主持项目：
南方医科大学南方医院院级项目：2026-07-08~2028-12-31,8万，在研，主持
广东省自然科学基金面上项目：2024-01-01~2027-12-31，15万，在研，主持
白云分院院长基金面上项目：2024-01-01~2025-12-31，5万，已结题，主持
2021年度广东省基础与应用基础研究基金自然科学基金面上项目：2021-01-01~2023-12-01， 10万，已结题，主持
2018年度院长基金：2019-01-01~2021-12-31，5万，已结题，主持
已发表期刊文章：
1）L C Wang; G F Zeng; C X Liao; H Zhang; I Hrynevych; X L Zeng; M Q Zhou; Y Feng; Z H Tian. Association between occlusal relationships during sleep bruxism and orofacial system diseases: a cross-sectional study of a self-established cohort in young and middle-aged adults. J Stomatol Oral Maxillofac Surg 127(2026)102908. 2026 Jul 21;127(5):102908.doi:10.1016/j.jormas. 2026.102908（JCR Q2, 通讯作者）
2）Chenxi Liao; Weiheng Lv; Jun Huang; Mariama Diallo; Zhihui Tian. Fibrinogen in extracellular matrix remodeling: functional switching, source heterogeneity, and biomaterial translation. Frontiers In Cell And Developmental Biology. 2026 Jun 17:14:1874458. doi: 10.3389/fcell.2026.1874458(JCR Q1, 通讯作者）
3）Tianyi Yang; Zhihui Tian; ChengKai Sun. Gene bridge metabolite–disease association prediction based on GCN-DeepSeekMoE contrastive learning and its applications in oral diseases. Analytical Biochemistry. 2026 Jun 17:14:1874458. doi: 10.3389/fcell.2026. 1874458(JCR Q3, 通讯作者、第二作者）
4）Chao Rong ； Jiayi Zhang ； Shaowei Li ； Jiangdie He ； Zhihui Tian. Focus on odontoblast polarization: Characteristics, regulatory factors and research platforms. International Endodontic Journal. 2025 Jul;58(7):930-951.DOI: 10.1111/iej.14238(JCR Q1, 通讯作者）
5）Jiayi Zhang；Jingyi Gao； Xiangliang Zeng； Zijie Wang； Chuying Chen； Chao Rong； Shaowei Li； Lingxuan Cai； Luchen Wang； Lin Zhang；Zhihui Tian. A novel Cdc42-YAP-fibronectin signaling axis regulates ameloblast differentiation during early enamel formation. 2025 Feb;1871(2):167570. doi:10.1016/j.bbadis.2024.167570(JCR Q1, 通讯作者）
6）Wang, Z.; Chen, C.; Zhang, J.; He, J.; Zhang, L.; Wu, J.; Tian, Z. Epithelium-derived SCUBE3 promotes polarized odontoblastic differentiation of dental mesenchymal stem cells and pulp regeneration. Stem Cell Res. Ther. 2023, 14, 130, doi:10.1186/s13287-023-03353-0. (JCR Q1, 通讯作者)
7）Gao, J.; Cai, S.; Wang, Z.; Li, D.; Ou, M.; Zhang, X.; Tian, Z. The optimization of ligature/bone defect-induced periodontitis model in rats. Odontology 2022, 110, 697-709, doi:10.1007/s10266-022-00715-7. (JCR Q2, 通讯作者)
8）Zhou, T.; Rong, M.; Wang, Z.; Chu, H.; Chen, C.; Zhang, J.; Tian, Z. Conditioned medium derived from 3D tooth germs: A novel cocktail for stem cell priming and early in vivo pulp regeneration. Cell Prolif. 2021, 54, e13129, doi:10.1111/cpr.13129. (JCR Q1, 通讯作者)
9）Rongrong, W.; Ru, L.; Sixiao, H.; Ziqing, W.; Junhao, H.; Liying, Z.; Zhihui, T.; Qiang, M. Multiphoton Microscopic Observation of Vessels in Mouse Liver Tissue. J. Vis. Exp. 2021, doi:10.3791/60932. (JCR Q3, 共同通讯作者)
10）Zhang, C.; Gao, J.; He, J.; Liu, C.; Lv, X.; Yin, X.; Deng, Y.; Lu, Z.; Tian, Z. Regulatory T-cell expansion in oral and maxillofacial Langerhans cell histiocytosis. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. 2020, 130, 547-556, doi:10.1016/ j. oooo.2020.08.005. (JCR Q2, 通讯作者)
11）Tian, Z.; Lv, X.; Zhang, M.; Wang, X.; Chen, Y.; Tang, P.; Xu, P.; Zhang, L.; Wu, B.; Zhang, L. Deletion of epithelial cell-specific Cdc42 leads to enamel hypermaturation in a conditional knockout mouse model. Biochim. Biophys. Acta-Mol. Basis Dis. 2018, 1864, 2623-2632, doi:10.1016/ j. bbadis.2018.04.015. (JCR Q1, 第一作者)
12）Zheng, J.; Nie, X.; He, L.; Yoon, A.J.; Wu, L.; Zhang, X.; Vats, M.; Schiff, M.D.; Xiang, L.; Tian, Z. et al. Epithelial Cdc42 Deletion Induced Enamel Organ Defects and Cystogenesis. J. Dent. Res. 2018, 97, 1346-1354, doi:10.1177/0022034518779546
13）Chen, X.; Zhang, M.; Chen, S.; Wang, X.; Tian, Z.; Chen, Y.; Xu, P.; Zhang, L.; Zhang, L.; Zhang, L. Peptide-Modified Chitosan Hydrogels Accelerate Skin Wound Healing by Promoting Fibroblast Proliferation, Migration, and Secretion. Cell Transplant. 2017, 26, 1331-1340, doi:10.1177/0963689717721216.
