目录
更新日期:2021年9月9日
姓 名 姜勇 性 别
民 族 汉族 导师层次 博士导师
技术职称 教授 导师类型 学术型
最后学历 博士研究生毕业 最后学位 医学博士
行政职务 教研室主任 Email jiang48231@163.com
工作单位 基础医学院 邮政编码 510515
个人简介

        姜勇教授是广东省蛋白质组学重点实验室主任,长期从事炎症与感染的细胞信号转导机制研究,为炎症相关信号分子的鉴定与功能研究做出了重要贡献。先后发表SCI论文128篇,包括Nature、AJRCCM、Hepatology、J Clin Invest、J Hepatol、Nat Commun、Cell Death Diff、EMBO J、Clin Infect Dis、J Control Release、Arterioscler Thromb Vasc Biol、J Immunol、J Biol Chem等重要国际期刊,合计影响因子超过700,被Science、Nature、Cell等国际期刊他引超过5600次。担任中国病理生理学会常务理事、休克专业委员会主任委员,Frontiers in Medicine Intensive Care Medicine and Anesthesiology 期刊副主编,Shock期刊编委、PLOS ONE期刊学术编辑,曾获军队科技进步一等奖1项、二等奖2项、国家科技进步三等奖1项、国家发明四等奖1项、广东省科学技术奖一等奖1项等科技成果。曾获中国青年科技奖、求是杰出青年(实用工程)奖,被评为解放军总后勤部科技银星、广州市第七届杰出青年、百千万人才工程国家级人选。先后负责承担了国家科技部“973”计划项目、国家“863”计划课题、国家自然科学基金杰出青年基金项目、国家自然科学基金重点项目、NSFC-广东联合基金重点项目等多项科研基金。被科技部聘为“973”计划项目首席科学家,被广东省政府聘为“珠江学者”特聘教授,被教育部聘为“长江学者”特聘教授。2019年入选“广东特支计划”杰出人才项目。

研究领域

炎症的细胞信号转导机制

脓毒症的分子基础及其治疗策略

个人成果
[1] Yan Z#, Luo H#, Xie B, Tian T, Li S, Chen Z, Liu J, Zhao X, Zhang L, Deng Y, Billiar TR*, Jiang Y*. Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis. Nat Commun 2021; 12(1):308.
[2] Li R#, Xie L#, Li L#, Chen X#, Yao T, Tian Y, Li Q, Wang K, Huang C, Li C, Li Y, Zhou H, Kaplowitz N, Jiang Y*, Chen P*, The gut microbial metabolite, 3,4-dihydroxyphenylpropionic acid, alleviates hepatic ischemia/reperfusion injury via mitigation of macrophage pro-inflammatory activity in mice, Acta Pharmaceutica Sinica B, https://doi.org/10.1016/j.apsb.2021.05.029. In Press
[3] Xu S, Dai Z, Guo P, Fu X, Liu S, Zhou L, Tang W, Feng T, Chen M, Zhan L, Wu T, Hu E, Jiang Y*, Bo X*, Yu G*. ggtreeExtra: Compact visualization of richly annotated phylogenetic data. Mol Biol Evol 2021;38(9):4039-42.
[4] Lan J#, Luo H#, Wu R, Wang J, Zhou B, Zhang Y, Jiang Y*, Xu J*. Internalization of HMGB1 (High Mobility Group Box 1) promotes angiogenesis in endothelial cells. Arterioscler Thromb Vasc Biol 2020; 40(12):2922-2940.
[5] Chen X, Liu Y, Dolin H, Liu J, Jiang Y*, Pan ZK*. Pinaverium bromide attenuates lipopolysaccharide-induced excessive systemic inflammation via inhibiting neutrophil priming. J Immunol. 2021;206(8):1858-1865.
[6] Wang J, Luan Y, Fan EK, Scott MJ, Li Y, Billiar TR, Wilson MA, Jiang Y*, Fan J*. TBK1/IKKε negatively regulate LPS-induced neutrophil necroptosis and lung inflammation. Shock 2021; 55(3):338-348.
