目录
更新日期:2024年10月25日
姓 名 张兆强 性 别
民 族 汉族 导师层次 硕士导师
技术职称 副主任医师 导师类型 学术&专业型
最后学历 硕士研究生毕业 最后学位 口腔医学硕士专业学位
行政职务 科员 Email 187234415@qq.com
工作单位 南方医科大学口腔医院 邮政编码 510280
个人简介

现就职于南方医科大学口腔医院口腔颌面外科门诊。曾于2011年至2013年间以访问学者身份先后在美国密歇根理工大学及美国凯斯西储大学进行研修。目前担任Associate Editor (European Journal of Medical Research)、Dentistry Advisory Board Member (Heliyon)、Guest Associate Editor (Frontiers in Chemistry)、Academic Editor (PLOS ONE)、中华口腔医学会第二届口腔急诊专业委员会青年委员、中国医学装备协会创面修复分会委员、广东省保健协会口腔保健分会第二届委员、广东省口腔医学会口腔急诊专业委员会青年委员、南方医科大学硕士研究生导师(学术型)。目前已发表国内外学术论著约90篇(其中SCI约60篇),主持广东省自然科学基金等多个课题,参与国家级和省市级课题多项,参编人民卫生出版社专著一部。

研究领域

口腔颌面部肿瘤防治,口腔颌面部软硬组织缺损重建与修复,药物临床研究

个人成果

1. Ding XQ, Zhang ZQ, Li S, Wang AX. Combretastatin A4 phosphate induces programmed cell death in vascular endothelial cells. Oncology Research, 2011, 19(7):303-309.

2. Zhang QB, Dong FS, Zhang ZQ, Yang B. Design considerations and animal experiment on a new bilateral mandibular distraction device. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2012.

3. Zhang QB, OY KX, Zhang ZQ (Co-first author), He JQ, P ZG. Iatrogenic mandibular fracture associated with third molar removal-A case report and preventive measures recommended. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 2012.

4. Choudhury N, Zhang ZQ, Zhao F, Gu L, Samarendra Mohanty. Label free detection of Channelrhodopsion-2 phase-sensitive Fourier domain optical coherence tomography. Visualization, Image Processing and Computation in Biomedicine, 2012. (cited:1).

5. Zhang QB, Zhang B, Zhang ZQ, Chen Q. The epidemiology of cranio-facial injuries caused by animals in southern-central China. Journal of Cranio-maxillofacial Surgery, 40, 2012.

6. Zhang ZQ (Co-first author), Zhang QB, Chen L, Chen D, Chen Y, Yan WX , Ding XQ. Infant Ectopic Cervical Thymus one case report: diagnostic and management difficulties. Journal of Cranio-maxillofacial Surgery, 2012.

7. Zhang QB, Zhang ZQ (Co-first author). Early extraction---a silver bullet to avoid nerve injury in lower third molar removal? International Journal of Oral and Maxillofacial Surgery, 2012.

8. Zhang QB, Zhang ZQ. Early extraction: A reliable silver bullet to minimize nerve injury in lower third molar removal. International Journal of Oral and Maxillofacial Surgery, 2012.

9. Zhang QB, Zhang ZQ, Chen D, Zhao Y. Epidemiology of maxillofacial injury in children under 15 years of age in southern China. Oral surgery, oral medicine, oral pathology and oral radiology, 2013, 115(4): 436-441.

10. Luo ZB, Zhang QB, Zhang ZQ, Chen D, Yan WX, Li KF,Chen Y. Performance of Coralline Hydroxyapatite in Sinus Floor Augmentation: a Retrospective Study. Clinical Oral Investigations, 2013.

11. Chai LP, Wang ZF, Liang WY, Chen L, Chen D, Wang AX, Zhang ZQ. In vitro and in vivo effect of 5-FC combined gene therapy with TNF-α and CD suicide gene on human laryngeal carcinoma cell line Hep-2[J]. PLoS One, 2013, 8(4): e61136.

