目录
更新日期:2026年9月4日
姓 名 麻丹丹 性 别 女
民 族 汉族 导师层次 博士导师
技术职称 教授 导师类型 学术&专业型
最后学历 博士研究生毕业 最后学位 医学博士学位
行政职务 主任 Email mdd@smu.edu.cn
工作单位 南方医科大学口腔医院 邮政编码 510515
个人简介

   2012年毕业于南方医科大学获博士学位,美国马里兰大学访问学者,现任南方医科大学博士生导师,南方医科大学口腔医院博士后合作导师,一直从事牙体牙髓病学专业的临床、教学及科研工作。临床上主要从事龋病,牙髓病及根尖周病等牙体牙髓疾病的微创无痛治疗,擅长牙齿大面积缺损的复杂充填治疗,前牙美容修复治疗,CAD/CAM嵌体及高嵌体的修复治疗,利用CBCT开展规范化显微根管治疗,减少病人术中及术后并发症的发生,积极开展显微根尖外科治疗。在科研方面,一直从事牙髓再生,牙髓生物学特性及牙髓干细胞分化机制的研究,通过一系列研究证实Stathmin负向调节牙髓干细胞分化,并通过SHH信号通过靶向调控,以第一或通讯作者共发表SCI 论文10余篇,主持国家自然科学基金2项,广东省自然科学基金博士启动项目1项,市级课题1项,校级、院级课题共4项,参与省级课题4项。

研究领域

牙髓生物学,牙髓再生,牙髓干细胞分化调控机制

个人成果

个人荣誉:

2015学年南方医科大学南方医院优秀临床带教

2015年度南方医科大学第5届中青年教师本科课程教学竞赛二等奖

2016年度南方医科大学第6届中青年教师本科课程教学竞赛二等奖

2016年度全国口腔院校青年教师理论授课技能竞赛三等奖

2016学年校级教学优秀三等奖

2018年广东省杰出青年医学人才

2018年广东省实力中青年医师

2018年住院医师规范化培训口腔医学专业师资培训研讨会二等奖

2021年第七届羊城好医生

2022年第二届昌岗地区十佳青年

学术专著:

口腔中级医师考试题集

代表性论文:

2026年度

1. Li F, Lu D, Li X, Ye Y, Zhi C, Chen X, Liu Y, Zhang K, Ma D*, Yang P*, Zhang X*. An amyloid-based hydrogel with remineralizing and antibacterial properties for interrupting dental caries. Acta Biomater. 2026;213:200-213. doi: 10.1016/j.actbio.2026.01.053. Epub 2026 Jan 28. PMID: 41616892. (IF2024=9.6, 中科院小类分区=1区)

2. Mo C, Zhang K, Cui H, Chen S, Tan S, Wen B, Ma D. Periodontal immune homeostasis: neutrophils as guardians and betrayers, and strategies for precision modulation. Int Immunopharmacol. 2026 Jun 1;178:116569. doi: 10.1016/j.intimp.2026.116569. Epub 2026 Mar 30. PMID: 41903304.综述(IF2024=4.7, 中科院小类分区=2区)

3. Ma Z, Zhang K, Luo J, Chen S, Tan S, Ma D. Liposome-based drug delivery systems for skin wound healing: a promising drug delivery strategy. Front Bioeng Biotechnol. 2026;14:1756872. doi: 10.3389/fbioe.2026.1756872. PMID: 41768129; PMCID: PMC12936863. 综述(IF2024=4.8, 中科院小类分区=3区)

4. Lei Q, Zou X, Luo X, Han X, Chen Y, Tan S, Wen B, Liu S, Ma D. Prevotella intermedia-Derived Extracellular Vesicles Promote Pulpitis. J Dent Res. 2026 Jul 24:220345261461507.. Epub ahead of print. PMID: 42499185.(IF:2025=6.6,中科院小类分区=1区)

2025年度

5. Pan Y#, Hua B#, Wang H#, Tan S, Lu T, Xiong F*, Ma D*. A novel phex gene variant causes non-syndromic tooth agenesis. BMC Oral Health. 2025 ;25(1):1452. doi: 10.1186/s12903-025-06827-0. (IF2024=3.1, 中科院小类分区=2区)

