南方医科大学教师信息

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1. 个人简介
2. 研究领域
3. 发表论文

更新日期：2024年2月6日

姓名	杨志禄	性别	男
民族	汉族	导师层次	博士导师
技术职称	研究员	导师类型	学术型
最后学历	博士研究生毕业	最后学位	工学博士
行政职务		Email	zhiluyang1029@smu.edu.cn
工作单位	南方医科大学第十附属医院	邮政编码	523059

个人简介

杨志禄，南方医科大学高层次引进人才，特聘研究员，博士/博士后导师，中国生物材料学会科学技术奖一等奖及四川省科学技术进步奖三等奖获得者，广州南创珠峰医疗科技有限公司董事会董事。现任国际期刊Smart Materials in Medicine（入选国家卓越计划高起点新刊）创刊主编、中国科协旗舰刊Research副主编（Deputy Editor）、Bioactive Materials编委及Engineered Regeneration编委。担任中国解剖学会血管分会副主任委员、中国生物材料学会康复器械与生物材料分会常务委员、以及中国生物材料学会下属二级分会等5学术组织的委员及青年委员等职。研究方向聚焦心血管动脉粥样硬化病理发病机制及用于心血管疾病治疗的心血管支架研究。主持国家自然科学基金内地-香港联合项目、广东省基础与应用基础研究基金--粤港澳研究团队项目及四川省杰出青年科学基金等省级/国家级项目10余项（在研科研项目经费1000余万）。以通讯/第一作者在包括PNAS, Nature Communications, Advanced Functional Materials, Research，Advanced Science, Biomaterials，Bioactive Materials等期刊共发表论文60余篇（IF＞10的论文35篇，其中近5年论文平均IF＞14）。获得授权发明专利26项（转化5项）。一项血管支架涂层专利技术以1500万作价入股实施了转化，研发的新一代具有调控病变血管再生修复功能的可降解镁合金支架进入到产业化工程和申报检验阶段。

研究领域

1）心血管动脉粥样硬化（AS）病理发病机制；

2）用于AS引起的心血管疾病预防性治疗的纳米机器人、微纳米靶向药物；

3）药物球囊；

4）具有调控病变血管再生修复及病灶治愈功能的冠脉、外周及颅内血管支架；

5）心血管植入/介入器械芯片；

6）具有长效抗凝、抗感染及超润滑功能的导管；

7）可回收下腔静脉滤器。

个人成果

一、主持科研及人才项目情况：

（9）东莞市社会发展科技项目（高水平医院建设专项）（项目号：20231800906311），具有原位调控病变血管再生修复功能的心血管支架研究，2023/03-2026/02，100万，主持（在研）。

（8）国家自然科学基金-国际(地区)合作与交流项目（项目号：32261160372），具有时序调控病变血管再生修复功能的Janus血管支架研究，2023/01-2026/12，100万（配套100万），主持（在研）。

（7）广东省基础与应用基础研究基金：区域联合基金-粤港澳研究团队项目，（项目号：2022B1515130010），具有原位调控病变血管再生修复功能的心血管支架研究，2022/10-2026/09，200万（配套200万），主持（在研）。

（6）南方医科大学高层次人才支持与发展计划（项目号：K202102），具有调控病变血管再生修复功能的血管支架研究，2021/06-2024/06，300万，主持（在研）。

（5）国家自然科学基金-面上项目（项目号：82072072），具有一氧化氮催化和免疫抑制剂可控释放的聚肟氨酯涂层改性镁合金血管支架研究，2021/01-2024/12，56万，主持（在研）。

（4）四川省国际科技创新合作项目（项目号：2021YFH0056），具有仿生内皮功能和细胞外基质结构的水凝胶支架涂层构建及抗再狭窄和抗血栓研究，2021/04-2023/03，30万，主持（在研）。

（3）四川省杰出青年基金（项目号：2016JQ0027），基于原位一氧化氮催化释放的内皮功能仿生涂层血管支架研究，2016/03-2019/03，50万，主持（结题）。

（2）国家自然科学基金-面上项目（项目号：31570957），原位催化持续、稳定、可控释放一氧化氮的内皮功能仿生涂层研究，2016/01-2019/12，61万，主持（结题）。