12. Zhu P, Lin H, Han Y, Lin Y, Xu Y, Zhang ZQ. A computational fluid dynamic analysis of peri-bracket salivary flow influencing the microbial and periodontal parameters. Plos One, 2013.

13. Xiaoxia XieLei ChenZhao-Qiang ZhangYan ShiJulin Xie. Clinical study on the treatment of chronic wound with negatively-charged aerosol. Int J Clin Exp Med. 2013.

14. Sheykholeslami KThimmappa VNava CBai XYu HZheng TZhang ZLi SLLiu SZheng QY. A New Mutation of the Atoh1 Gene in Mice with Normal Life Span Allows Analysis of Inner Ear and Cerebellar Phenotype in Aging,Plos One, 2013, 8(11):e79791.

15. Lei Chen, Yingbin Xu, Jingling Zhao, Zhaoqiang Zhang, Ronghua Yang, Julin Xie, Xusheng Liu, Shaohai Qi. Conditioned Medium from Hypoxic Bone Marrow-Derived Mesenchymal Stem Cells Enhances Wound Healing in Mice. Plos One, 2014, 9(4):e96161.

16. Jin Zhang, Min Xu, Qingyin Zheng, Yan Zhang, Weijun Ma, Zhaoqiang Zhang. Blocking macrophage migration inhibitory factor activity alleviates mouse acute otitis media in vivo. Immunology Letters, 2014.

17. Yu Chen, Wangxiang Yan, Shuqi He, Jiechun Chen, Dan Chen, Zhaoqiang Zhang, Zhiguo Liu, Xueqiang Ding, Anxun Wang. In vitro effect of iASPP on cell growth of oral tongue squamous cell carcinoma. Chinese Journal of Cancer Research 2014; 26(4):382-390.

18. Yue Xu, Mengdie Yan, Yihong Gong, Lei Chen, Feng Zhao, Zhaoqiang Zhang (Corresponding author). Response of Endothelial Cells to Decellularized Extracellular Matrix Deposited by Bone Marrow Mesenchymal Stem Cells. International Journal of Clinical & Experimental Medicine, 2014, 7(12):4997-5003.

19. Zhang ZQ (Co-first author), Fang SL, Zhang QB, Chen L, Liu YR, Li KF, Zhao Y. Analysis of complications in primary cleft lips and palates surgery, Journal of Craniofacial Surgery, 2014.

20. Xueying Chen, Xiangbo Kong, Zhaoqiang Zhang (Co-first author), Wei Chen, Jieyu Chen, Huanyang Li, Wanting Cao, Yaping Ge, Silian Fang. Alpha-2-macroglobulin as a radioprotective agent: a review. Chinese Journal of Cancer Research. 2014 Oct;26(5):611.

21. Jun Liang, Zhaoqiang Zhang (Co-first author and Corresponding author), Lizhong Liang, Yun Shen, Kexiong Ouyang. HIF-1α regulated tongue squamous cell carcinoma cell growth via regulating VEGF expression in a xenograft model. Annals of Translational Medicine, 2014

22. Q.B. Zhang, Z.Q. Zhang(Co-first author), S.L. Fang, Y.R. Liu, G. Jiang and K.F. Li. Effects of hypoxia on proliferation and osteogenic differentiation of periodontal ligament stem cells: an in vitro and in vivo study. Genetics and Molecular Research, 2014, 13(4):10204-10214.

23. Chen, Lei; Xu, Yingbin; Zhao, Jingling; Zhang, Zhaoqiang; Yang, Ronghua; Xie, Julin; Liu, Xusheng; Qi, Shaohai, Correction: Conditioned Medium from Hypoxic Bone Marrow-Derived Mesenchymal Stem Cells Enhances Wound Healing in Mice., 2015.

