目录
更新日期:2024年10月12日
姓 名 陈逢生 性 别
民 族 汉族 导师层次 博士导师
技术职称 主任医师 导师类型 专业型
最后学历 博士研究生毕业 最后学位 医学博士学位
行政职务 副主任 Email fsc0126@163.com
工作单位 中西医结合医院 邮政编码 510315
跨学科招生
跨学科招生专业1 中医内科学 招生层次类型1 学术学位硕导
跨学科招生专业2 招生层次类型2
个人简介

中国抗癌协会青年理事会理事、广州抗癌协会消化道肿瘤青年委员会副主任委员、广东省医院协会肿瘤防治管理分会肿瘤生物治疗专业委员会常委、广东省中西医结合学会肝胆胰肿瘤专业委员会委员兼秘书、广东省医学会肝癌分会委员、广州抗癌协会生物治疗专业委员会委员兼秘书、广东省肝脏病学会综合治疗专业委员会委员。曾于美国哈佛医学院附属麻省总医院及美国密西根州立大学医学院访问学习。主持及参与多项国家级及省级自然科学基金课题,发表SCI论文及国内核心期刊论文20余篇。医疗擅长:主要从事肝脏疾病及恶性肿瘤的临床工作,熟悉各种常见肝病的综合诊治及实体肿瘤的化疗、生物治疗、靶向治疗、微创治疗及综合治疗,以肝癌、胆囊癌及胰腺癌为主要研究方向,并擅长肝脏肿瘤的微创治疗。

 

 

研究领域

(1) FOXA1调控PI3K/AKT通路介导表观遗传改变影响肝细胞癌侵袭转移的研究

(2) FOXA1调控肝癌细胞Warburg效应的机制研究

(3) CDS1调控肝细胞癌侵袭转移的机制研究

个人成果

(1)Junhao Lin, Chunting Zeng, JiaKang Zhang, Zhenghui Song, Na Qi, Xinhui Liu, Ziyan Zhang, Aimin Li(*), Fengsheng Chen(*), EFNA4 promotes cell proliferation and tumor metastasis in hepatocellular carcinoma through a PIK3R2/GSK3β/β-catenin positive feedback loop, Molecular Therapy - Nucleic Acids, Volume 25, 2021, Pages 328-341

(2)He Jingcai(#); Zhang Wan; Li Aimin; *Chen Fengsheng; *Luo Rongcheng, Knockout of NCOA5 impairs proliferation and migration of hepatocellular carcinoma cells by suppressing epithelial-tomesenchymal transition, Biochemical and Biophysical Research Communications, 500(2), pp 177-183, 2018-6-2

(3)He S(#); Zhang J; Zhang W; Chen F(*); Luo R(*), FOXA1 inhibits hepatocellular carcinoma progression by suppressing PIK3R1 expression in male patients, Journal of Experimental & Clinical Cancer Research, 2017, 36(1): 175

(4)Liu X(#); Liu F(#); Gao S; Reske J; Li A; Wu CL; Yang C; Chen F; Luo R(*); Xiao H(*), A single non-synonymous NCOA5 variation in type 2 diabetic patients with hepatocellular carcinoma impairs the function of NCOA5 in cell cycle regulation, Cancer Letters, 2017, 391: 152~161

(5)Hu Y(#); Chen F; Liu F; Liu X; Huang N; Cai X; Sun Y; Li A(*); Luo R(*), Overexpression of TIP30 inhibits the growth and invasion of glioma cells, Molecular Medicine Reports, 2016, 13(1): 605~612

(6)Geng Q(#); Peng H(#); Chen F; Luo R(*); Li R(*), High expression of Sirt7 served as a predictor of adverse outcome in breast cancer, International Journal of Clinical & Experimental Pathology, 2015, 8(2): 1938~45

(7)Zhu Y(#); Cheng Y; Guo Y; Chen J; Chen F; Luo R(*); Li A(*), Protein kinase D2 contributes to TNF-α-induced epithelial mesenchymal transition and invasionviathe PI3K/GSK-3β/β-catenin pathway in hepatocellular carcinoma:, Oncotarget, 2015, 7(5): 5327~5341

(8)Shuai S(#); Yan X; Zhang J; Kang S; Chen F; Luo R(*); Li A(*), TIP30 nuclear translocation negatively regulates EGF-dependent cyclin D1 transcription in human lung adenocarcinoma, Cancer Letters, 2014, 354(1): 200~209

(9)Chen F(#); Li A(#); Gao S; Hollern D; Williams M; Liu F; Vansickle EA; Andrechek E; Zhang C; Yang C; Luo R(*); Xiao H(*), Tip30 controls differentiation of murine mammary luminal progenitor to estrogen receptor-positive luminal cell through regulating FoxA1 expression, Cell Death & Disease, 2014, 5(5): e1242

(10)Gao S(#); Li A; Liu F; Chen F; Williams M; Zhang C; Kelley Z; Wu CL; Luo R(*); Xiao H(*), NCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinoma, Cancer Cell, 2013, 24(6): 725~737

(11)Li A(#); Zhang C; Gao S; Chen F; Yang C; Luo R(*); Xiao H(*), TIP30 loss enhances cytoplasmic and nuclear EGFR signaling and promotes lung adenocarcinogenesis in mice, Oncogene, 2013, 32(18): 1~12

(12)Chen F(#); Luo X; Zhang J; Lu Y; Luo R(*), Elevated serum levels of TPS and CYFRA 21-1 predict poor prognosis in advanced non-small-cell lung cancer patients treated with gefitinib, Medical Oncology, 2010, 27(3): 950~957