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更新日期：2025年10月10日
姓 名 周美娟 性 别 女
民 族 汉族 导师层次 博士导师
技术职称 教授 导师类型 学术型
最后学历 博士研究生毕业 最后学位 医学博士学位
行政职务 主任 Email 80758598@qq.com
工作单位 公共卫生学院 邮政编码 510515
跨学科招生 是
跨学科招生专业1 军事预防医学 招生层次类型1 学术学位博导
跨学科招生专业2 招生层次类型2
个人成果

主持的国家级科研项目

 

  1. 国家自然科学基金委员会，面上项目，82473564，S100A8/A9+中性粒细胞释放NETs调控巨噬细胞极化促进放射性皮肤纤维化的机制研究，2025.1-2028.12，在研，主持。

 

  1. 国家自然科学基金委员会，面上项目，82273582，BCL11A/LSD1/CoREST复合物调控脂质代谢抑制皮肤光老化进程的机制研究，2023.1-2026.12，在研，主持。

 

  1. 国家自然科学基金委员会，面上项目，31971167，eIF4A3-circFBXW8-miR-664调控轴在UVB辐射损伤应激中的作用机制研究，2020.1-2023.12，结题，主持。

 

  1. 国家自然科学基金委员会，面上项目，81673105，14-3-3σ在皮肤角质形成细胞UVB辐射损伤应激中的作用及其机制的研究，2017.1-2020.12，结题，主持。

 

  1. 国家自然科学基金委员会，面上项目，81472922，MiR-664经由PI3K-Akt信号通路调节UVB辐射损伤的机制研，2015.1-2018.12，结题，主持。

 

  1. 国家自然科学基金委员会，面上项目，81202152，miRNAs对UVB致细胞G2/M期阻滞时p53和14-3-3σ相互调控通路的调节作用及其机制，2013.1-2015.12，结题，主持。

 

代表性论文：

 

  1. Xuyi Deng, Hui Liu, Xiaoxu Wang, Xinfeng Dong, Zhengzheng Fu, Xinli Niu, Zhi Guo, Peiqi Lian, Yinyun Deng, Zhenhua Ding, Yinghui Wang, Meijuan Zhou. BCL11A deficiency protects epidermis from UVB-induced damage through promotion of autophagy. communications biology 2025 Oct 2;8(1):1417

 

  1. Yinghui Wang, Xuyi Deng, Jing Xie, Tianhao Lu, Rui Qian, Zhi Guo, Xin Zeng, Jing Liao, Zhenhua Ding, Meijuan Zhou, Xinli Niu. The COP9 signalosome stabilized MALT1 promotes Non-Small Cell Lung Cancer progression through activation of NF-κB pathway. CELL BIOLOGY AND TOXICOLOGY 2024 Jun 12;40(1):45.

 

  1. Fuqiang Chen, Wenna Zhao, Chenghong Du, Zihan Chen, Jie Du, Meijuan Zhou.Bleomycin induces senescence and repression of DNA repair via downregulation of Rad51. MOLECULAR MEDICINE 2024 Apr 22;30(1):54.

 

  1. Shupeng Liu, Yinyun Deng, Hui Liu, Zhengzheng Fu, Yinghui Wang, Meijuan Zhou, Zhijun Feng. Causal Relationship between Meat Intake and Biological Aging: Evidence from Mendelian Randomization Analysis. Nutrients 2024 Jul 26;16(15):2433.

 

  1. Zhijun Feng, Yinghui Wang, Zhengzheng Fu, Jing Liao, Hui Liu, Meijuan Zhou. Exploring the Causal Effects of Mineral Metabolism Disorders on Telomere and Mitochondrial DNA: A Bidirectional Two-Sample Mendelian Randomization Analysis. Nutrients 2024 May 8;16(10):1417.

 

  1. Xia Hu, Shaojian Li, Zhongshan Shi, Wei-Jye Lin, Yuhua Yang, Yi Li, Honghong Li, Yongteng Xu, Meijuan Zhou, Yamei Tang. Partial Ablation of Astrocytes Exacerbates Cerebral Infiltration of Monocytes and Neuronal Loss After Brain Stab Injury in Mice. CELLULAR AND MOLECULAR NEUROBIOLOGY 2023 Mar;43(2):893-905.

 

  1. Xiangzhi Li, Yawen Yuan, Yimeng Wang, Kaisheng Xie, Sheng Lu, Fuqiang Chen, Meijuan Zhou, Peilin Zhen. MicroRNA-486-3p promotes the proliferation and metastasis of cutaneous squamous cell carcinoma by suppressing flotillin-2. JOURNAL OF DERMATOLOGICAL SCIENCE 2022 Jan;105(1):18-26.

