一、陈晓光教授承担的相关科研课题及完成情况：
1国家自然科学基金-盖茨基金会联合项目（82261128003/2022YFML1001），《高效实时户外疟疾媒介蚊虫诱捕监测技术和装置的研发》，资助金额312.5 万元，起止年月2022.10-2025.09，负责人，进行中
2.广东省重点领域研发计划项目(2022B1111030002)，重要外来入侵媒介和病原生物的防控技术和产品研发，资助金额500万元，起止年月2022.9-2025.8，负责人，进行中
3.国家科技部，重点研发计划项目，2020YFC12000100，重大外来入侵媒介和病原生物侦检与防控关键技术产品研发，2020-07至2023-06，1825万元，已结题，主持
4.国家自然科学基金委员会，重点项目，318300874，重要媒介蚊虫昼夜节律的分子调控机制，2019-01至2023-12，281万元，已资助期满，主持
5.国家自然科学基金委员会，海外及港澳学者合作项目，81829004，登革热媒介白纹伊蚊的杀虫剂抗性研究，2019-01至2022-12，180万元，已结题，主持
6.国家自然科学基金委员会，重点国际合作研究项目，81420108024，白蚊伊蚊雄性决定基因的筛选鉴定和功能研究，2015-01至2019-12，300万元，已结题，主持
7.国家自然科学基金委员会，面上项目，81371845，白纹伊蚊嗅觉系统的分子构成和功能研究，2014-01至2017-12，90万元，已结题，主持
8.美国国立卫生研究院，NIH R01课题，AI083202，Impacts of Urbanization on Vector Biology and Transmission of Dengue in China，2010-07至2014-06，67.5万美元，已结题，主持
9.国家自然科学基金委员会，NSFC-广东省联合基金，U0832004，白纹伊蚊microRNA的组学分析及其对登革病毒感染的调控研究，2009-01至2012-12，175万元，已结题，主持
10.国家自然科学基金委员会，面上项目，30771871，转基因抗疟蚊的构建及其实验室效果测试，2008-01至2010-12，35万元，已结题，主持
11.国家自然科学基金委员会，面上项目，30271162，按蚊Vg启动子和防御素基因的克隆及其转基因体系的建立，2003-01至2005-12，21万元，已结题，主持
二、陈晓光教授近五年来发表的相关研究论文（*通讯作者）
1. Liu P, Yang W, Kong L, Zhao S, Xie Z, Zhao Y, Wu Y, Guo Y, Xie Y, Liu T, Jin B, Gu J, Tu Z, James AA & Chen G. Nature Communications, 2023; 14:2292.
2.Guo Y, Hu K, Zhou J, Xie Z, Zhao Y, Zhao S, Gu J, Zhou X, Yan G, James AA and Chen XG. The dynamics of deltamethrin resistance evolution in Aedes albopictus has an impact on fitness and dengue virus type-2 vectorial capacity. BMC Biology, 2023;21:194.
3.Guo Y, Zhou J, Zhao Y, Deng J, Su X, Tang J, Zhu G, Zhou X, Gu J, Yan G, James AA, Chen XG. CRISPR/Cas9‑mediated F1534S substitution in the voltage‑gated sodium channel reveals its necessity and sufficiency for deltamethrin resistance in Aedes albopictus. Journal of Pest Science, 2023; 96:1173-1186.
4.Zhou J, Liu S, Liu H, Xie Z, Liu L, Lin L, Jiang J, Yang M, Zhou G, Gu J, Zhou X, Yan G, James AA, Chen XG. Interspecific mating bias may drive Aedes albopictus displacement of Aedes aegypti during its range expansion. PNAS Nexus, 2022;1(2):pgac041.
5.Liu S, Zhou J, Kong L, Cai Y, Liu H, Xie Z, Xiao X, James AA, Chen XG. Clock genes regulate mating activity rhythms in the vector mosquitoes, Aedes albopictus and Culex quinquefasciatus. PLoS Negl Trop Dis, 2022;16(12):e0010965.
6.Batool K, Xiao J, Xu Y, Yang T, Tao P, Zhao S, Chen J, Alam I, Xie Y, Gu J, Chen X. Densovirus oil suspension significantly improves the efficacy and duration of larvicidal activity against Aedes albopictus. Viruses, 2022;14(3):475.
