目录
更新日期:2025年9月25日
姓 名 何懿 性 别
民 族 汉族 导师层次 博士导师
技术职称 主任医师 导师类型 学术&专业型
最后学历 博士研究生毕业 最后学位
行政职务 主任 Email heyi1983@smu.edu.cn
工作单位 南方医科大学第三附属医院 邮政编码 510630
个人简介

何 懿  医学博士、主任医师,学术型博士研究生导师

南方医科大学第三附属医院风湿免疫科  主任

省杰出医学青年人才、市科普名师、羊城青年好医生

中国免疫学会自身免疫分会 委员

广东省医院协会风湿免疫管理专业委员会 青年主任委员

广东省医学会及广东省医师协会 风湿病学分会 委员

广东省医疗行业协会风湿免疫分会 副主任委员

广东省精准医学会高尿酸血症与痛风分会 副主任委员

第一完成人获广东省医学科技奖.科学普及奖

     主持国自然面上/青年项目、省国际合作重点项目、省自然、市科技计划等数十项课题。第一/通讯作者在Cell Host Microbe(IF:20.7)、Ann Rheum Dis (IF:20.3), Arthritis&Rheumatol (IF:15.48), Small (IF:15.12), Clin Rev Allerg Immu (IF:10.82)Br J DermatolIF 11)及 J Control Release(IF:10.5)等杂志发表SCI论文27篇(IF10分以上6篇)。打造“何懿医生”个人IP,全网粉丝近300万。

       联系邮箱:heyi1983@smu.edu.cn,联系电话/微信:13826080199

研究领域

1、不同细胞死亡方式在自身免疫性疾病(类风湿关节炎、系统性红斑狼疮、强直性脊柱炎、痛风等))发病及进展中的机制研究

2、肠道菌群在自身免疫病(类风湿关节炎、系统性红斑狼疮、强直性脊柱炎、痛风等))中的机制研究

3、新型材料在自身免疫病(类风湿关节炎、系统性红斑狼疮、强直性脊柱炎、痛风等))中的应用研究

个人成果

以第一作者及通讯作者(含并列)发表的论文如下(#代表第一作者、*代表标通讯作者):

1、Yi He#, Yuwei Luo, Xiaobin Lao, Liping Tan, Erwei Sun*, Cytokine signatures of human whole blood for monitoring immunosuppression, Central European Journal of Immunology. 2014;39(3):271-8. JCR 4区,IF:1.61

2、Jiaochan Han#, Qingyou Zhou#, Xing Li, Juan He, Yanping Han, Hongyu Jie, Yi He* and Erwei Sun*, Novel function of hydroxychloroquine: Down regulation of T follicular helper cells in collagen-induced arthritis, Biomedicine & Pharmacotherapy.. 2018 Jan;97:838-843. JCR 1区,IF:7.24

3、Pan Liao#, Yi He#, Fangyuan Yang, Guihu Luo, Jian Zhuang, Zeqing Zhai, Lili Zhuang ,Erwei Sun*,Polydatin effectively attenuates disease activity in lupus-prone mouse models by blocking ROS-mediated NET formation, Arthritis Research Therapy, 2018.11.20, 20(1): 254~254,JCR 2 IF:5.61

4、Xue-Chan Huang, Yi He#, Jian Zhuang, Juan He, Gui-Hu Luo, Jiao-Chan Han, Er-Wei Sun

Mycophenolic Acid Synergizing with Lipopolysaccharide to Induce Interleukin-1β Release via Activation of Caspase-1 Chinese Medical Journal. 2018 Jul 5;131(13):1533-1540. JCR 2 IF:6.13

5、Yaru Ji#, Yi He#,Xinying Nian,Erwei Sun*, Li Li *,Inflammatory or Neuropathic Pain: Characteristics and Their Relationships with Disease Activity and Functional Status in Axial Spondyloarthritis Patients, Pain Medicine, 2019 May 1;20(5):882-888 JCR 3区,IF:3.64

6、Yi He#, Fangyuan Yang,# Er‑Wei Sun(*),Neutrophil Extracellular Traps in Autoimmune Diseases, Chinese Medical Journal, 2018 Jul 5;131(13):1513-1519 JCR 2区, IF:6.13

7、Xinying Nian#, Yi He#, Yaru Ji, Yaobin Huang, Erwei Sun*, Li Li*,Associations Between Pain Patterns and Self-Reported Clinical Outcomes in Patients with Knee Osteoarthritis, Pain Medicine, 2019 Apr 1;20(4):818-825 JCR 3区,IF:3.64

8、Yang F#, He Y#, Zhai Z, Sun E*. Programmed Cell Death Pathways in the Pathogenesis of Systemic Lupus Erythematosus. Journal of Immunology Research. 2019 Dec 1;2019:3638562. JCR 3区,IF:4.49