（1）国家自然科学基金-青年科学基金项目（项目号：81501596），具有原位催化一氧化氮释放的内皮功能仿生涂层用于心血管支架表面改性研究，2016/01-2018/12，18万，主持（结题）。

二、代表性通讯/第一作者论文（注：^*表示通讯作者，^#表示共同第一作者）：

(41) Wentai Zhang, Jiangling Zhang, Fangkun Hu, Wenxuan Wang, Zeyu Du, You Ke, Qing Ma, Xiaohui Mou*, Jing Lu*, Zhilu Yang*. Active dual-protein coating assisted by stepwise protein-protein interactions assembly reduces thrombosis and infection. Advanced Science. 2024. (IF=15.1, Accept).

(40) Wentai Zhang, Linxian Cui, Chaoming Xie, Zeyu Du, Xiaohui Mou, You Ke, Qing Ma, Wenjie Tian*, Zhilu Yang*. Glycocalyx-inspired dynamic antifouling surfaces for temporary intravascular devices. Biomaterials. 2024;304:122427. (IF=14.0).

(39) Nan Lyu#, Daihua Deng#, Yuting Xiang, Zeyu Du, Xiaohui Mou, Qing Ma, Nan Huang, Jing Lu*, Xin Li, Zhilu Yang*, Wentai Zhang*. An insect sclerotization-inspired antifouling armor on biomedical devices combats thrombosis and embedding. Bioactive Materials. 2024;33:562-571. (IF=18.9).

(38) Xiaohui Mou, Wan Miao, Wentai Zhang, Wenxuan Wang, Qing Ma, Zeyu Du, Xin Li, Nan Huang*, Zhilu Yang*. Zwitterionic polymers-armored amyloid-like protein surface combats thrombosis and biofouling. Bioactive Materials. 2024;32:37-51. (IF=18.9, Cover).

(37) Jiajia Wei#, Wentai Zhang#, Xiaohui Mou, Haotian Meng, Qing Ma, Wenxuan Wang, Xin Li*, Qiufen Tu, Wenjie Tian*, Nan Huang, Zhilu Yang*. Bioinspired hemostatic and anti-infective armor for wound healing assisted by metal-phenol-polyamine system. Advanced Functional Materials. 2023;2306267. (IF=19.0).

(36) Jingdong Rao#, Xiaohui Mou#, Yongyi Mo, Ho-Pan Bei, Li Wang, Chuyang Y. Tang, Kai-Hang Yiu, Zhilu Yang*, Xin Zhao*. Gas station in blood vessels: an endothelium mimicking, self-sustainable nitric oxide fueling stent coating for prevention of thrombosis and restenosis. Biomaterials. 2023;302:122311. (IF=14.0).

(35) Qian Liu#, Xueliang Peng#, Xiaojia Liu, Xiaohui Mou, Yayuan Guo, Lihua Yang, Yufei Chen, Yaying Zhou, Zhuoya Shi, Zhilu Yang*, Zhuoyue Chen*. Advances in the application of bone morphogenetic proteins and their derived peptides in bone defect repair. Composites Part B. 2023;262:110805. (IF=13.1).

(34) Ying Wang*, Nan Huang, Zhilu Yang*. Revealing the role of zinc ions in atherosclerosis therapy via an engineered three-dimensional pathological model. Advanced Science. 2023;10: 2300475 (IF=15.1).

(33) Zhenglong Dou, Shuiling Chen, Jiacheng Wang, Li Xia, Manfred F. Maitz, Qiufen Tu, Wengtai Zhang, Zhilu Yang*, Nan Huang*. A “built-up” composite film with synergistic functionalities on Mg-2Zn-1Mn bioresorbable stents improves corrosion control effects and biocompatibility. Bioactive Materials. 2023;25:223–238. (IF=16.874).

(32) Lei Zhou, Lu Zhang, Peichuang Li, Manfred F. Maitz, Kebing Wang, Tengda Shang, Sheng Dai, Yudie Fu, Yuancong Zhao, Zhilu Yang*, Jin Wang*, Xin Li*. Adhesive and Self-Healing Polyurethanes with Tunable Multifunctionality. Research. 2022;2022:9795682. (IF=11.036).

