陈宏 教授、主任医师，博士研究生导师，博士后合作导师，南方医科大学珠江医院内分泌代谢科主任

        从事内分泌与代谢病专业35年，任中华医学会内分泌学分会委员、中国医师协会内分泌代谢科医师分会委员、广东省医学会内分泌学分会副主任委员、中国老年学和老年医学学会糖尿病分会副主任委员、广东省预防医学会内分泌代谢病防治专业委员会主任委员、广东省中西医结合学会肥胖与体重管理专业委员会主任委员、广东省卫生经济学会慢病与医养分会会长、广东省医师协会内分泌代谢科医师分会副主任委员等。临床经验丰富，致力于内分泌与代谢疾病中常见病、多发病、危重疾病相关诊治技术的提高与突破，尤其在糖尿病及其急慢性并发症、甲状腺相关疾病、垂体及肾上腺疾病、骨质疏松及骨代谢疾病、高尿酸血症、痛风、高血压病、肥胖和代谢综合征、医学体重管理、生长发育障碍、月经异常和性腺功能障碍等诊治方面积累了丰富的临床经验。主持国家自然科学基金面上项目5项、省部级基金项目4项，以第一/并列第一、通讯/并列通讯作者身份发表SCI论文30余篇，累计影响因子超过100，发表中文论文近100篇。担任南方医科大学《内分泌系统与代谢》整合课程负责人，该课程获国家级一流本科课程、省级一流本科课程、广东省系列在线开放课程项目；主持省级教改项目3项、校级教改项目3项；以主编、副主编、编委等身份参与编写/译专著6部，以第一/通讯作者身份发表教学论文10余篇。荣获第九届中国健康总评榜——年度健康科普先锋、第三届羊城好医生、第八届南医优秀教师、第二届珠江教学名师、“感动南医——我心中的好导师”、“感动南医——立德树人好导师”、校级教育教学成果奖二等奖、广东省2020年高校在线教学优秀案例（课程类）一等奖等，多次指导学生参加“挑战杯”创新创业大赛获省级金奖、国家级银奖，多次获南方医科大学教学优秀一等奖、优秀主任等荣誉。

肥胖症的发病机制与表观遗传学；糖脂代谢及脂肪细胞功能调控；糖尿病发病机制；糖尿病并发症防治研究。

1) Mai X, Liu Y, Fan J, Xiao L, Liao M, Huang Z, Chen Z, Huang S, Sun R, Jiang X, Huang L, Sun J, Xie L, Chen H*. Iron supplementation and iron accumulation promote adipocyte thermogenesis through PGC1α-ATGL-mediated lipolysis. J Biol Chem. 2024 Sep;300(9):107690.

2) Duan H, Chen S, Mai X, Fu L, Huang L, Xiao L, Liao M, Chen H*, Liu G, Xie L. Low-intensity pulsed ultrasound (LIPUS) promotes skeletal muscle regeneration by regulating PGC-1α/AMPK/GLUT4 pathways in satellite cells/myoblasts. Cell Signal. 2024 May;117:111097.

3) Li J, Wen W, Li J, Liu T, Sun J, Chen H*. CNOT7 regulates lipid deposition in nonalcoholic fatty liver disease. Biochem Biophys Res Commun. 2024 Aug 20;721:150003. doi: 10.1016/j.bbrc.2024.150003. Epub 2024 May 11. PMID: 38772212.

4) Zhao L, Cheng Z, Lu Y, Liu M, Chen H, Zhang M, Wang R, Yuan Y, Li X. Tirzepatide for Weight Reduction in Chinese Adults With Obesity: The SURMOUNT-CN Randomized Clinical Trial. JAMA. 2024 May 31. doi: 10.1001/jama.2024.9217. Epub ahead of print. PMID: 38819983.

5) Yao X, Mai X, Tian Y, Liu Y, Jin G, Li Z, Chen S, Dai X, Huang L, Fan Z, Pan G, Pan X, Li X, Michael Y, Sun J Ou J,Chen H*, Xie L*, Skeletal Muscle-specific Bambi deletion induces hypertrophy and oxidative switching coupling with adipocyte thermogenesis against metabolic disorders,  SCIENCE CHINA Life Sciences, 2024, https://doi.org/10.1007/s11427-023-2586-x.(http://www.sciengine.com/doi/10.1007/s11427-023-2586-x)

6）Zeng Y, Zhang Z, Liang S, Chang X, Qin R, Chen H*, Guo L. Paternal sleep deprivation induces metabolic perturbations in male offspring via altered LRP5 DNA methylation of pancreatic islets. J Pineal Res. 2023 May;74(4):e12863. doi: 10.1111/jpi.12863. Epub 2023 Mar 11. PMID: 36808627.

