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更新日期：2025年9月17日
姓 名 瞿少刚 性 别 男
民 族 汉族 导师层次 博士导师
技术职称 教授 导师类型 学术型
最后学历 博士研究生毕业 最后学位 哲学博士学位
行政职务 其他 Email sgq9528@163.com
工作单位 南方医科大学南方医院 邮政编码 510515
跨学科招生 是
跨学科招生专业1 法医学 招生层次类型1 学术学位博导
跨学科招生专业2 招生层次类型2
个人简介

瞿少刚，男，以色列希伯来大学博士，南方医科大学南方医院神经内科教授、博士生导师。在神经退行性疾病发病机制与防治领域开展了卓有成效的研究工作，取得了杰出的成绩，被广东省界定为“海外高层次留学人才”。目前担任中国分析测试协会生命组学专委会常委、中国医药生物技术协会生物诊断技术分会委员、广东省医学教育协会生物化学与分子生物学专业委员会副主任委员、广东省老年保健协会神经系统疑难疾病专业委员会副主任委员、广东省神经科学学会常务理事、广东省中西医结合学会帕金森病及运动障碍专业委员会常委、“精神健康研究”教育部重点实验室PI、广东省卒中学会卒中与帕金森病及神经调控分会常委。

主持国家自然科学基金联合基金重点项目1项、国家自然科学基金面上项目3项、国际遗传工程与生物技术中心（ICGEB）项目1项、教育部高等学校博士学科点专项科研基金1项、广东省高等学校人才引进项目1项、广东省自然科学基金面上项目1项、广东省科技计划项目3项、广州市重点研发计划项目1项等各级科研项目十余项。

瞿少刚教授具有丰富的科研经验，长期致力于帕金森病的发病机制及治疗方面的研究，并取得了重要的研究成果，以第一作者或通讯作者在Proc Natl Acad Sci U S A.（1区，2篇）、ACS Nano（1区）、Ecotoxicology and Environmental Safety（1区）、Zoological Research（1区）、Cell Death & Disease（2区，3篇）、Free Radical Biology and Medicine（2区）、Journal of Translational Medicine（2区，2篇）、J Biol Chem.（2区）、Molecular Neurobiology（2区）等期刊上发表SCI论文五十余篇。发表SCI论文被Science、Nature、Physiological reviews、Nature structural & molecularbiology、Proc Natl Acad Sci U S A.等SCI期刊论文引用。

以第一完成人获得2020年广东省自然科学二等奖，项目名称：重要转运体跨膜转运的分子机制及其在疾病发病中的作用研究，证书编号：粤府证【2021】0062号，项目编号：Z04-2-02-R01。

