张家明，华中科技大学临床医学八年制专业（外科学），哈佛大学博士后研究员，南方医科大学深圳医院副研究员，“珠江人才计划”青年拔尖人才，南方医科大学高层次人才。师从哈佛医学院、牙学院、麻省总医院内分泌科知名教授、美国骨与矿物质研究协会前任主席Dr. Roland Baron（h-index：103，论文总引45268次）。已发表SCI论文32篇，IF＞20共5篇，＞10共3篇，H因子19，论文总引用1086次，高被引论文1篇（Ageing Research Reviews，2023；IF=12.5；ESI: Highly Cited Paper, Top 1% of the Academic Field of Clinical Medicine，被引用101次），主持国家自然科学基金1项，担任Journal of Translational Internal Medicine、Burns & Trauma以及Asian Journal of Pharmaceutical Sciences的青年学术编委，参与Aging Cell、Journal of Nanobiotechnology等学术期刊的审稿工作。

长期致力于运动系统（骨与关节）衰老相关疾病的基础研究和靶向治疗。在博士期间开展机械力学刺激对软骨细胞线粒体动力学、线粒体自噬和细胞凋亡的调控作用（Journal of Cellular Physiology，2021；Frontiers in Genetics，2022），减重运动疗法对骨关节炎软骨和软骨下骨的治疗作用（Journal of Orthopaedic Research，2021；Bone & Joint Research，2022），以及骨关节炎软骨下骨的机械响应性转录组研究（Bone & Joint Research，2022）。此外，在博士后期间，通过体内条件性基因敲除技术开展了MMP13-CTSK调控轴在骨细胞生理和骨稳态的作用机制研究（ASBMR Annual Meeting 2022；ASBMR Annual Meeting 2023），以及PTH/PTHrP对骨细胞转录组调控作用的基础研究（JCI Insight，2023）。与日本东京医科齿科大学、日本昭和大学、武汉同济医院、河南省人民医院、南京鼓楼医院、重庆大学等机构共同开展了纳米脂质体、工程化外泌体等联合新型水凝胶在治疗软骨衰老、软骨下骨重塑和骨关节炎的研究（Advanced Composites and Hybrid Materials 2023，2024；Journal of Nanobiotechnology，2023），以及老年性骨关节炎临床样本的软骨、软骨下骨、脂肪垫多组织的单细胞多组学研究。

1. 骨细胞生理及其在人类疾病中的作用机制

2. 运动系统退行性疾病（骨与关节病）的基础研究

3. 药物递送系统和新型水凝胶在运动系统退行性疾病治疗中的应用

1. Junlai Wan^#, Zhiyi He^#, Yingchao Zhao^#, Xiaoxia Hao, Jiarui Cui, Anmin Chen^*, Jun Zhou^*, Jiaming Zhang^*: Novel strategy of senescence elimination via toxicity-exempted kinome perturbations by nanoliposome-based thermosensitive hydrogel for osteoarthritis therapy. Advanced Composites and Hybrid Materials 2023; 6: 104 (IF2023: 23.2; JCR: Q1, Top 1 of Materials Science, Composites).

2. Zhiyi He^#, Pengzhen Bu^#, Kai Xu^#, Renpeng Peng, Wei Xiong, Peng Cheng, Jiarui Cui, Anmin Chen, Haokun Mo, Xiong Zhang, Caiqi Cheng, Jun Zhou, Jiaming Zhang^*, Qian Feng^*, Zhenggang Wang^*: Remodeling of the pro-inflammatory microenvironment in osteoarthritis via hydrogel-based photothermal therapy. Advanced Composites and Hybrid Materials 2024; 7, 36. (IF2023: 23.2; JCR: Q1, Top 1 of Materials Science, Composites).