7) Sun J^#, Ruan Y^#, Xu N^#, Wu P^#, Lin N, Yuan K, An S, Kang P, Li S, Huang Q, Yingzhang, Li Y, Su J, Ma W, Chen B, Zhang X, Chen X, Liang Y, Lu Z, Deng G, Zhang Z, Wang Y, Wen W, Zhang H*, Chen H*. The effect of dietary carbohydrate and calorie restriction on weight and metabolic health in overweight/obese individuals: a multi-center randomized controlled trial. BMC Med. 2023 May 24;21(1):192. doi: 10.1186/s12916-023-02869-9. PMID: 37226271; PMCID: PMC10210464.

8) Wei W, Liu J, Chen S, Xu X, Guo D, He Y, Huang Z, Wang B, Huang H, Li Q, Chen J, Chen H*, Tan N*, Liu Y*. Sodium Glucose Cotransporter Type 2 Inhibitors Improve Cardiorenal Outcome of Patients With Coronary Artery Disease: A Meta-Analysis. Front Endocrinol (Lausanne). 2022 Mar 7;13:850836. doi: 10.3389/fendo.2022.850836.

9) Zhang S, Wu P, Tian Y, Liu B, Huang L, Liu Z, Lin N, Xu N, Ruan Y, Zhang Z, Wang M, Cui Z, Zhou H, Xie L, Chen H*, Sun J. Gut Microbiota Serves a Predictable Outcome of Short-Term Low-Carbohydrate Diet (LCD) Intervention for Patients with Obesity. Microbiol Spectr. 2021 Oct 31;9(2):e0022321. doi: 10.1128/Spectrum.00223-21. Epub 2021 Sep 15. PMID: 34523948; PMCID: PMC8557869.

10) Wen W, Wu P, Zhang Y, Chen Z, Sun J, Chen H*. Comprehensive Analysis of NAFLD and the Therapeutic Target Identified. Front Cell Dev Biol. 2021 Sep 20;9:704704. doi: 10.3389/fcell.2021.704704.

11) Guo B, Cheng Y, Yan L, Zhang J, Lu J, Qi H, Chen H*. LncRNA HOTAIR regulates the lipid accumulation in non-alcoholic fatty liver disease via miR-130b-3p/ROCK1 axis. Cell Signal. 2021 Nov 11:110190. doi: 10.1016/j.cellsig.

12) Ruan Y, Zhong J, Chen R, Zhang Z, Liu D, Sun J, Chen H*. Association of Body Fat Percentage with Time in Range Generated by Continuous Glucose Monitoring during Continuous Subcutaneous Insulin Infusion Therapy in Type 2 Diabetes. J Diabetes Res. 2021 May 28;2021:5551216. doi: 10.1155/2021/5551216.

13) Liu D, Zhong J, Ruan Y, Zhang Z, Sun J, Chen H*. The association between fat-to-muscle ratio and metabolic disorders in type 2 diabetes. Diabetol Metab Syndr. 2021 Nov 10;13(1):129. doi: 10.1186/s13098-021-00748-y.

14) Du D, Zhang Y, Zhu C, Chen H*, Sun J. Metabolic Regulation of Hypoxia-Inducible Factors in Hypothalamus. Front Endocrinol (Lausanne). 2021 Mar 8;12:650284. doi: 10.3389/fendo.2021.650284.

15) Liu D, Zhong J, Wen W, Ruan Y, Zhang Z, Sun J, Chen H*. Relationship Between Skeletal Muscle Mass to Visceral Fat Area Ratio and Cardiovascular Risk in Type 2 Diabetes. Diabetes Metab Syndr Obes. 2021 Aug 25;14:3733-3742. doi: 10.2147/DMSO.S326195.

16) Qing B, Wang N, Wang L, Li P, Li L, Chen H*. Association between geriatric nutrition risk index and bone mineral density in elderly Chinese people. Arch Osteoporos. 2021 Mar 11;16(1):55. doi: 10.1007/s11657-020-00862-w.

17) Xu N, Wang Y, Xu Y, Li L, Chen J, Mai X, Xu J, Zhang Z, Yang R, Sun J, Chen H*, Chen R. Effect of subclinical hyperthyroidism on osteoporosis: A meta-analysis of cohort studies. Endocrine. 2020 Jul;69(1):39-48. doi: 10.1007/s12020-020-02259-8.

