目录
更新日期:2025年12月31日
姓 名 张月 性 别
民 族 汉族 导师层次 博士导师
技术职称 研究员 导师类型 学术型
最后学历 博士研究生毕业 最后学位 理学博士学位
行政职务 Email yugi@smu.edu.cn
工作单位 基础医学院 邮政编码 510515
个人简介

Dr. Zhang’s research interests are making efforts to decipher the nature of osteoclast in shaping functions of skeletal or other organ systems in physiology, aging, regeneration and disease.

 

研究领域

cell biology, cell signal, bone remodeling imbalances, bone and systemic disease 

个人成果

【代表性论文】

1. Osteoclasts control endochondral ossification via regulating acetyl-CoA availability. Bone Research. 2024 Aug 28;12(1):49. (Daizhao Deng #, Xianming Liu#, Wenlan Huang#, Sirui Yuan, Genming Liu, Shanshan Ai, Yijie Fu, Haokun Xu, Xinyi Zhang, Shihai Li, Song Xu*, Xiaochun Bai*, Yue Zhang*.)

2. Rictor is a novel regulator of TRAF6/TRAF3 in osteoclasts. J Bone Miner Res. 2021 Jun 22. ( Xu Song#, Li Shihai#, Liu Xianming, Tan Kang, Zhang Jiahuan, Li Kai, Bai Xiaochun*, Zhang Yue*.)

3. TREM2 acts as a receptor for IL-34 to suppress acute myeloid leukemia in mice. Blood. 2023 Mar 31. (Xie X, Zhang W, Xiao M, Wei T, Qiu Y, Qiu J, Wang H, Qiu Z, Zhang S, Pan Y, Mao L, Li Y, Guo B, Yang W, Hu Y, Hu S, Gong Y, Yang J, Xiao G*, Zhang Y*, Bai X*. )

4.  mTORC1 inhibits NF-κB/NFATc1 signaling and prevents osteoclast precursor differentiation, in vitro and in mice. Z J Bone Miner Res. 2017 Sep;32(9):1829-1840. (Zhang Y#, Xu S#, Li K, Tan K, Liang K, Wang J, Shen J, Zou W, Hu L, Cai D, Ding C, Li M, Xiao G, Liu B, Liu A, Bai X*.)

5. TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42. Cell Death Differ. 2018 Sep;25(9):1549-1566 (Xu S#, Zhang Y#, Wang J#, Li K, Tan K, Liang K, Shen J, Cai D, Jin D, Li M, Xiao G, Xu J, Jiang Y, Bai X*. )

6.  LysM-positive neurons drive Tuberous Sclerosis Complex (TSC)-associated brain lesions. Cellular Signalling. 2022 Sep 14;110468. (Zhang JH#, Xu S#, Liang KY, Cao X, Ye ZX, Huang WL, Bai XC*, Zhang Y*. )

7. Neuronal mTORC1 Is Required for Maintaining the Nonreactive State of Astrocytes. J Biol Chem. 2017 Jan 6;292(1):100-111. (Zhang Y#, Xu S#, Liang KY#, Li K, Zou ZP, Yang CL, Tan K, Cao X, Jiang Y, Gao TM, Bai XC*. )

8.Activation of mTORC1 in B lymphocytes promotes osteoclast formation via regulation of beta-catenin and RANKL/OPG. J Bone Miner Res. 2016 Jul;31(7):1320-33. ( Xu S#, Zhang Y#, Liu B#, Li K, Huang B, Yan B, Zhang Z, Liang K, Jia C, Lin J, Zeng C, Cai D, Jin D, Jiang Y, Bai X*. )

9. Tyrosine kinase Fyn promotes osteoarthritis by activating the β-catenin pathway. Ann Rheum Dis. 2018 Jun;77(6):935-943. (Kai Li, Yue Zhang, Yuwei Zhang, Wenqing Jiang, Junhui Shen, Song Xu, Daozhang Cai, Jie Shen, Bin Huang, Mangmang Li, Qiancheng Song, Yu Jiang, Anling Liu, Xiaochun Bai. )