长期从事恶性肿瘤的临床与科研工作。目前主要从事胃肠肿瘤的综合诊疗，在疑难肿瘤病例诊治中具有丰富经验。同时，致力于胃肠肿瘤耐药、肿瘤微环境免疫代谢交互等领域的机制及转化研究。主要研究方向：构建基于分子检测的胃肠肿瘤个体化治疗；探索胃肠肿瘤化疗、靶向和免疫治疗的耐药机制及其逆转策略；开发基于生物信息学、数学建模的胃肠肿瘤精准治疗决策体系等。先后主持国家自然科学基金4项，广东省科技计划3项，横向科学课题基金8项，以骨干成员参与国家重点研发计划1项，以第一发明人获授权发明专利2项。以第一作者（共同一作）或通讯作者（共同通讯）在Cell Metabolism、Cell Reports Medicine、Med、Molecular Cancer、Cancer Research、Cancer Immunology Research、Cancer Communications、Oncogene等期刊发表SCI论文20余篇，其中IF>10共13篇，累计IF288.5。

1. Jiang Y^#, Wang Y^#, Chen G^#, Sun F, Wu Q, Huang Q, Zeng D, Qiu W, Wang J, Yao Z, Liang B, Li S, Wu J, Huang N, Wang Y, Chen J, Zhai X, Huang L, Xu B, Yamamoto M, Tsukamoto T, Nomura S, Liao W, Shi M^*. Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer. Cell Metab. 2024 Aug 6;36(8):1806-1822.e11. (IF:27.7,通讯作者)
2. Shi M^#, Yang Y^#, Huang N^#, Zeng D^#, Mo Z, Wang J, Zhang X, Liu R, Wang C, Rong X, Wu Z, Huang Q, Shang H, Tang J, Wang Z, Cai J, Huang G, Guan Y, Guo J, Mu Q, Wang J, Liao W. Genetic and microenvironmental evolution of colorectal liver metastases under chemotherapy. Cell Rep Med. 2024 Dec 17;5(12):101838. （IF: 11.7,第一作者）
3. Shi M^#, Zeng D^#, Luo H^#, Xiao J, Li Y, Yuan X, Huang N, Wu J, Zheng S, Wu J, Li S, Rong X, Wang C, Jiang L, Mao Q, Qiu W, Guo J, Deng Q, Sun H, Lu X, Yu Y, Lai Y, Fang Y, Zhou R, Wang L, Huang X, Kong Y, Li J, Liang L, Bin J, Liao Y, Liao W. Tumor microenvironment RNA test to predict immunotherapy outcomes in advanced gastric cancer: The TIMES001 trial. Med. 2024 Nov 8;5(11):1378-1392.e3.(IF: 12.8，第一作者)
4. Liang B^#, Wu Q^#, Wang Y^#, Shi Y, Sun F, Huang Q, Li G, Liu Y, Zhang S, Xu X, Yao G, Peng J, Zhai X, Wu J, Tan Y, Wu Z, Zhou R, Li S, Wu J, Yang M, Liao W, Shi M^*. Cdc42-driven endosomal cholesterol transport promotes collateral resistance in HER2-positive gastric cancer. Cancer Lett. 2024 Apr 10;587:216702.(IF:9.1,通讯作者)
5. Hu X^#, Ma Z^#, Xu B^#, Li S, Yao Z, Liang B, Wang J, Liao W, Lin L, Wang C, Zheng S, Wu Q, Huang Q, Yu L, Wang F, Shi M^*. Glutamine metabolic microenvironment drives M2 macrophage polarization to mediate trastuzumab resistance in HER2-positive gastric cancer. Cancer Commun (Lond). 2023 Aug;43(8):909-937.（IF:20.1,通讯作者）
6. Wang J^#, Huang Q^#, Hu X^#, Zhang S^#, Jiang Y, Yao G, Hu K, Xu X, Liang B, Wu Q, Ma Z, Wang Y, Wang C, Wu Z, Rong X, Liao W, Shi M^*. Disrupting circadian rhythm via the PER1-HK2 axis reverses trastuzumab resistance in gastric cancer. Cancer Res. 2022 Mar 7:canres.1820.2021.（IF: 13.312，通讯作者）