以第二完成人获得2019年湖北省科技进步三等奖，项目名称：帕金森病的疾病修饰治疗和临床应用，证书编号：2019J-244-3-123-097-R02。

研究领域

神经退行性疾病发病机制、防治及早期诊断研究

个人成果
发表主要论文
  1. Xu M, Zhao L, Xiao F, Zhou C, Ouyang Y, Qu S*. Muscone inhibits ferroptosis for neuroprotection in a Parkinson's disease model. Free Radical Biology and Medicine. 2025 Jul 31;239:298-316. doi: 10.1016/j.freeradbiomed.2025.07.052.
  2. Huang P, Wan Z, Qu S*. Targeting the RUNX3-miR-186-3p-DAT-IGF1R axis as a therapeutic strategy in a Parkinson's disease model. Journal of Translational Medicine. 2024 Aug 5;22(1):719. doi: 10.1186/s12967-024-05535-7. 
  3. He S, Qu Q, Chen X, Zhao L, Jiao Z, Wan Z, Kwok HF, Qu S*. Downregulation of Ambra1 by altered DNA methylation exacerbates dopaminergic neuron damage in a fenpropathrin-induced Parkinson-like mouse model. Ecotoxicology and Environmental Safety. 2024;271:115995.
  4. Lu H, Chai J, Xu Z, Wu J, He S, Liao H, Huang P, Huang X, Chen X, Jiang H, Qu S*, Xu X*. Cath-KP, a novel peptide derived from frog skin, prevents oxidative stress damage in a Parkinson’s disease model. Zoological Research.  2024 Jan 18;45(1):108-124.doi: 10.24272/j.issn.2095-8137.2023.101.
  5. He S, Wang Q, Chen L, He YJ, Wang X, Qu S*. miR-100a-5p-enriched exosomes derived from mesenchymal stem cells enhance the anti-oxidant effect in a Parkinson's disease model via regulation of Nox4/ROS/Nrf2 signaling. Journal of Translational Medicine. 2023 Oct 24;21(1):747. doi: 10.1186/s12967-023-04638-x.
  6. Xu K#, Huang P#, Wu Y, Liu T, Shao N, Zhao L, Hu X, Chang J, Peng Y*, Qu S*. Engineered Selenium/Human Serum Albumin Nanoparticles for Efficient Targeted Treatment of Parkinson's Disease via Oral Gavage. ACS Nano. 2023 Oct 24;17(20):19961-19980. doi: 10.1021/acsnano.3c05011.
  7. Wu Y#, Qu Q#, Wan Z#, Qu S*. Fenpropathrin Induces GLT-1 Ubiquitination and Increases IL-6 Secretion through the Mdm2-p53 Pathway. ACS Chemical Neuroscience. 2023; 14(11):2112-2122.
  8. Qu Q#, Zhang W#, Wang J, Mai D, Ren S*, Qu S*, Zhang Y*. Functional Investigation of SLC1A2 Variants Associated with Epilepsy. Cell Death & Disease. 2022 Dec 21;13(12):1063. doi: 10.1038/s41419-022-05457-6.
  9. Yip KM, Lee KM, Ng TB, Xu S, Yung KKL, Qu S*, Cheung AKL*, Sze SCW*. An anti-inflammatory and anti-fibrotic proprietary Chinese medicine nasal spray designated as Allergic Rhinitis Nose Drops (ARND) with potential to prevent SARS-CoV-2 coronavirus infection by targeting RBD (Delta)-angiotensin converting enzyme 2 (ACE2) binding. Chin Med. 2022 Jul 27;17(1):88. doi: 10.1186/s13020-022-00635-2.
  10. Qin S, Huang X*, Qu S*. Baicalin Induces a Potent Innate Immune Response to Inhibit Respiratory Syncytial Virus Replication via Regulating Viral Non-Structural 1 and Matrix RNA. Front Immunol. 2022 Jun 23;13:907047. doi: 10.3389/fimmu.2022.907047. eCollection 2022.
  11. Zeng C#, Meng X#, Mai D, Xu K, Qu S*. Overexpression of miR-132-3p contributes to neuronal protection in in vitro and in vivo models of Alzheimer’s disease. Behav Brain Res. 2022 Jan 24;417:113584. doi: 10.1016/j.bbr.2021.113584.