14）Wang, X.; Tang, P.; Guo, F.; Zhang, M.; Chen, Y.; Yan, Y.; Tian, Z.; Xu, P.; Zhang, L.; Zhang, L. et al. RhoA regulates Activin B-induced stress fiber formation and migration of bone marrow-derived mesenchymal stromal cell through distinct signaling. Biochim. Biophys. Acta-Gen. Subj. 2017, 1861, 3011-3018, doi:10.1016/ j. bbagen.2016.09.027.
15）Xiong, F.; Ji, Z.; Liu, Y.; Zhang, Y.; Hu, L.; Yang, Q.; Qiu, Q.; Zhao, L.; Chen, D.; Tian, Z. et al. Mutation in SSUH2 Causes Autosomal-Dominant Dentin Dysplasia Type I. Hum. Mutat. 2017, 38, 95-104, doi:10.1002/humu.23130
16）Yang, Q.; Chen, D.; Xiong, F.; Chen, D.; Liu, C.; Liu, Y.; Yu, Q.; Xiong, J.; Liu, J.; Li, K. et al. A splicing mutation in VPS4B causes dentin dysplasia I. J. Med. Genet. 2016, 53, 624-633, doi:10.1136/jmedgenet-2015-103619.
17）Chen, S.; Shi, J.; Zhang, M.; Chen, Y.; Wang, X.; Zhang, L.; Tian, Z.; Yan, Y.; Li, Q.; Zhong, W. et al. Mesenchymal stem cell-laden anti-inflammatory hydrogel enhances diabetic wound healing. Sci. Rep. 2015, 5, 18104, doi:10.1038/srep18104.
18）Wang, L.; Wu, B.; Zhang, Y.; Tian, Z. Hypoxia promotes the proliferation of MC3T3-E1 cells via the hypoxia-inducible factor-1alpha signaling pathway. Mol. Med. Rep. 2015, 12, 5267-5273, doi:10.3892/mmr.2015.4034.
19）Zou, Y.; Li, C.; Shu, F.; Tian, Z.; Xu, W.; Xu, H.; Tian, H.; Shi, R.; Mao, X. lncRNA expression signatures in periodontitis revealed by microarray: the potential role of lncRNAs in periodontitis pathogenesis. J. Cell. Biochem. 2015, 116, 640-647, doi:10.1002/jcb.25015.
20）Ran, W.; Tian, Z.H.; Guo, B.; Shu, D.L.; Nan, K.H.; Wang, Y.J. Superior biocompatibility and osteogenic efficacy of micro-arc oxidation-treated titanium implants in the canine mandible. Biomed. Mater. 2009, 4, 55003, doi:10.1088/1748-6041/4/5/055003.
21）刘翠娴; 田智慧; 阳奇; 马倩倩; 徐湘民; 熊符 一个掌跖角化牙周破坏综合征家系CTSC基因的突变鉴定. 中华医学遗传学杂志 2016, 33, 5.
22）田智慧; 张宇; 王立超; 南开辉 微弧氧化处理纯钛种植体表面在模拟体液中可诱导磷灰石沉积. 南方医科大学学报 2013, 33, 3.
23）田智慧; 陈敏; 房付春; 吴补领; 高杰 Bio-Oss联合Bio-Gide治疗牙周炎垂直型骨吸收的临床疗效观察. 北京口腔医学 2012, 20, 4.
24）田智慧; 冉炜; 郭冰; 舒大龙; 南开辉; 王迎军 微弧氧化处理纯钛种植体的表面性状分析. 中山大学学报：医学科学版 2008, 29, 4.
专利：
田智慧, 邵龙泉。发明专利: FGG在牙齿再生领域的应用及其试剂盒. 授权日: 2020-09-29. 专利号:ZL 2019 1 1010849.6