目录
关闭
更新日期：2026年3月25日
姓 名 杨志禄 性 别 男
民 族 汉族 导师层次 博士导师
技术职称 研究员 导师类型 学术型
最后学历 博士研究生毕业 最后学位 工学博士学位
行政职务 其他 Email zhiluyang1029@smu.edu.cn
工作单位 东莞市人民医院 邮政编码 523059
跨学科招生 是
跨学科招生专业1 生物医学工程 招生层次类型1 学术学位博导
跨学科招生专业2 招生层次类型2
个人简介

杨志禄，南方医科大学第十附属医院，研究员，博士生导师，连续入选斯坦福大学-Elsevier“2023-2025年度全球前2%顶尖科学家”，中国生物材料学会科学技术奖一等奖、天津市技术发明奖一等奖获得者，广州南创珠峰医疗科技有限公司董事会董事。现担任国际期刊Smart Materials in Medicine主编、中国科协旗舰刊Research（IF=10.9）副主编，中国解剖学会血管分会副主任委员，中国生物材料学会康复器械与生物材料分会常务委员等学术任职。研究方向聚焦心血管生物材料与再生医学研究。主持国家自然科学基金--国际(地区)合作与交流、广东省基础与应用基础研究基金--粤港澳研究团队项目及四川省杰出青年科学基金等省级/国家级项目10余项。以通讯/第一作者在包括PNAS, Nature Communications, Angewandte Chemie International Edition及 The Innovation等期刊共发表论文80余篇（IF＞10论文50余篇）。获得授权发明专利34项，其中一项血管支架涂层专利技术以1500万作价入股实施了转让。

 

研究领域

1）动脉粥样硬化（AS）病理发病机制；

2）器官芯片、类器官；

3）智能载药纳米靶向药物、微纳机器人；

4）血管支架表面功能仿生修饰；

5）工程化干细胞；

6）血管补片；

7）可降解医用金属植入/介入器械表面防腐及功能修饰

8）心肌再生修复

个人成果

一、主持科研及人才项目情况：

（10）国家自然科学基金-面上项目（项目号：32471376），口服策略给氢协同一氧化氮催化支架调控病变血管再生修复研究，2025/01-2028/12，50万（配套50万），主持（在研）。

（9）东莞市社会发展科技项目（高水平医院建设专项）（项目号：20231800906311），具有原位调控病变血管再生修复功能的心血管支架研究，2023/03-2026/02，100万，主持（在研）。

（8）国家自然科学基金-国际(地区)合作与交流项目（项目号：32261160372），具有时序调控病变血管再生修复功能的Janus血管支架研究，2023/01-2026/12，100万（配套100万），主持（在研）。

（7）广东省基础与应用基础研究基金：区域联合基金-粤港澳研究团队项目，（项目号：2022B1515130010），具有原位调控病变血管再生修复功能的心血管支架研究，2022/10-2026/09，200万（配套200万），主持（在研）。

（6）南方医科大学高层次人才支持与发展计划（项目号：K202102），具有调控病变血管再生修复功能的血管支架研究，2021/06-2024/06，300万，主持（在研）。

（5）国家自然科学基金-面上项目（项目号：82072072），具有一氧化氮催化和免疫抑制剂可控释放的聚肟氨酯涂层改性镁合金血管支架研究，2021/01-2024/12，56万，主持（在研）。

（4）四川省国际科技创新合作项目（项目号：2021YFH0056），具有仿生内皮功能和细胞外基质结构的水凝胶支架涂层构建及抗再狭窄和抗血栓研究，2021/04-2023/03，30万，主持（在研）。

（3）四川省杰出青年基金（项目号：2016JQ0027），基于原位一氧化氮催化释放的内皮功能仿生涂层血管支架研究，2016/03-2019/03，50万，主持（结题）。

（2）国家自然科学基金-面上项目（项目号：31570957），原位催化持续、稳定、可控释放一氧化氮的内皮功能仿生涂层研究，2016/01-2019/12，61万，主持（结题）。