(31) Xiaohui Mou^#, Hongbo Zhang^#, Hua Qiu^#, Wentai Zhang, Ying Wang, Kaiqin Xiong, Nan Huang*, Hélder A. Santos*, Zhilu Yang*. Mussel-inspired and bioclickable peptide engineered surface to combat thrombosis and infection. Research. 2022;9780879 (IF=11.036).

(30) Jie Sun, Yingkang Huang, Huan Zhao, Junjie Niu, Xuwei Ling, Can Zhu, Lin Wang, Huilin Yang, Zhilu Yang*, Guoqing Pan*, Qin Shi*. Bio-clickable mussel-inspired peptides improve titanium-based material osseointegration synergistically with immunopolarization-regulation. Bioactive Materials. 2022;9:1-14 (IF=16.874).

(29) Ying Wang, Ranjith Kumar Kankala, Caiwen Ou, Aizheng Chen*, Zhilu Yang*. Advances in hydrogel-based vascularized tissues for tissue repair and drug screening. Bioactive Materials. 2022;9:198-220 (IF=16.874).

(28) Yin Chen^#, Peng Gao^#, Lu Huang, Xing Tan, Ningling Zhou, Tong Yang, Hua Qiu, Xin Dai, Sean Michael, Qiufen Tu, Nan Huang, Zhihong Guo, Jianhua Zhou*, Zhilu Yang*, Hongkai Wu*. A tough nitric oxide-eluting hydrogel coating suppresses neointimal hyperplasia on vascular stent. Nature Communications. 2021;12:7079 (IF=17.694).

(27) Qing Ma^#, Xiuying Shi^#, Xing Tan, Rui Wang, Kaiqin Xiong, Manfred F. Maitz, Yuanyuan Cui, Zhangmei Hu, Qiufen Tu*, Nan Huang, Li Shen*, Zhilu Yang*. Durable endothelium-mimicking coating for surface bioengineering cardiovascular stents. Bioactive Materials. 2021;12:4786-4800 (IF=16.874).

(26) Han Yu^#, Hua Qiu^#, Wenmei Ma, Manfred F. Maitz, Qiufen Tu, Kaiqin Xiong, Jiang Chen*, Nan Huang*, Zhilu Yang*. Endothelium-Mimicking Surface Combats Thrombosis and Biofouling via Synergistic Long- and Short-Distance Defense Strategy. Small. 2021;2100729. (IF=15.153).

(25) Wenxuan Wang^#, Lei Lu^#, Bei Ho Pan^#, Xiangyang Li, Zeyu Du, Manfred F. Maitz, Qiufen Tu^*, Nan Huang, Xin Zhao^*, Zhilu Yang^*. Self-protonating, plasma polymerized, superimposed multi-layered biomolecule nanoreservoir as blood-contacting surfaces. Chemical Engineering Journal. 2021;410:128313. (IF=16.744).

(24) Hua Qiu, Qiufen Tu, Peng Gao, Xiangyang Li, Manfred F. Maitz, Kaiqin Xiong^*, Nan Huang, Zhilu Yang^*. Phenolic-amine chemistry mediated synergistic modification with polyphenols and thrombin inhibitor for combating the thrombosis and inflammation of cardiovascular stents. Biomaterials. 2021;269:120626 (IF=15.304).

(23) Han Yu, Shaoxing Yu, Hua Qiu, Peng Gao, Yingzhong Chen, Xin Zhao, Qiufen Tu, Minggang Zhou^*, Lin Cai, Nan Huang, Kaiqin Xiong^*, Zhilu Yang^*. Nitric oxide-generating compound and bio-clickable peptide mimic for synergistically tailoring surface anti-thrombogenic and anti-microbial dual-functions. Bioactive Materials. 2021;6:1618-1627 (IF=16.874).

(22) Nan Lyu, Zeyu Du, Hua Qiu, Peng Gao, Qin Yao, Kaiqin Xiong, Qiufen Tu, Xiangyang Li, Binghai Chen, Guoqing Pan^*, Nan Huang^*, Zhilu Yang^*. Mimicking the Nitric Oxide-Releasing and Glycocalyx Functions of Endothelium on Vascular Stent Surfaces. Advanced Science. 2020;7:202002330 (IF=17.521).