24. Shuqi He, Renfa Lai, Dan Chen, Wangxiang Yan, Zhaoqiang Zhang, Zhiguo Liu, Xueqiang Ding and Yu Chen. Downregulation of miR-221 Inhibits Cell Migration and Invasion through Targeting Methyl-CpG Binding Domain Protein 2 in Human Oral Squamous Cell Carcinoma Cells. BioMed Research International. 2015

25. Lijun Zhang, Qi Xing, Zichen Qian, Mitchell Tahtinen, Zhaoqiang Zhang, Emily Shearier, Shaohai Qi and Feng Zhao. Hypoxia Created Human Mesenchymal Stem Cell Sheet for Prevascularized 3D Tissue Construction. Adv. Healthcare Mater. 2016, 5(3):342-352

26. Dan Chen, Wangxiang Yan, Zhiguo Liu, Zhaoqiang Zhang, Lijun Zhu, Weidong Liu, Xueqiang Ding, Anxun Wang, Yu Chen. Downregulation of miR-221 enhances the sensitivity of human oral squamous cell carcinoma cells to Adriamycin through upregulation of TIMP3 expression. Biomedicine & Pharmacotherapy. 2016,77:72–78

27. Hui Zhou, Zhaoqiang Zhang, Ying Wu, Jianjiang Zhao. Effect of the long non-coding RNA AC007392.4 on growth, invasion and migration for tongue squamous cell carcinoma. Int J Clin Exp Med, 2016,9(3):5805-5812.

28. Jun Shen, Zhaoqiang Zhang, Xiao Jiang, Wei Guo, Shujuan Yang: An unusual case report of an early proliferative verrucous leukoplakia. Int J Clin Exp Pathol 2017;10(11):11276-11280.

29. Zhaoqiang Zhang, Kefeng Li, Mengdie Yan, Qiuping Lin, Jiahong Lv, Ping Zhu, Yue Xu. Metabolomics profiling of cleidocranial dysplasia[J]. Clinical Oral Investigations,2018: 1-10.

30. Yingtao Lv, Zhaoqiang Zhang (Co-first author), Yuan Su, Peiyan Yuan, Weiqun Ma, Wenhua Huang, Pingping Xu. Healing of root and surrounding periodontium after root damage with miniscrew implants: a histomorphologic study in dogs[J]. Clinical oral investigations, 2018, 22(2): 1103-1111.

31. Fang S L, Kong X B, Zhang Z Q. Association of toll-like receptors with the risk of oral squamous cell carcinoma[J]. Journal of cancer research and therapeutics, 2018, 14(8): 180-183.

32. Qingbin Zhang, Shixiang Lai, Xunyao Hou, Wei Cao, Ying Zhang, Zhaoqiang Zhang . Protective effects of PI3K/Akt signal pathway induced cell autophagy in rat knee joint cartilage injury. Am J Transl Res 2018;10(3)

33. Zhang Z, Ibrahim M, Fu Y, Wu X, Ren F, Chen L. Application of laser scanning confocal microscopy in the soft tissue exquisite structure for 3D scan. International journal of burns and trauma. 2018;8(2):17.

34. Chen X, Kong X, Cao W, Ge Y, Wang S, Zhang Z, Li H, Liu Y, Fang S. The Detection of Serum and Urine Levels of Alpha 2-Macroglobulin in Nasopharyngeal Carcinoma Patients Receiving Late Period Radiotherapy and its Significance. Int J Dentistry Oral Sci. 2018;5(3):611-617.

35. Jia, B., Zhang, Z., Qiu, X., Chu, H., Sun, X., Zheng, X., Zhao, J., Li, Q."Analysis of the miRNA and mRNA involved in osteogenesis of adipose‑derived mesenchymal stem cells". Exp Ther Med. 2018 Aug;16(2):1111-1120.

36. Sun, Xiang, Bo Jia, Xiao‑Ling Qiu, Hong‑Xing Chu, Zhao‑Qiang Zhang, Zhi‑Ping Wang, and Jian‑Jiang Zhao. "Potential functions of long non‑coding RNAs in the osteogenic differentiation of human bone marrow mesenchymal stem cells." Molecular medicine reports 19, no. 1 (2019): 103-114.

37. Sujuan Zeng, Ying Fang, Qingbin Zhang, Bo Peng, Zhaoqiang Zhang (Co- corresponding author), Wanghong Zhao, Lihong Ge. Effect of basic fibroblast growth factor on the gingiva-derived mesenchymal stem cells. Int J Clin Exp Med 2019;12(5):6347-6356.

