目录
更新日期:2022年3月9日
姓 名 白晓春 性 别
民 族 汉族 导师层次 博士导师
技术职称 教授 导师类型 学术型
最后学历 博士研究生毕业 最后学位 博士
行政职务 院长 Email baixc15@smu.edu.cn
工作单位 基础医学院 邮政编码 510515
个人简介

白晓春,现任南方医科大学基础医学院院长,广东省骨与关节退行性疾病重点实验室主任;教育部“长江学者”特聘教授,国家杰出青年基金获得者,万人计划科技创新领军人才,入选国家百千万人才工程;全国首批黄大年式教师团队和全国教育系统先进集体核心成员,获国务院特殊津贴,国家有突出贡献中青年专家,南方医科大学立德树人好导师等荣誉称号。

主要从事:(1)骨与关节退行病变的机制;(2)骨与软骨组织损伤与修复的研究。近年承担国家自然科学基金重大项目、重点项目、杰青等项目12项,获国家科技进步二等奖、中华医学科技一等奖、云南省自然科学一等奖、广东省科技进步二等奖各1项,以第一或通讯作者在ScienceDev CellNat AgingBloodPNASAnn Rheum DisAdv SciJ Cell BiolNat CommunPLOS Genet等期刊上发表论文95篇,论文他引4500多次,入选2020年中国高被引学者

 

 
研究领域

关键词:

骨生物学;细胞代谢;细胞信号转导;骨关节炎;骨质疏松;骨与软骨再生与修复;骨生物材料

Bone biology; Cell metabolism; Signal transduction; Osteoarthritis;Osteoporosis;Bone and cartilage regeneration and repair;Bone biomaterials

 