（1）国家自然科学基金-青年科学基金项目（项目号：81501596），具有原位催化一氧化氮释放的内皮功能仿生涂层用于心血管支架表面改性研究，2016/01-2018/12，18万，主持（结题）。

二、代表性通讯/第一作者论文（注：*表示通讯作者，#表示共同第一作者）：

期刊影响因子(2025年发布): PNAS (IF=9.4), Nature Communications (IF=15.7), Angewandte Chemie International Edition (IF=16.9), The Innovation (IF=25.7), Advanced Functional Materials (IF=19.0), Research (IF=10.9), Advanced Science (IF=14.1), Bioactive Materials (IF=20.3), Biomaterials (IF=12.9), Exploration (IF=22.5), BMEMat (IF=15.5), Composites Part B (IF=14.2), Journal of Materials Science and Technology (IF=14.3), Small (IF=12.1)

51. Jiannan Zhou, An Li, Jiahao Chen, Jingtao Dai, Wentai Zhang*, Zhilu Yang*, Ping Li*. Mapping immune-inflammatory niches on zirconia bone implants: Single-cell transcriptomic profiling. Research. 2026;9:1162.

50. Zhenglong Dou*, Jian He, Qiufen Tu, Zhilu Yang*, Nan Huang*. Extrusion-hot rolling assisted microstructure refinement and corrosion control in Mg alloy micro-tubes for vascular stents. Journal of Materials Science and Technology. 2026; 264:321-337. 

49. Yan Fu, Nan Lyu, Xiaohui Mou, Ying Wang, Wentai Zhang, Siwei Yin, Mu Li, Na Bai, Nan Huang, Xin Li, Yifeng Lei*, Jun Hou*, Zhilu Yang*. Glutathione peroxidase mimic-engineered α-lactalbumin self-assembling coatings tailor immunomodulatory vascular stents for suppressing restenosis. Bioactive Materials. 2026;58:89-106. 

48. Xiaohui Mou, Jieyuan Shi, Wentai Zhang, Qing Ma, Wenxuan Wang, Yuting Huang, Siwei Yin, Ying Wang, Nan Huang, Guoqing Pan*, Chengduan Yang*, Zhilu Yang*. Mimicking the macrophage immune mechanism for infection and thrombosis prevention on a dual-activity hybrid enzyme-assembled surface. Angewandte Chemie International Edition. 2025;e19702 (VIP, Outside back cover). 

47. Jing Liu, Mulan Zhu, Na Bai, Nan Huang, Wentai Zhang, Zhilu Yang*, Ying Wang*. Microfluidic perfusable pathological vasculature for atherosclerosis drug screening. Research. 2025;8:0902.

46. Zhenglong Dou#, Yan Fu#, Shuiling Chen, Manfred F. Maitz, Wengtai Zhang, Keyun Li, Jingcheng Zheng, Zhen Zhang*, Nan Huang*, Zhilu Yang*. A Hierarchical MgF2/Polyurethane/Pitavastatin coating alleviates degradation and enhances endothelialization of bioresorbable magnesium alloy stents. Bioactive Materials. 2025;54:509-530.

45. Xiaoyu Hu#, Xiaohui Mou#, Gaoxing Pan#, Yanyun Liu, Wenjing Song, Peijie Xiao, Lu Xu, Fenglu Li, Renjie Ruan, Yueqing Chen, Jinfeng Wu*,  Zhilu Yang*, Jin Zhang*. Vascular intima-biomimetic bilayer hydrogel coating of central venous catheters with dual-modal anti-coagulation and self-adaptive immunomodulation. Advanced Functional Materials. 2025;e11029. 

44. Xiaojia Liu, Zihan Xu, Yanan Che, Zichang Guo, Dongdong Jin, Qianqian Wang, Ning Liu*, Xing Ma*, Zhilu Yang*. Mechanical agitation assisted transmembrane drug delivery by magnetically powered spiky nanorobots. Research. 2025;8:0768.