38. Zhang, Zhaoqiang, Jiaqi Wu, Qin Mao, Wei Cao, Xiaolei Li, Yingjie Zhang, and Qingbin Zhang. "Anthropometric Research of Metric Characters in Zygomatic Complex Region." Journal of Craniofacial Surgery 31, no. 2 (2020): 570-572.

39. Chu, Hongxing, Zhengqiang Li, Fei Ren, Zinan Yang, Zhenzhen Wu, Mingdeng Rong, and Zhaoqiang Zhang (co-corresponding author). "Clinical Application of Flap or Flapless Buccal Surgery on the Extractions of Mesially/Horizontally Impacted 3rd molar with High or Medium Position Impact: a Comparative Study." Journal of Stomatology, Oral and Maxillofacial Surgery (2020).

40. Gao, Han, Jun Liang, Xiaoxue Xia, Zhaoming Deng, and Zhaoqiang Zhang (co-corresponding author). "Unusual clinical and histologic findings in a child with mixed dentition with hereditary gingival fibromatosis: a case report." Translational Pediatrics 9, no. 1 (2020): 74.

41. Zhang, Zhaoqiang, Lin Zhuang, Yi Lin, Mengdie Yan, Jiahong Lv, Xiaolei Li, Han Lin, Ping Zhu, Qiuping Lin, and Yue Xu. "Novel drug delivery system based on hollow mesoporous magnetic nanoparticles for head and neck cancers--targeted therapy in vitro and in vivo." American Journal of Cancer Research 10, no. 1 (2020): 350.

42. Zhang Y, Zhou L, Zhang Z (Co-first author), Ren F, Chen L, Lan Z. miR‑10a‑5p inhibits osteogenic differentiation of bone marrow‑derived mesenchymal stem cells. Molecular Medicine Reports. 2020 May 4.

43. Xianghuai Zheng, Jianjiang Zhao, Zhiping Wang, Bo Jia, Zhaoqiang Zhang, Jinyuan Guo, Zhaohui Duan & Xi Lin. Postoperative online follow-up improves the quality of life of patients who undergo extraction of impacted madibular third molars: a randomized controlled trial. Clin Oral Invest (2020). https://doi.org/10.1007/s00784-020-03388-0

44. Zehong Guo, Lin Chen, Yingyuan Ning, Xianglong Ding, Yan Gao, Lei Zhou, Shulan Xu, Zhaoqiang Zhang (co-corresponding author). Split-crest technique with inlay bone block grafts for narrow posterior mandibles: a retrospective clinical study with a 3-year follow-up. Am J Transl Res. 2020; 12(8): 4628–4638. Published online 2020 Aug 15. PMCID: PMC7476144

45. Yingjie Zhang; Peilin Zhuang; Bo Jia; Jing Xu; Qiuju Cui; Lihuan Nie;  Zhiping Wang;  Zhaoqiang Zhang (co-corresponding author). Persistent trismus following mandibular third molar extraction and its management: A case report and literature review. World Academy of Sciences Journal on November 09, 2020. doi.org/10.3892/WASJ.2020.73

46. Xin Lei, Qiong Liu, Shiyi Li, Zhaoqiang Zhang & Xiaoyu Yang (2021) Effects of fluid shear stress on expression of focal adhesion kinase in MG-63 human osteoblastlike cells on different surface modification of titanium, Bioengineered, 12:1, 4962-4971, DOI: 10.1080/21655979.2021.1962686

47. Zheng Q, Zheng T, Zhang A, Yan B, Li B, Zhang Z, Zhang Y. Hearing Loss in Id1−/−; Id3+/− and Id1+/−; Id3−/− Mice Is Associated With a High Incidence of Middle Ear Infection (Otitis Media). Frontiers in Genetics. 2021:1377.