  12. Qu Q#, Wang J#, Li G, Chen R* and Qu S*. The Conformationally Sensitive Spatial Distance Between the TM3-4 Loop and Transmembrane Segment 7 in the Glutamate Transporter Revealed by Paired-Cysteine Mutagenesis. Front. Cell Dev. Biol. 2021;9:737629. doi: 10.3389/fcell.2021.737629
  13. Meng X, Zhong J, Zeng C, Yung KKL, Zhang X, Wu X, Qu S*. MiR-30a-5p Regulates GLT-1 Function via a PKCα-Mediated Ubiquitin Degradation Pathway in a Mouse Model of Parkinson's Disease. ACS Chem Neurosci. 2021 May 5;12(9):1578-1592. doi: 10.1021/acschemneuro.1c00076. 
  14. He S, Wang F, Yung KKL, Zhang S, Qu S*. Effects of α-Synuclein-Associated Post-Translational Modifications in Parkinson's Disease. ACS Chem Neurosci. 2021 Apr 7;12(7):1061-1071. doi: 10.1021/acschemneuro.1c00028.
  15. Wu Y, Jiao Z, Wan Z, Qu S*. Role of autophagy and oxidative stress to astrocytes in fenpropathrin-induced Parkinson-like damage. Neurochem Int. 2021 May;145:105000. doi: 10.1016/j.neuint.2021.105000.
  16. Mai D, Chen R, Wang J, Zheng J, Zhang X, Qu S*. Critical amino acids in the TM2 of EAAT2 are essential for membrane-bound localization, substrate binding, transporter function, and anion currents. Journal of Cellular and Molecular Medicine. 2021 Mar;25(5):2530-2548. doi: 10.1111/jcmm.16212. 
  17. Wang J, Qu S*. Conformationally Sensitive Proximity Between the TM3–4 Loop and Hairpin Loop 2 of the Glutamate Transporter EAAT2 Revealed by Paired-Cysteine Mutagenesis. ACS Chemical Neuroscience.  2021; 12(1):163-175. doi: 10.1021/acschemneuro.0c00645. 
  18. Wang J, Wang F, Mai D, Qu S*. Molecular Mechanisms of Glutamate Toxicity in Parkinson’s Disease. Frontiers in Neuroscience. 2020 Nov 26;14:585584. doi: 10.3389/fnins.2020.585584. eCollection 2020. 
  19. Zeng X, Xu K, Wang J, Xu Y*, Qu S*. Pretreatment of Ascorbic Acid Inhibits MPTP-Induced Astrocytic Oxidative Stress through Suppressing NF- κ B Signaling. Neural Plasticity. 2020 Nov 17;2020:8872296. doi: 10.1155/2020/8872296. eCollection 2020.  
  20. Jiao Z#, Wu Y and Qu S*. Fenpropathrin induces degeneration of dopaminergic neurons via disruption of the mitochondrial quality control system. Cell Death Discovery. 2020 Aug 25;6:78. doi: 10.1038/s41420-020-00313-y. eCollection 2020.   
  21. Zhang Y#, Meng X#, Jiao Z, Liu Y, Zhang X, Qu S*. Generation of a novel mouse model of Parkinson's disease via targeted knockdown of glutamate transporter GLT-1 in the substantia nigra. ACS Chem Neurosci. 2020 Feb 5;11(3):406-417. doi: 10.1021/acschemneuro.9b00609. 
  22. Qu S*, Meng X, Liu Y, Zhang X, Zhang Y*. Ginsenoside Rb1 prevents MPTP-induced changes in hippocampal memory via regulation of the α-synuclein/PSD-95 pathway. Aging (Albany NY). 2019 Apr 4;11(7):1934-1964. doi: 10.18632/aging.101884. 
  23. Qu S*, Zhang W, He S, Zhang X. Paired-cysteine scanning reveals conformationally sensitive proximity between the TM4b-4c loop and TM8 of the glutamate transporter EAAT1. ACS Chem Neurosci. 2019 May 15;10(5):2541-2550. doi: 10.1021/acschemneuro.9b00048.
  24. Wu X#, Meng X#, Tan F#, Jiao Z, Zhang X, Tong H, He X, Luo X*, Xu P*, Qu S*. Regulatory Mechanism of miR-543-3p on GLT-1 in a Mouse Model of Parkinson's Disease. ACS Chem Neurosci. 2019;10(3):1791-1800. 