6. Ruan Q#, Qiu G#, Tan S, Guo L, Hu W, Wen J*, Ma D*. 3D Bioprinted Cellular Scaffolds Containing Monetite for the Treatment of Critical Bone Defects. ACS Biomater Sci Eng. 2025 Dec 4. doi: 10.1021/acsbiomaterials.5c01099. Epub ahead of print. PMID: 41346092. (IF2024=5.5, 中科院小类分区=3区)

7. Peng X#, Cui H#, Tan S, Wen B, Luo X, Chen S, Luo J, Zhong P, Ning T*, Ma D*. The engineered bone marrow mesenchymal stem cell-derived exosome: A new strategy for the treatment of inflammatory diseases. Int Immunopharmacol. 2025 Sep 23;162:115136. doi: 10.1016/j.intimp.2025.115136. Epub 2025 Jul 1. (IF 2024=4.7, 中科院小类分区=2区) 综述

8. Zhong PL#, Zhao YY#, Cui H, Cheng GW, Xia LZ, Tian Z, Liu W, Wu JX, Yu JX, Peng XY, Yu GT*, Ma DD*. Biomimetic photosynthesis nanoreactors based thylakoid synergy with metformin for reversing tumor immunosuppressive microenvironment therapy. CHEMICAL ENGINEERING JOURNAL. 2025 JUL 1; 515.doi: 10.1016/j.cej.2025.163368. (IF2024=13.2, 中科院小类分区=1区)

9. Luo X#, Wang Y#, Ning T#, Lei Q, Cui H, Zou X, Chen Y, Chen S, Zhang X, Tan S, Ma D*. Outer membrane vesicles of Porphyromonas gingivalis impede bone regeneration by inducing ferroptosis via the Hippo-YAP signaling pathway. J Nanobiotechnology. 2025 May 17;23(1):358. doi: 10.1186/s12951-025-03457-0. PMID: 40382634. (IF2024=12.6,中科院小类分区=1区)

10. Pan Y#, Li Y, Zhao F, Zeng Y, Tan S, He F, Xiong F*, Ma D*. The dominant negative mutation of PAX9 in nonsyndromic tooth agenesis. Clin Oral Investig. 2025 Apr 14;29(5):247. doi: 10.1007/s00784-025-06308-2. PMID: 40227334. (IF2024=3.1,中科院小类分区=3区)

11. Zhao YY#, Meng QF#, Cui H, Liu W, Chen Y, Lan Z, Chen H, Ma DD*, Rao L*, Yu GT*. Injectable cellular vesicle-based bone meal for inflammatory bone defect repair through restoring immune homeostasis. Theranostics. 2025;15(10):4465-4480. doi: 10.7150/thno.110795. PMID: 40225579; PMCID: PMC11984383. (IF2024=13.3,中科院小类分区=1区)

12. Yang X#, Zhou Y#, Zhou F#, Bao L, Wang Z, Li Z, Ding F, Kuang H, Liu H, Tan S, Qiu X, Jing H, Liu S*, Ma D*. T Cell-Derived Apoptotic Extracellular Vesicles Ameliorate Bone Loss via CD39 and CD73-Mediated ATP Hydrolysis. Int J Nanomedicine. 2025;20:1083-1100. doi: 10.2147/IJN.S491222. (IF2024=6.5,中科院小类分区=2区)

13. Tan S#, Wang Q#, Feng C#, Pu X, Li D, Jiang F, Wu J, Huang S, Fan J, Zhong R, Mo C, Luo J, Zhong P, Liu J*, Ma D*. Biomimetic mineralized DCPA/ anti-CD47 containing thermo-sensitive injectable hydrogel for bone-metastatic prostate cancer treatment. Mater Today Bio. 2025;31:101573. doi: 10.1016/j.mtbio.2025.101573.(IF2024=10.2,中科院小类分区=2区)

14. Tan S#, Luo X#, Wang Y#, Chen S, Jiang T, Yang X, Peng X, Zhang X, Zhang S, Zhang C, Liu Z*, Ma D*. Biomimetic non-collagenous proteins-calcium phosphate complex with superior osteogenesis via regulating macrophage IL-27 secretion. Biomaterials. 2025;315:122917.(IF2024=12.9,中科院小类分区=1区)