43. Muyuan Chai, Haolin Bu, Rui Zheng, Zhilu Yang*,  Xuetao Shi*. Immersion phase separation 3D printing for strain-stiffening hydrogel scaffolds. Research. 2025;8:0742.

42. Zeyu Du, Yuting Huang, Wentai Zhang, Qing Maa, Yan Fu, Nan Huang, Xin Li*, Zhilu Yang*, Wenjie Tian*. Mytilus edulis foot protein mimics for tailoring long-acting endothelium-mimicking anti-thrombotic surfaces. Bioactive Materials. 2025;50:1-13.

41. Jingdong Rao#, Di Suo#, Qing Ma#, Yongyi Mo, Ho-Pan Bei, Li Wang, Chuyang Y. Tang, Kai-Hang Yiu, Shuqi Wang, Zhilu Yang*, Xin Zhao*. Riding a vascular time train to spatiotemporally attenuate thrombosis and restenosis by double presentation of therapeutic gas and biomacromolecules. Exploration. 2025;0:270004.

40. Chuanzhe Wang, Jie Lv, Xin Li*, Mengyi Yang, Yan Fu, Wenxuan Wang, Zhilu Yang*, Jing Lu*. Recent advances in surface functionalization of cardiovascular stents. Bioactive Materials. 2025;44:389-410. 

39. Wenxuan Wang, Qing Ma, Da Li, Wentai Zhang,  Zhilu Yang*, Wenjie Tian*, Nan Huang*. Engineered endothelium-mimicking antithrombotic surfaces via combination of nitric oxide-generation with fibrinolysis strategies. Bioactive Materials. 2025;43:319-329. 

38. Siyuan Yue, Wentai Zhang, Qing Ma, Zhen Zhang*, Jing Lu*, Zhilu Yang*. Engineering anti-thrombogenic and anti-infective catheters through a stepwise metal-catechol-(amine) surface engineering strategy. Bioactive Materials. 2024;42:366-378.

37. Tian Yue#,  Wentai Zhang#,  Haifeng Pei, Dunzhu Danzeng, Jian He, Jiali Yang, Yong Luo, Zhen Zhang, Shiqiang Xiong, Xiangbo Yang, Qisen Ji, Zhilu Yang*, Jun Hou*. Monascus pigment-protected bone marrow-derived stem cells for heart failure treatment. Bioactive Materials. 2024;42:270-283.

36. Qing Ma, Wentai Zhang, Xiaohui Mou, Nan Huang, Haimang Wang*, Hongyu Zhang*, Zhilu Yang*. Bioinspired zwitterionic block polymer-armored nitric oxide-generating coating combats thrombosis and biofouling. Research. 2024;7:0423.

35. Muyuan Chai, Wenwen Zhong, Shengtao Yan, Tan Ye, Rui Zheng, Zhilu Yang*, Xuetao Shi*. Diffusion‐induced phase separation 3D printed scaffolds for dynamic tissue repair. BMEMat. 2024;2:e12108.

34. Zeyu Du, Feng Qiao, Liping Tong, Wentai Zhang, Xiaohui Mou, Huaiyu Wang*, Xin Zhao, Manfred F. Maitz, Nan Huang, Zhilu Yang*. Mimicking Mytilus edulis foot protein: A versatile strategy for robust biomedical coatings. The Innovation. 2024;5:100671.

33. You Ke#, Haotian Meng#, Zeyu Du#, Wentai Zhang, Qing Ma, Yuting Huang, Linxian Cui*, Yifeng Lei*,  Zhilu Yang*. Bioinspired super-hydrophilic zwitterionic polymer armor combats thrombosis and infection of vascular catheters. Bioactive Materials. 2024;37:493-504.