[7] Wang J#, Han Q#, Liu H, Luo H, Li L, Liu A*, Jiang Y*. Identification of Radiotherapy-Associated Genes in Lung Adenocarcinoma by an Integrated Bioinformatics Analysis Approach. Front Mol Biosci. 2021;8: 624575.
[8] Bei T, Cao X, Liu Y, Li J, Luo H, Huang L, Tian T, Li L, Jiang Y*. Antioxidant fusion protein SOD1-Tat increases the engraftment efficiency of total bone marrow cells in irradiated mice. Molecules 2021; 26(11): 3395.
[9] Han Q#, Wang J#, Luo H#, Li L, Lu X, Liu A*, Deng Y*, Jiang Y*. TMBIM6, a potential virus target protein identified by integrated multiomics data analysis in SARS-CoV-2-infected host cells. Aging 2021;13(7):9160-9185.
[10] Li K#, Chen G#, Luo H, Li J, Liu A, Yang C, Wang J, Xu J, Chen P*, Jiang Y*. MRP8/14 mediates macrophage efferocytosis through RAGE and Gas6/MFG-E8, and induces polarization via TLR4-dependent pathway. J Cell Physiol 2021; 236(2):1375-1390.
[11] Wang LG, Lam TT, Xu S, Dai Z, Zhou L, Feng T, Guo P, Dunn CW, Jones BR, Bradley T, Zhu H, Guan Y, Jiang Y, Yu G*. Treeio: An R package for phylogenetic tree input and output with richly annotated and associated data. Mol Biol Evol 2020; 37(2):599-603.
[12] Qu Y, Yang C, Li X, Luo H, Li S, Niu M, Chen P*, Yan Z*, Jiang Y*. CpG-oligodeoxynucleotides alleviate tert-butyl hydroperoxide-induced macrophage apoptosis by regulating mitochondrial function and suppressing ROS production. Oxid Med Cell Longev 2020; 2020:1714352
[13] Lin M, Luo H, Liang S, Chen J, Liu A*, Niu L*, Jiang Y*. Pembrolizumab plus allogeneic NK cells in advanced non-small cell lung cancer patients. J Clin Invest 2020; 130(5):2560-2569.
[14] Lu X, Wang J, Chen X, Jiang Y*, Pan ZK*. Rolipram protects mice from gram-negative bacterium Escherichia coli-induced inflammation and septic shock. Sci Rep 2020; 10(1):175.
[15] Zhang Y#, Zhao J#, Cai J#, Ye JC, Xiao YT, Mei Y, Zeng MS, Xie CM*, Jiang Y*, Feng GK*. Integrin α6-targeted magnetic resonance imaging of hepatocellular carcinoma in mice. Mol Imaging Biol 2020; 22: 864-872.
[16] Niu M#, Luo Z#, Gong S, Win S, Kaplowitz N, Jiang Y*, Chen P*. Intestinal epithelial chemokine (C-C motif) ligand 7 overexpression enhances acetaminophen-induced hepatotoxicity in mice. Am J Pathol 2020; 190(1): 57-67.
[17] Wang F#, Gong S#, Wang T#, Li L#, Luo H, Wang J, Huang C, Zhou H, Chen G, Liu Z, Zhang Q, Jiang Y*, Chen P*. Soyasaponin II protects against acute liver failure through diminishing YB-1 phosphorylation and Nlrp3-inflammasome priming in mice. Theranostics 2020; 10(6): 2714-2726.
[18] Li L#, Chen L#, Lu X#, Huang C#, Luo H, Jin J, Mei Z, Liu J, Liu C, Shi J, Chen P, Jiang Y*. Data-independent acquisition-based quantitative proteomics analysis reveals dynamic network profiles during the macrophage inflammatory response. Proteomics 2020; 20(2): e1900203.
