李旭，博士，南方医科大学南方医院，主任医师，教授，学术型博士研究生导师，博士后合作导师。入选广东省“千百十工程”第六批省级培养对象。主要从事肝脏、肺脏损伤及器官衰竭机理研究。主持国家自然科学基金项目9项，第一完成人获得广东省科学技术二等奖1项。在Nature Medicine, Microbiome, Nanobiotechnology,Redox Biology, British Journal of Pharmacology, Antioxidant Redox Signaling, Free Radical Biology Medicine, Am J Respir Cell Mol Biol等杂志发表SCI论著40余篇。

学术任职:

国家自然科学基金委员会医学科学部终审专家  

国家科学技术奖励评审专家 

中国人体健康科技促进会门急诊管理专委会副主任委员

中华医学会急诊医学分会危重病学组 委员

中华医学会急诊医学分会临床研究学组 副组长

中华医学会消化病学分会消化生物样本库转化学组委员

广东省预防医学会急症预防与救治专委会 主任委员

广东省精准医学运用学会急诊创伤分会 主任委员 

广东省医学会急诊医学分会 副主任委员

广东省医师协会急诊医学分会第五届委员会 副主任委员

广东省卫生健康人才高级职称评审委员会专家库 专家 

广东省基层卫生协会院前急救专委会 副主任委员 

广东省医学教育协会动物伤害防治专业委员会第一届 副主任委

全国高等学校五年制本科临床医学专业第十轮规划教材《急诊与灾难医学》（第4版）编委  

全国高等学校五年制本科临床医学专业第十轮规划教材《急诊与灾难医学》（第4版）数字编委  

全国高等学校临床药学专业第三轮规划教材《诊断学》（第3版） 副主编   

《中国急救医学》杂志第九届编辑委员会 编委  

 肝脏、肺脏纤维化机理; 脓毒症肠-肝轴调控机理研究

获得奖励：

广东省科学技术二等奖:肝脏肾素-血管紧张素-醛固酮系统在肝纤维化中的 作用机制。李旭,张艺军,孟莹,王卫卫,吴平生,杨希山,张振书,桑显富。 粤府证:[2009]1502 项目编号:A-04-0-2-04-R01

主持课题：

1.        国家自然科学基金面上项目, 82470663, 肠道ACE2-色氨酸-5-MTP轴改善脓毒症肠道屏障功能及抑制肝损伤的机制研究, 2025/01-2028/12,46万元,在研,主持

2.        国家自然科学基金面上项目, 82170641, ACE2/Ang-（1-7）/Mas受体轴对脓毒症继发胆汁淤积性肝损伤的调控机制研究, 2022/01-2025/12,58万元,在研,主持

3.        国家自然科学基金面上项目, 81873583，LPS诱导巨噬细胞释放包含HMGB1外泌体引起肝细胞焦亡在肝衰竭中的机制研究 ,2019/01-2022/12,58万元,结题,主持

4.        国家自然科学基金面上项目,81670556,醛固酮诱导肝窦内皮细胞外泌体GAS5 lncRNA/miR-21失衡促进肝星状细胞活化的机理研究 ,2017/01-2020/12,60万元,结题,主持

5.        国家自然科学基金面上项目,81270520,醛固酮通过 caveolin-1 介导的非基因组效应对 HSC 收缩、肝窦血管生成和重构的调节作用:门脉高压调控的新途径,2013/01-2016/12,80万元,结题,主持

6.        国家自然科学基金面上项目,81070338,肝脏 ACE-ANGII-AT1 受体轴 /ACE2-ANG(1-7)-Mas 轴对肝内细胞EMT/MET 的调控作用:肝纤维化的新机制,2011/01-2013/12,35 万元,结题,主持

7.        国家自然科学基金面上项目 ,30871155, 肝脏 RAS 新组分: ACE2-ANG(1-7)-Mas 受体轴对肝星状细胞收缩及门静脉高压的调控机制, 2009/01-2011/12,33 万元,结题,主持

8.        国家自然科学基金面上项目,30770974,新发现的 RAAS 组分-血管紧张素转化酶 2/血管紧张素(1-7) 对肝纤维化的影响, 2008/01-2008/08,8 万元结题,主持。

9.        国家自然科学基金面上项目 30500243,AT-1 受体和 ACE 基因静默对肝纤维化影响的实验研究,2006/01-2008/12,25 万元,结题,主持

