目录
更新日期:2021年9月13日
姓 名 徐湘民 性 别
民 族 汉族 导师层次 博士导师
技术职称 教授 导师类型 学术型
最后学历 硕士研究生毕业 最后学位 硕士
行政职务 其他 Email xixm@smu.edu.cn
工作单位 基础医学院 邮政编码 510515
个人简介

徐湘民教授,国家杰青,中华医学会医学遗传分会主任委员,全国产前诊断专家组成员,遗传咨询师国家职业标准专家委员会成员,出生缺陷防控关键技术国家工程实验室技术委员会委员,广东省遗传学会理事长,广东“特支计划”杰出人才入选者。主持国家科技支撑计划及国家自然科学基金重点基金项目等42项,带领团队从事我国南方重大区域性遗传性疾病—地中海贫血的基础及临床应用研究35年,阐明了该病的主要遗传病因,推动了临床诊断和人群预防,出版专著《临床遗传咨询》和《地中海贫血预防控制操作指南》,在Am J Hum Genet, PNAS和Blood等杂志上发表论文190篇。获国家科技进步二等奖1项,遗传检测技术获5项国家发明专利。

研究领域

血红蛋白病

医学遗传咨询

单基因病分子机制研究

个人成果
1.Gong Y, Zhang X, Zhang Q, Zhang Y, Ye Y, Yu W, Shao C, Yan T, Huang J, Zhong J, Wang L, Li Y, Wang L, Xu X. A natural DNMT1 mutation elevates the fetal hemoglobin via epigenetic de-repression of γ-globin gene in β-thalassemia. Blood. 2020 Nov 23:blood.2020006425. doi: 10.1182/blood.2020006425. Online ahead of print.(IF:17.794)
2.Huang P, Zhao Y, Zhong J, Zhang X, Liu Q, Qiu X, Chen S, Yan H, Hillyer C, Mohandas N, Pan X, Xu X. Putative regulators for the continuum of erythroid differentiation revealed by single-cell transcriptome of human BM and UCB cells. Proc Natl Acad Sci U S A. 2020 Jun 9;117(23):12868-12876.(IF:9.35)
3.Li Z, Shang X, Luo S, Zhu F, Wei X, Zhou W, Ye Y, Yan T, Cai R, Xu X. Characterization of two novel Alu element-mediated α-globin gene cluster deletions causing α0-thalassemia by targeted next-generation sequencing. Mol Genet Genomics. 2020 Mar;295(2):505-514.(IF:2.797)
4.Cheng Y, Cai D, Shang X, Pang D, Wei X, Zhong J, Xu X. A combination of the (αα)GZ and --SEA deletions causing a severe form of hemoglobin H disease. Int J Lab Hematol. 2020 Apr;42(2):e80-e83.(IF:2.14)
5.Zhang L, Zhang Q, Tang Y, Cong P, Ye Y, Chen S, Zhang X, Chen Y, Zhu B, Cai W, Chen S, Cai R, Guo X, Zhang C, Zhou Y, Zou J, Liu Y, Chen B, Yan S, Chen Y, Zhou Y, Ding H, Li X, Chen D, Zhong J, Shang X, Liu X, Qi M, Xu X. LOVD-DASH: A Comprehensive LOVD Database Coupled with Diagnosis and an At-risk Assessment System for Hemoglobinopathies. Hum Mutat. 2019 Dec;40(12):2221-2229.(IF:4.45)
6.Pang D, Shang X, Cai D, Zhu F, Cheng Y, Zhong J, Yi S, Zhang Q, Xu X. Thalassaemia intermedia caused by coinheritance of a β-thalassaemia mutation and a de novo duplication of α-globin genes in the paternal allele. Br J Haematol. 2019 Aug;186(4):620-624.(IF:5.51)
7.Zhu F, Wei X, Cai D, Pang D, Zhong J, Liang M, Zuo Y, Xu X, Shang X. A novel 223 kb deletion in the beta-globin gene cluster was identified in a Chinese thalassemia major patient. Int J Lab Hematol. 2019, 41 (4), 456-460(IF:2.14)
8.Yang X, Zhou Q, Zhou W, Zhong M, Guo X, Wang X, Fan X, Yan S, Li L, Lai Y, Wang Y, Huang J, Ye Y, Zeng H, Chuan J, Du Y, Ma C, Li P, Song Z, Xu X. A Cell-free DNA Barcode-Enabled Single-Molecule Test for Noninvasive Prenatal Diagnosis of Monogenic Disorders: Application to β-Thalassemia. Adv Sci (Weinh). 2019 Apr 1; 6(11):1802332. (IF:15.804)
