目录
更新日期:2024年10月24日
姓 名 郭霞 性 别
民 族 汉族 导师层次 博士导师
技术职称 研究员 导师类型 学术型
最后学历 博士研究生毕业 最后学位 医学博士学位
行政职务 主任 Email guoxia0504_sz@163.com
工作单位 南方医科大学深圳医院 邮政编码 518000
个人简介
南方医科大学肿瘤学 研究员、博士生导师、博士后合作导师
 
深圳市高层次人才、宝安区人才
 
现任南方医科大学深圳医院科技创新部部长
 
深圳市病毒肿瘤学重点实验室副主任
 
教育部学位中心“学位与研究生教育评估专家库”专家
国家自然科学基金  函评专家
深圳市国家高技术产业创新中心产业集群 专家顾问
中国研究型医院病毒肿瘤学专委会副主委
深圳市医院管理者协会科技与转化专委会副主委
广东省医院协会医院科教与成果转化管理专业委员会常委
 
一直致力于病毒相关性肿瘤发病机制与预警方面的研究,承担了此领域相关多项课题,包括国家自然科学3项,省自然科学基金2项,深圳市科创委科技计划-创新载体组建项目子课题1项、面上项目2项,深圳SMART重点项目1项(285万),以第一或者通讯作者(共同)在Advanced Science(2023, IF:15.1)、Trends in Pharmacological Sciences(2024,IF:13.9)、Cancer Letter(2024,IF:9.7)、J Exp Clin Cancer Res(2022,IF:12.5)、Int J Biol Sci(2024,IF:9.2)、PLOS Pathogens(2018,IF:6.7)、J Med Chem(2024,IF: 7.3)、INT J BIOL MACROMOL(2024, IF: 7.7)、等发表了文章30余篇,获得发明专利3项,宫颈癌领域省科技进步三等奖1项。
 
研究领域

1. 病毒(HPV、EBV)相关性肿瘤(宫颈癌、鼻咽癌)发病机制与预警研究;

2. 肿瘤免疫-代谢微环境研究;

3. 肿瘤表观遗传学机制研究(RNA甲基化与乙酰化修饰、超级增强子)。

 

个人成果
 

1.  Zhijie Wang, Xiaotong Liao, Haiqi He, Xia Guo*, Jianjun Chen* Targeting the STAT3 pathway with STAT3 Degraders. Trends in Pharmacological Sciences, Trends Pharmacol Sci. 2024 Sep;45(9):811-823. doi: 10.1016/j.tips.2024.07.003.(IF:13.9,中科院TOP小类1区 )

2. Xiaona Chen#, Yi Hao#, Yong Liu#, Sheng Zhong, Yuehua You, Keyi Ao, Tuotuo Chong, Xiaomin Luo, Minuo Yin, Ming Ye, Hui He, Anwei Lu, Jianjun Chen, Xin Li *, Jian Zhang*, Xia Guo*. NAT10/ac4C/FOXP1 promotes malignant progression and facilitates immunosuppression by reprogramming glycolytic metabolism in cervical cancer. Advanced Science, 2023 Nov;10(32):e2302705. (IF:15.1004,中科院TOP小类1区 )

3. Manli Peng #, Yanqing Zhou# , Yuanbin Zhang #, Ying Cong , Min Zhao , Fei Wang , Tengteng Ding , Changlin Liu , Chuping Ni , Junjie Ding , Wenwen Sun , Xiaoming Lyu , Chao Fan , Dengke Li , Xia Guo* , Xiong Liu* , Xin Li* Small extracellular vesicle CA1 as a promising diagnostic biomarker for nasopharyngeal carcinoma. Int J Biol Macromol. 2024 Jun 23;275(Pt 1):133403. (IF:7.7,中科院小类1区 )

4. Wang Z, Yuan L, Liao X, Xia Guo*, Chen*, Reducing PD-L1 Expression by Degraders and Downregulators as a Novel Strategy to Target the PD-1/PD-L1 Pathway. J Med Chem. 2024 Apr 25;67(8):6027-6043. (IF:7.3,中科院小类1区药化顶刊)

5. Keyi Ao#, Minuo Yin#, Xiaoming Lyu#, Yue Xiao3, Xiaona Chen, Sheng Zhong, Xiuli Wen, Jianli Yuan, Ming Ye, Jiaming Zhang*, Xin Li* , Yi Hao*, Xia Guo* . METTL3-mediated HSPA9 m6A modification promotes malignant transformation and inhibits cellular senescence by regulating exosomal mortalin protein in cervical cancer. Cancer Letters, 2024 Jan 20:216658. doi: 10.1016/j.canlet.2024.216658.(IF:9.7,中科院1区)