(21) Zhilu Yang^#, Xin Zhao^#, Rui Hao, Qiufen Tu, Xiaohua Tian, Yu Xiao, Kaiqin Xiong, Miao Wang, Yonghai Feng, Nan Huang^*, Guoqing Pan^*. Bio-clickable and Mussel Adhesive Peptide Mimics for Engineering Vascular Stent Surfaces. PNAS. 2020;117:16127-16137 (IF=12.779).

(20) Yu Xiao, Wenxuan Wang, Xiaohua Tian, Xing Tan, Tong Yang, Peng Gao, Kaiqing Xiong, Qiufen Tu, Miao Wang, Manfred F. Maitz, Nan Huang, Guoqing Pan^*, Zhilu Yang^*. A Versatile Surface Bioengineering Strategy Based on Mussel-Inspired and Bioclickable Peptide Mimic. Research. 2020;7236946 (IF=11.036).

(19) Ying Yang, Peng Gao, Juan Wang, Qiufen Tu, Long Bai, Kaiqin Xiong, Hua Qiu, Xin Zhao, Manfred F. Maitz, Huaiyu Wang, Xiangyang Li, Qiang Zhao, Yin Xiao, Nan Huang^*, Zhilu Yang^*. Endothelium-Mimicking Multifunctional Coating Modified Cardiovascular Stents via a Stepwise Metal-Catechol-(Amine) Surface Engineering Strategy. Research. 2020;9203906 (IF=11.036).

(18) Peng Gao, Hua Qiu, Kaiqin Xiong, Xiangyang Li, Qiufen Tu, Huaiyu Wang, Nan Lyu, Xiao Chen, Nan Huang^*, Zhilu Yang^*. Metal-Catechol-(Amine) Networks for Surface Synergistic Catalytic Modiﬁcation: Therapeutic Gas Generation and Biomolecule Grafting. Biomaterials. 2020;248:119981 (IF=15.304).

(17) Xiangyang Li^#, Jingxia Liu^#, Tong Yang, Hua Qiu, Lei Lu, Qiufen Tu, Kaiqing Xiong, Nan Huang^*, Zhilu Yang^*. Mussel-inspired “built-up” surface chemistry for combining nitric oxide catalytic and vascular cell selective properties. Biomaterials. 2020;241:119904 (IF=15.304).

(16) Tong Yang, Zeyu Du, Hua Qiu, Peng Gao, Xin Zhao, Huaiyu Wang, Qiufen Tu, Kaiqin Xiong, Nan Huang, Zhilu Yang^*. From surface to bulk modification: Plasma polymerization of amine-bearing coating by synergic strategy of biomolecule grafting and nitric oxide loading. Bioactive Materials. 2020;5:17-25 (IF=16.874).

(15) Hua Qiu^#, Pengkai Qi^#, Xing Tan, Yu Xiao, Jingxia Liu, Lei Lu, Peng Gao, Ying Yang, Nan Huang^*, Zhilu Yang^*. Biomimetic Engineering Endothelium-like Coating on Cardiovascular Stent through Heparin and Nitric Oxide-Generating Compound Synergic Modification Strategy. Biomaterials. 2019;207:10-22 (IF=15.304).

(14) Feng Zhang^#, Qiang Zhang^#, Xiangyang Li, Nan Huang, Xin Zhao^*, Zhilu Yang^*. Mussel-inspired dopamine-Cu^II coatings for sustained in situ generation of nitric oxide for prevention of stent thrombosis and restenosis. Biomaterials. 2019;194:117-129 (IF=15.304).

(13) Xiangyang Li, Peng Gao, Jianying Tan, Kaiqin Xiong, Changjiang Pan, Hongkai Wu, Yin Chen, Zhilu Yang^*, Nan Huang^*. Assembly of Metal-Phenolic/Catecholamine Networks for Synergistically Anti-Inflammatory, Antimicrobial and Anticoagulant Coatings. ACS Applied Materials & Interfaces. 2018;10:40844-40853 (IF=10.383).

(12) Zhilu Yang^*, Ying Yang, Kaiqin Xiong, Jin Wang, Haeshin Lee^*, Nan Huang^*, Metal-Phenolic Surfaces for Generating Therapeutic Nitric Oxide Gas. Chemistry of Materials. 2018;30:5220-5226 (IF=10.508).

