一、代表性论文
1. Zixin Fan#, Shuo Yang#, Xiaofeng Lu, Sifan Zhang, Xianlu Zeng, Lin Lin, Duo Yuan, Jian Zeng, Guoming Zhang*. Alteration of tear metabolomics profiling in infants with retinopathy of prematurity. Invest Ophthalmol Vis Sci, 2025 Jun 2;66(6):61. doi: 10.1167/iovs.66.6.61.
2. Dongting Wu#, Zixin Fan#, Yarou Hu, Yi Chen, Ruyin Tian, Cui Wang, Honghui He, Yuhang Yang, Guoming Zhang*. Identifying potential tear biomarkers in premature infants with retinopathy of prematurity based on proteome and transcriptome analysis. Graefes Arch Clin Exp Ophthalmol. 2025 May 9.doi: 10.1007/s00417-025-06838-1. Online ahead of print.
3. Zixin Fan, Xinyi Jiang, Suwen Zhao , Ningxin Dou , Fei Yao, Shaochong Zhang, Gangpei Cai, Yang Li, Yiheng Wu, Weidong He, Guoming Zhang*, Shengli Mi*.Topography-guided, patterned, customized corneal crosslinking for non-invasive astigmatism correction. Eye (Lond),2025 Apr;39(6):1193-1202.doi: 10.1038/s41433-025-03602-x. Epub 2025 Jan 18.
4. Yuhang Yang, Lijun Dong, Hui Qi, Yinsheng Zhang, Yulin Zhang, Jie Sun, Xiaoyan Chai, Xiaofeng Lu, Zixin Fan, Dongting Wu, Guoming Zhang*, Hetian Lei *. Metabolic correlations between kidney and eye in a mouse model of oxygen-induced retinopathy and retinopathy of prematurity. BMJ Open Ophthalmol,2025 May 1;10(1):e001955.doi: 10.1136/bmjophth-2024-001955.
5. Xionggao Huang#, Wenyi Wu#, Hui Qi#, Xiaohe Yan, Lijun Dong, Yanhui Yang, Qing Zhang, Gaoen Ma, Guoming Zhang*, Hetian Lei*. Exploitation of enhanced prime editing for blocking aberrant angiogenesis. Journal of Advanced Research, 2024 Jul 10:S2090-1232(24)00272-8. doi: 10.1016/j.jare.2024.07.006.
6. Xinyu Zhao#, Zhenquan Wu#, Yaling Liu#, Honglang Zhang, Yarou Hu 1, Duo Yuan , Xiayuan Luo , Mianying Zheng , Zhen Yu , Dahui Ma , Guoming Zhang* .Eyecare-cloud: an innovative electronic medical record cloud platform for pediatric research and clinical care. EPMA journal,2024 Jul 11;15(3):501-510.doi: 10.1007/s13167-024-00372-6. eCollection 2024 Sep.
7. Yizhou Zhong#, Yuhang Yang#, Linan Zhang, Dahui Ma, Kailiang Wen, Jiachun Cai, Zhanmou Cai, Cui Wang, Xiaoyan Chai, Jingwen Zhong, Boxuan Liang, Yuji Huang, Hongyi Xian, Zhiming Li, Xingfen Yang, Da Chen, Guoming Zhang*, Zhenlie Huang*. Revealing new insights: Two-center evidence of microplastics in human vitreous humor and their implications for ocular health. Sci Total Environ, 2024 Apr 15:921:171109.doi: 10.1016/j.scitotenv.2024.171109. Epub 2024 Feb 21.
8. Xiaofeng Lu#, Zixin Fan#, Shuo Yang , Lei Zheng , Zhen Yu , Yuhang Yang , Mianying Zheng , Jian Zeng , Guoming Zhang*. Role of angiopoietin-like 4 in neovascularization associated with retinopathy of prematurity. Experimental Eye Research, 2024 Dec:249:110145.doi: 10.1016/j.exer.2024.110145. Epub 2024 Nov 2.
9. Huiling Hu, Danyao Nie, Min Fang, Wenling He, Jing Zhang, Xinhua Liu*, Guoming Zhang*. Muller cells under hydrostatic pressure modulate retinal cell survival via TRPV1/PLCγ1 complex-mediated calcium influx in experimental glaucoma. FEBS Journal,2024 Jun;291(12):2703-2714.doi: 10.1111/febs.17075. Epub 2024 Feb 23.