9、Yang F#, Luo X#, Luo G, Zhai Z, Zhuang J, He J, Han J, Zhang Y, Zhuang L, Sun E * and He Y *,  Inhibition of NET formation by polydatin protects against collagen-induced arthritis. International Immunopharmacology,2019 Dec;77:105919. JCR 2 IF:5.71

10、Yang F#, Zhai Z#, Luo X, Luo G, Zhuang L, Zhang Y, Li Y, Sun E * and He Y*, Bioinformatics identification of key candidate genes and pathways associated with systemic lupus erythematosus. Clinical Rheumatology. 2020 Feb;39(2):425-434; (JCR 4 IF=3.65)

11、Jian Zhuang#, Haiyan Cui#, Lili Zhuang, Zeqing Zhai, Fangyuan Yang, Guihu Luo, Juan He, Haijin Zhao, Wenqu Zhao, Yi He* and Erwei Sun*. Bronchial epithelial pyroptosis promotes airway inflammation in a murine model of toluene diisocyanate-induced asthma. Biomedicine & Pharmacotherapy. 2020 May;125:109925 JCR 1 IF:7.24

12Yehao Li#, Yanan Zhang#, Wenchao Xu, Jianheng Liang, Xiaoqing Luo, Xinai Han, Xingliang Shi, Hongyu Jie, Xing Li, Yi He*, Erwei Sun* Activated coagulation is associated with the disease activity of axial spondyloarthritis, International Immunopharmacology. 2020 Nov;88:106979. JCR 2 IF:5.71

13、Jie Li#, Lili Zhuang#, Xiaoqing Luo, Jianheng Liang, Erwei Sun* and Yi He* Protection of MCC950 against Alzheimer's disease via inhibiting neuronal pyroptosis in SAMP8 mice, Experimental Brain Research. 2020 Nov;238(11):2603-2614. JCR 4 IF:2.06

14、Jiaochan Han# , Xing Li# , Xiaoqing Luo, Juan He , Xuechan Huang , Qingyou Zhou , Yanping Han , Hongyu Jie , Jian Zhuang , Yehao Li , Fangyuan Yang , Zeqing Zhai , Shufan Wu , Yi He*, Bin Yang* and Erwei Sun* The mechanisms of hydroxychloroquine in rheumatoid arthritis treatment: Inhibition of dendritic cell functions via Toll like receptor 9 signaling. Biomedicine & Pharmacotherapy. 2020 Dec;132:110848.IF: JCR 17.24

15、Zeqing Zhai#, Fangyuan Yang#, Wenchao Xu#, Jiaochan Han, Guihu Luo, Yehao Li, Jian Zhuang, Hongyu Jie, Xing Li, Xingliang Shi, Xinai Han, Xiaoqing Luo, Rui Song, Yonghong Chen, Jianheng Liang, Shufan Wu, Yi He*, Erwei Sun*, Attenuation of Rheumatoid Arthritis Through the Inhibition of Tumor Necrosis Factor-Induced Caspase 3/Gasdermin E-Mediated Pyroptosis, Arthritis & Rheumatology, 2022 Mar;74(3):427-440. JCR 1IF:15.48

16、Guihu Luo#, Yi He#, Fangyuan Yang, Zeqing Zhai, Jiaochan Han, Wenchao Xu, Jialin Zhang, Lili Zhuang, Yanan Zhang, Yehao Li, Rui Song, Xiaoqing Luo, Jianheng Liang, Erwei Sun*, Blocking GSDME-mediated pyroptosis in renal tubular epithelial cells alleviates disease activity in lupus mice, Cell Death Discovery. 2022 Mar 12;8(1):113. JCR 2 IF: 7.1

17、Lili Zhuang#, Xiaoqing Luo#, Shufan Wu, Zhangmei Lin, Yanan Zhang, Zeqing Zhai, Fangyuan Yang, Yehao Li, Jian Zhuang, Guihu Luo, Wenchao xu, Yi He*, Erwei Sun*. Disulfiram alleviates pristane-induced lupus via inhibiting GSDMD-mediated pyroptosis. Cell Death Discovery. 2022 Sep 3;8(1):379JCR 2区,IF7.11

18、Xingliang Shi #, Lili Zhuang#, Zeqing Zhai 1 2, Yi He*, Erwei Sun*Polydatin protects against gouty nephropathy by inhibiting renal tubular cell pyroptosis,International Journal of Rheumatic Diseases. 2022;00:1–8. JCR 4区,IF2.55