代表性论著：

1. Jun Wang, Jierui Li, Yuhan Li, Weichang Huanga, Chongyang Huangb, Qihan Xub, Jing Suna, Jiacheng Gonga, Xiaoxin Mae, Guozhen Wang, Ying Meng, Xu Li. Angiotensin-(1-7) Alleviates Intestinal Barrier Dysfunction and Dysbiosis in Mice with Polymicrobial Sepsis, British Journal of Pharmacology. 2025，accepted, in press, Co-Corresponding Author. (IF:7.7)

2. Cai Z, Yang Y, Qu P, Fu S, Li X. Unveiling the genetic biomarkers for ageing: evidence from a large sample genome-wide association study and in vivo validation. J Glob Health. 2025, 15:04279.Corresponding Author. (IF:4.3)

3. Liang Z, Liu S, Guo W, Deng Z, Bin W, Yu A, Hu J, Wu L, Li Z, Huang W, Li H, Cheng D, Li S, Guo Q, Zhang D, Yan X, Wang C, Cai W, Ding B, Li W, Li X, Xu B, He L, Ouyang Y, Zhan H, Wang J, Zhao Y, Liu X, Xiang W, Zhang M, Zhang Z, Ding J, Kuang X, Zheng W, Liao H, Wang W, Wang C. Recombinant monoclonal antibody siltartoxatug versus plasma-derived human tetanus immunoglobulin for tetanus: a randomized, double-blind, active-controlled, phase 3 trial. Nat Med. 2025,31(8):2673-2681. (IF:50)

4. Jiacheng Gong, Haoyang Lu, Yuhan Li, Qihan Xu, Yuanyuan Ma, Anni Lou, Wanfu Cui, Weihua Song, Peng Qu, Zhuoer Chen, Linghao Quan, Xi Liu, Ying Meng, Xu L. ACE2 shedding exacerbates sepsis induced gut leak via loss of microbial metabolite 5-Methoxytryptophan.Microbiome,2025,13:136 Co-Corresponding Author. (IF:13.8)

5. Wu L, Geng S, Zhou Y, Jiao R, Ouyang H, Cheng S, Shang Z, Yan W, Wang J, Jia Y, Li X, Liu W. Direct and Indirect Effects of Risk Perception and Risk Information on PTSD in Frontline Healthcare Workers. Neuropsychiatr Dis Treat. 2025,21:663-676. Co-Corresponding Author.

6. Wenhan Li, Yuhan Li, Linjie Xiao, Zhanzhan Xie, Jun Peng, Wenhui Huang, Xu Li, Ying Meng. Micheliolide attenuates sepsis-induced acute lung injury by suppressing mitochondrial oxidative stress and PFKFB3-driven glycolysis. J Transl Med.2025,23:181 Co-Corresponding Author. (IF:6.1)

7. Huang W, Lou A, Wang J, Wang Y, Zhang W, Li J, Wang S, Geng S, Wang G, Li X. TMBIM1 ameliorates sepsis-induced cardiac dysfunction by promoting Parkin-mediated mitophagy. FASEB J. 2025, 39(4):e70397. Co-Corresponding Author.

8. Lin Y, Zhang Y, Li Y, Xu Q, Zhang Y, Chen T, Wang J, Li J, Gong J, Chen Z, Yang Q, Li X. EGCG suppressed activation of hepatic stellate cells by regulating the PLCE1/IP3/Ca²⁺ pathway. Eur J Nutr. 2024 Sep 26. Epub ahead of print. Corresponding Author. (IF:4.1)

9. Wang G, Ma X, Huang W, Wang S, Lou A, Wang J, Tu Y, Cui W, Zhou W, Zhang W, Li Y, Geng S, Meng Y, Li X. Macrophage biomimetic nanoparticle-targeted functional extracellular vesicle micro-RNAs revealed via multiomics analysis alleviate sepsis-induced acute lung injury. Journal of Nanobiotechnology. 2024, 22(1):362. Co-Corresponding Author. (IF:10.2)

10. Fang J, Huang P, Cui W, Lin Y, Rong D, Li X. COMPREHENSIVE THERAPEUTIC EFFICACY ANALYSIS OF INTRAVENOUS IMMUNOGLOBULIN IN TREATING SEPSIS-INDUCED COAGULOPATHY: A SINGLE-CENTER, RETROSPECTIVE OBSERVATIONAL STUDY. Shock. 2024,62(1):4-12. Co-Corresponding Author (IF:2.7)