2024年度

15. Yu GT#*, Zhu WX#, Zhao YY#, Cui H, Chen H, Chen Y, Ning TT, Rong MD*, Rao L*, Ma DD*. 3D-printed bioink loading with stem cells and cellular vesicles for periodontitis-derived bone defect repair. Biofabrication. 2024;16(2). (IF2023=8.2,中科院小类分区=2区)

16. Zou X#, Yin J#, Lei Q, Luo X, Chen S, Yang X, Tan S*, Ma D*. Bosutinib Laden Three-Dimensional Printed Zein Scaffolds Promote Osteogenesis[J]. ACS Applied Polymer Materials, 2024,6(6):3082-93. (IF2023=4.4,中科院小类分区=2区)

17. Guo L, Ruan Q, Ma D*, Wen J*. Revealing quorum-sensing networks in Pseudomonas aeruginosa infections through internal and external signals to prevent new resistance trends. Microbiol Res. 2024 Dec;289:127915.. doi: 10.1016/j.micres.2024.127915. Epub 2024 Sep 24. PMID: 39342746. (IF2023=5.07,中科院小类分区=2区)综述

18. Hu W#, Chen S#, Zou X, Chen Y, Luo J, Zhong P, Ma D*. Oral microbiome, periodontal disease and systemic bone-related diseases in the era of homeostatic medicine. J Adv Res. 2024 Aug 17:S2090-1232(24)00362-X. doi: 10.1016/j.jare.2024.08.019(IF2023=11.4,中科院小类分区=1区)综述

19. Luo J#, Ning T#, Li X, Jiang T, Tan S, Ma D*. Targeting IL-12 family cytokines: A potential strategy for type 1 and type 2 diabetes mellitus. Biomed Pharmacother. 2024;170:115958. (IF2023=6.9,中科院小类分区=1区) 综述

2023年度

20. Luo X#, Feng W#, Huang S#, Miao S, Jiang T, Lei Q, Yin J, Zhang S, Bai X, Hao C, Li W*, Ma D*. Odontoblasts release exosomes to regulate the odontoblastic differentiation of dental pulp stem cells. Stem Cell Res Ther. 2023;14(1):176. (IF2023=7.1,中科院小类分区=2区)

21. Jiang T#, Miao S, # Shen J, Song W, Tan S, Ma D*. Enhanced effects of antagomiR-3074-3p-conjugated PEI-AuNPs on the odontogenic differentiation by targeting FKBP9. J Tissue Eng. 2023;14:20417314231184512. (IF2023=6.7,中科院小类分区=1区)

22. Yin J#, Lei Q#, Luo X, Jiang T, Zou X, Schneider A, H K Xu H, Z Zhao L*, Ma D*. Degradable hydrogel fibers encapsulate and deliver metformin and periodontal ligament stem cells for dental and periodontal regeneration. J Appl Oral Sci. 2023;31:e20220447. (IF2023=2.2,中科院小类分区=4区)

23. Tan S#, Chen S#, Lei Q, Ma D*. A novel rapidly mineralized biphasic calcium phosphate with high acid-resistance stability for long-term treatment of dentin hypersensitivity. Dent Mater. 2023;39(3):260-274.(IF 2023=4.6, 中科院小类分区=1区)

24. Wang Y, Luo X, Xiang X, Hao C, Ma D*. Roles of bacterial extracellular vesicles in systemic diseases. Front Microbiol. 2023;14:1258860. (IF2023=4,中科院小类分区=3区) 综述

25. Zou X, Lei Q, Luo X, Yin J, Chen S, Hao C, Shiyu L*, Ma D*. Advances in biological functions and applications of apoptotic vesicles. Cell Commun Signal. 2023;21(1):260. (IF2023=8.2,中科院小类分区=2区) 综述

26. Chen S, Lei Q, Zou X, Ma D*. The Role and Mechanisms of Gram-negative Bacterial Outer Membrane Vesicles in Inflammatory Diseases. Front Immunol. 2023;14:1157813. (IF2023=5.7,中科院小类分区=2区) 综述

27. Ruan Q, Tan S, Guo L, Ma D*, Wen J*. Prevascularization techniques for dental pulp regeneration: potential cell sources, intercellular communication and construction strategies. Front Bioeng Biotechnol. 2023;11:1186030. (IF2023=4.3,中科院小类分区=3区) 综述