32. Wentai Zhang, Jiangling Zhang, Fangkun Hu, Wenxuan Wang, Zeyu Du, You Ke, Qing Ma, Xiaohui Mou*, Jing Lu*, Zhilu Yang*. Active dual-protein coating assisted by stepwise protein-protein interactions assembly reduces thrombosis and infection. Advanced Science. 2024;11:2310259

31. Wentai Zhang, Linxian Cui, Chaoming Xie, Zeyu Du, Xiaohui Mou, Qing Ma, Wenjie Tian*, Zhilu Yang*. Glycocalyx-inspired dynamic antifouling surfaces for temporary intravascular devices. Biomaterials. 2024;304:122427. 

30. Nan Lyu#, Daihua Deng#, Yuting Xiang, Zeyu Du, Xiaohui Mou, Qing Ma, Nan Huang, Jing Lu*, Xin Li, Zhilu Yang*, Wentai Zhang*. An insect sclerotization-inspired antifouling armor on biomedical devices combats thrombosis and embedding. Bioactive Materials. 2024;33:562-571. 

29. Xiaohui Mou, Wan Miao, Wentai Zhang, Wenxuan Wang, Qing Ma, Zeyu Du, Xin Li, Nan Huang*, Zhilu Yang*. Zwitterionic polymers-armored amyloid-like protein surface combats thrombosis and biofouling. Bioactive Materials. 2024;32:37-51 (Cover).

28. Jiajia Wei#, Wentai Zhang#, Xiaohui Mou, Haotian Meng, Qing Ma, Wenxuan Wang, Xin Li*, Qiufen Tu, Wenjie Tian*, Nan Huang, Zhilu Yang*. Bioinspired hemostatic and anti-infective armor for wound healing assisted by metal-phenol-polyamine system. Advanced Functional Materials. 2023;2306267. 

27. Jingdong Rao#, Xiaohui Mou#, Yongyi Mo, Ho-Pan Bei, Li Wang, Chuyang Y. Tang, Kai-Hang Yiu, Zhilu Yang*, Xin Zhao*. Gas station in blood vessels: an endothelium mimicking, self-sustainable nitric oxide fueling stent coating for prevention of thrombosis and restenosis. Biomaterials. 2023;302:122311. 

26. Qian Liu#, Xueliang Peng#, Xiaojia Liu, Xiaohui Mou, Yayuan Guo, Lihua Yang, Yufei Chen, Yaying Zhou, Zhuoya Shi, Zhilu Yang*, Zhuoyue Chen*. Advances in the application of bone morphogenetic proteins and their derived peptides in bone defect repair. Composites Part B. 2023;262:110805.

25. Ying Wang*, Nan Huang, Zhilu Yang*. Revealing the role of zinc ions in atherosclerosis therapy via an engineered three-dimensional pathological model. Advanced Science. 2023;2300475. 

24. Zhenglong Dou, Shuiling Chen, Jiacheng Wang, Li Xia, Manfred F. Maitz, Qiufen Tu, Wengtai Zhang,  Zhilu Yang*, Nan Huang*. A “built-up” composite film with synergistic functionalities on Mg-2Zn-1Mn bioresorbable stents improves corrosion control effects and biocompatibility. Bioactive Materials.  2023;25:223-238. 

23. Lei Zhou, Lu Zhang, Peichuang Li, Manfred F. Maitz, Kebing Wang, Tengda Shang, Sheng Dai, Yudie Fu, Yuancong Zhao, Zhilu Yang*, Jin Wang*, Xin Li*. Adhesive and Self-Healing Polyurethanes with Tunable Multifunctionality. Research. 2022;2022:9795682. 

22. Xiaohui Mou#, Hongbo Zhang#, Hua Qiu#, Wentai Zhang, Ying Wang, Kaiqin Xiong, Nan Huang*, Hélder A. Santos*, and Zhilu Yang*. Mussel-inspired and bioclickable peptide engineered surface to combat thrombosis and infection. Research. 2022;9780879. 

