主持科研项目:
(1) 2017年南方医科大学顺德医院研究生导师科研专项基金(10.00万):依托咪酯与七氟烷麻醉对腹腔镜下直结肠癌手术老年患者术中应激反应及术后早期认知功能障碍影响的比较。(2017.10-2021.10)
(2) 2018年佛山市首届杰出青年医学人才系列项目(60.00万):高通量测序筛选骨癌疼痛小鼠脊髓液中差异表达的环状RNA并研究其功能。(2019.01-2021.12)
(3) 2019年广东省医学科学技术研究基金(1.75万):hsa_circ_0137693/miR-338-5p通过LPAR1参与调控骨癌疼痛。(项目编号:A2019045)(2019.07-2021.06)
(4) 2019年南方医科大学顺德医院临床研究启动计划项目(30.00万):右美托咪定对老年患者腹部手术术后睡眠和认知功能影响的随机、双盲、对照研究。(项目编号:CRSP2019003)(2019.01-2021.12)
(5) 2019年佛山市科技计划项目(自筹经费):hsa_circ_0137693通过靶基因LPAR1参与调控骨癌疼痛的作用和机制。(项目编号:1920001000687)(2019.11-2021.10)
(6) 2021年度广东省卫生健康委办公室适宜技术推广项目(2万):基于信息化构建晚期癌痛患者疼痛管理与宁养服务网络
(7) 2021年南方医科大学顺德医院科研启动计划重点专科专项(培育项目)(12万):乳腺癌来源外泌体circStrn3通过Lin28A-GFAP促进骨癌疼痛吗啡耐受的机制研究 (项目编号:SRSP2021039)(2021.12-2023.11)
(8) 2022年广东省科学技术厅国际和港澳台人才项目“海外名师”基金(5万):《右美托咪定对晚期癌痛患者睡眠和认知的影响》(项目编号:粤科智字2022.232号)(2022.12-2024.12)
(9) 2023年中国白求恩公益基金会恩泽疼痛管理医学研究基金课题资助项目(10万):羟考酮术后镇痛对脆弱性老年患者术后认知功能障碍的影响(No:ezmr2023-007);
(10) 2023年广东省普通高校重点科研平台和项目(15万):乳腺癌来源外泌体circStrn3通过Lin28A-GFAP促进骨癌疼痛吗啡耐受的机制研究(No:2023ZDZX2008)
(11) 2023年度广东省基础与应用基础研究基金粤佛联合基金(30万):α2AR-STING调节星形胶质细胞极化在糖尿病神经病理性疼痛中的作用和机制研究。(No:2023A1515140142)
(12) 2024年中国吴阶平医学基金会-急性疼痛优化管理专项研究项目(5万):奥赛利定用于剖宫产术后患者自控镇痛的优效性临床研究。
(13) 2024年中国初级卫生保健基金会临床研究项目:( 5万):艾司氯胺酮预防全麻手术诱导期低血压发生率真实世界研究 。(项目编号:KYLS20240309)(2024.01-2026.12)
(14) 评价布洛芬注射液治疗术后中、重度疼痛有效性和安全性的随机、双盲、安慰剂平行对照、多中心临床研究,(5万),2024年GCP基金项目
(15) 2024年国家卫生健康委医药卫生科技发展研究中心创新药物临床研究科研专项(30万):术前应用右美托咪定鼻喷雾剂联合超声引导下布比卡因脂质体髂筋膜间隙阻滞对老年髋部骨折患者术后睡眠质量的影响:一项单中心、双盲、随机、对照试验。(项目编号:WKZX2024CX301206)(2024.12-2027.12)
(1) Wu XP, Yang YP, She RX, Xing ZM, Chen HW, Zhang YW. microRNA-329 reduces bone cancer pain through the LPAR1-dependent LPAR1/ERK signal transduction pathway in mice. THER ADV MED ONCOL. 2019, 11: 432476937.(IF2.87)
(2) Zhang YW, Zhang XX, Xing ZM, Tang SY, Chen HW, Zhang ZQ, Li JY, Li YL. circStrn3 is involved in bone cancer pain regulation in a rat model. ACTA BIOCH. BIOPH. SIN. 2020, 52(5): 495-505.(IF2.836)
(3) Chen HW,Zhang XX, Peng ZD,Xing ZM, Zhang YW, Li YL *. The circular RNA circSlc7a11 promotes bone cancer pain pathogenesis in rats by modulating LLC WRC 256 cell proliferation and apoptosis, Molecular and Cellular Biochemistry, 2021, Jan, 12.(IF2.795)
(4) 张忠其,许亚菲,张艳静,刘晓磊,张奕文.丙泊酚复合小剂量艾司氯胺酮时抑制患者胃镜置入反应的有效剂量.[J]. 临床麻醉学杂志.2021,37(09):949-952.(通讯作者)
(5) 李集源,刘健欣,陈汉文,张奕文,张艳静,康翠瑶,邢祖民.不同剂量咪达唑仑对术前中重度焦虑结直肠癌 老年患者术后早期神经认知功能的影响..[J] .中国现代医学杂志.2021,31(17):5-11.(通讯作者)
(6) Zheng YL, Xu YF, Huang BX, Mai Y, Zhang YW, Zhang ZQ. Effective dose of propofol combined with a low-dose esketamine for gastroscopy in elderly patients: A dose finding study using dixon's up-and-down method. Front Pharmacol. 2022 Sep 20;13:956392.(IF 5.81)
(7) Xu YF, Zheng YL, Tang TY, Chen LL, Zhang YW, Zhang ZQ. The effectiveness of esketamine and propofol versus dezocine and propofol sedation during gastroscopy: A randomized controlled study. J Clin Pharm Ther. 2022 Sep;47(9):1402-1408.(IF 2.215)