9.Pu J, Zhang L, Wei X, Xu X. Clinical Genotyping by Next Generation Sequencing Reveals a Novel, De Novo β-Globin Gene Mutation Causing Hemolytic Anemia in a Chinese Individual. Hemoglobin. 2018 Oct 2:1-5.(IF:0.52)
10.Zhao S, Xiang J, Fan C, Asan, Shang X, Zhang X, Chen Y, Zhu B, Cai W, Chen S, Cai R, Guo X, Zhang C, Zhou Y, Huang S, Liu Y, Chen B, Yan S, Chen Y, Ding H, Guo F, Wang Y, Zhong W, Zhu Y, Wang Y, Chen C, Li Y, Huang H, Mao M, Yin Y, Wang J, Yang H, Xu X, Sun J, Peng Z. Pilot study of expanded carrier screening for 11 recessive diseases in China: results from 10,476 ethnically diverse couples. Eur J Hum Genet. 2018 Oct 1(IF:3.657)
11.Li Y, Liu D, Zhang X, Li Z, Ye Y, Liu Q, Shen J, Chen Z, Huang H, Liang Y, Han X, Liu J, An X, Mohandas N, Xu X. miR-326 regulates HbF synthesis by targeting EKLF in human erythroid cells. Exp Hematol. 2018 Jul; 63: 33-40.
(IF:2.82)
12.He F, Zhou W, Cai R, Yan T, Xu X. Systematic assessment of the performance of whole-genome amplification for SNP/CNV detection and β-thalassemia genotyping. J Hum Genet. 2018 Apr; 63(4):407-416. doi: 10.1038/s10038-018-0411-5.(IF:2.83)
13.Li Y, Liu D, Li Z, Zhang X, Ye Y, Liu Q, Shen J, Chen Z, Huang H, Liang Y, Han X, Liu J, An X, Mohandas N, Xu X. Role of tissue-specific promoter DNA methylation in regulating the human EKLF gene. Blood Cells Mol Dis. 2018 Jul; 71: 16-22. doi: 10.1016/j.bcmd.2018.01.004.(IF:2.46)
14.Chen D, Zuo Y, Zhang X, Ye Y, Bao X, Huang H, Tepakhan W, Wang L, Ju J, Chen G, Zheng M, Liu D, Huang S, Zong L, Li C, Chen Y, Zheng C, Shi L, Zhao Q, Wu Q, Fucharoen S, Zhao C, Xu X. A Genetic Variant Ameliorates β-Thalassemia Severity by Epigenetic-Mediated Elevation of Human Fetal Hemoglobin Expression. Am J Hum Genet. 2017 Jul 6;101(1):130-138. (IF:9.0249)(IF:10.5)
15.Shang X, Peng Z, Ye Y, Asan, Zhang X, Chen Y, Zhu B, Cai W, Chen S, Cai R, Guo X, Zhang C, Zhou Y, Huang S, Liu Y, Chen B, Yan S, Chen Y, Ding H, Yin X, Wu L, He J, Huang D, He S, Yan T, Fan X, Zhou Y, Wei X, Zhao S, Cai D, Guo F, Zhang Q, Li Y, Zhang X, Lu H, Huang H, Guo J, Zhu F, Yuan Y, Zhang L, Liu N, Li Z, Jiang H, Zhang Q, Zhang Y, Juhari WKW, Hanafi S, Zhou W, Xiong F, Yang H, Wang J, Zilfalil BA, Qi M, Yang Y, Yin Y, Mao M, Xu X. Rapid Targeted Next-Generation Sequencing Platform for Molecular Screening and Clinical Genotyping in Subjects with Hemoglobinopathies. EBio Medicine. 2017 Aug 17. pii: S2352-3964(17)30332-8.(IF:6.68)
16.Shang X, Xu X. Update in the genetics of thalassemia: What clinicians need to know? Best Pract Res Clin Obstet Gynaecol. 2017 Jan;38(1):95-104.  pii: S1521-6934(16)30120-1.(IF:3.99)