目录
更新日期:2025年2月26日
姓 名 赵海金 性 别
民 族 汉族 导师层次 博士导师
技术职称 主任医师 导师类型 学术&专业型
最后学历 博士研究生毕业 最后学位 医学博士学位
行政职务 其他 Email 157975178@qq.com
工作单位 南方医科大学南方医院 邮政编码 510515
个人简介

赵海金,三级主任医师,博士生导师,博士后合作导师,医学博士,南方医科大学南方医院慢性气道疾病实验室负责人。.

现任中国医师协会呼吸分会哮喘与变态反应学组委员,中华医学会呼吸病分会肺功能学组委员,中华医学会变态反应分会呼吸过敏性疾病学组委员,广东省医学会呼吸病学青委前副主任委员,中国哮喘联盟网站编委病例讨论(版主),广东省医学会呼吸分会哮喘学组副组长,广东省医学会变态反应分会常委兼肺过敏学组组长,广东省医师协会慢性气道疾病专业组成员,广东省预防医学会呼吸病预防与控制会慢病亚专业组长,广东省呼吸与健康学会过敏专委会副主任委员,广东胸部疾病协会肺功能专委会副主任委员,ERS会员,国家自然科学基金同行评议专家,国际呼吸杂志通迅编委,南方医科大学学报特约编委,J Applied Physiology,中国医学科学院学报特约审稿人。

曾获2023年广东省变态反应学“学术成就奖”,2019年广东省科技进步二等奖(2/7);2015年首届“全国优秀青年呼吸医师”;2012年中华医学会慢阻肺防治杰出中青年。2006年广州市科技进步三等奖(R4)。主持国家自然科学基金面上4项,省自然、省科技及市科技计划项目共5项。在Redox Biology, Allergy、Brit J Pharm、Clin Exp Allergy、J thorac Dis等发表SCI论著30余篇,在网站,公众号,报纸等发表科谱宣教文章100余篇。

 

研究领域

慢性气道疾病包括哮喘、慢性阻塞性肺疾病、哮喘慢阻肺重叠(ACO) 和慢性咳嗽。主要研究方向:基于临床大数据探讨哮喘、慢阻肺及慢性咳嗽表型、药物选择及预后指标;建立和优化重症或激素抵抗型哮喘模型,研究气道上皮细胞在哮喘气道炎症的启动作用,深入探讨肺代谢紊乱、RAGE/β-catenin轴和线粒体功能失常在哮喘的作用、分子机制及靶向药物筛选,为哮喘防治提供新的理论依据。

个人成果
DAMP分子-HMGB1在气道上皮对哮喘气道炎症关键介质TSLP的作用及机制研究 NSFC 2013
HDAC1通过RAGE/β-catenin轴对TDI哮喘气道炎症的调控及机制研究 NSFC 2017
丁酸盐通过靶向HDAC1影响RAGE/β-catenin轴改善激素抵抗型TDI哮喘模型气道炎症的分子机制 NSFC 2021
RAGE/β-catenin轴经mPTP异常开放调控线粒体稳态参与TDI激素抵抗哮喘气道炎症的分子机制 NSFC 2024
RAGE/β-catenin信号轴与Hippo-YAP/TAZ通路Cross-Talk介导线粒体损伤参与TDI激素抵抗型哮喘气道炎症的机制研究 GDFC 2023
中性粒细胞胞外陷阱通过靶向气道上皮RAGE/β-catenin轴调控激素抵抗型TDI哮喘模型气道炎症 GDFC 2022

Targeting PGAM5 attenuates airway inflammation in asthma by inhibiting HMGB1 release in bronchial epithelium

Free Radic Biol Med(2025)

7.1

Bongkrekic acid alleviates airway inflammation via breaking the mPTP/mtDAMPs/RAGE feedback loop in a steroid-insensitive asthma model

Biomed Pharmacother(2024) 6.9
Inhibition of xanthine oxidase by allopurinol suppresses HMGB1 secretion and ameliorates experimental asthma Redox Biol(2024) 11.4
The value of bronchodilator response in FEV1 and FeNO for differentiating between chronic respiratory diseases: an observational study

Eur J Med Res(2024)

2.8

A Low Eosinophil to Platelet Ratio as a Worse Prognostic Index for Emergency Department Attendance in Acute Exacerbation of COPD

Int J Chron Obstruct Pulmon Dis(2024)

2.3

Blockade of neutrophil extracellular traps ameliorates toluene diisocyanate-induced steroid-resistant asthma

Int  Immunopharmacol(2023) 4.932
Mitoquinone ameliorated airway inflammation by stabilizing β-catenin destruction complex in a steroid-insensitive asthma model

Biomed Pharmacother(2023)

7.5
Blockade of β-catenin signaling attenuates toluene diisocyanate-induced experimental asthma Allergy(2017) 13.146
The receptor for advanced glycation end products is required for beta-catenin stabilization in a chemical-induced asthma model  Br J Pharmacol(2016) 8.739
 Toluene diisocyanate enhances human bronchial epithelial cells' permeability partly through the vascular endothelial growth factor pathway Clin Exp Allergy(2009) 5.018
Phosphorylation of low density lipoprotein receptor-related protein 6 is involved in receptor for advanced glycation end product-mediated β-catenin stabilization in a toluene diisocyanate-induced asthma model Int Immunopharmacol(2018) 4.932
Ethyl pyruvate decreases airway neutrophil infiltration partly through a high mobility group box 1-dependent mechanism in a chemical-induced murine asthma model. Int Immunopharmacol(2014) 4.932
Short Thymic Stromal Lymphopoietin Attenuates Toluene Diisocyanate-induced Airway Inflammation and Inhibits High Mobility Group Box 1-Receptor for Advanced Glycation End Products and Long Thymic Stromal Lymphopoietin Expression Toxicol Sci(2017) 4.849
Phosphatidylinositol 3-Kinase Mediates β-Catenin Dysfunction of Airway Epithelium in a Toluene Diisocyanate-Induced Murine Asthma Model Toxicol Sci(2015) 4.849
RAGE mediates β-catenin stabilization via activation of the Src/p-Cav-1 axis in a chemical-induced asthma model Toxicol Lett(2018) 4.372
JNK modulates RAGE/β-catenin signaling and is essential for allergic airway inflammation in asthma Toxicol Lett(2021) 4.372
Chicken IgY facilitates allergic airway inflammation in a chemical-induced murine asthma model by potentiating IL-4 release Toxicol Lett(2015) 4.372
Phosphatidylinositol 3-kinases pathway mediates lung caspase-1 activation and high mobility group box 1 production in a toluene-diisocyanate induced murine asthma model Toxicol Lett(2015) 4.372
High-mobility group box 1 impairs airway epithelial barrier function through the activation of the RAGE/ERK pathway Int J Mol Med(2016) 4.101
RAGE mediates airway inflammation via the HDAC1 pathway in a toluene diisocyanate-induced murine asthma model BMC Pulm Med(2022) 3.317
Fractional exhaled nitric oxide was not associated with the future risk of exacerbations in Chinese asthmatics: a non-interventional 1-year real-world study. J Thorac Dis(2019) 2.89
Fractional exhaled nitric oxide was not associated with the future risk of exacerbations in Chinese asthmatics: a non-interventional 1-year real-world study J Thorac Dis(2020) 2.89