学术及社会任职

科研成果

课题

2.国家自然科学基金委员会, 面上项目, 82172012, 抑郁症奖赏系统多巴胺能神经元投射异常的多模态MRI表征及机制研究, 2022-01-01 至 2025-12-31, 55万元, 在研, 主持

3.广东省基础与应用基础研究基金委员会, 广东省自然科学基金-面上项目, 2020A1515010469, 利用多模态MRI探讨mTOR营养感受通路介导抑郁症能量代谢障碍的机制, 2019-10 至 2022-09, 10万元, 结题, 主持。

4.广州市科技计划项目，201607010357，多模态脑连接分析方法在APOE-4影像-基因研究中的应用与验证，2017/01-2019/12，20万元，结题，主持。

近5年代表论文

1. Xu Z, Gao Y, Zhang L, Gao Y, Liao Y, Liang Y, Yuan Z, Li Y, Zhao B, Wen G. Multifunctional nanoagent for enhanced cancer radioimmunotherapy via pyroptosis and cGAS-STING activation. J Nanobiotechnology. 2025 Jul 21;23(1):527.

2. Cheng D, Wen J, Ding N, Duan Z, Lin B, Yang Y, Wu Y, Wang H, Ma J, Zhang J, Xu Z, Zhao H, Liu Y, Wen G. Synthetic MRI study of brain volume and subcortical myelin in various Parkinson's disease motor subtypes. NPJ Parkinsons Dis. 2025 Aug 23;11(1):255. 

3. Wu Z, Gong L, Luo J, Chen X, Yang F, Wen J, Hao Y, Wang Z, Gu R, Zhang Y, Liao H, Wen G. An interpretable CT-based machine learning model for predicting recurrence risk in stage II colorectal cancer. Insights Imaging. 2025 Jul 31;16(1):162. 

4.Gao L, Chen Z, Wu Z, Wen J, Li Z, Guo Y, Luo J, Gong L, Chen Z, Wang L, Jing L, Yin H, Wen G. The gray matter microstructure and psychological resilience in patients with depression: A preliminary study using DSI/NODDI imaging. J Psychiatr Res. 2025 Sep;189:335-342. 

5.Xu Z, Zhong S, Gao Y, Huo J, Xu W, Huang W, Huang X, Zhang C, Zhou J, Dan Q, Li L, Jiang Z, Lang T, Xu S, Lu J, Wen G, Zhang Y, Li Y. Optimizing breast lesions diagnosis and decision-making with a deep learning fusion model integrating ultrasound and mammography: a dual-center retrospective study. Breast Cancer Res. 2025 May 14;27(1):80.

6.Cheng D, Wen J, Liu Y, Ding N, Duan Z, Yang Y, Wu Y, Wang H, Ma J, Zhang J, Xu Z, Zhao H, Wen G. Explainable classification of Parkinson's disease with different motor subtypes by analyzing the synthetic MRI quantitative parameters of subcortical nuclei. Eur J Radiol. 2025 Sep;190:112272.

7.Xu, Z., Lin, Y., Huo, J., Gao, Y., Lu, J., Liang, Y., Li, L., Jiang, Z., Du, L., Lang, T., Wen, G., & Li, Y. (2024). A bimodal nomogram as an adjunct tool to reduce unnecessary breast biopsy following discordant ultrasonic and mammographic BI-RADS assessment.European radiology, 34(4), 2608–2618. 

8. Cui W, Chen C, Gong L, Wen J, Yang S, Zheng M, Gao B, You J, Lin X, Hao Y, Chen Z, Wu Z, Gao L, Tang J, Yuan Z, Sun X, Jing L, Wen G. PGAM5 knockout causes depressive-like behaviors in mice via ATP deficiency in the prefrontal cortex. CNS Neurosci Ther. 2024 Feb;30(2):e14377.

9.Han S, Zheng Q, Zheng Z, Su J, Liu X, Shi C, Li B, Zhang X, Zhang M, Yu Q, Hou Z, Li T, Zhang B, Lin Y, Wen G, Deng Y, Liu K, Xu K. Exosomal miR-1202 mediates Brodmann Area 44 functional connectivity changes in medication-free patients with major depressive disorder: An fMRI study. J Affect Disord. 2024 Jul 1;356:470-476.

10. Deng Y, Gong P, Han S, Zhang J, Zhang S, Zhang B, Lin Y, Xu K, Wen G, Liu K. Reduced cerebral cortex thickness is related to overexpression of exosomal miR-146a-5p in medication-free patients with major depressive disorder. Psychol Med. 2023 Oct;53(13):6253-6260.

11.Zhang L, Jiang Y, Jin Z, Jiang W, Zhang B, Wang C, Wu L, Chen L, Chen Q, Liu S, You J, Mo X, Liu J, Xiong Z, Huang T, Yang L, Wan X, Wen G, Han XG, Fan W, Zhang S. Real-time automatic prediction of treatment response to transcatheter arterial chemoembolization in patients with hepatocellular carcinoma using deep learning based on digital subtraction angiography videos. Cancer Imaging. 2022 May 12;22(1):23.

12.Yan W, Xie L, Bi Y, Zeng T, Zhao D, Lai Y, Gao T, Sun X, Shi Y, Dong Z, Wen G, Gao L, Lv Z. Combined rs-fMRI study on brain functional imaging and mechanism of RAGE-DAMPs of depression: Evidence from MDD patients to chronic stress-induced depression models in cynomolgus monkeys and mice. Clin Transl Med. 2021 Oct;11(10):e541.