南方医科大学教师信息

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1. 个人简介
2. 研究领域
3. 发表论文

更新日期：2025年2月14日

姓名	付霞霏	性别	女
民族	汉族	导师层次	博士导师
技术职称	主任医师	导师类型	学术&专业型
最后学历	博士研究生毕业	最后学位
行政职务	副主任	Email	fxf1997@163.com
工作单位	南方医科大学珠江医院	邮政编码	510282

个人简介

付霞霏，女，南方医科大学珠江医院妇产医学中心生殖科副主任，主任医师，医学博士，博士研究生导师。本人进行女性生殖内分泌疾病如早发性卵巢功能不全、多囊卵巢综合征、闭经及不孕症研究十余年，在早发性卵巢功能不全、干细胞及细胞外囊泡等方面有深入研究。近年来主持了国家自然科学基金、广东高校优秀青年创新人才培养计划项目育苗工程、广东省自然科学基金、广东省科技计划项目、广东省医学科研基金、广州市科技计划项目等多项科研课题，并参与国家及省市级科研基金多项。作为第一作者和通讯作者在《Stem Cell Res Ther》、《Reproductive Biomedicine online》、《Cell Biol Toxicol》、《J Immunol Res》等杂志发表国内外论著50余篇。

研究领域

在普通妇科、妇科肿瘤、女性生殖内分泌疾病、不孕症及计划生育等方面具有丰富的临床经验。尤其擅长女性生殖内分泌疾病如早发性卵巢功能不全、多囊卵巢综合征、闭经、围绝经期综合征等及不孕症的诊治，妇科微创手术包括腹腔镜、宫腔镜手术及阴式系列手术。

个人成果

[1]Tang L, Yang Y, Yang M, Xie J, Zhuo A, Wu Y, Mao M, Zheng Y, Fu X. miR-21-loaded bone marrow mesenchymal stem cell-derived exosomes inhibit pyroptosis by targeting MALT1 to repair chemotherapy-induced premature ovarian insufficiency. Cell Biol Toxicol. 2024 Dec 20;41(1):3. doi: 10.1007/s10565-024-09946-6.

[2]Yang Y, Tang L, Xiao Y, Huang W, Gao M, Xie J, Yang M, Wu Y, Fu X. miR-21-5p-loaded bone mesenchymal stem cell-derived exosomes repair ovarian function in autoimmune premature ovarian insufficiency by targeting MSX1. Reprod Biomed Online. 2024 Jan 9;48(6):103815. doi: 10.1016/j.rbmo. 2024 Jan 9;48(6):103815.

[3] Xie J, Yang Y, Zhuo A, Gao M, Tang L, Xiao Y, Zhu H, Fu X. Exosomes derived from mesenchymal stem cells attenuate NLRP3-related pyroptosis in autoimmune premature ovarian insufficiency via the NF-κB pathway. Reprod Biomed Online. 2024 Jan 9;48(6):103814. doi: 10.1016/j.rbmo. 2024 Jan 9;48(6)

[4] Ma W, Zhuo A, Xiao Y, Gao M, Yang Y, Tang L, Wu Y, Tian D, Fu X. Human Bone Marrow Derived-Mesenchymal Stem Cells Treatment for Autoimmune Premature Ovarian Insufficiency. Stem Cell Rev Rep. 2024 Feb;20(2):538-553.

[5] Wang Y, Zhuo A, Yang Y, Wang Q, Xie J, Ma W, Chen Y, Gao M, Tang L, Fu X. Regulatory T Cells Overexpressing Peli1 Show Better Efficacy in Repairing Ovarian Endocrine Function in Autoimmune Premature Ovarian Insufficiency. Lab Invest. 2023. 103(2):100005.

[6] Li X, Xie J, Wang Q, Cai H, Xie C, Fu X. miR-21 and Pellino-1 Expression Profiling in Autoimmune Premature Ovarian Insufficiency, J Immunol Res, 2020: 3582648.

[7] Qing Wang, Xinran Li, Qingru Wang, Jiaxin Xie, Chuhai Xie and Xiafei Fu. Heat shock pretreatment improves mesenchymal stem cell viability by heat shock proteins and autophagy to prevent cisplatin-induced granulosa cell apoptosis. Stem Cell Research & Therapy 2019.10:348.

[8] Fu X, He Y, Wang X, Peng D, Chen X, Li X, Wan Q. MicroRNA-16 Promotes Ovarian Granulosa Cell Proliferation and Suppresses Apoptosis Through Targeting PDCD4 in Polycystic Ovarian Syndrome. Cell Physiol Biochem. 2018;48(2): 670- 682.

[9] Chen X, Wang Q, Li X, Wang Q, Xie J, Fu X. Heat shock pretreatment of mesenchymal stem cells for inhibiting the apoptosis of ovarian granulosa cells enhanced the repair effect on chemotherapy-induced premature ovarian failure. Stem Cell Res Ther. 2018;9(1):240.

[10] Fu X, He Y, Wang X, Peng D, Chen X, Li X, Wang Q. Overexpression of miR-21 in stem cells improves ovarian structure and function in rats with chemotherapy-induced ovarian damage by targeting PDCD4 and PTEN to inhibit granulosa cell apoptosis. Stem Cell Res Ther, 2017, 8(1): 187-199.

[11] Fu X, He Y, Xie C, Liu W. Bone marrow mesenchymal stem cell transplantation improves ovarian function and structure in rats with chemotherapy-induced ovarian damage. Cytotherapy, 2008, 10(4): 353-363.