7.Yang W, Zhao S, Xie Y, Liu T, Kong L, Guo Y, Xie Z, Liu P, Chen XG. Armigeres subalbatus is a potential vector for Zika virus but not dengue virus. Infect Dis Poverty, 2022;11(1):62.
8.Lai Z, Wu J, Xiao X, Xie L, Liu T, Zhou J, Xu Y, Cai Y, Lin F, Li B, Gan L, James AA, Chen XG. Development and evaluation of an efficient and real-time monitoring system for the vector mosquitoes, Aedes albopictus and Culex quinquefasciatus. PLoS Negl Trop Dis, 2022;16(9):e0010701.
9.Zhao Y, Jin B, Liu P, Xiao X, Cai L, Xie Z, Kong L, Liu T, Yang W, Wu Y, Gu J, Tu Z, James AA, Chen XG. The AalNix3&4 isoform is required and sufficient to convert Aedes albopictus females into males. PLoS Genet, 2022;18(6):e1010280.
10.Liu T, Xie Y, Liu F, Xie L, Yang W, Su X, Ou CQ, Luo L, Xiao Q, Gan L, Chen XG. A long-lasting biological larvicide against the dengue vector mosquito Aedes albopictus. Pest Manag Sci, 2021;77(2):741-8.
11.Chen XG*, Jiang X, Gu J, Xu M, Wu Y, Deng Y, Zhang C, Bonizzoni M, Dermauw W, Vontas J, Armbruster P, Huang X, Yang Y, Zhang H, He W, Peng H, Liu Y, Wu K, Chen J, Lirakis M, Topalis P, Van Leeuwen T, Hall AB, Jiang X, Thorpe C, Mueller RL, Sun C, Waterhouse RM, Yan G, Tu ZJ, Fang X*, James AA*. Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals insights into its biology, genetics, and evolution. Proc Natl Acad Sci U S A. 2015 Nov 3,112(44):E5907-15.
12. Liu Z, Zhou T, Lai Z, Zhang Z, Jia Z, Zhou G, Williams T, Xu J, Gu J, Zhou X, Lin L, Yan G, Chen XG*. Competence of Aedes aegypti, Ae. albopictus, and Culex quinquefasciatus Mosquitoes as Zika Virus Vectors, China[J]. Emerg Infect Dis, 2017,23(7):1085-1091.
13. Liu, T., Y. Wu, Y. Xie, P. Liu, L. Xie, F. Lin, C. Li, J. Gu, K. Wu, G. Yan*, and Chen XG*. Construction of an efficient genomic editing system with CRISPR/Cas9 in the vector mosquito Aedes albopictus. Insect Science. 2018;26(6):1045-1054.
14. Lai Z#, Zhou T#, Zhou J, Liu S, Xu Y, Gu J, Yan G*, Chen XG*. Vertical transmission of zika virus in Aedes albopictus. PLoS Negl Trop Dis, 2020; 14(10): e0008776.
15. Liu P#, Jin B#, Li X#, Zhao Y, Gu J, James K. Biedlerb, Zhijian Jake Tu*, Chen XG*. Nix is a male-determining factor in the Asian tiger mosquito Aedes albopictus. Insect Biochemistry and Molecular Biology, 2020;118:103311.
16. Zhou T#, Lai Z#, Liu S, Zhou J, Liu Y, Wu Y, Xu Y, Wu K, Gu J, Cheng G, Chen XG*. Susceptibility and interactions between Aedes mosquitoes and Zika viruses. Insect Science, 2020 https://doi. org/10. 1111/1744-7917.12858.
17. Liu T#, Xie Y#, Lin F#, Xie L#, Yang W, Su X, Ou CQ, Luo L, Xiao Q, Gan L, ChenXG*. A long-lasting biological larvicide against the dengue vector mosquito Aedes albopictus. Pest Manag Sci, 2021; 71:741-748.
18. 刘通， 吴恙，刘培文，杨文强，金彬彬，顾金保， 陈晓光*. 媒介蚊虫的嗅觉发生和性别决定. 中国寄生虫学与寄生虫病杂志， 2021, 39(1): 1-7.
19. Jin B, Zhao Y, Dong Y, Liu P, Sun Y, Li X, Zhang X, Chen XG*, Gu J*. Alternative splicing patterns of doublesex reveal a missing link between Nix and doublesex in the sex determination cascade of Aedes albopictus. Insect Science, 2020； https://doi.org/10.1111/1744 -7917.12886.