10. Xiaoxia Fang, Fan Yang, Wei Huang, Saiguang Ling, Bing Liang, Weizhong Zeng, Huiling Hu*, Guoming Zhang*. Comparative analysis of retinal microvascular parameters in healthy individuals with or without carotid artery stenosis or plaque. European Journal of Ophthalmology,2024 Oct 15:11206721241291224.doi: 10.1177/11206721241291224.
11. Shaobin Chen#, Xinyu Zhao#, Zhenquan Wu, Kangyang Cao , Yulin Zhang , Tao Tan , Chan-Tong Lam , Yanwu Xu , Guoming Zhang*, Yue Sun *. Multi‑risk factors joint prediction model for risk prediction of retinopathy of prematurity. EPMA journal, 2024 May 9;15(2):261-274. doi: 10.1007/s13167-024-00363-7.
12. Xinyu Zhao #, Shaobin Chen# , Sifan Zhang# , Yaling Liu, Yarou Hu, Duo Yuan, Liqiong Xie , Xiayuan Luo , Mianying Zheng , Ruyin Tian, Yi Chen , Tao Tan , Zhen Yu, Yue Sun*, Zhenquan Wu* , Guoming Zhang*. A fundus image dataset for intelligent retinopathy ofprematurity system. Scientific data，2024 May 27;11(1):543. doi: 10.1038/s41597-024-03362-5.
13. Yaling Liu#, Hai Xie#, Xinyu Zhao#, Jiannan Tang , Zhen Yu , Zhenquan Wu , Ruyin Tian , Yi Chen , Miaohong Chen , Dimitrios P Ntentakis , Yueshanyi Du , Tingyi Chen , Yarou Hu , Sifan Zhang* , Baiying Lei* , Guoming Zhang*. Automated detection of nine infantile fundus diseases and conditions in retinal images using a deep learning system. EPMA journal， 2024 Feb 15;15(1):39-51. doi: 10.1007/s13167-024-00350-y.
14. Ya Tian , Zixin Fan , Xianlu Zeng , Zhen Yu , Xiaofeng Lu , Xinyu Zhao , Zhenquan Wu, Honghui He , Jian Zeng , Lei Zheng , Linlin Zhang , Victor S M C Correa , Guishuang Ying , Shaochong Zhang , Guoming Zhang*. Long-term follow-up of the cognitive function in children after intravitreal ranibizumab for retinopathy of prematurity. Graefes Arch Clin Exp Ophthalmol，2024 Apr 21. doi: 10.1007/s00417-024-06486-x.
15. Zixin Fan#, Yarou Hu#, Laijiao Chen , Xiaofeng Lu , Lei Zheng , Dahui Ma , Zhiqiang Li , Jingwen Zhong , Lin Lin , Sifan Zhang , Guoming Zhang*. Multiplatform tear proteomic profiling reveals novel non-invasive biomarkers for diabetic retinopathy. Eye (Lond)，2024 Jun;38(8):1509-1517. doi: 10.1038/s41433-024-02938-0. Epub 2024 Feb 9.
16. Shuo Yang#, Zixin Fan# , Xiaofeng Lu , Hui Liu , Ziying Zhou , Hui Qi , Jian Zeng , Mianying Zheng , Xuan Zou* , Shisong Fang* , Guoming Zhang*. Response of Human Retinal Microvascular Endothelial Cells to Influenza A (H1N1) Infection and the Underlying Molecular Mechanism. Invest Ophthalmol Vis Sci， 2024 Jan 2;65(1):38. doi: 10.1167/iovs.65.1.38.
17. Huiling Hu, Xinhua Liu , Danyao Nie , Min Fang, Jing Zhang , Guoming Zhang*. Insights into CD154-mediated pathways in ocular hypertensive glaucoma: The role of Müller cells and P2X7 in retinal neuroprotection and therapeutic potential. Cell Biol Int，2023 Aug;47(8):1441-1452.doi: 10.1002/cbin.12030. Epub 2023 May 3.
18. Yaling Liu , Yueshanyi Du , Xi Wang, Xinyu Zhao , Sifan Zhang , Zhen Yu , Zhenquan Wu , Dimitrios P Ntentakis, Ruyin Tian , Yi Chen , Cui Wang , Xue Yao , Ruijiang Li , Pheng-Ann Heng* , Guoming Zhang*. An Artificial Intelligence System for Screening and Recommending the Treatment Modalities for Retinopathy of Prematurity. Asia Pac J Ophthalmol, 2023 Sep-Oct;12(5):468-476. doi: 10.1097/APO.0000000000000638. Epub 2023 Sep 22.