48. Heng Luo, Xuefei Xu, HaiGao, Jibiao Zhang, Zhaoqiang Zhang (co-corresponding author). Relationship of Anxiety and Depression with Perfectionism in Patients with Aesthetic All-Ceramic Repair of Anterior Teeth Med Sci Monit, 2021; 27: e931593 DOI: 10.12659/MSM.931593

49. Xiaoqin Yang, Manyi Wang, Wenfeng Gao, Di Wan, Junfa Zheng, Zhaoqiang Zhang (co-corresponding author). Chondroblastoma of mandibular condyle: Case report and literature review. Open Medicine, vol. 16, no. 1, 2021, pp. 1372-1377. https://doi.org/10.1515/med-2021-0352

50. Lei Chen, Zhiyong Li, Yongtai Zheng, Fei Zhou, Jingling Zhao, Qiyi Zhai, Zhaoqiang Zhang, Tianrun Liu, Yongming Chen, Shaohai Qi. 3D-printed dermis-specific extracellular matrix mitigates scar contraction via inducing early angiogenesis and macrophage M2 polarization. Bioactive Materials. https://doi.org/10.1016/j.bioactmat.2021.09.008.

51. Qiyue Chen, Yong Shi, Zhaoqiang Zhang, Guangbao Song. A Single-Center Study of a Resin Inlay Dental Implant-Fixed Prosthesis for Closing Proximal Contact Loss in 89 Patients Who Underwent 3-Year Follow-Up. Med Sci Monit 2021; 27:e933809. DOI: 10.12659/MSM.933809

52. Lin J, Huang J, Zhang Z (Co-first author), Yu X, Cai X, Liu C. Periodontal ligament cells under mechanical force regulate local immune homeostasis by modulating Th17/Treg cell differentiation. Clin Oral Investig. 2022 Jan 14. doi: 10.1007/s00784-021-04346-0. Epub ahead of print. PMID: 35029749.

53. Yu X-Y, Zhang Z-Q (Co-first author), Huang J-C, Lin J-Y, Cai X-P and Liu C-F (2022) IL-7-Treated Periodontal Ligament Cells Regulate Local Immune Homeostasis by Modulating Treg/Th17 Cell Polarization. Front. Med. 9:754341. doi: 10.3389/fmed.2022.754341

54. Zheng, Xianghuai; Lin, Xi; Zhang, Zhaoqiang (co-corresponding author). Technical Strategies for Custom-Made Surgical Guide in Removal of Impacted Supernumerary Mandibular Premolars, Journal of Craniofacial Surgery: March 10, 2022 - Volume - Issue -doi: 10.1097/SCS.0000000000008634

55. Jingjing Pan, Shuqin Wang, Zhaoqiang Zhang (co-corresponding author), Lijun Zhu. Dermatofibrosarcoma protuberans of face: A case report and literature review, Asian Journal of Surgery, https://doi.org/10.1016/j.asjsur.2022.05.169

56. Xiong, Y., Xu, Y., Zhou, F., Hu, Y., Zhao, J., Liu, Z., Zhai, Q., Qi, S., Zhang, Z (co-corresponding author). and Chen, L. (2022), Bio-functional hydrogel with antibacterial and anti-inflammatory dual properties to combat with burn wound infection. Bioeng Transl Med. Accepted Author Manuscript e10373. https://doi.org/10.1002/btm2.10373

57. Zhang, Jie; Li, Dichen; Liu, Yingjie ME; Zhang, Zhaoqiang ; Fan, Yunjian; Shi, Jiayu; Liu, Shuguang. Application of Patient-Specific PEEK Implant for Aesthetic Considerations in Paranasal Augmentation. The Journal of Craniofacial Surgery: August 15, 2022 - Volume - Issue - 10.1097/SCS.0000000000008824 doi: 10.1097/SCS.0000000000008824

58. Wang, Shuqin; Li, Xiaoxing; Li, Jun; Huang, Lidan; Peng, Yixin ; Chen, Qiyue; Zhang, Zhaoqiang; Zhu, Lijun. OK-432 Sclerotherapy of Giant Cervicomediastinal Cystic Hygroma. The Journal of Craniofacial Surgery: September 6, 2022 - Volume - Issue - 10.1097/SCS.0000000000008692. doi: 10.1097/SCS.0000000000008692