20. Liu H, Liu L, Cheng P, Yang L, Chen J, Lu Y, Wang H, Chen XG*, Gong M*. Bionomics and insecticide resistance of Aedes albopictus in Shandong, a high latitude and high-risk dengue transmission area in China. Parasites & Vectors, 2020; 13: 11.
21. 吴恙，周腾飞，赖泽钿，谢李华，谢雨谷，刘培文，刘通，杨文强，金彬彬，孔翎，郭怡佳，赵宜洁，邓洁琳，顾金保， 陈晓光*。蚊虫组学研究进展。环境昆虫学报， 2020，
42（4）： 789-797.
22. Su X, Guo Y, Deng J, Xu J, Zhou G, Zhou T, Li Y, Zhong D, Kong L, Wang X, Liu M, Wu K, Yan G*, Chen XG*. Fast emerging insecticide resistance in Aedes albopictus in Guangzhou, China: Alarm to the dengue epidemic. PLoS Negl Trop Dis, 2019.
23. Xie L, Yang W, Liu H, Liu T, Xie Y, Lin F, Zhou G, Zhou X, Wu K, Gu J, Yan G, Chen XG*. Enhancing attraction of the vector mosquito Aedes albopictus by using a novel synthetic odorant blend. Parasites & Vectors 2019, 12(1): 382.
24. Qi Y#, Wu Y#, Saunders R, Chen XG, Mao C, Biedler J K*, Tu Z J*. Guy1, a Y-linked embryonic signal, regulates dosage compensation in Anopheles stephensi by increasing X gene expression. eLife, 2019. 8 : e43570.
25. Liu M, Li F, Li C, Li X, Chen L, Wu K, Yang P, Lai Z, Liu T, Sullivan W J, Cui L, Chen XG*. Characterization of protein arginine methyltransferase of TgPRMT5 in Toxoplasma gondii. Parasites & Vectors, 2019,12(1):221.
26. Wu P, Sun P, Nie K, Zhu Y, Shi M, Xiao C, Liu H, Liu Q, Zhao T, Chen XG, Zhou H, Wang P, Cheng G. A Gut Commensal Bacterium Promotes Mosquito Permissiveness to Arboviruses. CELL HOST MICROBE 2019, 25(1): 101-112.
27. Li X#, Jin B#, Dong Y, Chen XG*, Tu Z, Gu J*. Two of the three Transformer-2 genes are required for ovarian development in Aedes albopictus. Insect Biochemistry and Molecular Biology 2019, 109: 92-105.
28. Liu H, Xie L, Cheng P, Xu J, Huang X, Wang H, Song X, Liu L, Wang H, Kou J, Yan G, Chen XG*, Gong M*. Trends in insecticide resistance in Culex pipiens pallens over 20 years in Shandong, China. Parasites & Vectors 2019; 12: 167.
29. Wu Y, Hu W, Biedler JK, Chen XG*, Tu ZJ*. Pure early zygotic genes in the Asian malaria mosquito Anopheles stephensi. Parasites & Vectors 2018; 11(Suppl 2): 652.
30. Xu J, Bonizzoni M, Zhong D, Li Y, Su X, Zhou G, Nguyen H, Tong S, Yan G, Chen XG*. Comparative transcriptome analysis and RNA interference reveal CYP6A8 and SNPs related to pyrethroid resistance in Aedes albopictus. PLoS Negl Trop Dis. 2018;12(11):e0006828.
31. Chen, L., X. Han, F. Li, Y. Yao, J. Fang, X. Liu, X. Li, K. Wu, M. Liu*, and Chen XG*. Comparative studies of Toxoplasma gondii transcriptomes: insights into stage conversion based on gene expression profiling and alternative splicing. Parasit Vectors. 2018; 11: 402.
32. Wang, X., T. Liu, Y. Wu, D. Zhong, G. Zhou, X. Su, J. Xu, C. F. Sotero, A. A. Sadruddin, K. Wu*, Chen XG*, and G. Yan*. Bacterial microbiota assemblage in Aedes albopictus mosquitoes and its impacts on larval development. Molecular Ecology 2018; 27 (14):2972
-2985.
33. Li Y, Xu J, Zhong D, Zhang H, Yang W, Zhou G, Su X, Wu Y, Wu K, Cai S, Yan G* and Chen XG*. Evidence for multiple-insecticide resistance in urban Aedes albopictus populations in southern China. Parasit Vectors 2018;11(1):4.