11. Chen T, Zhang Y, Zhang Y, Ning Z, Xu Q, Lin Y, Gong J, Li J, Chen Z, Meng Y, Li Y, Li X. Autophagic degradation of MVBs in LSECs promotes Aldosterone induced-HSCs activation. Hepatol Int. 2024, 18(1):273-288. Corresponding Author. (IF:9.1)

12. Zhang Y, Zhang Y, Chen T, Lin Y, Gong J, Xu Q, Wang J, Li J, Meng Y, Li Y, Li X. Caveolin-1 depletion attenuates hepatic fibrosis via promoting SQSTM1-mediated PFKL degradation in HSCs. Free Radic Biol Med. 2023, 204:95-107. Co-Corresponding Author. (IF:8.1)

13. Guo Q, Qu P, Cui W, Liu M, Zhu H, Chen W, Sun N, Geng S, Song W, Li X, Lou A. Organism type of infection is associated with prognosis in sepsis: an analysis from the MIMIC-IV database. BMC Infect Dis. 2023, 23(1):431. Co-Corresponding Author. (IF:3.7)

14. Wang J, Li J, Lou A, Lin Y, Xu Q, Cui W, Huang W, Wang G, Li Y, Sun J, Gong J, Guo Q, Qiu H, Meng Y, Li X. Sacubitril/valsartan alleviates sepsis-induced acute lung injury via inhibiting GSDMD-dependent macrophage pyroptosis in mice. FEBS J. 2023,290(8):2180-2198. Co-Corresponding Author. (IF:5.2)

15. Wang W, Zhang Y, Huang W, Yuan Y, Hong Q, Xie Z, Li L, Chen Y, Li X, Meng Y. Alamandine/MrgD axis prevents TGF-β1-mediated fibroblast activation via regulation of aerobic glycolysis and mitophagy. J Transl Med. 2023,21(1):24. Co-Corresponding Author. (IF:8.4)

16. Hong Q, Zhang Y, Lin W, Wang W, Yuan Y, Lin J, Xie Z, Li X, Meng Y. Negative Feedback of the cAMP/PKA Pathway Regulates the Effects of Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome Activation on Type II Alveolar Epithelial Cell Pyroptosis as a Novel Mechanism of BLM-Induced Pulmonary Fibrosis. J Immunol Res. 2022. 2022: 2291877.（IF:4.1）Co-Corresponding Author  (IF:4.1)

17. Ouyang H, Geng S, Zhou Y, Wang J, Zhan J, Shang Z, Jia Y, Yan W, Zhang Y, Li X, Liu W. The increase of PTSD in front-line health care workers during the COVID-19 pandemic and the mediating role of risk perception: a one-year follow-up study. Transl Psychiatry. 2022, 12(1):180. Co-Corresponding Author. (IF:7.9)

18. Yue Zhang , Ting Li , Miaoxia Pan , Wei Wang , Wenhui Huang , Yafei Yuan, Zhanzhan Xie, Yixin Chen, Jun Peng , Xu Li , Ying Meng.SIRT1 prevents cigarette smoking-induced lung fibroblasts activation by regulating mitochondrial oxidative stress and lipid metabolism. J Transl Med,2022,20(1):222. Co-Corresponding Author. (IF:8.4)

19. Yuan Y, Wang W, Zhang Y, Hong Q, Huang W, Li L, Xie Z, Chen Y, Li X, Meng Y. Apelin-13 Attenuates Lipopolysaccharide-Induced Inflammatory Responses and Acute Lung Injury by Regulating PFKFB3-Driven Glycolysis Induced by NOX4-Dependent ROS. J Inflamm Res. 2022, 15:2121-2139. Co-Corresponding Author. (IF:6.9)

20. Wang G, Jin S, Huang W, Li Y, Wang J, Ling X, Huang Y, Hu Y, Li C, Meng Y, Li X. LPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome. Cell Death Discov. 2021;7(1):337. Co-Corresponding Author. (IF:7.1)

21. Guozhen Wang^#, Weichang Huang^#, Shuanghu Wang^#, Jun Wang^#, Wanfu Cui, Wenyong Zhang, Anni Lou, Shiyu Geng, Xu Li^*. Macrophagic Extracellular Vesicle CXCL2 Recruits and Activates the Neutrophil CXCR2/PKC/NOX4 Axis in Sepsis. The Journal of Immunology 2021 Oct 15;207(8):2118-2128. (IF:5.42)  Corresponding Author. 

