,中国颅神经疾患诊疗协作组委员。广东省医学教育协会脑血管病专业委员会主任委员,神经外科专业委员会副主任委员。曾荣获省市级科技进步奖五项。2016年度王忠诚中国神经外科青年医师奖获得者。已授权专利九项。发表第一/通讯作者SCI论著66篇。主编、主译专著三部。主持国家自然科学基金面上项目三项,省市级项目十余项。2020年7月全国神经外科专家学术影响力排名第29位。2021年中国神经修复学年会大会主席。2023年广东省教育厅脑病研究创新团队负责人。

擅长显微手术治疗胶质瘤、脑膜瘤、垂体腺瘤、颅咽管瘤、听神经瘤、脑室内肿瘤、颅底肿瘤、脑干肿瘤、颅颈交界区肿瘤、脑转移癌、脊髓髓内肿瘤、小儿神经肿瘤、颅内动脉瘤、脑血管畸形、海绵状血管瘤、烟雾病、三叉神经痛、面肌痉挛、颅底凹陷症等。擅长神经内镜手术、颅内外动脉搭桥术治疗烟雾病和复杂动脉瘤,颈动脉内膜剥脱术治疗颈动脉重度狭窄等脑血管疾病。研究方向:神经干细胞及其外泌体治疗脑缺血性卒中等神经系统疾病。

 

研究领域

1、神经干细胞及其外泌体治疗脑缺血性卒中等神经系统疾病。

2、中西医结合治疗神经系统疾病。

个人成果

近十年SCI收录文章:

  1. Chen L. Detection of ischemia in endovascular therapy of cerebral aneurysms: a perspective in the era of neurophysiological monitoring. Asian J Neurosurg. 2010 Jan;5(1):60-7. IF=2.259.
  2. Chen L, White WL, Xu B, Tian X. Transnasal transsphenoid approach: a minimally invasive approach for removal of cavernous haemangiomas located at inferomedial part of orbital apex. Clin Exp Ophthalmol. 2010 Jul;38(5):439-43. IF=1.776.
  3. Chen L, White WL, Spetzler RF, Xu B. A prospective study of nonfunctioning pituitary adenomas: presentation, management, and clinical outcome. J Neurooncol. 2011 Mar;102(1):129-38. IF=3.214.
  4. Chen L, Spetzler RF, McDougall CG, Albuquerque FC, Xu B. Detection of ischemia in endovascular therapy of cerebral aneurysms: a perspective in the era of neurophysiological monitoring. Neurosurg Rev. 2011 Jan;34(1):69-75.  IF=2.036.
  5. Chen L, Chen E, Chotai S, Tian X. An endovascular approach to ruptured aneurysms of the circumferential branch of the basilar artery. J Clin Neurosci. 2012 Apr;19(4):527-31. IF=1.253.
  6. Chen L, Miao W, Tang X, Zhang H, Wang S, Luo F, Yan J. The expression and significance of neuropilin-1 (NRP-1) on glioma cell lines and glioma tissues. J Biomed Nanotechnol. 2013 Apr;9(4):559-63. IF=7.578.
  7. Chen L, Miao W, Tang X, Zhang H, Wang S, Luo F, Yan J. Inhibitory effect of neuropilin-1 monoclonal antibody (NRP-1 MAb) on glioma tumor in mice. J Biomed Nanotechnol. 2013 Apr;9(4):551-8. IF=7.578.
  8. Yi GQ, Gu B, Chen LK*. The safety and efficacy of magnetic nano-iron hyperthermia therapy on rat brain glioma. Tumour Biol. 2014 Mar;35(3):2445-9. IF=3.611.
  9. Chen L, Qiu R, Li L. The role of nanotechnology in induced pluripotent and embryonic stem cells research. J Biomed Nanotechnol. 2014 Dec;10(12):3431-61. IF=5.338.
  10. Chen L, Fan X, Jin G, Wan X, Qiu R, Yi G, You Y, Xu Q. Treatment of rat with traumatic brain injury and MR tracing in vivo via combined transplantation of bone marrow stromal cells labeled with superparamagnetic iron oxide and Schwann cells. J Biomed Nanotechnol. 2014 Feb;10(2):205-15. IF=5.338.
  11. Chen L, Miao W, Zhang H, Zeng F, Cao C, Qiu R, Yang J, Luo F, Yan J, Lv H, Xu Q. The inhibitory effects of a monoclonal antibody targeting neuropilin-1 on adhesion of glioma cells to fibronectin. J Biomed Nanotechnol. 2014 Nov;10(11):3373-80. IF=5.338.
  12. Chen L, Qiu R, Li L, He D, Lv H, Wu X, Gu N. The role of exogenous neural stem cells transplantation in cerebral ischemic stroke. J Biomed Nanotechnol. 2014 Nov;10(11):3219-30. IF=5.338.
  13. Chen L, Qiu R, Xu Q. Mesenchymal stem cell therapy for neurodegenerative diseases. J Nanosci Nanotechnol. 2014 Jan;14(1):969-75. IF=1.556.
  14. Chen L, Qiu R, Xu Q. Stem cell therapy for ischemic stroke. J Nanosci Nanotechnol. 2014 Jan;14(1):976-82. IF=1.556.
  15. Chen L, Zhang G, Shi Y, Qiu R, Khan AA. Neuropilin-1 (NRP-1) and Magnetic Nanoparticles, a Potential Combination for Diagnosis and Therapy of Gliomas. Curr Pharm Des. 2015;21(37):5434-49. IF=3.452.
  16. Chen L, Zhang G, Gu Y, Guo X. Meta-Analysis and Systematic Review of Neural Stem Cells therapy for experimental ischemia stroke in preclinical studies. Sci Rep. 2016 Aug 24;6:32291. IF=4.259.
  17. Zhang G, Chen L*, Sun K, Khan AA, Yan J, Liu H, Lu A, Gu N. Neuropilin-1 (NRP-1)/GIPC1 pathway mediates glioma progression. Tumour Biol. 2016 Oct;37(10):13777-13788. IF=3.650.
  18. Chen L, Zhang G, Khan AA, Guo X, Gu Y. Clinical Efficacy and Meta-Analysis of Stem Cell Therapies for Patients with Brain Ischemia. Stem Cells Int. 2016;2016:6129579.  IF=3.54.
  19. Chen L. Microvascular decompression of trigeminal motor root: a considerable surgical cure for hemimasticatory spasm. J Neurosurg Sci. 2017 Nov 7.  IF=1.767.
  20. Zhang G, Chen L*, Khan AA, Li B, Gu B, Lin F, Su X, Yan J. miRNA-124-3p/neuropilin-1(NRP-1) axis plays an important role in mediating glioblastoma growth and angiogenesis. Int J Cancer. 2018 Aug 1;143(3):635-644. IF=7.36.
  21. Zhang G, Chen L*, Chen W, Li B, Yu Y, Lin F, Guo X, Wang H, Wu G, Gu B, Miao W, Kong J, Jin X, Yi G, You Y, Su X, Gu N. Neural Stem Cells Alleviate Inflammation via Neutralization of IFN-γ Negative Effect in Ischemic Stroke Model. J Biomed Nanotechnol. 2018 Jun 1;14(6):1178-1188.  IF=5.068.
  22. Zhang G, Chen L*, Guo X, Wang H, Chen W, Wu G, Gu B, Miao W, Kong J, Jin X, Yi G, You Y, Su X, Gu N. Comparative Analysis of microRNA Expression Profiles of Exosomes Derived from Normal and Hypoxic Preconditioning Human Neural Stem Cells by Next Generation Sequencing. J Biomed Nanotechnol. 2018 Jun 1;14(6):1075-1089. IF=5.068.
  23. Guo X, Wu G, Wang H, Chen L*. Pep-1&borneol-Bifunctionalized Carmustine-Loaded Micelles Enhance Anti-Glioma Efficacy Through Tumor-Targeting and BBB-Penetrating. J Pharm Sci. 2019 May;108(5):1726-1735. IF=3.197.
  24. Wang H, Zhu Z, Zhang G, Lin F, Liu Y, Zhang Y, Feng J, Chen W, Meng Q, Chen L*. AS1411 Aptamer/Hyaluronic Acid-Bifunctionalized Microemulsion Co-Loading Shikonin and Docetaxel for Enhanced Antiglioma Therapy. J Pharm Sci. 2019 Nov;108(11):3684-3694. IF=3.197.
  25. Feng J, Waqas A, Zhu Z, Chen L*. Exosomes: Applications in Respiratory Infectious Diseases and Prospects for Coronavirus Disease 2019 (COVID-19). J Biomed Nanotechnol. 2020 Apr 1;16(4):399-418.  IF=4.483.
  26. Belykh E, Shaffer KV, Lin C, Byvaltsev VA, Preul MC, Chen L*. Blood-Brain Barrier, Blood-Brain Tumor Barrier, and Fluorescence-Guided Neurosurgical Oncology: Delivering Optical Labels to Brain Tumors. Front Oncol. 2020 Jun 5;10:739.  IF=4.848.
  27. Chen W, Li Q, Zhang G, Wang H, Zhu Z, Chen L*. LncRNA HOXA-AS3 promotes the malignancy of glioblastoma through regulating miR-455-5p/USP3 axis. J Cell Mol Med. 2020 Sep 11. IF=4.658.
  28. Lin CQ, Chen LK*. Cerebral dopamine neurotrophic factor promotes the proliferation and differentiation of neural stem cells in hypoxic environments. Neural Regen Res. 2020 Nov;15(11):2057-2062.  IF=3.171.
  29. Zhang G, Zhu Z, Wang H, Yu Y, Chen W, Waqas A, Wang Y, Chen L*. Exosomes derived from human neural stem cells stimulated by interferon gamma improve therapeutic ability in ischemic stroke model. J Adv Res. 2020 May 25;24:435-445..  IF=6.992.
  30. Chen W, Wang H, Zhu Z, Feng J, Chen L*. Exosome-shuttled circSHOC2 from ischemic-preconditioned astrocytes regulates neuronal autophagy and ameliorates ischemic brain injury via miR-7670-3p/SIRT1 axis, Molecular Therapy-Nucleic Acid, 2020, 22: 657-672. IF=7.032
  31. Chen W, Wang H, Feng J, Chen L*. Overexpression of circular RNA circUCK2 attenuates cell apoptosis in cerebral ischemia-reperfusion injury via miR-125b-5p/GDF11 signaling, Molecular Therapy-Nucleic Acid, 2020, 22: 673-683. IF=7.032