目录
更新日期:2023年3月18日
姓 名 赵亮 性 别
民 族 汉族 导师层次 博士导师
技术职称 主任医师 导师类型 学术&专业型
最后学历 博士研究生毕业 最后学位 临床医学博士专业学位
行政职务 副主任 Email lzhaonf@126.com
工作单位 南方医科大学南方医院 邮政编码 510515
个人简介

赵亮

教授,博生生导师(学术型及专业型)

行政副主任,主任医师

 

       现任南方医科大学南方医院骨科科室行政副主任,主任医师,教授,博士生导师。获广东省高层次人才,广东省杰出青年医学人才称号,胡润-平安中国好医生称号两届获得者。

       第一军医大学七年制本硕,骨科学博士。美国Kansas University和Maryland University双博士后。美国纽约Hospital for Special Surgery(全美骨科排名第一)和德州Baylor 医学院(全美排名第五)临床骨外科双fellow,Columbia University,Cornell University,Texas University 和Southwestern 医学中心访问教授。先后主持科研课题15 项,其中国家自然基金项目3 项,共计约900余万元。以通讯、共同通讯、第一作者或主要作者发表论文56 篇(SCI文章36 篇),总影响因子155.653,在Biomaterials(IF:8.557),Nature Communications(IF:12.353),eLife (IF:7.551),Acta Biomaterialia(IF:6.383),南方医科大学学报(中国科技期刊卓越行动计划期刊,百种中国杰出学术期刊,PubMed 和PubMed Central(PMC)收录),Dental Materials(IF:4.818),J Tissue Engineering and Regenerative Medicine (IF:4.71)等期刊发表SCI 论文共55 篇,获得中国发明专利授权2 项,正在实质审查发明专利4 项,获中国实用新型专利授权1 项。

研究领域

长期从事骨与软骨再生医学、骨关节炎方向研究工作(详见赵亮教授课题组网站:www.lzhaolab.com),主要研究领域包括:

(1)以生物活化技术开发构建临床可应用的新型骨与软骨生物复合修复材料。

(2)利用新型复合生物材料及多种干细胞和生物因子促进骨骼组织再生 (实验室,动物模型及前期临床应用)。

(3)骨与软骨再生的分子机制。

(4)干细胞在骨及软骨再生中的应用。

 

个人成果
  1. Qiu G, Huang M, Liu J, Ma T, Schneider A, Oates TW, Lynch CD, Weir MD, Zhang K, Zhao Liang(corresponding author), Xu HHK: Human periodontal ligament stem cell encapsulation in alginate-fibrin-platelet lysate microbeads for dental and craniofacial regeneration. Journal of Dentistry. 2022 Sep;124:104219.
  2. Liao Z, Jin Y, Chu Y, Wu H, Li X, Deng Z, Feng S, Chen N, Luo Z, Zheng X, Bao L, Xu Y, Tan H, Zhao Liang(corresponding author): Single-cell transcriptome analysis reveals aberrant stromal cells and heterogeneous endothelial cells in alcohol-induced osteonecrosis of the femoral head. Communications Biology. 2022 Apr 6;5(1):324. 
  3. Li X, Liao Z, Deng Z, Chen N, Zhao Liang(corresponding author): Combining bulk and single-cell RNA-sequencing data to reveal gene expression pattern of chondrocytes in the osteoarthritic knee. Bioengineered. 2021 Dec;12(1):997-1007.
  4. Qiu G, Wu H, Huang M, Ma T, Schneider A, Oates TW, Weir MD, Xu HHK, Zhao Liang(corresponding author): Novel calcium phosphate cement with biofilm-inhibition and platelet lysate delivery to enhance osteogenesis of encapsulated human periodontal ligament stem cells.Materials Science and Engineering: C, 2021, 128:112306.
  5. Qiu G, Huang M, Liu J, Wang P, Schneider A, Ren K, Oates TW, Weir MD, Xu HHK, Zhao Liang(corresponding author). Antibacterial calcium phosphate cement with human periodontal ligament stem cell-microbeads to enhance bone regeneration and combat infection. J Tissue Eng Regen Med. 2021 Mar;15(3):232-243.
  6. Xiaoyu Li, Zheting Liao, Zhonghao Deng, Nachun Chen, Liang Zhao(responding author), Combining bulk and single-cell RNA-sequencing data to reveal gene expression pattern of chondrocytes in the osteoarthritic knee, Bioengineered, 2021, 12(1): 997-1007.
  7. Xianling Gao, Wei Qin, Lingling Chen, Wenguo Fan, Tao Ma, Abraham Schneider, Mengyao Yang, Obinna N. Obianom, Jiayao Chen, Michael D. Weir, Yan Shu, Zhao Liang(corresponding author), Zhengmei Lin, Hockin H. K. Xu. Effects of targeted delivery of metformin and dental pulp stem cells on osteogenesis via demineralized dentin matrix under high glucose conditions. ACS Biomaterials Science & Engineering.
  8. Yingzhi Gu, Xianju Xie, Rui Zhuang, Michael D. Weir, Thomas W. Oates, Yuxing Bai, Zhao Liang(corresponding author), Hockin H.K. Xu, A Biphasic Calcium Phosphate Cement Enhances Dentin Regeneration by Dental Pulp Stem Cells and Promotes Macrophages M2 Phenotype In Vitro, Tissue Engineering: Part A.2021.
  9. Yang Xia, Jianfei Sun, Zhao Liang(corresponding author), Feimin Zhang, Xing-Jie Liang, Yu Guo, Michael D. Weir, Mark A. Reynolds, Ning Gu, Hockin H. K. Xu. Magnetic field and nano-scaffolds with stem cells to enhance bone regeneration. Biomaterials.
  10. Ping Wang, Lin Wang, Chongyun Bao, Qianming Chen, Michael D. Weir, Laurence C. Chow4, Liang Zhao(co-corresponding author), Xuedong Zhou, Hockin H. K. Xu, Mark A. Reynolds. A new generation of calcium phosphate cement constructs with stem cells and biologics for bone tissue engineering. Bone Research (Invited review article, 2017) (IF:9.326)
  11. Zhao, L, Weir MD, Xu Huakun. Human umbilical cord stem cell encapsulation in calcium phosphate scaffolds for bone engineering. Biomaterials. 31(14): 3848-3857(2010).