李琳，基础医学院病理生理学教研室副主任，教授，博士生导师、博士后合作导师。国家级青年人才项目获得者，科技部重点研发计划青年项目首席科学家，广东省杰出青年基金获得者。在单细胞组学技术开发和哺乳动物生殖系发育领域取得了一些进展，在Cell、Nature Cell Biology、Cell Research等SCI期刊发表11篇原创性论文，其中人类原始生殖细胞工作入选2015年度“中国科学十大进展”和“中国生命科学领域十大进展”。

原始生殖细胞产生于胚胎发育的早期，是发育为成熟的精子和卵细胞的前体细胞，对早期胚胎以及原始生殖细胞发育过程的研究，是进一步深入理解反复流产、胚胎停止、不孕不育等疾病的重大理论基础。本人的工作主要是建立了单细胞多组学技术（Single-cell multi-omics sequencing technology，scCOOL-seq），利用该技术在单细胞分辨率，系统地解析了小鼠和人类早期胚胎以及原始生殖细胞发育过程中，DNA甲基化组和染色质状态组的重编程过程，以及染色质状态与DNA甲基化之间的相互关系等生物学特征。

代表性论著

1. Teng Wang#, Junhua Peng#, Jiaqi Fan#, Ni Tang#, Rui Hua#, Xueliang Zhou, Zhihao Wang, Longfei Wang, Yanling Bai, Xiaowan Quan, Zimeng Wang, Li Zhang, Chen Luo, Weiqing Zhang, Xiangjin Kang, Jianqiao Liu, Lei Li^*,  Lin Li^* , Single-cell multi-omics profiling of human preimplantation embryos identifies cytoskeletal defects during embryonic arrest, Nature Cell Biology, 2024, 26(2):263-277. (IF=21.3, JCR 1区)

2. Yaping Huang#, Lin Li#, Geng An#, Xinyan Yang#, Manman Cui#, Xiuling Song, Xiaoling Zhang, Jing Lin, Cai Zhou, Jiexiang Zhao, Zhaokai Yao, Ke Song, Shaofang Ren, Xinyu Xia, Cong Wan, Xin Fu, Yu Lan, Xuesong Hu, Wen Wang, Mei Wang, Yi Zheng, Kai Miao, Xiaochun Bai, Andrew Paul Hutchins, Gang Chang^*, Shuai Gao^*, Xiao-Yang Zhao^*, Single-cell multi-omics sequencing of human spermatogenesis reveals a DNA demethylation event associated with male meiotic recombination, Nature Cell Biology, 2023, 25(10):1520-153. (IF=21.3, JCR 1区)

3. Li Zhang#, Jiyuan Zou#, Zhihao Wang, Lin Li*, A Subpathway and Target Gene Cluster-Based Approach Uncovers lncRNAs Associated with Human Primordial Follicle Activation，International Journal of Molecular Sciences, 2023, 24(13):10525. (IF=5.6, JCR 2区)

4. Jing Wang^#, Cai Zhou^#, Shuai Gao^#, Xiuling Song^#, Xinyan Yang^#, Jiaqi Fan, Shaofang Ren, Linzi Ma, Jiexiang Zhao, Manman Cui, Ke Song, Mei Wang, Chaohui Li, Yi Zheng, Fang Luo, Kai Miao, Xiaochun Bai, Andrew P. Hutchins, Lin Li^*, Gang Chang^*, Xiao-Yang Zhao^*, Single-cell multiomics sequencing reveals the reprogramming defects in embryos generated by round spermatid injection, Science Advances, 2022, 8(32): eabm3976. (IF=13.6, JCR 1区)

5. Lin Li^#, Fan Guo^#, Yun Gao ^#, Yixin Ren ^#, Peng Yuan, Liying Yan, Rong Li, Ying Lian, Jingyun Li, Boqiang Hu, Junpeng Gao, Lu Wen, Fuchou Tang^*, Qiao J^*, Single-cell multi-omics sequencing of human early embryos, Nature Cell Biology, 2018, 20(7): 847-858. (IF=21.3, JCR 1区)