19. Yarou Hu, Zixin Fan, Xinyu Zhao, Victor S M C Correa, Zhenquan Wu, Xiaofeng Lu, Xianlu Zeng, Laijiao Chen, Zhen Yu, Lei Zheng, Jicang He, Guoming Zhang*. Refractive status and biometric characteristics of children with familial exudative vitreoretinopathy. Invest Ophthalmol Vis Sci. 2023 Oct 3;64(13):27.doi: 10.1167/iovs.64.13.27.
20. Yulin Zhang#, Xiaoyan Chai#, Zixin Fan , Sifan Zhang*, Guoming Zhang*. Research hotspots and trends in retinopathy of prematurity from 2003 to 2022: a bibliometric analysis. Front Pediatr. 2023 Oct 3:11:1273413. doi: 10.3389/fped.2023.1273413. eCollection 2023.
21. Bingzhi Yang, Chaohui Lian, Ruyin Tian, Yi Chen, Song Tang, Haishan Xiang, Honghui He, Guoming Zhang*.Twelve-year outcomes of bedside laser photocoagulation for severe retinopathy of prematurity. Front Pediatr，2023 Jun 23:11:1189236.doi:10.3389/fped.2023.1189236. eCollection 2023.
22. Zixin Fan , Yueshanyi Du, Caiyun Tang, Ruyin Tian, Xiaofeng Lu, Lei Zheng, Shaochong Zhang, Guoming Zhang*. Awareness, Prevalence, and Knowledge of Dry Eye Among Internet Professionals: A Cross-sectional Study in China. Eye & Contact Lens: Science and Clinical Practice，2023 Mar 1;49(3):92-97.doi: 10.1097/ICL.0000000000000968. Epub 2023 Jan 27.
23. Shaobin Chen#, Zhenquan Wu#, Mingzhu Li, Yun Zhu, Hai Xie, Peng Yang, Cheng Zhao, Yongtao Zhang, Shaochong Zhang, Xinyu Zhao, Tianfu Wang, Lin Lu*, Guoming Zhang*, Baiying Lei*. FIT-Net: Feature Interaction Transformer Network for Pathologic Myopia Diagnosis. IEEE Trans Med Imaging. 2023 Sep;42(9):2524-2538.doi: 10.1109/TMI.2023.3260990.
24. Xie H, Liu Y, Lei H, Song T, Yue G, Du Y, Wang T, Zhang G*, Lei B*. Adversarial learning-based multi-level dense-transmission knowledge distillation for AP-ROP detection. Med Image Anal. 2023 Feb;84:102725. doi: 10.1016/j.media.2022.102725. Epub 2022 Dec 9.
25. Guoming Zhang, Xianlu Zeng, Xin Hao, Beibei Qin, Yinsheng Zhang*. TraineR:A crowd training platform for deep learning image labeling tasks. Software Impacts, 2022 Dec 1. DOI:https://doi.org/10.1016/j.simpa.2022.100450.
26. Ya-Ling Liu, Ya-Rou Hu, Miao-Hong Chen, Zhen Yu, Guo-Ming Zhang*. Role of the ultra-wide-field imaging system in the diagnosis of pigmented paravenous chorioretinal atrophy. Int J Ophthalmol, 2022 Nov 18;15(11):1878-1880. doi: 10.18240/ijo.2022.11.21. eCollection 2022.
27. Xiaofeng Lu#, Xianlu Zeng#, Miaohong Chen, Zixin Fan, Lei Zheng, Ya Tian, Shaochong Zhang, Ji C He*, Guoming Zhang*. Refractive and biometrical characteristics of children with retinopathy of prematurity who received laser photocoagulation or intravitreal ranibizumab injection. Graefes Arch Clin Exp Ophthalmol, 2022 Oct;260(10):3213-3219. doi: 10.1007/s00417-022-05663-0. Epub 2022 May 12.
28. Xianlu Zeng, Miaohong Chen, Lei Zheng, Ruyin Tian, Yi Chen, Honghui He, Jian Zeng, Jicang He* and Guoming Zhang*. Study of the Biological Developmental Characteristics of the Eye in Children After Laser Surgery for the Treatment of Retinopathy of Prematurity. Frontiers in Medicine,2022 Jan 25;8:783552. doi: 10.3389/fmed.2021.783552.