(8) Wong, R, Zhang YW, Zhao HL, Ma DQ. Circular RNAs in organ injury: recent development. J Transl Med 20, 533 (2022).(IF 8.44)(并列第一作者)
(9) Tang Shuyi,Zhang Zhongqi,Zheng Yuling,Xu Yafei,Li Huibo,Su Yuqi,and Zhang Yiwen. Median effective dose of an etomidate-propofol mixture with dezocine in inhibiting the response to gastroscope insertion: Gender differences in a randomized controlled study using the Dixon's up-and-down method[J].Hindawi Journal of Clinical Pharmacy and Therapeutics Volume 2023, Article ID 4221852, 7 pages,doi.org/10.1155/2023/42218522(IF 2.145)(通讯作者)
(10) Chen Z, Hao Q, Sun R, Zhang Y, Fu H, Liu S, Luo C, Chen H, Zhang Y. Predictive value of the geriatric nutrition risk index for postoperative delirium in elderly patients undergoing cardiac surgery. CNS Neurosci Ther. 2023 Jul 5. doi: 10.1111/cns.14343. Epub ahead of print. PMID: 37408469.(IF 5.50,一区)(通讯作者)
(11) 刘健欣,李集源,吴东妮,王冠华,张奕文.保留自主呼吸喉罩全身麻醉对胸科手术患者脑血管二氧化碳反应性及术后早期认知功能的影响[J]. 中国现代医学杂志, 2024, 34(3): 1-7. (通讯作者)
(12) 陈添辉,张莹珊 ,李集源,张艳静,李晓菁,张奕文.右美托咪定辅助术后镇痛对老年患者腹部手术后睡眠质量的影响.[J]. 临床麻醉学杂志.2024,40(09):928-931.(通讯作者)
(13) Haobin Peng,Jiajun Wen,Manli Chen,Zhengyuan Xia,Ying Jiang, Kaiqi Xie ,Weitao Huang ,Bangsheng Cui,Peixing Li,Yiwen Zhang,Xianping Wu.Preoperative Analgesia Efficacy of Liposomal Bupivacaine Following Pericapsular Nerve Group (PENG) Block in Patients with Hip Fracture: A Randomized Controlled Observer-Blinded Study.Pain Ther. 2025 Feb;14(1):283-296.doi: 10.1007/s40122-024-00683-6. Epub 2024 Dec 3. (IF 4.1)(并列通讯作者)
(14) Danru Xie, Yanjing Zhang, Feifei Li, Yaoheng Yang, Mengjiao Che, Geng Li, Hanwen Chen, Yiwen Zhang.Efficacy and safety of ciprofol for gastroscopy in patients with obesity: a randomised clinical controlled trial using different weight-based dosing scales.BMC Anesthesiology.2025.DOI: 10.1186/s12871-025-02974-7.(IF 2.3)(通讯作者)
(15) (11) Zhang Y, Xie D, Li F*, Che M, Yang Y, Li G, Zhang Y#. Effects of ciprofol on respiratory-related adverse incidence in patients with obesity during painless gastroscopy: a prospective, randomized clinical trial. Perioperative Medicine . 2025 Apr 29;14(1):49.(IF 2.0)(通讯作者)
(16)Yiwen Zhang, Ryan Wong, Qian Chen, Hailin Zhao, Daqing Ma.Histone and HMGB1 released by cancer cells contribute to astrocyte activation in vitro.British Journal of Anaesthesia,https://doi.org/10.1016/j.bja.2024.11.008.(中科院1区TOP期刊, IF = 9.1, 第一作者)
(17) Sen Huang,Yuxin Xie,Zhaochun Zhan,Fengdong Liu,Peiyang Liu,Fei Xu,Tingting Xu,Zhenning Fang,Zhiqiang Chen,Qingjian Han,Ligang Jie,Rougang Xie,Hongfei Zhang,Shiyuan Xu,Yiwen Zhang,Kai Mo,Xin Luo.Geranyl hydroquinone alleviates rheumatoid arthritis-associated pain by suppressing neutrophils accumulation, N1 polarization and ROS production in mice, Redox Biology,2025.l DOI: 10.1016/j.redox.2025.103603(中科院1区TOP期刊, IF = 10.7, 共同通讯作者)
张忠其,许亚菲,张艳静,刘晓磊,张奕文