3. Pengzhen Bu^#, Renpeng Peng^#, Jiaming Zhang^#, Zhiyi He, Shuangquan Gou, Xuezhe Liu, Xingan Qiu, Bikun Zhou, Weilin Meng, Huixia Fu, Haiyan Zhu, Bo Gao, Maciej Serda^*, Feng Li^*, Qian Feng^*, Kaiyong Cai^*: A One-Stone-Two-Birds Strategy for Intervertebral Disc Repair: Constructing a Reductive Chelation Hydrogel to Mitigate Oxidative Stress and Promote Disc Matrix Reconstruction. Advanced Materials 2024; 37(6):e2411290. (IF2023: 27.4; JCR: Q1; 中科院一区).

4. Junlai Wan^#, Zhiyi He^#, Renpeng Peng^#, Xiaopei Wu, Ziqing Zhu, Jiarui Cui, Xiaoxia Hao, Anmin Chen^*, Jiaming Zhang^*, Peng Cheng^*: Injectable photocrosslinking spherical hydrogel-encapsulated targeting peptide-modified engineered exosomes for osteoarthritis therapy. Journal of Nanobiotechnology 2023; 21(1), 284. (IF2023: 10.6; JCR: Q1; 中科院一区).

5. Zhengtao Lv^#, Jiaming Zhang^#, Shuang Liang, Chenhe Zhou, Dorothy Hu, Daniel J Brooks, Mary L Bouxsein, Beate Lanske, Paul Kostenuik, Francesca Gori, Roland Baron^*: Comparative study in estrogen-depleted mice identifies skeletal and osteocyte transcriptomic responses to abaloparatide and teriparatide. JCI Insight 2023. (IF2023: 6.3; JCR: Q1; 中科院一区).

6. Jiarui Cui ^#, Yo Shibata, Tianmin Zhu, Jun Zhou^*, Jiaming Zhang^*: Osteocytes in bone aging: Advances, challenges, and future perspectives. Ageing Research Reviews 2022;77:101608. (IF2023: 12.5; JCR: Q1, Top 2 of Geriatrics & Gerontology; ESI: Highly Cited Paper, Top 1% of the Academic Field of Clinical Medicine, 高被引论文; 中科院一区).

7. Jiaoxiang Chen^#, Xin Gan^#, Shenkai Su^#, Sizhe Jiao^#, Zailing Gong, Ziqiang Liu, Xiaopei Wu, Jun Jiang^*, Jiaming Zhang^*, Junlai Wan^*: Conditional sequential delivery of ginkgetin and rapamycin orchestrates inflammation and autophagy to alleviate intervertebral disc degeneration. Journal of Controlled Release 2025;19:S0168-3659(25)00166-X. (IF2023: 10.5; JCR: Q1; 中科院一区).

8. Rui Lu^#, Yunkun Qu, Zhenggang Wang, Zhiyi He, Shimeng Xu, Peng Cheng, Zhengtao Lv, Hongbo You, Fengjing Guo, Anmin Chen^*, Jiaming Zhang^*, Shuang Liang^*: TBK1 pharmacological inhibition mitigates osteoarthritis through attenuating inflammation and cellular senescence in chondrocytes. Journal of Orthopaedic Translation 2024; 47:207-222. (IF2023: 6.6; JCR: Q1; 中科院一区).

9. Wenchao Wan^#, Zhenkai Ma, Xuemin Feng, Jiabin Ren, Shengyao Sun, Yuandong Shao, Weimin Zhang, Xiaoxia Yang, Jiaming Zhang^*, Xingzhi Jing^*: TfR1 mediated iron metabolism dysfunction as a potential therapeutic target for osteoarthritis. Arthritis Research and Therapy 2024; 26(71). (IF2023: 4.4; JCR: Q1; 中科院二区).

10. Zhengtao Lv^#, Yingchao Zhao^#, Jiarui Cui^#, Jiaming Zhang^*: Genetically proxied sarcopenia-related muscle traits and depression: Evidence from the Finngen cohort. American Journal of Geriatric Psychiatry 2024; 32(1):32-41. (IF2023: 4.4; JCR: Q1; 中科院一区).