19、Chao Yang#, Yi He#, Fangman Chen, Fan Zhang, Dan Shao*, Zheng Wang*,Leveraging β-Adrenergic Receptor Signaling Blockade for Improved Cancer Immunotherapy Through Biomimetic Nanovaccine,Small. 2023 Apr;19(14):e2207029JCR 1区,IF15.18

20、Zhi-Bin Zhao #, Zhen-Hua Bian # , Zhang-Mei Lin, Shu-Fan Wu, Jie Long, Yang Cui , Yang Li, Wende Li, Er-Wei Sun*, Zhe-Xiong Lian*, Yi He*,Single-Cell Analysis of Patients with Axial Spondyloarthritis After Anti-TNFα Treatment: Experimental Data and Review of the Literature,Clinical Reviews in Allergy & Immunology. 2023 Mar 8 JCR 1区,IF10.81

21、Xiaoqing Luo #, Zeqing Zhai #, Zhangmei Lin #, Shufan Wu, Wenchao Xu, Yehao Li, Jian Zhuang, Jie Li, Fangyuan Yang*, Yi He*Cyclophosphamide induced intestinal injury is alleviated by blocking the TLR9/caspase3/GSDME mediated intestinal epithelium pyroptosis, International Immunopharmacology, 2023 May 1. JCR 2区,IF:5.71

22、Ying Huang #, Jialin Deng, Jinghua Liu, Fangyuan Yang, Yi He*,Autoimmune congenital heart block: a case report and review of the literature related to pathogenesis and pregnancy management, Arthritis Research & Therapy,2024 Jan 2;26(1):8. JCR 2区,IF:4.9

23、Zhenglan Ban #, Madi Sun #, Huihong Ji #, Quanxin Ning, Chuanxu Cheng, Tongfei Shi, Minghao He, Xuenian Chen, Huanfen Lu, Xuan He, Chenyang Guo, Yan He*, Dan Shao*, Yi He*, Immunogenicity-masking delivery of uricase against hyperuricemia and gout, J Control Release

. 2024 Aug:372:862-873JCR 1区,IF:10.7

24、Tangming Guan #, Zhenhua Bian #, Hongbin Gao #, Yi He #, Junru Yuan, Hongping Wan, Shuangjie Tang, Yongfeng Li, Jianming Qiu, Panyue Luo, Xiaolan Ye, Shi Liang, Siyu Chen, Nvlue Cai, Yezhi Guan, Jianxin Liu, Zhibin Zhao, Huanhuan Jia*, Wei Yang*, Wende Li*, Altered CD8+ T cell subpopulation in the bone marrow microenvironment of cynomolgus monkeys with spontaneous ankylosing spondylitis, Ann Rheum Dis, 2024 Jul 17:ard-2024-226018JCR 1区,IF:20.3

25、Yingfei Li#, Yi He# , Fangyuan Yang, Rongmei Liang, Wenchao Xu, Yehao Li, Jingbo Cheng, Baozhu Liang, Ming Tang, Xingliang Shi, Jian Zhuang, Minshuang Luo, Liuying Li, Ruilin Zhang, Huijuan Liu, Hongyu Jie, Xing Li, Xinai Han, Erwei Sun*, Zeqing Zhai*,Gasdermin E-mediated keratinocyte pyroptosis participates in the pathogenesis of psoriasis by promoting skin inflammation,

Br J Dermatol. 2024 Aug 14,(JCR1区,IF 11)

26、Zixiao Lu #, Qingqing Zou #, Menghong Wang #, Xinai Han, Xingliang Shi, Shufan Wu, Zhuoyao Xie, Qiang Ye, Liwen Song, Yi He*, Qianjin Feng*, Yinghua Zhao*,Artificial intelligence improves the diagnosis of human leukocyte antigen (HLA)-B27-negative axial spondyloarthritis based on multi-sequence magnetic resonance imaging and clinical features,Quant Imaging Med Surg. 2024 Aug 1;14(8):5845-5860. doi: 10.21037/qims-24-729. Epub 2024 Jul 30.(JCR3区 IF2.9)

27、Yunong Zeng#, Rong Wu#, Yi He#, Qian Zhang#, Ze Wang, Ping Qin, Fangyuan Yang, Yingshi Han, Mingjing Hao, Yujian Zheng, Lei Gao, Xia Chen, Xiaoshan Zhao, Zhenhua Zeng, Zhe-Xiong Lian, Weidong Xiao*, Zhanguo Liu*, Zhi-Bin Zhao*, Shenhai Gong*,Cohabitation facilitates microbiome shifts that promote isoflavone transformation to ameliorate liver injury, Cell Host Microbe, 2025 May 14;33(5):688-704.e10. Epub 2025 May 2. doi: 10.1016/j.chom.2025.04.011. (JCR1区,IF20.6).