  25. He S, Zhang X, Qu S*. Glutamate, Glutamate Transporters, and Circadian Rhythm Sleep Disorders in Neurodegenerative Diseases. ACS Chem Neurosci. 2019;10(1):175-181.
  26. Jiao Z#, Zhang W#, Chen C, Zhu X, Chen X, Zhou M, Peng G, Liu H, Qiu J, Lin Y, Huang S, Mo M, Yang X*, Qu S*, Xu P*. Gene Dysfunction Mediates Immune Response to Dopaminergic Degeneration in Parkinson’s Disease. ACS Chem Neurosci. 2019;10(2):803-811. 
  27. Zhang W, Zhang X, Qu S*. Substrate-Induced Motion between TM4 and TM7 of the Glutamate Transporter EAAT1 Revealed by Paired Cysteine Mutagenesis. Mol Pharmacol. 2019;95(1):33-42.
  28. Tong H, Zhang X, Meng X, Lu L, Mai D, Qu S*. Simvastatin Inhibits Activation of NADPH Oxidase/p38 MAPK Pathway and Enhances Expression of Antioxidant Protein in Parkinson Disease Models. Front Mol Neurosci. 2018;11:165. 
  29. Zhang W, Zhang X, Qu S*. Cysteine Scanning Mutagenesis of TM4b-4c Loop of Glutamate Transporter EAAT1 Reveals Three Conformationally Sensitive Residues.Mol Pharmacol. 2018;94(1):713-721. 
  30. Xiao Y#, Chen X#, Huang S, Li G, Mo M, Zhang L, Chen C, Guo W, Zhou M, Wu Z, Cen L, Long S, Li S, Yang X*, Qu S*, Pei Z*, Xu P*. Iron promotes α-synuclein aggregation and transmission by inhibiting TFEB-mediated autophagosome-lysosome fusion. J Neurochem. 2018;145(1):34-50. 
  31. Huang S#, Tong H#, Lei M#, Zhou M#, Guo W, Tang X, Li Z, Mo M, Zhang X, Chen X, Cen L, Wei L, Xiao Y, Li K, Huang Q, Yang X, Liu W, Zhang L, Qu S*, Li S*, Xu P*. Astrocytic glutamatergic transporters are involved in Aβ-induced synaptic dysfunction. Brain Research. 2018;1678:129-137. 
  32. Zhang Y#, He X#, Wu X, Lei M, Wei Z, Zhang X, Wen L, Xu P*, Li S*, and Qu S*. Rapamycin upregulates glutamate transporter and IL-6 expression in astrocytes in a mouse model of Parkinson’s disease. Cell Death & Disease. 2017;8(2):e2611.
  33. Zhang Y, He X, Meng X, Wu X, Tong H, Zhang X and Qu S*. Regulation of glutamate transporter trafficking by Nedd4-2 in a Parkinson’s disease model. Cell Death & Disease. 2017;8(2):e2574.
  34. Lu L, Zhang X, Tong H, Zhang W, Xu P* and Qu S*. Central administration of 5Z-7-oxozeaenol protects experimental autoimmune encephalomyelitis mice by inhibiting microglia activation. Frontiers in Pharmacology. 2017; 8:789.
  35. Chen X#, Xiao Y#, Wei L#, Wu Y, Lu J, Guo W, Huang S, Zhou M, Mo M, Li Z, Cen L, Li S, ChaohaoYang, Wu Z, Hu S, Pei Z, Yang X, Qu S*, Xu P*. Association of DNMT3b gene variants with sporadic Parkinson's disease in a Chinese Han population. J Gene Med. 2017;19(11):360-365. 
  36. Cen L, Yang C, Huang S, Zhou M, Tang X, Li K, Guo W, Wu Z, Mo M, Xiao Y, Chen X, Yang X, Huang Q, Chen C*, Qu S*, Xu P*. Peripheral Lymphocyte Subsets as a Marker of Parkinson's Disease in a Chinese Population. Neurosci Bull. 2017;33(5):493-500. 
  37. Tong H#, Zhang X#, Meng X, Xu P*, Zou X* and Qu S*. Amyloid-beta peptide decreases expression and function of glutamate transporters in nervous system cells. The International Journal of Biochemistry & Cell Biology. 2017, 85:75-84.