徐佳佳，南方医科大学研究员，博士研究生导师、博士后合作导师，国家高层次青年人才（海外）、南方医院脊柱脊髓损伤研究实验室负责人。博士毕业于中国科学院上海生命科学研究院，师从骨科生物力学专家戴尅戎院士。聚焦于干细胞分化和组织再生方向，主持国家海外高层次青年人才项目、国家重点研发计划子课题、国家自然科学基金面上项目、广东省基础与应用基础基金2项、广州市基础与应用基础基金、南方医院杰青培育计划A类等。发表SCI文章53篇，其中第一作者或通讯作者文章17篇，包括Science Translational Medicine (2023, IF: 15.8), Science Advances (2022, IF: 13.6), Molecular Therapy (2024, IF: 12.1), Cell Death & Differentiation (2016, IF: 8.339), Bone Research (2020 & 2022, IF: 13.567)，Theranostics (2020, IF: 11.556)和eLife (2019 & 2020, IF: 8.14)等，特邀综述4篇，申请专利3项。引用超2300次，h指数24。国际会议特邀报告9次，获ASBMR和ORS青年研究员奖，与国际众多著名研究学者有着广泛的合作。担任Theranostics、Angiogenesis、Stem Cells和International Journal of Biological Sciences等国际学术杂志的审稿人，中国医师协会神经修复学专业委员会基础与转化学组委员，广东省科技咨询专家库专家，广州市科技专家库专家，广东省青年科学家协会第六届常务理事，IMED期刊青年编委。

教育背景：

2011.9-2017.2  中国科学院上海生命科学研究院，细胞生物学，硕博连读，博士学位

2007.9-2011.7  东华大学化学化工与生物工程学院，生物工程 & 国际经济与贸易，工学学士 & 经济学学士学位

工作经历：

2024.11-至今        南方医科大学南方医院脊柱骨科，研究员

2022.02-至今        南方医科大学南方医院脊柱骨科，副教授

2017.03-2021.07  美国约翰霍普金斯大学（Johns Hopkins University）医学院，博士后

学会会员：

1）美国骨科研究学会（ORS）会员

2）美国骨科研究学会国际骨折修复分会（ORS ISFR）会员

3）美国骨与矿物质研究协会（ASBMR）会员

4）欧洲骨科研究学会（EORS）会员

5）国际华人骨研学会（ICMRS）会员

获奖及荣誉：

2024  美国骨与矿物质研究协会（ASBMR）Young Investigator Emerging Country Travel Grant

2023  Bone Research杂志年度杰出论文奖（2022–2023年度）

2021  国际骨科研究学会（ORS）青年研究员奖

2021  国际骨科研究学会国际骨折修复分会（ORS ISFR）学生/实习生奖

2020  美国骨与矿物质研究协会（ASBMR）青年研究员奖

1）间充质干细胞分化调控机制研究；

2）干细胞介导的组织再生修复；

3）骨代谢及骨骼退行性疾病防治；

4）神经与骨骼的交互作用。

课题组长期招募医学、生物、生信或交叉学科背景的本科生、研究生或博士后，欢迎对干细胞、再生/转化医学、神经生物学感兴趣的同学加入我们团队。（只接收学术型硕士读博）

（一）发表论文：

1. Fei, C.*, Chen, Y.*, Tan, R.*, Yang, X., Wu, G., Li, C., Shi, J., Le, S., Yang, W., Xu, J.^#, Wang, L.^#, Zhang, Z.^# (2025). Single-cell multi-omics analysis identifies SPP1+ macrophages as key drivers of ferroptosis-mediated fibrosis in ligamentum flavum hypertrophy. Biomarker Research, 13:33. (IF: 11.5，中科院小类2区)

2. Li, Z.*, Meng, K.*, Lan, S., Ren, Z., Lai, Z., Ao, X., Liu, Z., Xu, J.^#, Mo, X.^#, Zhang, Z.^# (2025). The Role of mRNA Modifications in Bone Diseases. Int J Biol Sci, 21(3):1065-1080. (IF: 10，中科院小类2区)

3. Gao, Y.^*, Zou, Y.^*, Sokolowskei, D., Xing, X., Tower, R. J., Lai, Z., Shi, J., Zhu, L., Zheng, Q., James, A. W.^#, Xu, J.^# and Zhang, Z.^# (2024). Nr4a1 enhances Wnt4 transcription to promote mesenchymal stem cell osteogenesis and alleviates inflammation-inhibited bone regeneration. Molecular Therapy, 32(5):1479-1496. (IF: 12.4，中科院小类1区)

4. Cherief, M.^*, Xu, J.^*, Li, Z. ^*, Tower, R. J., Ramesh, S., Qin, Q., Gomez-Salazar, M., Yea, J., Lee, S., Negri, S., Xu, M., Price, T., Kendal, A., Fan, C., Clemens, T., Levi, B., James, A. W. (2023). TrkA-mediated sensory innervation of injured mouse tendon supports tendon sheath progenitor cell expansion and tendon repair. Science Translational Medicine, 15(727):eade4619. (共同一作，封面论文，IF: 17.1，中科院小类1区)

5. Xu, J.^*, Li, Z.^*, Tower, R. J.^*, Negri, S., Wang, Y., Meyers, C. A., Sono, T., Qin, Q., Lu, A., Xing, X., McCarthy, E. F., Clemens, T. L., & James, A. W. (2022). NGF-p75 signaling coordinates skeletal cell migration during bone repair. Science Advances, 8(11), eabl5716. (IF: 13.6，中科院小类1区)