[19] Gong S#, Yan Z#, Liu Z#, Niu M#, Fang H, Li N, Huang C, Li L, Chen G, Luo H, Chen X, Zhou H, Hu J, Yang W, Huang Q, Schnabl B, Chang P*, Billiar TR, Jiang Y*, Chen P*. Intestinal microbiota mediates the susceptibility to polymicrobial sepsis-induced liver injury by granisetron generation in mice. Hepatology 2019; 69(4): 1751-1767.
[20] Zhong Y, Ye P, Mei Z, Huang S, Huang M, Li Y, Niu S, Zhao S, Cai J, Wang J, Zou H, Jiang Y*, Liu J*. The novel methyltransferase SETD4 regulates TLR agonist-induced expression of cytokines through methylation of lysine 4 at histone 3 in macrophages. Mol Immunol 2019; 114:179-188. 
[21] Gao K#, Jin J#, Huang C#, Li J, Luo H, Li L, Huang Y, Jiang Y*. Exosomes derived from septic mouse serum modulate immune responses via exosome-associated cytokines. Front Immunol 2019; 10:1560.
[22] Li L, Zhang Y, Luo H, Huang C, Li S, Liu A, Jiang Y*. Systematic identification and analysis of expression profiles of mRNAs and lncRNAs in macrophage inflammatory response. Shock 2019; 51(6): 770-779.
[23] Jia L#, Zhao J#, Yang C, Liang Y, Long P, Liu X, Qiu S, Wang L, Xie J, Li H, Liu H, Guo W, Wang S, LI P, Zhu B, Hao R, Ma H*, Jiang Y*, Song H*. Severe pneumonia caused by coinfection with influenza virus followed by methicillin-resistant staphylococcus aureus induces higher mortality in mice. Front Immunol 2019; 9:3189.
[24] Zhang Y#, Luo H#, Lv X, Liu J, Chen X, Li Y, Liu A*, Jiang Y*. Axin-1 binds to Caveolin-1 to regulate the LPS-induced inflammatory response in AT-I cells. Biochem Biophys Res Commun 2019; 513(1): 261-268.
[25] Mei ZZ*, Sun H, Ou X, Li L, Cai J, Hu S, Wang J, Luo H, Liu J*, Jiang Y*. The natural antisense transcript NATTD regulates the transcription of decapping scavenger (DcpS) enzyme. Int J Biochem Cell Biol 2019; 110: 103-110.
[26] Gong S#, Lan T#, Zeng L, Luo H, Yang X, Li N, Chen X, Liu Z, Li R, Win S, Liu S, Zhou H, Schnabl B, Jiang Y*, Kaplowitz N, Chen P*. Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice. J Hepatol 2018; 69(1): 51-59.
[27] Weng J#, Yu L#, Chen Z, Su H, Yu S, Zhang Y, Lei X, Chen L, Cui Y, Huang Q*, Jiang Y*, Guo X*. β-catenin phosphorylation at Y654 and Y142 is crucial for high mobility group box-1 protein-induced pulmonary vascular hyperpermeability. J Mol Cell Cardiol 2018; 127: 174-184.
[28] Yang J#, Zhang R#, Jiang X#, Lv J, Li Y, Ye H, Liu W, Wang G, Zhang C, Zheng N, Dong M, Wang Y, Chen P, Santosh K, Jiang Y*, Liu J*. Toll-like receptor 4 induced ryanodine receptor 2 oxidation and sarcoplasmic reticulum Ca2+ leakage promote cardiac contractile dysfunction in sepsis. J Biol Chem 2018; 293(3): 794-807.
[29] Huang Y, Liu A, Liang L, Jiang J, Luo H, Deng W, Lin G, Wu M, Li T*, Jiang Y*. Diagnostic value of blood parameters for community-acquired pneumonia. Int Immunopharmacol 2018; 64: 10-15.
[30] Wu W, Zhou H, He F, Xiao Z, Jiang Y*, Zhao M*. Arsenate-mediated G2 cell cycle arrest in U-2OS cells involves phosphorylation of human polycomb protein 2 by p38 MAPK. FEBS Lett 2018; 592(24): 4087-4097.