34. Liu T, Xu Y, Wang X, Gu J, Yan G, Chen XG*. Antiviral systems in vector mosquitoes, Developmental and Comparative Immunology. 2018, 83:34-43.
35. 贾志荣,刘转转,王晓明,Tricia WILLIAMS,刘培文,李小聪,闫桂云,陈晓光*。 白纹伊蚊抗溴氰菊酯品系的筛选及其对登革病毒的易感性.昆虫学报,2018,61(01):11-17.
36. Liu Z# , Zhang Z# , Lai Z, Zhou T, Jia Z, Gu J, Wu K and Chen XG*. Temperature Increase Enhances Aedes albopictus Competence to Transmit Dengue Virus. Front. Microbiol. 2017;8:2337
37. Xu J, Bonizzoni M, Zhong D, Zhou G, Cai S, Li Y, Wang X, Lo E, Lee R, Sheen R, Duan J, Yan G*, Chen XG*. Multi-country Survey Revealed Prevalent and Novel F1534S Mutation in Voltage-Gated Sodium Channel (VGSC) Gene in Aedes albopictus. PLoS Negl Trop Dis. 2016;10(5):e0004696
38. Li Y, Su X, Zhou G, Zhang H, Puthiyakunnon S, Shuai S, Cai S, Gu J, Zhou X, Yan G, Chen XG*. Comparative evaluation of the efficiency of the BG-Sentinel trap, CDC light trap and Mosquito-oviposition trap for the surveillance of vector mosquitoes Parasit Vectors. 2016;9(1):446
39. Huang X, Chen XG, Armbruster PA. Comparative performance of transcriptome assembly methods for non-model organisms. BMC Genomics. 2016;17:523
40. Chang X, Zhong D, Lo E, Fang Q, Bonizzoni M, Wang X, Lee MC, Zhou G, Zhu G, Qin Q, Chen XG, Cui L, Yan G. Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in Anopheles sinensis. Parasit Vectors 2016;9:228
41. Battaglia V, Gabrieli P, Brandini S, Capodiferro MR, Javier PA, Chen XG, Achilli A, Semino O, Gomulski LM, Malacrida AR, Gasperi G, Torroni A, Olivieri A. The Worldwide Spread of the Tiger Mosquito as Revealed by Mitogenome Haplogroup Diversity. Frontiers in Genetics. 2016;7:208
42. Liu P, Dong Y, Gu J*, Puthiyakunnon S, Wu Y, Chen XG*. Developmental piRNA profiles of the invasive vector mosquito Aedes albopictus. Parasit Vectors. 2016;9(1):524
43. Liu P, Li X, Gu J*, Dong Y, Liu Y, Santhosh P, Chen XG*. Development of non-defectiverecombinant densovirus vectors for microRNA delivery in the invasive vector mosquito, Aedes albopictu Sci Rep. 2016;6:20979
44. Liu YX, Li FX, Liu ZZ, Jia ZR, Zhou YH, Zhang H, Yan H, Zhou XQ, Chen XG*. Integrated analysis of miRNAs and transcriptomes in Aedes albopictus midgut reveals the differential expression profiles of immune-related genes during dengue virus serotype-2 infection. Insect Sci. 2016;23(3):377-85
45. Liu H, Liu T, Xie L, Wang X, Deng Y, Chen CH, James AA, Chen XG*. Functional analysis of Orco and odorant receptors in odor recognition in Aedes albopictus Parasit Vectors. 2016;9(1):363
三、主要科研奖励
1.2019年三月二十七日：陈晓光、林立丰、顾金保、郑学礼、陈清、周晓红、蔡松武、王春梅、吴焜、刘礼平、李华、段金花完成的“重要媒介蚊虫防制的关键科学技术”，获2018年广东省科学进步一等奖，广东省人民政府。
2.2018年十二月二十八日：陈晓光、林立丰、顾金保、郑学礼、陈清、周晓红、蔡松武、王春梅、吴焜、刘礼平、李华、段金花完成的“重要媒介蚊虫防制的关键科学技术”，获2018年中华医学科技奖三等奖。中华医学会。
3.2018年十月十日：陈晓光、林立丰、顾金保、郑学礼、陈清、周晓红、蔡松武、王春梅、吴焜、刘礼平、李华、段金花完成的“重要媒介蚊虫防制的关键科学技术”，获2018年华夏医学科技奖三等奖。中国医疗保健国际交流促进会
4.2017年一月四日：陈晓光获第十四届广东省丁颖科技奖。广东省科协。