28. Ruan Q, Guan P, Qi W, Li J, Xi M, Xiao L, Zhong S, Ma D*, Ni J*. Porphyromonas gingivalis regulates atherosclerosis through an immune pathway. Front Immunol. 2023,14;14:1103592.(IF 2023=5.7, 中科院小类分区=2区)综述

29. Luo X#, Yin J, Miao S, Feng W, Ning T, Xu S, Huang S, Zhang S, Liao Y, Hao C, Wu B, Ma D*. mTORC1 promotes mineralization via p53 pathway. FASEB J. 2021;35(2):e21325.(IF 2021=5.834, 中科院小类分区=2区)

30. Yin JY, Luo XH, Feng WQ, Miao SH, Ning TT, Lei Q, Jiang T, Ma DD*. Multidifferentiation potential of dental-derived stem cells. World J Stem Cells. 2021;13(5):342-365. IF 2021=5.247, 中科院小类分区=3区)综述

31. Ning T#, Shao J, Zhang X, Luo X, Huang X, Wu H, Xu S, Wu B*, Ma D*. Ageing affects the proliferation and mineralization of rat dental pulp stem cells under inflammatory conditions. Int Endod J. 2020,53(1):72-83.(IF 2020= 5.264, 中科院小类分区=2区)

32. Zhang X#, Ning T, Wang H, Xu S, Yu H, Luo X, Hao C, Wu B*, Ma D*. Stathmin regulates the proliferation and odontoblastic/osteogenic differentiation of human dental pulp stem cells through Wnt/β-catenin signaling pathway. J Proteomics. 2019,202:103364.(IF 2019=3.509, 中科院小类分区=2区)

33. Yu H, Zhang X, Song W, Pan T, Wang H, Ning T, Wei Q, Xu HHK, Wu B*, Ma D*. Effects of 3D Bioprinting Alginate/Gelatin Hydrogel Scaffold Extract on Proliferation and Differentiation of Human Dental Pulp Stem Cells. J Endod. 2019,45(6):706-715.(IF 2019=3.118, 中科院小类分区=2区)

34. Wang H, Ning T, Song C, Luo X, Xu S, Zhang X, Deng Z, Ma D*, Wu B*. Priming integrin α5 promotes human dental pulp stem cells odontogenic differentiation due to extracellular matrix deposition and amplified extracellular matrix-receptor activity. J Cell Physiol. 2019,234(8):12897-12909.(IF 2019=5.546, 中科院小类分区=2区)

35. Ma D#, Yu H#, Xu S, Wang H, Zhang X, Ning T, Wu B*. Stathmin Inhibits Proliferation and Differentiation of dental pulp stem cells Via Sonic Hedgehog/Gli. J Cell Mol Med. 2018,22(7):3442-3451.(IF 2018=4.658, 中科院小类分区=2区)

36. Ma D#, Cui L#, Gao J, Yan W, Liu Y, Xu S, Wu B*. Proteomic analysis of mesenchymal stem cells from normal and deep carious dental pulp. PLoS One. 2014,9(5):e97026.(IF 2014=3.534, 中科院小类分区=3区)

37. Ma D#, Gao J, Yue J, Yan W, Fang F, Wu B*. Changes in proliferation and osteogenic differentiation of stem cells from deep caries in vitro. J Endod. 2012,38(6):796-802.(IF 2012=2.179, 中科院小类分区=2区)

38. Ma D#, Ma Z#, Zhang X, Wang W, Yang Z, Zhang M, Wu G, Lu W, Deng Z, Jin Y*. Effect of age and extrinsic microenvironment on the proliferation and osteogenic differentiation of dental pulp stem cells in vitro. J Endod. 2009,35(11):1546-1553.(IF 2009=2.465, 中科院小类分区=2区)

39. 麻丹丹,王贺,于海悦,吴补领.数字化切片在口腔组织病理学实验教学中的应用效果.中华口腔医学杂志(电子版).2017,11(4):246-248

40. 麻丹丹,于海悦,吴补领.牙髓细胞条件培养液对大鼠牙髓干细胞矿化能力影响的研究.广东牙病防治.2015, 23(8):414-416.

41. 麻丹丹,项小诊,吴补领.数码显微互动教学系统对口腔组织病理实验教学的影响.中华医学教育探索杂志. 2015,14(9):898-901.