22. Sun Na-Na^#, Zhang Yue^#, Huang Wen-Hui, Zheng Bo-Jun, Jin Si-Yi, Li Xu^*,  Meng Ying^*. Macrophage exosomes transfer angiotensin II type 1 receptor to lung fibroblasts mediating bleomycin-induced pulmonary fibrosis. Chinese Medical Journal 2021, 134(18): 2175-2185  (IF:2.63)  Co-Corresponding Author

23. Yue Zhang^#, Wenhui Huang^#, Zemao Zheng^#, Wei Wang, Yafei Yuan, Qiaohui Hong, Jiajia Lin, Xu Li^*, Ying Meng^*. Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis. Free Radic Biol Med 2021;166:116-127.  (IF:7.38)  Co-Corresponding Author

24. Geng S^#, Zhou Y^#, Zhang W^#, Lou A, Cai Y, Xie J, Sun J, Zhou W^*, Liu W^*, Li X^*. The influence of risk perception for COVID-19 pandemic on posttraumatic stress disorder in healthcare workers: A survey from four designated hospitals. Clin Psychol Psychother 2021 Feb 16:10.1002/cpp.2564. Epub ahead of print. (IF:2.94)Co-Corresponding Author

25. Qu R^#, Hu L^#, Ling Y, Hou Y, Fang H, Zhang H, Liang S, He Z, Fang M, Li J, Li X^*, Chen C^*. C-reactive protein concentration as a risk predictor of mortality in intensive care unit: a multicenter, prospective, observational study. BMC Anesthesiol 2020 20(1):292. (IF:2.22)Co-Corresponding Author

26. Huang Y^#, Li Y^#, Lou A, Wang GZ, Hu Y, Zhang Y, Huang W, Wang J, Li Y, Zhu X, Chen T, Lin J, Meng Y^*, Li X^*. Alamandine attenuates hepatic fibrosis by regulating autophagy induced by NOX4-dependent ROS. Clin Sci (Lond) 2020; 134(7):853-869. (IF:6.12) Co-Corresponding Author

27. Yue Li, Xintao Zhud, Guozhen Wanga, Huasheng Tongd, Lei Su^*, Xu Li^*. Proteomic analysis of extracellular vesicles released from heat-stroked hepatocytes reveals promotion of programmed cell death pathway. Biomedicine & Pharmacotherapy, 2020,129 :110489. (IF:6.53) Co-Corresponding Author

28. Li Y^#, Zhang YJ^#, Chen TT^#, Huang Y, Zhang Y, Geng SY and Li X*. Role of aldosterone in the activation of primary mice hepatic stellate cell and liver fibrosis via NLRP3 inflammasome. Journal of Gastroenterology and Hepatology 2020;35(6):1069-1077. (IF:4.03) Corresponding Author

29. Guozhen Wang^#, Siyi Jin^#, Xuguang Ling^#, Yang Li, Ye Hu, Yijie Zhang, Yun Huang, Tingting Chen, Jiayi Lin, Zuowei Ning, Ying Meng^*, Xu Li^*. Proteomic profiling of LPS-induced macrophage exosomes indicate their involvement in acute liver injury. Proteomics 2019;19(3):e1800274.  (IF:5.39) Co-Corresponding Author

30. Ying Meng ^*, Miaoxia Pan, Bojun Zheng, Yan Chen, Wei Li, Qianjie Yang, Zemao Zheng, Nana Sun, Yue Zhang, Xu Li^*, Autophagy attenuates angiotensin II-induced pulmonary fibrosis by inhibiting redox imbalance-mediated NLRP3 inflammasome activation, Antioxidants & Redox Signaling 2019;30(4): 520-541.  (IF:8.40) Corresponding Author

31. Ming Zhang, Xintao Zhu , Huasheng Tong, Anni Lou , Yue Li , Yang Li , Lei Su ^*, Xu Li^*. AVE 0991 Attenuates Pyroptosis and Liver Damage after Heatstroke by Inhibiting the ROS-NLRP3 Inflammatory Signalling Pathway. Biomed Res Int 2019:1806234. (IF:3.40) Co-Corresponding Author

32. Yue-hua You^#, Yun H^#, Dan Wang^#, Yang Li^#, Guo-zhen Wang, Si-yi Jin，Xin-tao Zhu, Bin Wu, Xin-ya Du, Xu Li^*. Angiotensin (1-7) inhibits arecoline-induced migration and collagen synthesis in human oral myofibroblasts via inhibiting NLRP3 inflammasome. J Cell Physiol 2019;234(4):4668-4680.  (IF:6.38) Corresponding Author