6. Xu, J.^*, Wang, Y.^*, Li, Z., Tian, Y., Li, Z., Lu, A., Hsu, C. Y., Negri, S., Tang, C., Tower, R. J., Morris, C., & James, A. W. (2022). PDGFRα reporter activity identifies periosteal progenitor cells critical for bone formation and fracture repair. Bone Research, 10(1), 7. (IF: 12.7，中科院小类1区)

7. Xu, J., Li, D., Hsu, C. Y., Tian, Y., Zhang, L., Wang, Y., Tower, R. J., Chang, L., Meyers, C. A., Gao, Y., Broderick, K., Morris, C., Hooper, J. E., Nimmagadda, S., Peault, B., & James, A. W. (2020). Comparison of skeletal and soft tissue pericytes identifies CXCR4⁺ bone forming mural cells in human tissues. Bone Research, 8(1), 22. (IF: 12.7，中科院小类1区，被Nature Reviews Molecular Cell Biology (IF：112.7)综述突出引用)

8. Xu, J., Wang, Y., Li, J., Zhang, X., Geng, Y., Huang, Y., Dai, K.^#, & Zhang, X.^# (2016). IL-12p40 impairs mesenchymal stem cell-mediated bone regeneration via CD4⁺ T cells. Cell Death Differ, 23(12), 1941-1951. (IF: 12.4，中科院小类1区)

9. Xu, J., Li, J., Hu, Y., Dai, K., Gan, Y., Zhao, J., Huang, M., & Zhang, X. (2020). IL-23, but not IL-12, plays a critical role in inflammation-mediated bone disorders. Theranostics, 10(9), 3925-3938. (IF: 12.4，中科院小类1区)

10. Xu, J., Wang, Y., Hsu, C. Y., Gao, Y., Meyers, C. A., Chang, L., Zhang, L., Broderick, K., Ding, C., Peault, B., Witwer, K., & James, A. W. (2019). Human perivascular stem cell-derived extracellular vesicles mediate bone repair. eLife, 8. (IF: 7.7，中科院小类1区)

11. Xu, J., Liu, J., Gan, Y., Dai, K., Zhao, J., Huang, M., Huang, Y., Zhuang, Y., & Zhang, X. (2020). High-Dose TGF-beta1 Impairs Mesenchymal Stem Cell-Mediated Bone Regeneration via Bmp2 Inhibition. J Bone Miner Res, 35(1), 167-180. (IF: 6.2，中科院小类1区)

12. Xu, J.^*, Wang, Y.^*, Hsu, C. Y., Negri, S., Tower, R. J., Gao, Y., Tian, Y., Sono, T., Meyers, C. A., Hardy, W. R., Chang, L., Hu, S., Kahn, N., Broderick, K., Peault, B., & James, A. W. (2020). Lysosomal protein surface expression discriminates fat- from bone-forming human mesenchymal precursor cells. eLife, 9. (IF: 7.7，中科院小类1区)

13. Xing, X.^*, Li, Z.^*, Xu, J.^*, Chen, A. Z., Archer, M., Wang, Y., Xu, M., Wang, Z., Zhu, M., Qin, Q., Thottappillil, N., Zhou, M., James, A. W. (2024). Requirement of Pdgfrα⁺ cells for calvarial bone repair. Stem Cells Transl Med, 13(8), 791-802. (IF: 5.4)

14. Wang, Y.^*, Xu, J.^*, Meyers, C. A., Gao, Y., Tian, Y., Broderick, K., Peault, B., & James, A. W. (2020). PDGFRalpha marks distinct perivascular populations with different osteogenic potential within adipose tissue. Stem Cells, 38(2), 276-290. (IF: 5.2)

15. Xu, J.^*, Wang, Y.^*, Gomez-Salazar, M. A.^*, Hsu, G. C., Negri, S., Li, Z., Hardy, W., Ding, L., Peault, B., & James, A. W. (2021). Bone-forming perivascular cells: Cellular heterogeneity and use for tissue repair. Stem Cells, 39(11), 1427-1434. (IF: 5.2)

16. Xu, J.^*, Zhang, Z.^*, Zhao, J., Meyers, C. A., Lee, S., Qin, Q., & James, A. W. (2022). Interaction between the nervous and skeletal systems. Front Cell Dev Biol, 10, 976736. (IF: 5.5)

17. Xu, J., Wang, Y., Hsu, C. Y., Negri, S., Presson, B., Peault, B., & James, A. W. (2020). Functional heterogeneity of perivascular precursor cells. Current Tissue Microenvironment Reports, 1, 183-186.

18. Xu, J., Gan, Y., Tong, W., Li, J., Dai, K.^#, & Zhang, X.^# (2016). The differentiation regulation and cytotherapy based on stem cells in bone and cartilage. Chinese Bulletin of Life Sciences, 28(8), 921-927.

（二）专著：

1. Meyers, C. A., Hindle, P., Hardy, W. R., Xu, J., Yan, N., Broderick, K., Asatrian, G., Ting, K., Soo, C., Peault, B., & James, A. W. (2019). Perivascular Progenitor Cells for Bone Regeneration. In: Duscher D, Shiffman MA, editors. Regenerative Medicine and Plastic Surgery: Skin and Soft Tissue, Bone, Cartilage, Muscle, Tendon and Nerves. Cham: Springer International Publishing; p. 223-229.

2. Meyers, C. A., Wang, C., Xu, J., Pan, H. C., Shen, J., Ting, K., Soo, C., Peault, B. M., & James, A. W. (2021). Assessing the Bone-Forming Potential of Pericytes. In: Péault B.M. (eds). Pericytes: Methods and Protocols, Methods in Molecular Biology. Vol. 2235. p. 127-137.