21. Jie Sun, Yingkang Huang, Huan Zhao, Junjie Niu, Xuwei Ling, Can Zhu, Lin Wang, Huilin Yang, Zhilu Yang*, Guoqing Pan*, Qin Shi*. Bio-clickable mussel-inspired peptides improve titanium-based material osseointegration synergistically with immunopolarization-regulation. Bioactive Materials. 2022;9:1-14 

20. Ying Wang, Ranjith Kumar Kankala, Caiwen Ou, Aizheng Chen*, Zhilu Yang*. Advances in hydrogel-based vascularized tissues for tissue repair and drug screening. Bioactive Materials. 2022;9:198-220.

19. Yin Chen#, Peng Gao#, Lu Huang, Xing Tan, Ningling Zhou, Tong Yang, Hua Qiu, Xin Dai, Sean Michael, Qiufen Tu, Nan Huang, Zhihong Guo, Jianhua Zhou*, Zhilu Yang*, Hongkai Wu*. A tough nitric oxide-eluting hydrogel coating suppresses neointimal hyperplasia on vascular stent. Nature Communications. 2021;12:7079.

18. Qing Ma#, Xiuying Shi#, Xing Tan, Rui Wang, Kaiqin Xiong, Manfred F. Maitz, Yuanyuan Cui, Zhangmei Hu, Qiufen Tu*, Nan Huang, Li Shen*, Zhilu Yang*. Durable endothelium-mimicking coating for surface bioengineering cardiovascular stents. Bioactive Materials. 2021;12:4786-4800.

17. Han Yu#, Hua Qiu#, Wenmei Ma, Manfred F. Maitz, Qiufen Tu, Kaiqin Xiong, Jiang Chen*, Nan Huang*, Zhilu Yang*. Endothelium-Mimicking Surface Combats Thrombosis and Biofouling via Synergistic Long- and Short-Distance Defense Strategy. Small. 2021;2100729.

16. Hua Qiu, Qiufen Tu, Peng Gao, Xiangyang Li, Manfred F. Maitz, Kaiqin Xiong*, Nan Huang, Zhilu Yang*. Phenolic-amine chemistry mediated synergistic modification with polyphenols and thrombin inhibitor for combating the thrombosis and inflammation of cardiovascular stents. Biomaterials. 2021;269:120626.

15. Han Yu, Shaoxing Yu, Hua Qiu, Peng Gao, Yingzhong Chen, Xin Zhao, Qiufen Tu, Minggang Zhou*, Lin Cai, Nan Huang, Kaiqin Xiong*, Zhilu Yang*. Nitric oxide-generating compound and bio-clickable peptide mimic for synergistically tailoring surface anti-thrombogenic and anti-microbial dual-functions. Bioactive Materials. 2021;6:1618-1627.

14. Nan Lyu, Zeyu Du, Hua Qiu, Peng Gao, Qin Yao, Kaiqin Xiong, Qiufen Tu, Xiangyang Li, Binghai Chen, Guoqing Pan*, Nan Huang*, Zhilu Yang*. Mimicking the Nitric Oxide-Releasing and Glycocalyx Functions of Endothelium on Vascular Stent Surfaces. Advanced Science. 2020;7:202002330.

13. Zhilu Yang#, Xin Zhao#, Rui Hao, Qiufen Tu, Xiaohua Tian, Yu Xiao, Kaiqin Xiong, Miao Wang, Yonghai Feng, Nan Huang*, Guoqing Pan*. Bio-clickable and Mussel Adhesive Peptide Mimics for Engineering Vascular Stent Surfaces. PNAS. 2020;117:16127-16137.

12. Yu Xiao, Wenxuan Wang, Xiaohua Tian, Xing Tan, Tong Yang, Peng Gao, Kaiqing Xiong, Qiufen Tu, Miao Wang, Manfred F. Maitz, Nan Huang, Guoqing Pan*, Zhilu Yang*. A Versatile Surface Bioengineering Strategy Based on Mussel-Inspired and Bioclickable Peptide Mimic. Research. 2020;7236946.