29. Yuhang Yang, Qian Yang, Sisi Luo, Yinsheng Zhang, Chaohui Lian, Honghui He, Jian Zeng, and Guoming Zhang*. Comparative Analysis Reveals Novel Changes in Plasma Metabolites and Metabolomic Networks of Infants With Retinopathy of Prematurity. Invest Ophthalmol Vis Sci. 2022 Jan 3;63(1):28. doi: 10.1167/iovs.63.1.28.
30. Rugang Zhang#，Jinfeng Zhao#，Hai Xie，Tianfu Wang，Guozhen Chen，Guoming Zhang*，Baiying Lei*. Automatic diagnosis for aggressive posterior retinopathy of prematurity via deep attentive convolutional neural network. Expert Systems With Applications, 2022，doi:10.1016/j.eswa.2021.115843.
31. Baiying Lei#, Xianlu Zeng#, Shan Huang, Rugang Zhang, Guozhen Chen, Jinfeng Zhao, Tianfu Wang, Jiantao Wang*, Guoming Zhang*. Automated detection of retinopathy of prematurity by deep attention network. Multimed Tools Appl (2021). https://doi.org/10.1007/s11042-021-11208-0（IF2.2020）
32. Yinsheng Zhang*，Qian Shang，Guoming Zhang*. pyDRMetrics - A Python toolkit for dimensionality reduction quality assessment. Heliyon. 2021 Feb 6;7(2):e06199.doi: 10.1016/j.heliyon.2021.e06199. （最新IF3.776 Q1）
33. Xie Hai, Zeng Xianlu, Lei Haijun, Du Jie, Wang Jiantao, Zhang Guoming*, Cao Jiuwen, Wang Tianfu, Lei Baiying*. Cross-attention Multi-branch Network for Fundus Diseases Classification Using SLO Images [J]. Medical Image Analysis, 2021 Jul;71:102031.doi: 10.1016/j.media.2021.102031. （2020IF=11.148, Top, 中科院一区）
34. Zhenquan Wu,Jinfeng Zhao,Waiching Lam,Jian Zeng, Guoming Zhang*. Comparison of Clinical Outcomes of Conbercept versus Ranibizumab Treatment for Retinopathy of Prematurity: A Multi-central Prospective Randomized Controlled Trial. Br J Ophthalmol. 2022 Jul;106(7):975-979. doi: 10.1136/bjophthalmol-2020-318026. Epub 2021 Feb 26.
35. Hai Xie , Haijun Lei, Xianlu Zeng, Yejun He, Guozhen Chen, Ahmed Elazab, Guanghui Yue, Jiantao Wang , Guoming Zhang*, Baiying Lei*. AMD-GAN: Attention encoder and multi-branch structure based generative adversarial networks for fundus disease detection from scanning laser ophthalmoscopy images[J]. Neural networks : the official journal of the International Neural Network Society. 2020 Dec;132:477-490. doi: 10.1016/j.neunet.2020.09. 005. Epub 2020 Sep 17.(IF=5.7850)
36. Jinfeng Zhao，Zhenquan Wu，Waiching Lam，Mingmin Yang，Lu Chen，Lei Zheng，Fuyan Zhang，Jian Zeng，Jiantao Wang，Guoming Zhang*. Comparison of OCT angiography in children with a history of intravitreal injection of ranibizumab versus laser photocoagulation for retinopathy of prematurity. Br J Ophthalmol , 2020 Nov;104(11):1556-1560. doi:10.1136/bjophthalmol-2019-315520. (IF:3.615)
37. Guoming Zhang* , Mingmin Yang#, Zhenquan Wu ， Waiching Lam , Chaohui Lian , Guanglin Zhao , Jian Zeng, Yuxing Qiu, Na Li, Runsen Zhuang, Shenzhen Screening for Retinopathy of Prematurity Cooperative Group. Changes in the Incidence of Retinopathy of Prematurity in Extremely Low Birth Weight Infants in South China From 2004 to 2018. Ophthalmic Epidemiol,2021 Aug;28(4):359-364. doi: 10.1080/09286586.2020.1826542.
