胡宇，南方医科大学南方医院肾内科教授，博士生导师，南方医科大学高层次引进人才。2002年获得内蒙古大学学士学位，2011年在中科院上海生化细胞所获得博士学位。2011年至2020年在哈佛医学院/波士顿儿童医院任职博士后/讲师，2020年全职加入南方医科大学南方医院。主要研究方向为T细胞在免疫调控及应答中的作用。代表成果之一揭示CD1a识别并递呈脂类分子抗原通过促进抗原特异性T细胞分泌IL-17以及IL-22进而引起皮肤炎症，为皮肤炎症的治疗提供了潜在的药物靶点。另外一部分工作揭示TMEM16F通过负性调控T细胞受体信号通路，从而阻止T细胞过度活化导致的功能衰竭，对维持机体抵抗慢性病毒感染起到了关键的调节作用。已在Nature Immunology， J. Exp. Med., Cell Research，J. Immunology等一流期刊上发表共计13篇论文（第一或者共同第一作者4篇），论文总引大于1000次，h-index =12（Google Scholar）。实验室目前研究方向为探究肾脏疾病尤其是自身免疫性肾病的免疫致病机制。已获得南方医科大学高层次人才启动经费和2项国家自然科学基金项目支持。
1. CD4+ T细胞在自身免疫性肾病如膜性肾病中的致病作用及机制
2. 免疫耐受紊乱对自身免疫性肾病发病的影响及作用原理
3. IgG4相关疾病（IgG4-RD）的发病机制研究
1. Czechowicz A, Palchaudhuri R, Scheck A, Hu Y, Hoggatt J, Saez B, Pang WW, Mansour MK, Tate TA, Chan YY, Walck E, Wernig G, Shizuru JA, Winau F, Scadden DT, Rossi DJ. Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation. Nat. Commun. 2019 Feb 6;10(1):617.
2. Beyaz S, Kim JH, Pinello L, Xifaras ME, Hu Y, Huang J, Kerenyi MA, Das PP, Barnitz RA, Herault A, Dogum R, Haining WN, Yilmaz OH, Passegue E, Yuan GC, Orkin SH, and Winau F (2017). The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells. Nat. Immunol. 18, 184-195.
3. Hu Y*, Kim JH*, He K, Wan Q, Kim J, Flach M, Kirchhausen T, Vortkamp A, and Winau F (2016). Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion. J. Exp. Med. 213, 2759-2772. *Co-first author.
4. Kim JH*, Hu Y*, Yongqing T, Kim J, Hughes VA, Le Nours J, Marquez EA, Purcell AW, Wan Q, Sugita M, Rossjohn J, and Winau F (2016). CD1a on Langerhans cells controls inflammatory skin disease. Nat. Immunol. 17, 1159-1166. *Co-first author.
5. Mao K, Chen S, Chen M, Ma Y, Wang Y, Huang B, He Z, Zeng Y, Hu Y, Sun S, Li J, Wu X, Wang X, Strober W, Chen C, Meng G, and Sun B (2013). Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock. Cell Res. 23, 201-212.
6. Hu Y*, Wang J*, Yang B, Zheng N, Qin M, Ji Y, Lin G, Tian L, Wu X, Wu L, and Sun B (2011). Guanylate binding protein 4 negatively regulates virus-induced type I IFN and antiviral response by targeting IFN regulatory factor 7. J. Immunol. 187, 6456-6462. *Co-first author.
7. Hu Y*, Mao K*, Zeng Y, Chen S, Tao Z, Yang C, Sun S, Wu X, Meng G, and Sun B (2010). Tripartite-motif protein 30 negatively regulates NLRP3 inflammasome activation by modulating reactive oxygen species production. J. Immunol. 185, 7699-7705. *Co-first author.