[31] Wang W#, Weng J#, Yu L, Huang Q*, Jiang Y*, Guo X*. Role of TLR4-p38 MAPK-HSP27 signal pathway in LPS-induced pulmonary epithelial hyperpermeability. BMC Pulm Med 2018; 18(1): 178. 
[32] Hu S, Musante L, Tataruch D, Xu X, Kretz O, Henry M, Meleady P, Luo H, Zou H, Jiang Y*, Holthofer H*. Purification and identification of membrane proteins from urinary extracellular vesicles using Triton X-114 phase partitioning. J Proteome Res 2018; 17(1): 86-96.
[33] Li J, Yan G, Liu S, Jiang T, Zhong M, Yuan W, Chen S, Zheng Y, Jiang Y*, Jiang Y*. Target of rapamycin complex 1 and Tap42-associated phosphatases are required for sensing changes in nitrogen conditions in the yeast saccharomyces cerevisiae. Mol Microbiol 2017; 106(6): 938-948.
[34] Liu J*, Wang J, Luo H, Li Z, Zhong T, Tang J, Jiang Y*. Screening cytokine/chemokine profiles in serum and organs from an endotoxic shock mouse model by LiquiChip. Sci China Life Sci 2017; 60(11): 1242-1250.
[35] Mei Z*, Chen X, Hu S, Wang N, Ou X, Wang J, Luo H, Liu J*, Jiang Y*. Kelch-like protein 21 (KLHL21) targets IκB kinase-β to regulate nuclear factor κ-light chain enhancer of activated B cells (NF-κB) signaling negatively. J Biol Chem 2016; 291(35): 18176-18189. 
[36] Zhong M, Zhao X, Li J, Yuan W, Yan G, Tong M, Guo S, Zhu Y, Jiang Y*, Liu Y*, Jiang Y*. Tumor suppressor folliculin regulates mTORC1 through primary cilia. J Biol Chem 2016; 291(22): 11689-11697. 
[37] Li X, Han Y, Zhou Q, Jie H, He Y, Han J, He J, Jiang Y*, Sun E*. Apigenin, a potent suppressor of dendritic cell maturation and migration, protects against collagen-induced arthritis. J Cell Mol Med 2016; 20(1): 170-180.
[38] Li Z, Scott MJ, Fan EK, Li Y, Liu J, Xiao G, Li S, Billiar TR, Wilson MA, Jiang Y*, Fan J*. Tissue damage negatively regulates LPS-induced macrophage necroptosis. Cell Death Differ 2016; 23(9): 1428-1447. 
[39] Liu J#, Wang F#, Luo H, Liu A, Li K, Li C, Jiang Y*. Protective effect of butyrate against ethanol-induced gastric ulcers in mice by promoting the anti-inflammatory, anti-oxidant and mucosal defense mechanisms. Int Immunopharmacol 2016; 30: 179-187.
[40] Bao J, He M, Liu Y, Lu Y, Hong Y, Luo H, Ren Z, Zhao S*, Jiang Y*. AGE/RAGE/Akt pathway contributes to prostate cancer cell proliferation by promoting Rb phosphorylation and degradation. Am J Cancer Res 2015; 5(5): 1741-1750.
[41] Wang F, Liu J, Luo H, Liu A, Jiang Y*. Potential protective effects of Clostridium butyricum on experimental gastric ulcers in mice. World J Gastroenterol 2015, 21(27): 8340-8351.
[42] Wang J, Vodovotz Y, Fan L, Yuehua Li, Liu Z, Namas R, Barclay D, Zamora R, Billiar TR, Wilson M, Fan J*, Jiang Y*. The injury-induced MRP8/MRP14 stimulates IP-10/CXCL10 in monocytes/macrophages. FASEB J 2015; 29(1): 250-262.
[43] Tang J, Liu J, Li X, Zhong Y, Zhong T, Liu Y, Wang J, Jiang Y*. PRAK interacts with DJ-1 and prevents oxidative stress-induced cell death. Oxid Med Cell Longev 2014; 2014: 735618.