6.  Sheng Zhong#, Quanwei Guo#, Xiaona Chen#, Xiaomin Luo#, Yufei Long, Tuotuo Chong, Ming Ye , Hui He, Anwei Lu, Keyi Ao, Minuo Yin, Aimin Xu,Xin Li *, Yi Hao*, Xia Guo* The inhibition of YTHDF3/m6A/LRP6 reprograms fatty acid metabolism and suppresses lymph node metastasis in cervical cancer. Int J Biol Sci 2024; 20(3):916-936. doi:10.7150/ijbs.87203(IF:9.2,中科院小类2区)

7. Yufei Long # , Tuotuo Chong # , Xiaoming Lyu #, Lujia Chen # , Xiaomin Luo #, Oluwasijibomi Damola Faleti, Simin Deng, Fei Wang, Mingliang He, Zhipeng Qian, Hongli Zhao, Wenyan Zhou, Xia Guo*, Ceshi Chen*, Xin Li*. FOXD1-dependent RalA-ANXA2-Src complex promotes CTC formation in breast cancer. J Exp Clin Cancer Res. 2022 Oct 13;41(1):301. (IF:12.6575,中科院小类1区)

8. Lyu X#, Wang J#, Guo X#, Wu G, Jiao Y, Faleti OD, Liu P, Liu T, Long Y, Chong T,Yang X, Huang J, He M, Tsang CM, Tsao SW, Wang Q, Jiang Q*, Li X*.EBV-miR-BART1-5P activates AMPK/mTOR/HIF1 pathway via a PTEN independent manner to promote glycolysis and angiogenesis in nasopharyngeal carcinoma.PLoS Pathog. 2018 Dec 17;14(12):e1007484.(IF:6.463,中科院小类1区)

9. Dongmei Lin , Hui Wang , Lu Liu , Liang Zhao , Jing Chen , Hongyan Tian , Lei Gao , Beibei Wu , Jing Zhang, Xia Guo*, Yi Hao*. IETA Ultrasonic Features Combined with GI-RADS Classification System and Tumor Biomarkers for Surveillance of Endometrial Carcinoma: An Innovative Study. Cancers (Basel). 2022 Nov 16;14(22):5631. doi: 10.3390/cancers14225631.(IF:6.5749,中科院小类2区)

10. Xiaona Chen#, Hui He#, Yue Xiao, Ayshamgul Hasim , Jianlin Yuan , Min Ye , Xin Li* , Yi Hao* , Xia Guo*. CXCL10 Produced by HPV-Positive Cervical Cancer Cells Stimulates Exosomal PDL1 Expression by Fibroblasts via CXCR3 and JAK-STAT Pathways. Front Oncol. 2021 Aug 6;11:629350.  (IF:6.24,中科院2区)

11. Dongmei Lin, Liang Zhao , Yunxiao Zhu, Yujun Huang, Kun Yuan , Wenfen Liu, Shengli Li*, Xia Guo*, Yi Hao* Combination IETA Ultrasonographic Characteristics Simple Scoring Method With Tumor Biomarkers Effectively Improves the Differentiation Ability of Benign and Malignant Lesions in Endometrium and Uterine Cavity. Front Oncol. 2021 Aug 30;11:605847. (IF:6.24,中科院2区)

12. Yi Hao#, Ming Ye#, Xiaona Chen, Hongli Zhao, Ayshamgul Hasim*, Xia Guo*  Discovery and validation of FBLN1 and ANT3 as potential biomarkers for early detection of cervical cancer. Cancer Cell Int, 2021, 21, 125. (IF: 4.175,中科院2区)

13. Yi Hao#, Wei Yang#, WenYi Zheng#, XiaoNa Chen, Hui Wang,Liang Zhao1,JinFeng Xu*,Xia Guo*.Tumor elastography and its association with cell-free tumor DNA in the plasma of breast tumor patients: a pilot study. Quantitative Imaging in Medicine and Surgery.Feb 12, 2021.  (IF:3.837, 中科院小类2区)

14. Hao Y, Xiao Y, Zhang Z, Zhao H, Zhou W, Guo X*, Lu A*, Li X*.Transition of the abnormal Savda syndrome to the hepatic carcinoma shifted unfolded protein response to autophagy was partly reversed by Savda Munziq in a rat model. Biomed Pharmacother. 2020 Jan;121:109643.(IF: 7.545, 中科院小类1区)

15. Yi Hao#, Guanghui Ren#, Wei Yang#, WenYi Zheng, YuMing Wu, Xin Li*, YingJia Li*, Xia Guo*. Combination diagnosis with elastography strain ratio and molecular markers effectively improves the diagnosis rate of small breast cancer and lymph node metastasis. Quant Imaging Med Surg. 2020 Mar;10(3):678-691 (IF:3.837, 中科院小类2区)