6. Li Li^#, Lin Li^#, Qingqing Li^#, Xixi Liu^#, Xinyi Ma^#, Jun Yong, Shuai Gao, Xinglong Wu, Yuan Wei, Xiaoye Wang, Wei Wang, Rong Li, Jie Yan, Xiaohui Zhu, Lu WEN, Jie Qiao, Liying Yan^*, Fuchou Tang^*, Dissecting the epigenomic dynamics of human fetal germ cell development at single-cell resolution, Cell Research, 2021, Apr;31(4):463-477. (IF=44.1, JCR 1区)

7. Yun Gao^#, Lin Li^#, Peng Yuan^#, Fan Zhai^#, Yixin Ren, Liying Yan, Rong Li, Ying Lian, Xiaohui Zhu, Xinglong Wu, Kehkooi Kee, Lu Wen, Jie Qiao^*, Fuchou Tang^*, 5-Formylcytosine Landscapes of Human Preimplantation Embryos at Single-cell Resolution, PloS Biology, 2020, Jul 30;18(7):e3000799. (IF=9.8, JCR 1区)

8. Teng Wang^#, Xianglong Zhang^#, Zhanguo Liu^#, Tong Yao^#, Dongying Zheng, Jianwei Gan, Shuang Yu, Lin Li^*, Peng Chen^*, Jian Sun^*, Single-cell RNA sequencing reveals the sustained immune cell dysfunction in the p athogenesis of sepsis secondary to bacterial pneumonia, Genomics, 2021, 113(3): 1219-1233. (IF=4.4, JCR 2区)

9. Baojiang Wu ^#, Lin Li^#, Bojiang Li, Junpeng Gao, Yanglin Chen, Mengyi Wei, Zhiqing Yang, Baojing Zhang, Shudong Li, Kexin Li, Changshan Wang, M. Azim Surani, Xihe Li, Fuchou Tang^*, Siqin Bao^*, Activin A and BMP4 Signaling Expands Potency of Mouse Embryonic Stem Cells in Serum-Free Media, Stem Cell Reports, 2020, 14(2): 241-255. (IF=5.9, JCR 2区)

10. Fan Guo^#*, Lin Li^#, Jingyun Li^#, Xinglong Wu, Boqiang Hu, Ping Zhu, Lu Wen, Fuchou Tang^*, Single-cell multi-omics sequencing of mouse early embryos and embryonic stem cells, Cell Research, 2017, 27(8): 967-988. (IF=44.1, JCR 1区) 封面论文，入选“第四届中国科协优秀科技论文”

11. Fan Guo^#, Liying Yan^#, Hongshan Guo^#, Lin Li^#, Boqiang Hu, Yangyu Zhao, Jun Yong, Yuqiong Hu, Xiaoye Wang, Yuan Wei, Wei Wang, Rong Li, Jie Yan, Xu Zhi, Yan Zhang, Hongyan Jin, Wenxin Zhang, Yu Hou, Ping Zhu, Jingyun Li, Ling Zhang, Sirui Liu, Yixin Ren, Xiaohui Zhu, Lu Wen, Yi Qin Gao, Fuchou Tang^*, Jie Qiao^*, The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells, Cell, 2015, 161(6): 1437-1452. (IF=64.5, JCR 1区) 封面论文、ESI高被引论文

12. Li Lin, Gao Shuai^*, Single-cell sequencing: New insights into pre-implantation development, pluripotency, and germ cells, Science Foundation in China, 2019, 27(2): 52-65. (《中国科学基金》英文版) 封面论文

代表性课题

1.国基金面上项目，2021/01-2024/12，58万，结题，主持

2.国基金青年项目，2022/01-2024/12，30万，结题，主持

3.国基金面上项目，2026/01-2029/12，50万，在研，主持

4.国家重点研发计划，2021/12-2026/06，500万，在研，主持

5.广东省自然科学基金杰出青年基金，2022/01-2025/12，100万，在研，主持

6.广东省重点领域研发计划，2020/01-2024/12，30万，结题，项目骨干