11. Ying Yang, Peng Gao, Juan Wang, Qiufen Tu, Long Bai, Kaiqin Xiong, Hua Qiu, Xin Zhao, Manfred F. Maitz, Huaiyu Wang, Xiangyang Li, Qiang Zhao, Yin Xiao, Nan Huang*, Zhilu Yang*. Endothelium-Mimicking Multifunctional Coating Modified Cardiovascular Stents via a Stepwise Metal-Catechol-(Amine) Surface Engineering Strategy. Research. 2020;9203906.

10. Peng Gao, Hua Qiu, Kaiqin Xiong, Xiangyang Li, Qiufen Tu, Huaiyu Wang, Nan Lyu, Xiao Chen, Nan Huang*, Zhilu Yang*. Metal-Catechol-(Amine) Networks for Surface Synergistic Catalytic Modification: Therapeutic Gas Generation and Biomolecule Grafting. Biomaterials. 2020;248:119981.

9. Xiangyang Li#, Jingxia Liu#, Tong Yang, Hua Qiu, Lei Lu, Qiufen Tu, Kaiqing Xiong, Nan Huang*, Zhilu Yang*. Mussel-inspired “built-up” surface chemistry for combining nitric oxide catalytic and vascular cell selective properties. Biomaterials. 2020;241:119904.

8. Tong Yang, Zeyu Du, Hua Qiu, Peng Gao, Xin Zhao, Huaiyu Wang, Qiufen Tu, Kaiqin Xiong, Nan Huang, Zhilu Yang*. From surface to bulk modification: Plasma polymerization of amine-bearing coating by synergic strategy of biomolecule grafting and nitric oxide loading. Bioactive Materials. 2020;5:17-25.

7. Hua Qiu#, Pengkai Qi#, Xing Tan, Yu Xiao, Jingxia Liu, Lei Lu, Peng Gao, Ying Yang, Nan Huang*, Zhilu Yang*. Biomimetic Engineering Endothelium-like Coating on Cardiovascular Stent through Heparin and Nitric Oxide-Generating Compound Synergic Modification Strategy. Biomaterials. 2019;207:10-22.

6. Feng Zhang#, Qiang Zhang#, Xiangyang Li, Nan Huang, Xin Zhao*, Zhilu Yang*. Mussel-inspired dopamine-CuII coatings for sustained in situ generation of nitric oxide for prevention of stent thrombosis and restenosis. Biomaterials. 2019;194:117-129.

5. Zhilu Yang*, Ying Yang, Li Zhang, Kaiqin Xiong, Xiangyang Li, Feng Zhang, Jin Wang, Xin Zhao*, Nan Huang*, Mussel-inspired Catalytic Selenocystamine-Dopamine Coatings for Long-Term Generation of Therapeutic Gas on Cardiovascular Stents. Biomaterials. 2018;178:1-10.

4. Zhilu Yang*, Ying Yang, Kaiqin Xiong, Xiangyang Li, Pengkai Qi, Qiufen Tu, Fengjuan Jing, Yajun Weng, Jin Wang*, Nan Huang*. Nitric oxide producing coating mimicking endothelium function for multifunctional vascular stents. Biomaterials. 2015;63:80-92.

3. Zhilu Yang, Qiufen Tu*, Manfred F. Maitz, Shou Zhou, Jin Wang, Nan Huang*. Direct thrombin inhibitor-bivalirudin functionalized plasma polymerized allylamine coating for improved biocompatibility of vascular devices. Biomaterials. 2012;33:7959-7971.

2. Zhilu Yang*, Qiufen Tu, Jin Wang*, Nan Huang*. The role of heparin binding surface in the direction of endothelial and smooth muscle cell fate and re-endothelialization. Biomaterials. 2012;33:6615-6625.

1. Zhilu Yang, Jin Wang*, Rifang Luo, Manfred F. Maitz, Fengjuan Jing, Hong Sun, Nan Huang. The covalent immobilization of heparin to pulsed-plasma polymeric allylamine films on 316L stainless steel and the resulting effects on hemocompatibility. Biomaterials. 2010;31:2072–2083.