33. Xiaoying Luo^#, Dan Wang^#, Xintao Zhu^#, Guozhen Wang, Yuehua You, Zuowei Ning, Yang Li, Siyi Jin, Yun Huang, Ye Hu, Tingting Chen, Ying Meng^*,  Xu Li^*, Autophagic degradation of caveolin-1 promotes liver sinusoidal endothelial cells defenestration, Cell Death＆Disease 2018;9(5):576. (IF:8.47)  Co-Corresponding Author

34. Xiaoying Luo^#，Dan Wang^#，Xuan Luo，Xintao Zhu，Guozhen Wang，Zuowei Ning，Yang Li，Xiaoxin Ma，Renqiang Yang，Siyi Jin，Yun Huang，Ying Meng ^*，Xu Li^* .Caveolin 1-related autophagy initiated by aldosterone-induced oxidation promotes liver sinusoidal endothelial cells defenestration. Redox Biol 2017;13:508-521. (IF: 11.8)  Co-Corresponding Author

35. Zuo-Wei Ning, Xiao-Ying Luo, Guo-Zhen Wang, Yang Li, Miao-Xia Pan, Ren-Qiang Yang, Xu-Guang Ling, Shan Huang, Xiao-Xin Ma , Si-Yi Jin , Dan Wang , Xu Li^*. MicroRNA-21 Mediates Angiotensin II-Induced Liver Fibrosis by Activating NLRP3 Inflammasome/IL-1β Axis via Targeting Smad7 and Spry1. Antioxid Redox Signal 2017;27(1):1-20.  (IF:8.4) Corresponding Author

36. Shuang-Ming Cai^#, Ren-Qiang Yang^#, Yang Li^#, Zuo-Wei Ning, Li-Li Zhang,Gao-Su Zhou, Wei Luo, Da-Huan Li, Yan Chen, Miao-Xia Pang, Li X^*.Angiotensin-(1-7) improve liver fibrosis by regulating the NLRP3 inflammasome via redox balance modulation. Antioxid Redox Signal 2016;24(14):795-812.  (IF:8.4) Corresponding Author

37. Li-Li Zhang^#, Shan Huang^#,Xiao-Xin Ma^#, Wen-Yong Zhang, Dan Wang, Si-Yi Jin, Yan-Ping Zhang, Yang Li, Xu Li^*.Angiotensin(1-7) attenuated Angiotensin II-induced hepatocyte EMT by inhibiting NOX-derived H2O2-activated NLRP3 inflammasome/IL-1beta/Smad circuit. Free Radic Biol Med 2016; 97: 531-543.  (IF:7.38) Corresponding Author

38. Ying Meng, Ting Li, Gaosu Zhou, Yan Chen, Changhui Yu, Miaoxia Pang, WeiLi, Yang Li, Wenyong Zhang, Xu Li^*. The Angiotensin- converting enzyme2/Angiotensin (1-7)/MasR axis Protects against Lung Fibroblast Migration and Lung Fibrosis by Inhibiting the NOX4-derived ROS-mediated RhoA/Rho kinase Pathway. Antioxid Redox Signal 2015; 22(3):241-258(IF:8.4) Corresponding Author

39. Ying Meng, Changhui Yu, Wei Li, Ting Li, Wei Luo, Shan Huang, Pingsheng Wu,Shaoxi Cai, Xu Li^*. Angiotensin-converting enzyme 2/Angiotensin-(1-7)/MasR axis protects against lung fibrosis by inhibiting the MAPK/NF-κB pathway. Am J Respir Cell Mol Biol 2014;50(4): 723-736. (IF:6.9) Corresponding Author

40. Huang ML^#, Li X^#, Meng Y, Xiao B, Ma Q, Ying SS, Wu PS, Zhang ZS^*. Upregulation of angiotensin-converting enzyme (ACE) 2 in hepatic fibrosis by ACE inhibitors. Clin Exp Pharmacol Physiol 2010;37(1):e1-6. 

41. Li X*, Meng Y*, Wu P, Zhang Z, Yang X. Angiotensin II and Aldosterone stimulating NF-kappaB and AP-1 activation in hepatic fibrosis of rat. Regul Pept 2007;138(1):15-25.