南方医科大学南方医院肿瘤科主任医师,博士研究生导师,科室副主任,医学博士,中山大学博士后,曾任美国南加州大学Norris综合癌症中心副研究员。广东省药学会肿瘤精准诊疗专家委员会主任委员;广东省胸部疾病学会肺癌多学科协作委员会副主任委员;广东省医师协会肿瘤科分会常委,广东省胸部疾病学会免疫专业委员会常委,广东省医药企业管理协会医药成果转化应用分会常务理事,广东抗癌协会食管癌专业委员会委员,广州抗癌协会肺癌专业委员会常委,欧美同学会.广东分会理事,ASCO,ESMO,ATS会员。从事肿瘤学的临床、教学与科研工作三十余年,主攻肺癌的诊断和治疗,对乳腺癌、卵巢癌、宫颈癌、头颈部肿瘤、食管癌、胃癌、结直肠癌等恶性肿瘤的诊断和治疗及肿瘤免疫治疗、分子靶向治疗、化疗和肿瘤急症处理积累丰富经验。主持和参研国家、省市级科研课题二十余项,发表论文四十余篇,主编和参编专著6部。
肿瘤分子诊断和靶向治疗;肿瘤微环境和免疫治疗,菌群和肺癌发生发展
代表性论文:
1.Immune cells mediated the causal relationship between the gut microbiota and lung cancer: a Mendelian randomization study. Front Microbiol. 2024 May 3:15.
2.Gut microbiota and pancreatic cancer risk, and the mediating role of immune cells and inflammatory cytokines: a Mendelian randomization study. Front Immunol. 2024 Jul 25:15.
3.Veillonella parvula promotes the proliferation of lung adenocarcinoma through the nucleotide oligomerization domain 2/cellular communication network factor 4/nuclear factor kappa B pathway. Discov Oncol. 2023 Jul 14;14(1):129.
4. Alterations of lung microbiota in patients with non-small cell lung cancer. Bioengineered. 2022 ;13(3):6665-6677.
5. Kinectin1 depletion promotes EGFR degradation via the ubiquitin-proteosome system in cutaneous squamous cell carcinoma. Cell Death Dis. 2021;12(11):995.
6. Anti-angiogenic therapy for advanced primary pulmonary lymphoepithelioma-like carcinoma: a retrospective multicenter study. J Cancer Res Clin Oncol. 2022 Apr 4.
7. MicroRNA-365 promotes lung carcinogenesis by downregulating the USP33/SLIT2/ROBO1 signalling pathway. Cancer Cell Int. 2018 ;18:64.