 

  1. Jie Du, Fuqiang Chen, Jiahua Yu, Lijun Jiang, Meijuan Zhou. The PI3K/mTOR Inhibitor Ompalisib Suppresses Nonhomologous End Joining and Sensitizes Cancer Cells to Radio- and Chemotherapy 2021 Nov;19(11):1889-1899.

 

  1. Xiangzhi Li, Chen Zhang, Yawen Yuan, Yimeng Wang, Sheng Lu, Zhaoming Zhou, Peilin Zhen, Meijuan Zhou. Downregulation of ARMC8 promotes tumorigenesis through activating Wnt/beta-catenin pathway and EMT in cutaneous squamous cell carcinomas. JOURNAL OF DERMATOLOGICAL SCIENCE 2021 Jun;102(3):184-192.

 

  1. Liu R, Zhang Q, Shen L, Chen S, He J, Wang D, Wang Q, Qi Z, Zhou M, Wang Z. Long noncoding RNA lnc-RI regulates DNA damage repair and radiation sensitivity of CRC cells through NHEJ pathway. Cell biology and toxicology 2020;36: 493-507.

 

  1. He X, Gao J, Peng L, Hu T, Wan Y, Zhou M, Zhen P, Cao H. Bacterial O-GlcNAcase genes abundance decreases in ulcerative colitis patients and its administration ameliorates colitis in mice. Gut 2020.

 

  1. Deng X, Zhen P, Niu X, Dai Y, Wang Y, Zhou M. APE1 promotes proliferation and migration of cutaneous squamous cell carcinoma. Journal of dermatological science 2020;100: 67-74.

 

  1. Zhang Y, Gao L, Ma S, Ma J, Wang Y, Li S, Hu X, Han S, Zhou M, Zhou L, Ding Z. MALAT1-KTN1-EGFR regulatory axis promotes the development of cutaneous squamous cell carcinoma. Cell death and differentiation 2019;26: 2061-73.

 

  1. Yu C, Chen F, Jiang J, Zhang H, Zhou M. Screening key genes and signaling pathways in colorectal cancer by integrated bioinformatics analysis. Molecular medicine reports 2019;20: 1259-69.

 

  1. Wang Y, Deng X, Dai Y, Niu X, Zhou M. miR-27a Downregulation Promotes Cutaneous Squamous Cell Carcinoma Progression via Targeting EGFR. Frontiers in oncology 2019;9: 1565.

 

  1. Liu H, Wang H, Wu J, Wang Y, Zhao L, Li G, Zhou M. Lymphocyte nadir predicts tumor response and survival in locally advanced rectal cancer after neoadjuvant chemoradiotherapy: Immunologic relevance. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2019;131: 52-9.

 

  1. Li X, Zhou C, Zhang C, Xie X, Zhou Z, Zhou M, Chen L, Ding Z. MicroRNA-664 functions as an oncogene in cutaneous squamous cell carcinomas (cSCC) via suppressing interferon regulatory factor 2. Journal of dermatological science 2019;94: 330-8.

 

  1. Huang J, Qi Z, Chen M, Xiao T, Guan J, Zhou M, Wang Q, Lin Z, Wang Z. Serum amyloid A1 as a biomarker for radiation dose estimation and lethality prediction in irradiated mouse. Annals of translational medicine 2019;7: 715.

 

  1. Zhou L, Wang Y, Zhou M, Zhang Y, Wang P, Li X, Yang J, Wang H, Ding Z. HOXA9 inhibits HIF-1alpha-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development. Nature communications 2018;9: 1480.

 

  1. Ding Z, Jian S, Peng X, Liu Y, Wang J, Zheng L, Ou C, Wang Y, Zeng W, Zhou M. Loss of MiR-664 Expression Enhances Cutaneous Malignant Melanoma Proliferation by Upregulating PLP2. Medicine 2015;94: e1327.

 

  1. Zhou M, Zhou L, Zheng L, Guo L, Wang Y, Liu H, Ou C, Ding Z. miR-365 promotes cutaneous squamous cell carcinoma (CSCC) through targeting nuclear factor I/B (NFIB). PloS one 2014;9: e100620.

 

  1. Zhou M, Liu W, Ma S, Cao H, Peng X, Guo L, Zhou X, Zheng L, Guo L, Wan M, Shi W, He Y, et al. A novel onco-miR-365 induces cutaneous squamous cell carcinoma. Carcinogenesis 2013;34: 1653-9.