7. Huang N^#, Zeng D^#, Rong X^#, Wang C, Wu Z, Guo J, Wang Y, Li J, Li J, Wang J, Zheng S, Huang G, Bin J, Liao Y, Li Q, Yi X, Liao W, Shi M^*. Evolution of tumor microenvironment in colorectal liver metastases under treatment stress. Cancer Commun (Lond). 2022 Jan 15.（IF: 20.1，通讯作者）
8. Wu Q^#, Huang Q^#, Jiang Y, Sun F, Liang B, Wang J, Hu X, Sun M, Ma Z, Shi Y, Liang Y, Tan Y, Zeng D, Yao F, Xu X, Yao Z, Li S, Rong X, Huang N, Sun L, Liao W, Shi M^*. Remodeling Chondroitin-6-Sulfate-Mediated Immune Exclusion Enhances Anti-PD-1 Response in Colorectal Cancer with Microsatellite Stability. Cancer Immunol Res. 2022 Feb;10(2):182-199. （IF: 12.020，通讯作者）
9. Huang Q^#, Li S^#; Hu X, Sun M, Wu Q, Dai H, Tan Y, Sun F, Wang C, Rong X, Liao W, Peng J, Xiao J, Huang L, Wang J, Liang B, Lin K, Liu Y, Shi M^*. Shear stress activates ATOH8 via autocrine VEGF promoting glycolysis dependent-survival of colorectal cancer cells in the circulation, J Exp Clin Cancer Res, 2020;39(1):25.（IF: 12.658，通讯作者）
10. He W^#, Liang B^#, Wang C^#, Li S, Zhao Y, Huang Q, Liu Z, Yao Z, Wu Q, Liao W, Zhang S, Liu Y, Xiang Y, Liu J, Shi M^*. MSC-regulated lncRNA MACC1-AS1 promotes stemness and chemoresistance through fatty acid oxidation in gastric cancer. Oncogene. 2019; 38(23): 4637-4654.（IF：8.756，通讯作者）
11. Tan Y^#, Lin K^#, Zhao Y^#, Wu Q, Chen D, Wang J, Liang Y, Li J, Hu J, Wang H, Liu Y, Zhang S, He W, Huang Q, Hu X, Yao Z, Liang B, Liao W,  Shi M^*. Adipocytes fuel gastric cancer omental metastasis via PITPNC1-mediated fatty acid metabolic reprogramming. Theranostics. 2018;8(19):5452-5468.（IF：11.600，通讯作者）
12. Zhang S^#, Liu Y^#, Derakhshanfar S, He W, Huang Q, Dong S, Rao J, Luo GX, Zhong W, Liao W,  Shi M^*, Xing M^*. Polymer Self-Assembled BMSCs with Cancer Tropism and Programmed Homing. Adv Healthc Mater. 2018;7(23):e1800118.（IF：11.092，共同通讯作者）
13. Zhao Y^#, Liu Y^#, Lin L, Huang Q, He W, Zhang S, Dong S, Wen Z, Rao J, Liao W,  Shi M^*. The lncRNA MACC1-AS1 promotes gastric cancer cell metabolic plasticity via AMPK/Lin28 mediated mRNA stability of MACC1. Mol Cancer. 2018;17(1):69. （IF：41.444，通讯作者）
14. Zhao Y^#, Hu X^#, Liu Y, Dong S, Wen Z, He W, Zhang S, Huang Q, Shi M*. ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway. Mol Cancer. 2017;16(1):79.（IF：41.444，通讯作者）
15. Chen J^#, Shi M^#, Liu P, Ko A, Zhong W, Liao W^*, Xing MM^*. Reducible polyamidoamine-magnetic iron oxide self-assembled nanoparticles for doxorubicin delivery. Biomaterials. 2014;35(4):1240-1248.（IF：15.304，共同一作）