18) Wu P, Wen W, Li J, Xu J, Zhao M, Chen H*, Sun J. Systematic Review and Meta-Analysis of Randomized Controlled Trials on the Effect of SGLT2 Inhibitor on Blood Leptin and Adiponectin Level in Patients with Type 2 Diabetes. Horm Metab Res. 2019 Aug;51(8):487-494. doi: 10.1055/a-0958-2441.

19) Wen W, Gong J, Wu P, Zhao M, Wang M, Chen H*, Sun J. Mutations in gliclazide-associated genes may predict poor bladder cancer prognosis. FEBS Open Bio. 2019 Feb 6;9(3):457-467. doi: 10.1002/2211-5463.12583.

20) Wang JY, Cheng YZ, Yang SL, An M, Zhang H, Chen H*, Yang L. Dapagliflozin Attenuates Hyperglycemia Related Osteoporosis in ZDF Rats by Alleviating Hypercalciuria. Front Endocrinol (Lausanne). 2019 Nov 5;10:700. doi: 10.3389/fendo.2019.00700.

21) Zhang Z, Hu Y, Xu N, Zhou W, Yang L, Chen R, Yang R, Sun J, Chen H*. A New Way for Beta Cell Neogenesis: Transdifferentiation from Alpha Cells Induced by Glucagon-Like Peptide 1.[J] .J Diabetes Res, 2019, 2019: 2583047. doi:10.1155/2019/2583047.

22) Wen W, Wu P, Li J, Wang H, Sun J, Chen H*.Predictive values of the selected inflammatory index in elderly patients with papillary thyroid cancer. J Transl Med. 2018 Sep 21;16(1):261.

23) Wen W, Wu P, Gong J, Zhao M, Zhang Z, Chen R, Chen H*, Sun J.Association of Pioglitazone with Increased Risk of Prostate Cancer and Pancreatic Cancer: A Functional Network Study.Diabetes Ther. 2018 Sep 25. : doi:10.1007/s13300-018-0509-y.

24) Chen H*, Zhou W, Ruan Y, Yang L, Xu N, Chen R, Yang R, Sun J, Zhang Z.Reversal of angiotensin ll-induced beta-cell dedifferentiation via inhibition of  NF-kappab signaling[J]. Mol Med,2018,24(1):43.

25) Ruan Y, Lin N, Ma Q, Chen R, Zhang Z, Wen W, Chen H*, Sun J. Circulating LncRNAs Analysis in Patients with Type 2 Diabetes Reveals Novel Genes Influencing Glucose Metabolism and Islet β-Cell Function. CELLULAR PHYSIOLOGY & BIOCHEMISTRY. 2018;46(1):335-350.

26) Zhang Z#, Zeng H, Lin J, Hu Y, Yang R*, Sun J*, Chen R*, Chen H*.Circulating LECT2 levels in newly diagnosed type 2 diabetes mellitus and their association with metabolic parameters: An observational study.Medicine (Baltimore). 2018 Apr;97(15):e0354.

27) Zhang SS#, Wu Z, Zhang Z, Xiong ZY, Chen H*, Huang QB*. Glucagon-like peptide-1 inhibits the receptor for advanced glycation endproducts to prevent podocyte apoptosis induced by advanced oxidative protein products. Biochem Biophys Res Commun. 2017 Jan 22;482(4):1413-1419 . doi:10.1097/MD.0000 000000010354.

28) Sun J#, Ruan Y#, Wang M, Chen R, Yu N, Sun L, Liu T, Chen H*. Differentially expressed circulating LncRNAs and mRNA identified by microarray analysis in obese patients. Scientific Reports, 2016, 6:35421. doi:10.1038/srep35421.

29) Yi M#, Chen RP#, Yang R, Chen H*. Increased prevalence and risk of non-alcoholic fatty liver disease in overweight and obese patients with Type 2 diabetes in South China. Diabetic Medicine, 2017 Apr;34(4):505-513.doi: 10.1111/dme.13174 .

30) Zhang Z#, Yang L, Lei L, Chen R, Chen H*, Zhang H*. Glucagon-like peptide-1 attenuates advanced oxidation protein product-mediated damage in islet microvascular endothelial cells partly through the RAGE pathway. International Journal of Molecular Medicine, 2016, 38(4):1161-1169. doi: 10.3892/ijmm.2016. 2711.

31) Sun J#, Luo J#, Ruan Y, Xiu L, Fang B, Zhang H, Wang M, Chen H*. Free Fatty Acids Activate Renin-Angiotensin System in 3T3-L1 Adipocytes through Nuclear Factor-kappa B Pathway. J Diabetes Res. 2016;2016:1587594. doi: 10.1155/2016/1587594.