42. 麻丹丹,吴补领.淫羊藿苷对人牙髓干细胞增殖及骨向分化的作用.牙体牙髓牙周病学杂志.2015,25(9):525-529.

43. 麻丹丹,高杰,吴补领.改良组织块酶消化法培养人龋损牙髓干细胞的实验研究.牙体牙髓牙周病学杂志. 2011,21(7): 371-374.

44. 麻丹丹,陆伟,唐亮,金岩.沉默Mcpr1促进大鼠牙乳头细胞增殖. 牙体牙髓牙周病学杂志.2008,18(12): 665-668.

 

研究课题

1.项目负责人(1/8).国家自然科学基金(面上项目). 弱碱-镁微环境刺激牙髓细胞产生G3P促进管状牙本质再生的机制研究.课题经费:45万.起止时间:2025.01-2028.12.项目编号:82470963

2.项目负责人.广州市基础与应用基础研究专题(科技菁英“领航”项目). 中间普氏菌外膜囊泡促进巨噬细胞Necroptosis释放IL-17D调控牙髓细胞内质网应激参与牙髓炎发生及机制研究.课题经费:30万元.起止时间:2024.01-2026.12.31.项目编号:2024A04J6614

3.项目负责人.南方医科大学口腔医院.成牙本质细胞外泌体调节牙髓干细胞分化与牙髓炎修复及其机制研究.课题编号:PY2021001.课题直接经费:20万.起止时间:2021.02-2025.01

4.项目负责人(1/7). 国家自然科学基金(面上项目). 课题名称: 成牙本质细胞外泌体调节牙髓干细胞分化与牙髓炎修复及其机制研究. 课题编号: 81970930. 课题直接经费: 55万. 起止时间: 2020.01-2023.12

5.项目负责人(1/7). 国家自然科学基金(青年项目). 课题名称: Stathmin在人牙髓干细胞成牙本质向分化过程中的作用及分子机制研究. 课题编号: 81400495. 课题直接经费: 23万. 起止时间: 2015.01-2017.12

6.项目负责人(1/7). 广东省自然科学基金(博士启动项目). 课题名称: Stathmin调控Shh信号通路促进牙髓干细胞成牙本质向分化的作用机制研究. 课题编号: 2015A030310101. 课题直接经费: 10万. 起止时间:2015.08-2018.08

7.课题负责人(1/5). 广东省口腔医学重点实验室开放课题. 课题名称: Shh信号通路在Stathmin调控牙髓干细胞成牙本质向分化的作用研究. 课题直接经费: 2万. 起止时间: 2016.01-2017.09

8.课题负责人(1/7).南方医科大学科研启动计划.课题名称: 人深龋牙髓干细胞蛋白组学分析及矿化相关基因Stathmin功能及分子机制的研究. 课题直接经费: 3万. 起止时间: 2012.11-2014.10

9.课题负责人(1/6). 南方医科大学南方医院院长基金.课题名称: 炎症微环境Stathmin通过Wnt信号通路调控牙髓干细胞分化与修复的作用及机制研究.课题编号:2018B005,课题直接经费: 5万. 起止时间:2019.01-2021.12

10.课题组成员(3/8). 国家自然科学基金(面上项目). 课题名称: 晶界偏析对不同氧化物掺杂牙科氧化锆低温时效效应的影响. 课题编号: 51672122.课题直接经费:62万.起止时间: 2017.01-2020.12

11.合作单位负责人(2/8). 海南省重点研发计划项目. 课题名称: 炎症微环境下Stathmin调控牙髓干细胞成牙本质向分化与修复中的作用及机制研究.课题编号:ZDYF2019216.课题直接经费:40万.起止时间:2019.04-2022.04

12.合作单位负责人(2/8).海南省重点研发计划项目.课题名称:mTORC1信号通路调节成牙本质细胞外泌体对牙髓干细胞分化的影响及机制研究.课题编号:ZDYF2022SHFZ017.课题直接经费:30万.起止时间:2022.03-2024.03

13.项目负责人.南方医科大学口腔医院临床研究启动计划.开窗根尖切除一体化导板辅助下显微镜根尖手术效果的多中心、前瞻性临床探究.课题编号:KQIIT2021002.课题直接经费:40万.起止时间:2021.10-2026.10