38. Lu Chen#, Meizhou Liu#, Zheng Zhang, Kun Qiao, Ting Huang, Miaohong Chen, Na Xin, Zuliang Huang, Lei Liu*, Guoming Zhang*, Jiantao Wang*. Ocular manifestations of a hospitalised patient with confirmed 2019 novel coronavirus disease. Br J Ophthalmol. 2020 Jun;104(6):748-751.doi: 10.1136/bjophthalmol-2020-316304. Epub 2020 Apr 7. (IF:3.615)
39. Yuhang Yang, Zhenquan Wu, Sitao Li, Mingmin Yang, Xin Xiao, Chaohui Lian, Wei Wen, Honghui He, Jian Zeng, Jiantao Wang, and Guoming Zhang*. Targeted Blood Metabolomic Study on Retinopathy of Prematurity. Invest Ophthalmol Vis Sci. 2020;61(2):12. https://doi.org/10.1167/iovs.61.2.12.
二、指南与专家共识
1. 张国明,魏文斌,林浩添,等. 人工智能技术辅助早产儿视网膜病变诊疗专家共识(2023)[Ｊ]. 山东大学耳鼻喉眼学报,2025年3月.
2. 中华医学会眼科学分会眼底病学组,中国医师协会眼科医师分会眼底病专委会.中国早产儿视网膜病变分类和治疗专家共识（2023年）.中华眼底病杂志,2023年9月；
3. 中华医学会眼科学分会眼底病学组，中国医师协会眼科医师分会眼底病学组.中国年龄相关性黄斑变性临床诊疗指南（2023年）,中华眼科杂志,2023年5月；
4. 中华医学会眼科学分会眼底病学组，中国医师协会眼科医师分会眼底病学组.我国糖尿病视网膜病变临床诊疗指南（2022年）.中华眼底病杂志,2023年2月；
5. 海峡两岸医药卫生交流协会眼科专业委员会小儿视网膜学组，中华医学会眼科学分会眼底病学组.早产儿视网膜病变玻璃体腔注射抗血管内皮生长因子药物治疗的专家共识. 中华眼底病杂志，2021年11月.
三、课题：
1. 深圳医学科学院，医学研究专项项目，C2301005，融合大数据智能分析构建早产儿视网膜病变的早期诊断及预后评估新模型研究，200万，2024/1-2027/12，主持；
2. 国家自然科学基金委员会，面上项目, 82271103,二十烷二酸结合PPARδ促进ANGPTL4表达在早产儿视网膜病变病理性新生血管生成中的作用机制研究，52万，2023/1-2026/12，主持；
3. 广东省基础与应用基础研究基金委员会，面上项目，2022A1515012326，PI3Kδ 促进乙酰辅酶 A 羧化酶的表达在 ROP 早期病理性新生血管生成中的作用机制研究，10万，2022/1/1-2024/12/31，主持；
4. 深圳市科技创新委员会，深港联合资助项目（A类），SGDX20190920110403741：基于深度注意力网络和纵向学习用于早产儿视网膜病变自动诊断和疗效评估的研究. 300万，2020/9/17-2022/9/17，主持。
四、奖励：
1. 张国明（1/10）：小儿致盲性视网膜疾病发病机理研究及诊疗技术推广应用. 中国医药教育协会科学技术奖二等奖，2023/11/18；
2. 张国明（1/8）：小儿致盲性视网膜疾病关键诊疗技术系列研究. 深圳市科技进步奖二等奖, 2023/06；
3. 张国明（1/9）：小儿视力残疾临床康复前移体系研究. 广东省康复医学会科学技术奖二等奖，2022/7/20；
4. 张国明（2/7）：早产儿视网膜病诊疗的关键技术与应用. 广东省医学科技奖三等奖，2022/1/13；
5. 张国明（2/8）：早产儿视网膜病防治体系创新与应用.全国妇幼健康科学技术奖三等奖，2019。
五、专著：
1. 张国明（主编）：《新生儿视网膜疾病筛查与防治》，人民卫生出版社，2021年；
2. 张国明（主译） ：《儿童视网膜血管疾病——从血管造影到玻璃体切割术》（译作），广东科技出版社，2023年；
3. 张国明（副主编）：《图说小儿眼底病》，人民卫生出版社, 2018。
六、发明专利
1. 张国明（2/5）：利用增强的先导编辑阻断异常血管生成的药剂及制备方法，2024/11/22，ZL 2023 1 1711932.2；
2. 张国明（1/10）：早产儿视网膜病变治疗方式的自动识别方法及系统，2024/9/24，ZL 2023 1 0748335.0；
3. 张国明（1/13）：视网膜病变检测方法、装置及计算机可读存储介质，2023/5/26,ZL 2018 1 1642037.9；
4. 张国明（2/6）：一种眼科模拟教学设备及方法，2022/10/25，ZL 2022 1 0112036.3.