59.   Zehong Guo, Liqing Yang, Yujie Kang, Zhiping Wang, Fei Ren, Xuan Sun, Hong Yang, Zhaoqiang Zhang (co-corresponding author). Clinical evaluations of alveolar ridge preservation in compromised extraction sockets with cortical-lamina anchoring technique: Case series study. Clin Implant Dent Relat Res. 2022; 1- 11. doi:10.1111/cid.13141

60.   Liang, H., Du, Y., Zhu, C., Zhang, Z., Liao, G., Liu, L., & Chen, Y. (2023). Nanoparticulate Cationic Poly (amino acid) s Block Cancer Metastases by Destructing Neutrophil Extracellular Traps. ACS nano.

61.   Kang, Yujie ; Zheng, Xianghuai; Zhang, Danya; Li, Shaobing; Xu, Shulan; Chen, Lei; Zhang, Zhaoqiang (co-corresponding author); Lin, Xi. One-Abutment at One-Time in Posterior Edentulism: A Systematic Review and Meta-Analysis. The Journal of Craniofacial Surgery 34(8):p e720-e724, November/December 2023. | DOI: 10.1097/SCS.0000000000009428.

62.   Long, Jiazhen; Zhang, Jie; Kang, Jianfeng; Fan, Yunjian; Zhang, Zhaoqiang; Shi, Jiayu; Zhang, Zhen; Huang, Yuanjin; Liu, Shuguang. Customed 3D-printed Polyetheretherketone (PEEK) Implant for Secondary Salvage Reconstruction of Mandibular Defects: Case Report and Literature Review. The Journal of Craniofacial Surgery 34(8):p 2460-2463, November/December 2023. | DOI: 10.1097/SCS.0000000000009420.

63.   Wang T, Wang Z, Zhang Z, Zheng X, Du Y, Guo J. A modified triangular flap suture method used for inferior third molar extraction: A three-arm randomized clinical trial for the assessment of quality of life. Med Oral Patol Oral Cir Bucal. 2023 Jun 18:25859. doi: 10.4317/medoral.25859. Epub ahead of print. PMID: 37330952.

64.   Liu, Xinpeng, Xinping Li, Menglan Xie, Jinyuan Guo, Xianghuai Zheng, Shanwei Shi, Qiuju Cui, Danya Zhang, Zhaoqiang Zhang (co-corresponding author), and Zhiping Wang. "Association of Gut Microbiome and Oral Cavity Cancer: A Two Sample Mendelian Randomization and Case-control Study." Journal of Stomatology, Oral and Maxillofacial Surgery (2023): 101736.

65.   Liu, Shuchang, Zhaoyu Lin, Yujie Kang, Shuguang Liu, Rui Bao, Menglan Xie, Zhiping Wang, Jinsong Li, and Zhaoqiang Zhang (co-corresponding author). "Fibular Free Flap Necrosis after Mandibular Reconstruction Surgery with Osteoradionecrosis: Establishment and Verification of an Early Warning Model." Journal of Stomatology, Oral and Maxillofacial Surgery (2023): 101730.

66.   Kang Y, Xiong Y, Lu B, Wang Y, Zhang D, Feng J, Chen L, Zhang Z (co-corresponding author). Application of In Situ Mucoadhesive Hydrogel with Anti-Inflammatory and Pro-Repairing Dual Properties for the Treatment of Chemotherapy-Induced Oral Mucositis. ACS Applied Materials & Interfaces. 2024 Jul 6.

67.   Shuying Chen, Yahui Xiong, Fan Yang, Yanke Hu, Jinghao Feng, Fei Zhou, Zhonghua Liu, Hengdeng Liu, Xiaogang Liu, Jingling Zhao, Zhaoqiang Zhang (co-corresponding author), Lei Chen. Approaches to scarless burn wound healing: application of 3D printed skin substitutes with dual properties of anti-infection and balancing wound hydration levels. eBioMedicine, Volume 106, August 2024, 105258