教授，博士生导师，主要从事生物医用纳米药物的设计制备及其体内纳米生物效应的研究，所涉及的研究工作涵盖材料化学、纳米医药、纳米生物学等多学科的融合交叉，以新型智能医用纳米药物体系的开发创制为出发点，深入研究纳米药物在生物体内的纳米生物效应，优化提升纳米药物在体内应用中的生物学性能。研究成果以第一作者/通讯作者发表于药学、化学、材料等国际著名期刊(Nature Communications、Journal of the American Chemical Society、Angewandte Chemie International Edition、Accounts of Chemical Research、Journal of Controlled Release、Biomaterials、Advanced Functional Materials)。所开发的纳米材料已获授权国家发明专利五项。主持国家自然科学基金项目三项，省部级基金项目两项，南方医科大学高层次人才引进项目一项。承担研究生基础课程《生物材料导论》和本科生基础课程《生物材料基础》的教学工作，指导培养多名硕博研究生。

主要研究方向：

主要从事生物医用纳米药物的设计制备及其体内纳米生物效应的研究，所涉及的研究工作涵盖材料化学、纳米医药、纳米生物学等多学科的融合交叉，以新型智能医用纳米药物体系的开发创制为出发点，深入研究纳米药物在生物体内的纳米生物效应，优化提升纳米药物在抗肿瘤临床应用中的生物学性能。

[1] K. W. Liu, Y. Q. Peng, M. H. Xu, K. Yuan, Y. C. Li, C. M. Lin, X. L. Zhao, J. Zhu, Y. Chang, Z. Z. Lin, S. Y. Pan, H. R. Ma*, X. R. Wang*, K. B. Huang*, "Brain-Targeted 9-Phenanthrol-Loaded Lipid Nanoparticle Prevents Brain Edema after Cerebral Ischemia-Reperfusion Injury by Inhibiting the Trpm4 Channel in Mice", Advanced Functional Materials, 2024, 2401173-2401191. (1区，IF = 18.500, 通讯作者)

[2] K. Yuan^#, K. R. Lai^#, G. F. Miao^#, J. B. Zhang, X. X. Zhao, G. Z. Tan, X. W. Wang*, and X. R. Wang*, "Cholinized-Polymer Functionalized Lipid-Based Drug Carrier Facilitate Liver Fibrosis Therapy Via Ultrafast Liver-Targeting Delivery", Biomacromolecules, 2024, DOI: 10.1021/acs.biomac.4c00691. (1区，IF = 5.5, 通讯作者)

[3] G. F. Miao¹, Y. J. He¹, K. R. Lai, Y. Zhao, P. Y. He, G. Z. Tan, X. R. Wang*, "Accelerated blood clearance of PEGylated nanoparticles induced by PEG-based pharmaceutical excipients", Journal of Controlled Release, 2023, 363, 12-26. (1区，IF = 10.800, 通讯作者)

[4] G. F. Miao,^† Y. J. He,^† Z. H. Shang, P. Y. He, M. H. Xu, X. X. Zhao, and X. R. Wang*, "Combined Effects of Core Rigidity and Surface Charge of Polymeric Nanomicelles on the Cellular Uptake Efficiency", Macromolecules, 2023, 56, 7663-7674. (1区，IF = 5.500, 通讯作者)

[5] Y. Wang, K. Yuan, Z. H. Shang, G. Z. Tan, Q. J. Zhong , Y. J. He, G. F. Miao, K. R. Lai, Y. L. Li, X. R. Wang*, "Construction of nanohydrogels for enhanced delivery of hydrophilic and hydrophobic drugs and improving chemotherapy efficacy", European Polymer Journal, 2023, 186, 111838-111846. (2区，IF = 5.546, 通讯作者)

[6] G. Z. Tan, Y. Wang, Y. J. He, G. F. Miao, Y. Li, X. R. Wang*, "Bioinspired poly(cation-π) micelles drug delivery platform for improving chemotherapy efficacy", Journal of Controlled Release, 2022, 349, 486-501. (1区，IF = 11.467, 通讯作者)

[7] X. R. Wang, J. M. Hu*, S. Y. Liu*, "Overcoming the Dilemma of Permeability and Stability of Polymersomes through Traceless Cross-Linking", Accounts of Chemical Research, 2022, 55, 3404-3416. (1区，IF = 24.466, 第一作者)

[8] X. P. Song, X. R. Wang, J. Zhang, S. Shen, W. M. Yin, G. L. Ye, L. Y. Wang, H. H. Hou, X. Z. Qiu*, "A tunable self-healing ionic hydrogel with microscopic homogeneous conductivity as a cardiac patch for myocardial infarction repair", Biomaterials, 2021, 273, 120811-120821. (1区，IF = 15.304, 共同一作)

[9] X. R. Wang, C. Z. Yao, G. Y. Zhang, and S. Y. Liu*, "Regulating Vesicle Bilayer Permeability and Selectivity via Stimuli-Triggered Polymersome-to-PICsome Transition", Nature Communications, 2020, 11, 1524-1536. (1区，IF = 17.694, 第一作者)

[10] X. R. Wang, J. M. Hu, G. H. Liu, J. Tian, H. J. Wang, M. Gong, and S. Y. Liu*, "Reversibly Switching Bilayer Permeability of Photochromic Polymersomes Synergistically Stabilized via Cooperative Noncovalent Interactions", Journal of the American Chemical Society, 2015, 137, 15262-15275. (1区，IF = 16.383, 第一作者)

[11] X. R. Wang, J. M. Hu, G. Y. Zhang, S. Y. Liu*, "Highly Selective Fluorogenic Multianalyte Biosensors Constructed via Enzyme-Catalyzed Coupling and Aggregation-Induced Emission", Journal of the American Chemical Society, 2014, 136, 9890-9893. (1区，IF 16.383, ESI Highly cited paper, 第一作者)

[12] X. R. Wang, G. H. Liu, J. M. Hu, G. Y. Zhang, S. Y. Liu*, "Concurrent Block Copolymer Polymersome Stabilization and Bilayer Permeabilization via Stimuli-Regulated 'Traceless' Crosslinking", Angewandte Chemie International Edition, 2014, 53, 3138-3142. Highlighted by Nature Chemistry; DOI: 10.1038/nchem.1915. Highlighted by Materials Views China. (1区，IF 16.823, ESI Highly cited paper, 第一作者)