个人成果

白晓春代表作2022

  1. Zhang H, Shao Y, Yao Z, Liu L, Zhang H, Yin J, Xie H, Li K, Lai P, Zeng H, Xiao G, Zeng C, Cai D*, Bai X*. Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7. Ann Rheum Dis. 2022 Jan 20:annrheumdis-2021-221513. IF= 19.103JCR小类1区)
  2. Wu X, Lai Y, Chen S, Zhou C, Tao C, Fu X, Li J, Tong W, Tian H, Shao Z, Liu C, Chen D, Bai X *, Cao H *, Xiao G *. Kindlin-2 preserves   integrity   of   the   articular   cartilage   to   protect   against osteoarthritis.  Nat Aging.2022 Feb 10.
  3. Gong Y, Li Z, Zou S, Deng D, Lai P, Hu H, Yao Y, Hu L, Zhang S, Li K, Wei T, Zhao X, Xiao G, Chen Z, Jiang Y, Bai X*, Zou Z*. Vangl2 limits chaperone-mediated autophagy to balance osteogenic differentiation in mesenchymal stem cells. Dev Cell. 2021 Jul 26;56(14):2103-2120(IF=12.270,JCR小类1区)
  4. Xiao M#, Zhang W#, Li W#, Mao L, Yang J, Hu L, Zhang S, Zheng Y, Liu A,  Song Q, Li Y, Xiao G, Zou Z*, Bai X*. Osteocytes regulate neutrophil development through IL-19: A potent cytokine for neutropenia treatment. Blood. 2021 Jun 24;137(25):3533-3547. (IF=22.113,JCR小类1区) 配Blood专题评述、基金委网站报道
  5. Lai M, Zou W, Han Z, Zhou L, Qiu Z, Chen J, Zhang S, Lai P, Li K, Zhang Y, Liang L, Jiang Y, Zou Z*, Bai X*.. Tsc1 regulates tight junction independent of mTORC1. Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):e2020891118. (IF= 11.205,JCR小类1区)
  6. Guo J, Tian X, Xie D, Rahn K, Gerhard E, Kuzma M, Zhou D, Dong C, Bai X*, Lu Z*,  Yang J*. Citrate‐Based Tannin‐Bridged Bone Composites for Lumbar Fusion. Advanced Functional Materials. 2020 April 30;30(27):2070179(IF= 18.808,JCR小类1区)
  7. Lin C, Liu L, Zeng C, Cui Z, Chen Y, Lai P, Wang H, Shao Y , Zhang H, Zhang R, Zhao C, Fang H, Cai D*, Bai X*. Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12. Bone Res.2019,7: 5. Nat Rev Rheum评述 (highlight)(IF= 13.567JCR小类1区)
  8. Zhang H, Lin C, Zeng C, Wang Z, Wang H, Lu J, Liu X, Shao Y, Zhao C, Pan J, Xu S, Zhang Y, Xie D, Cai D*, Bai X*. Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2. Ann Rheum Dis. 2018 Oct;77(10):1524-1534IF= 19.103JCR小类1区)
  9. Li K, Zhang Y, Zhang Y, Jiang W, Shen J, Xu S, Cai D, Shen J, Huang B, Li M, Song Q, Jiang Y, Liu A, Bai X*. Tyrosine kinase Fyn promotes osteoarthritis by activating the β-catenin pathway. Ann Rheum Dis. 2018 Jun;77(6):935-943.Nat Rev Rheum评述(highlight) IF=19.103JCR小类1区)
  10. Zou W, Lai M, Zhang Y, Zheng, Xing Z, Li T, Zou Z, Song Q,Zhao X, Xia L, Yang J, Liu A,Zhang H, Cui Z*, Jiang Y*, Bai X*. Exosome Release Is Regulated by mTORC1. Adv Sci. 2018 Dec 11;6(3):1801313IF= 16.806JCR小类1区)
  11. Ma C, Tian X, Kim JP, Xie D, Ao X, Shan D, Lin Q, Hudock MR, Bai X*, Yang J*. Citrate-based materials fuel human stem cells by metabonegenic regulation. Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11741-E11750IF= 11.205JCR小类1区)
  12. Xu S, Zhang Y, Wang J, Li K, Tan K, Liang K, Shen J, Cai D, Jin D, Li M, Xiao G, Xu J, Jiang Y, Bai X*. TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42. Cell Death Differ. 2018 Jan 22. doi: 10.1038/s41418-017-0049-4. IF= 15.828JCR小类2区)
  13. Xiao M, Wang Y, Tao C, Wang Z, Yang J, Chen Z, Zou Z, Li M, Liu A, Jia C, Huang B, Yan B, Lai P, Ding C, Cai D, Xiao G, Jiang Y, Bai X*. Osteoblasts support megakaryopoiesis through production of interleukin-9. Blood. 2017 Jun 15;129(24):3196-3209. IF= 22.113JCR小类1区)
  14. Huang B, Wang W, Li Q, Wang Z , Yan B, Zhang Z, Wang L , Huang M, Jia C, Lu J, Liu S, Chen H, Li M, Cai D, Jiang Y, Jin D*, Bai X*. Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone, Nat Commun. 2016 Dec 14;7:13885.F1000推荐IF= 14.919JCR小类1区)
  15. Yang J, Zhou X, Fan X, Xiao M, Yang D, Liang B, Dai M, Shan L, Lu J, Lin Z, Liu R, Liu J, Wang L, Zhong M, Jiang Y, Bai X*. mTORC1 promotes aging-related venous thrombosis in mice via elevation of platelet volume and activation. Blood. 2016 Aug 4;128(5):615-24. with commentaryIF= 22.113JCR小类1区)
  16. Yan B, Zhang Z, Jin D, Cai C, Jia C, Liu W, Wang T, Li S, Zhang H, Huang B, Lai P, Wang H, Liu A, Zeng C, Cai D, Jiang Y, Bai X*. mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation. Nat Commun. 2016 Apr 4;7:11151. IF=14.919JCR小类1区)
  17. Zou Z, Chen J, Liu A, Zhou X, Song Q, Jia C, Chen Z, Lin J, Yang C, Li M, Jiang Y, Bai X*. mTORC2 promotes cell survival through c-Myc-dependent up-regulation of E2F1. J Cell Biol. 2015 Oct 12;211(1):105-22. (IF: 10.539JCR小类2区) In this issue, with commentary
  18. Huang MJ, Wang L, Jin DD, Zhang ZM, Chen TY, Jia CH, Wang Y, Zhen XC, Huang B, Yan B, Chen YH, Li SF, Yang JC, Dai YF, Bai XC*. Enhancement of the synthesis of n-3 PUFAs in fat-1 transgenic mice inhibits mTORC1 signalling and delays surgically induced osteoarthritis in comparison with wild-type mice. Ann Rheum Dis, 2014, 73(9):1719-27. IF= 19.103JCR小类1区)
  19. Chen Z, Dong H, Jia C, Song Q, Chen J, Zhang Y, Lai P, Fan X, Zhou X, Liu M, Lin J, Yang C, Li M, Gao T, Bai X*. Activation of mTORC1 in collecting ducts causes hyperkalemia. J Am Soc Nephrol, 2014, 25(3):534-45. IF=10.121JCR小类1区)
  20. Song Q, Xu Y, Yang C, Chen Z, Jia C, Chen J, Zhang Y, Lai P, Fan X, Zhou X, Lin J, Li M, Ma W, Luo S, Bai X*. miR-483-5p promotes invasion and metastasis of lung adenocarcinoma by targeting RhoGDI1 and ALCAM. Cancer Res, 2014 ,74(11):3031-42. SCI引用130IF= 12.701JCR小类2区)
  21. Jia CH, Li M, Liu J, Zhao L, Lin J, Lai PL, Zhou X, Zhang Y, Chen ZG, Li HY, Liu AL, Yang CL, Gao TM, Jiang Y, Bai XC*. IKK-β mediates hydrogen peroxide induced cell death through p85 S6K1. Cell Death Differ, 2013, 20(2):248-58. IF= 15.828JCR小类2区)
  22. Bai XC, Ma DZ, Liu AL, Shen XY, Wang QM, Liu YJ, Jiang Y*. Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38. Science, 2007, 318(5852): 977-980. HighlightF1000推荐,with commentarySCI引用283IF= 47.728JCR小类1区)
  23. Bai XC, Lu D, Bai J, Zheng H, Ke ZY, Li XM, Luo SQ*. Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB. Biochem Biophys Res Commun. 2004 Jan 30;314(1):197-207. SCI引用397IF= 3.575JCR小类4区)