[44] Xu J, Jiang Y*, Wang J, Shi X, Liu Q, Liu Z, Li Y, Scott MJ, Xiao G, Li S, Fan L, Billiar TR, Wilson MA, Fan J*. Macrophage endocytosis of high mobility group box 1 (HMGB1) triggers pyroptosis. Cell Death Differ 2014; 21(8): 1229-1239.
[45] Liu Z, Liu J, Wang J, Xu J, Liu Y, Sun X, Su L, Wang JH*, Jiang Y*. Role of testis specific high mobility group protein in transcriptional regulation of inducible nitric oxide synthase expression in the liver of endotoxic shock mice. FEBS J 2014; 281(9): 2202-2213.
[46] Wang L, Luo H, Chen X, Jiang Y*, Huang Q*. Functional characterization of S100A8 and S100A9 in altering monolayer permeability of human umbilical endothelial cells. PLoS One 2014; 9(3): e90472.
[47] Yang M, Liu C, Niu M, Hu Y, Guo M, Zhang J, Luo Y, Yuan W, Yang M, Yun M, Guo L, Yan J, Liu D, Liu J, Jiang Y*. Phage-display library biopanning and bioinformatic analysis yielded a high-affinity peptide to inflamed vascular endothelium both in vitro and in vivo. J Control Release 2014; 174: 72-80.
[48] Zou H#, Lai Y#, Zhao X, Yan G, Ma D, Cardenes N, Shiva S, Liu Y, Bai X, Jiang Y*, Jiang Y*. Regulation of mammalian target of rapamycin complex 1 by Bcl-2 and Bcl-XL. J Biol Chem 2013; 288(40): 28824-28830.
[49] Liu Z, Jiang Y*, Li Y, Wang J, Fan L, Scott MJ, Xiao G, Li S, Billiar TR, Wilson MA, Fan J*. TLR4 signaling augments monocyte chemotaxis by regulating G protein-coupled receptor kinase 2 translocation. J Immunol 2013; 191(2): 857-864.
[50] Gong X*, Luo T, Deng P, Liu Z, Xiu J, Shi H, Jiang Y*. Stress-induced interaction between p38 MAPK and HSP70. Biochem Biophys Res Commun 2012; 425(2): 357-362.
[51] Liu W#, Deng J#, Xu J, Wang H, Yuan M, Liu N, Jiang Y*, Liu J*. High-mobility group box 1 (HMGB1) downregulates cardiac transient outward potassium current (Ito) through downregulation of Kv4.2 and Kv4.3 channel transcripts and proteins. J Mol Cell Cardiol 2010; 49(3): 438-448.
[52] Gong X#, An Z#, Wang Y, Guan L, Fang W, Strömblad S, Jiang Y*, Zhang H*. Kindlin-2 controls sensitivity of prostate cancer cells to cisplatin-induced cell death. Cancer Lett 2010; 299(1): 54-62.
[53] Gong X*, Ming X, Deng P, Jiang Y*. Mechanisms regulating the nuclear translocation of p38 MAP kinase. J Cell Biochem 2010; 110(6): 1420-1429.
[54] Gong X*, Liu A, Ming X, Deng P, Jiang Y*. UV-induced interaction between p38 MAPK and p53 serves as a molecular switch in determining cell fate. FEBS Lett 2010; 584(23): 4711-4716.
[55] Xu J, Zhong S, Liu J, Li L, Li Y, Wu X, Li Z, Deng P, Zhang J, Zhong N, Ding Y, Jiang Y*. Detection of severe acute respiratory syndrome coronavirus in brain: potential role of the chemokine Mig in pathogenesis. Clin Infect Dis 2005; 41(8): 1089-1096.
[56] Jiang Y#*, Xu J#*, Zhou C, Wu Z, Zhong S, Liu J, Luo W, Chen T, Qin Q, Deng P. Characterization of cytokine/chemokine profiles of severe acute respiratory syndrome. Am J Respir Crit Care Med 2005; 171(8): 850-857.