(11) Zhilu Yang^*, Ying Yang, Li Zhang, Kaiqin Xiong, Xiangyang Li, Feng Zhang, Jin Wang, Xin Zhao*, Nan Huang^*, Mussel-inspired Catalytic Selenocystamine-Dopamine Coatings for Long-Term Generation of Therapeutic Gas on Cardiovascular Stents. Biomaterials. 2018;178:1-10 (IF=15.304).

(10) Xiangyang Li, Hua Qiu, Peng Gao, Ying Yang, Zhilu Yang^*, Nan Huang^*, Synergetic coordination- and catecholamine chemistry for catalytic generation of nitric oxide on vascular stents. NPG Asia Materials. 2018;10:482-496 (IF=10.761).

(9) Ying Yang, Xiangyang Li, Hua Qiu, Ping Li, Manfred F. Maitz, Tianxue You, Ru Shen, Zhilu Yang^*, Wenjie Tian^*, and Nan Huang^*. Polydopamine modified TiO₂ nanotube arrays for long term controlled elution of bivalirudin and improved hemocompatibility. ACS Applied Materials & Interfaces. 2018;10:7649−7660 (IF=10.383).

(8) Zhilu Yang*, Hua Qiu, Xiangyang Li, Peng Gao, Nan Huang*, Plant-inspired gallolamine catalytic surface chemistry for engineering an efficient nitric oxide generating coating. Acta Biomaterialia. 2018;76:89-98 (IF=10.633).

(7) Zhilu Yang^*, Ying Yang, Kaiqin Xiong, Xiangyang Li, Pengkai Qi, Qiufen Tu, Fengjuan Jing, Yajun Weng, Jin Wang^*, Nan Huang^*. Nitric oxide producing coating mimicking endothelium function for multifunctional vascular stents. Biomaterials. 2015;63:80-92 (IF=15.304).

(6) Zhilu Yang^*, Kaiqin Xiong, Pengkai Qi, Ying Yang, Qiufen Tu, Jin Wang^*, Nan Huang^*. Gallic acid tailoring surface functionalities of plasma-polymerized allylamine-coated 316L SS to selectively direct vascular endothelial and smooth muscle cell fate for enhanced endothelialization. ACS Applied Materials & Interfaces. 2014;6:2647-2656 (IF=10.383).

(5) Ying Yang, Pengkai Qi, Feng Wen, Xiangyang Li, Qin Xia, Manfred F. Maitz, Zhilu Yang^*, Ru Shen, Qiufen Tu, Nan Huang^*. Mussel-inspired one-step adherent coating rich in amine groups for covalent immobilization of heparin: hemocompatibility, growth behaviors of vascular cells and tissue response. ACS Applied Materials & Interfaces. 2014;6:14608-14620 (IF=10.383).

(4) Zhilu Yang^#,*, Ying Yang^#, Wei Yan, Qiufen Tu^*, Jin Wang^*, Nan Huang. Construction of polyfunctional coatings assisted by gallic acid to facilitate co-immobilization of diverse biomolecules. ACS Applied Materials & Interfaces. 2013;5:10495-10501 (IF=10.383).

(3) Zhilu Yang, Qiufen Tu^*, Manfred F. Maitz, Shou Zhou, Jin Wang, Nan Huang^*. Direct thrombin inhibitor-bivalirudin functionalized plasma polymerized allylamine coating for improved biocompatibility of vascular devices. Biomaterials. 2012;33:7959-7971 (IF=15.304).

(2) Zhilu Yang^*, Qiufen Tu, Jin Wang^*, Nan Huang^*. The role of heparin binding surface in the direction of endothelial and smooth muscle cell fate and re-endothelialization. Biomaterials. 2012;33:6615-6625 (IF=15.304).

(1) Zhilu Yang, Jin Wang^*, Rifang Luo, Manfred F. Maitz, Fengjuan Jing, Hong Sun, Nan Huang. The covalent immobilization of heparin to pulsed-plasma polymeric allylamine films on 316L stainless steel and the resulting effects on hemocompatibility. Biomaterials. 2010;31:2072–2083 (IF=15.304).